ATE84547T1 - Gereinigtes interleukin-1. - Google Patents

Gereinigtes interleukin-1.

Info

Publication number
ATE84547T1
ATE84547T1 AT85301752T AT85301752T ATE84547T1 AT E84547 T1 ATE84547 T1 AT E84547T1 AT 85301752 T AT85301752 T AT 85301752T AT 85301752 T AT85301752 T AT 85301752T AT E84547 T1 ATE84547 T1 AT E84547T1
Authority
AT
Austria
Prior art keywords
new
amino acid
cloning vector
interleukin
daltons
Prior art date
Application number
AT85301752T
Other languages
English (en)
Inventor
Douglas P Cerretti
Iii Paul J Conlon
David J Cosman
Kenneth H Grabstein
Thomas P Hopp
Shirley R Kronheim
Alf D Larsen
Carl J March
Virginia L Price
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE84547(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/676,533 external-priority patent/US5484887A/en
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of ATE84547T1 publication Critical patent/ATE84547T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT85301752T 1984-06-19 1985-03-13 Gereinigtes interleukin-1. ATE84547T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US62220184A 1984-06-19 1984-06-19
US63500684A 1984-07-27 1984-07-27
US67455584A 1984-11-26 1984-11-26
US06/676,533 US5484887A (en) 1984-06-19 1984-11-30 Homogeneous interleukin 1
US68764684A 1984-12-31 1984-12-31
EP85301752A EP0165654B1 (de) 1984-06-19 1985-03-13 Gereinigtes Interleukin-1

Publications (1)

Publication Number Publication Date
ATE84547T1 true ATE84547T1 (de) 1993-01-15

Family

ID=27542003

Family Applications (2)

Application Number Title Priority Date Filing Date
AT91201769T ATE195344T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen
AT85301752T ATE84547T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT91201769T ATE195344T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen

Country Status (10)

Country Link
EP (2) EP0456332B1 (de)
JP (3) JP3217698B2 (de)
AT (2) ATE195344T1 (de)
AU (1) AU579142B2 (de)
CA (2) CA1341433C (de)
DE (2) DE3588224T2 (de)
DK (2) DK168048B1 (de)
IE (1) IE61353B1 (de)
MX (1) MX9203654A (de)
NZ (1) NZ211386A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
EP0569687B1 (de) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
DE3587605T2 (de) * 1984-12-25 1994-03-17 Dainippon Pharmaceutical Co Interleukin-1 und dessen Derivat.
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
EP0200986B2 (de) * 1985-04-25 1998-03-11 F. Hoffmann-La Roche Ag Rekombinantes Humaninterleukin-1
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4894333A (en) * 1987-05-28 1990-01-16 Immunex Corporation Bovine interleukin-1α
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
GB9010356D0 (en) * 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
DE60231845D1 (de) * 2001-12-11 2009-05-14 Univ New Jersey Med Diagnoseverfahren für proteinprofilierung
RU2302460C1 (ru) * 2005-11-02 2007-07-10 Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBi101-IL18, КОДИРУЮЩАЯ СИНТЕЗ ИНТЕРЛЕЙКИНА-18 ЧЕЛОВЕКА В ТРАНСГЕННЫХ РАСТЕНИЯХ
JP2008543975A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378128D1 (en) * 1982-04-20 1988-11-03 Sloan Kettering Inst Cancer Purification of interleukin 2
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene

Also Published As

Publication number Publication date
DK37293A (da) 1993-03-30
CA1340978C (en) 2000-05-02
DE3588224T2 (de) 2001-10-25
DK168048B1 (da) 1994-01-24
JP3217698B2 (ja) 2001-10-09
DE3586972T2 (de) 1993-07-08
EP0456332B1 (de) 2000-08-09
AU3986385A (en) 1986-01-02
EP0456332A1 (de) 1991-11-13
CA1341433C (en) 2003-06-24
JPH09118697A (ja) 1997-05-06
ATE195344T1 (de) 2000-08-15
EP0165654A2 (de) 1985-12-27
IE850614L (en) 1986-09-08
JP2000060577A (ja) 2000-02-29
DE3586972D1 (de) 1993-02-25
AU579142B2 (en) 1988-11-17
JP3009381B2 (ja) 2000-02-14
DK37293D0 (da) 1993-03-30
NZ211386A (en) 1989-04-26
JPH10279598A (ja) 1998-10-20
DK110485D0 (da) 1985-03-11
EP0165654B1 (de) 1993-01-13
IE61353B1 (en) 1994-11-02
EP0165654A3 (en) 1988-05-04
MX9203654A (es) 1992-07-01
DE3588224D1 (de) 2000-09-14
DK110485A (da) 1985-12-20

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EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee