ATE195348T1 - Polysaccharide mit hohem anteil an iduronsäure - Google Patents

Polysaccharide mit hohem anteil an iduronsäure

Info

Publication number: ATE195348T1
Authority: AT; Austria
Prior art keywords: pct; polysaccharides; iduronic acid; sulfation; sec
Prior art date: 1994-11-04

Application number

AT95937026T

Other languages

English (en)

Inventor

Giorgio Zoppetti

Pasqua Oreste

Giovanni Cipolletti

Original Assignee

Inalco Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-04

Filing date

1995-10-30

Publication date

2000-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11369805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE195348(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-10-30 Application filed by Inalco Spa filed Critical Inalco Spa

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE195348T1 publication Critical patent/ATE195348T1/de

Links

150000004676 glycans Chemical class 0.000 title abstract 3
229920001282 polysaccharide Polymers 0.000 title abstract 3
239000005017 polysaccharide Substances 0.000 title abstract 3
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 title abstract 2
AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical compound OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 title abstract 2
229920002971 Heparan sulfate Polymers 0.000 abstract 3
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
238000005670 sulfation reaction Methods 0.000 abstract 2
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
241000588724 Escherichia coli Species 0.000 abstract 1
239000007995 HEPES buffer Substances 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
102000004879 Racemases and epimerases Human genes 0.000 abstract 1
108090001066 Racemases and epimerases Proteins 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
239000007853 buffer solution Substances 0.000 abstract 1
238000003381 deacetylation reaction Methods 0.000 abstract 1
238000006345 epimerization reaction Methods 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
235000011164 potassium chloride Nutrition 0.000 abstract 1
239000001103 potassium chloride Substances 0.000 abstract 1
239000012429 reaction media Substances 0.000 abstract 1
230000019635 sulfation Effects 0.000 abstract 1
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Materials Engineering (AREA)
Biotechnology (AREA)
Polymers & Plastics (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT95937026T 1994-11-04 1995-10-30 Polysaccharide mit hohem anteil an iduronsäure ATE195348T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI942240A IT1271057B (it)	1994-11-04	1994-11-04	Polisaccaridi aventi un elevato contenuto di acido iduronico
PCT/EP1995/004241 WO1996014425A1 (en)	1994-11-04	1995-10-30	Polysaccharides having a high iduronic acid content

Publications (1)

Publication Number	Publication Date
ATE195348T1 true ATE195348T1 (de)	2000-08-15

Family

ID=11369805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937026T ATE195348T1 (de)	1994-11-04	1995-10-30	Polysaccharide mit hohem anteil an iduronsäure

Country Status (13)

Country	Link
US (1)	US5958899A (de)
EP (1)	EP0789777B1 (de)
JP (1)	JP3640259B2 (de)
CN (1)	CN1094977C (de)
AT (1)	ATE195348T1 (de)
AU (1)	AU3926195A (de)
CA (1)	CA2204366A1 (de)
DE (1)	DE69518333T2 (de)
DK (1)	DK0789777T3 (de)
ES (1)	ES2150589T3 (de)
IT (1)	IT1271057B (de)
PT (1)	PT789777E (de)
WO (1)	WO1996014425A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1282994B1 (it) *	1996-05-10	1998-04-03	Inalco Spa	Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
SE9701454D0 (sv) *	1997-04-18	1997-04-18	Ulf Lindahl	new DNA sequences and a process for enzyme manufacture
US8088604B2 (en) *	1998-04-02	2012-01-03	The Board Of Regents Of The University Of Oklahoma	Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US20060188966A1 (en) *	1998-04-02	2006-08-24	Deangelis Paul L	Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US20080108110A1 (en) *	1998-04-02	2008-05-08	Deangelis Paul L	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7223571B2 (en) *	1998-04-02	2007-05-29	The Board Of Regents Of The Universtiy Of Oklahoma	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7307159B2 (en) *	2001-05-08	2007-12-11	The Board Of Regents Of The University Of Oklahoma	Heparin/heparosan synthase from P. multocida and methods of making and using same
US20040197868A1 (en) *	2001-05-08	2004-10-07	Deangelis Paul L.	Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
CN1098354C (zh) *	1998-11-12	2003-01-08	武汉大学	双酶催化法合成1－β－D－呋喃核糖苷－1，2，4－三氮唑－3－甲酰胺
US6608042B2 (en)	2000-03-28	2003-08-19	Aventis Pharma, S.A.	Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US8227449B2 (en)	2000-03-30	2012-07-24	Glycores 2000 S.R.L.	Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) *	2000-03-30	2003-08-25	Inalco Spa	Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en)	2000-03-30	2002-05-23	Pasqua Oreste	Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
WO2002046379A2 (en)	2000-12-08	2002-06-13	Biotie Therapies Corp.	Glucuronyl c5-epimerase, dna encoding the same and uses thereof
ITMI20032498A1 (it)	2003-12-17	2005-06-18	Pasqua Anna Oreste	Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) *	2001-02-27	2002-08-27	Giorgio Zoppetti	Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
US8580290B2 (en) *	2001-05-08	2013-11-12	The Board Of Regents Of The University Of Oklahoma	Heparosan-based biomaterials and coatings and methods of production and use thereof
US7575886B2 (en)	2002-03-11	2009-08-18	Momenta Pharmaceuticals, Inc.	Analysis of sulfated polysaccharides
MXPA04012805A (es) *	2002-06-18	2005-08-19	Glycores 2000 Srl	Polisacarido sulfatado en exceso de bajo peso molecular.
US8513407B2 (en) *	2002-06-18	2013-08-20	Glycores 2000 S.R.L.	Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US20120253029A1 (en)	2002-06-18	2012-10-04	Pasqua Anna Oreste	Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
GB0216861D0 (en) *	2002-07-19	2002-08-28	Univ Birmingham	Saccharide libraries
US20040171819A1 (en)	2002-10-10	2004-09-02	Aventis Pharma S.A.	Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
ITMI20031618A1 (it) *	2003-08-06	2005-02-07	Inalco Spa	Derivati polisaccaridici dotati di alta attivita'
FI20065035A7 (fi) *	2006-01-19	2007-07-20	Polysackaridforskning I Uppsal	Olennaisesti puhdas entsyymi
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
US20090035787A1 (en) *	2007-07-23	2009-02-05	The University Of North Carolina At Chapel Hill	Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
US9687559B2 (en)	2008-03-19	2017-06-27	The Board Of Regents Of The University Of Oklahoma	Heparosan polymers and methods of making and using same for the enhancement of therapeutics
US9925209B2 (en)	2008-03-19	2018-03-27	The Board Of Regents Of The University Of Oklahoma	Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
CN101591401A (zh) *	2009-02-27	2009-12-02	江南大学	一种制备高活性低分子量肝素的方法
CN102791742B (zh) *	2010-01-19	2014-12-24	动量制药公司	评价肝素制剂
WO2012088416A2 (en)	2010-12-23	2012-06-28	The University Of North Carolina At Chapel Hill	Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
WO2012115952A1 (en)	2011-02-21	2012-08-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
EP2831237B1 (de)	2012-03-30	2017-11-29	The Board of Regents of the University of Oklahoma	Hochmolekulare heparosanpolymere sowie verfahren zur herstellung und verwendung davon
JP6670235B2 (ja)	2013-06-17	2020-03-18	ザユニバーシティオブノースカロライナアットチャペルヒルＴｈｅＵｎｉｖｅｒｓｉｔｙＯｆＮｏｒｔｈＣａｒｏｌｉｎａＡｔＣｈａｐｅｌＨｉｌｌ	可逆的ヘパリン分子、その製法及びその使用方法
EP3279220B1 (de) *	2015-03-31	2024-12-04	Seikagaku Corporation	Verfahren zur sulfatierung von glykosaminoglykan
WO2018165656A1 (en)	2017-03-10	2018-09-13	The University Of North Carolina At Chapel Hill	Short-acting heparin-based anticoagulant compounds and methods
US11993627B2 (en)	2017-07-03	2024-05-28	The University Of North Carolina At Chapel Hill	Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
US11865137B2 (en)	2017-11-03	2024-01-09	The University Of North Carolina At Chapel Hill	Sulfated oligosaccharides having anti-inflammatory activity
CN108486187A (zh) *	2018-02-02	2018-09-04	南京微构医药科技有限公司	一种艾杜糖醛酸的制备工艺
WO2019246264A1 (en)	2018-06-20	2019-12-26	The University Of North Carolina At Chapel Hill	Cell protective methods and compositions
CN110577559B (zh) *	2019-08-19	2023-02-17	江西科技师范大学	α-L-艾杜糖醛酸酶测定用荧光糖苷酶底物的合成方法
WO2021097345A1 (en)	2019-11-13	2021-05-20	The University Of North Carolina At Chapel Hill	Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2254083A (en) *	1991-03-28	1992-09-30	Italfarmaco Spa	Anticoagulants from e.coli saccharide

1994
- 1994-11-04 IT ITMI942240A patent/IT1271057B/it active IP Right Grant
1995
- 1995-10-30 AT AT95937026T patent/ATE195348T1/de not_active IP Right Cessation
- 1995-10-30 AU AU39261/95A patent/AU3926195A/en not_active Abandoned
- 1995-10-30 CN CN95196040A patent/CN1094977C/zh not_active Expired - Fee Related
- 1995-10-30 WO PCT/EP1995/004241 patent/WO1996014425A1/en not_active Ceased
- 1995-10-30 JP JP51501996A patent/JP3640259B2/ja not_active Expired - Fee Related
- 1995-10-30 PT PT95937026T patent/PT789777E/pt unknown
- 1995-10-30 DK DK95937026T patent/DK0789777T3/da active
- 1995-10-30 DE DE69518333T patent/DE69518333T2/de not_active Expired - Fee Related
- 1995-10-30 US US08/628,690 patent/US5958899A/en not_active Expired - Fee Related
- 1995-10-30 EP EP95937026A patent/EP0789777B1/de not_active Expired - Lifetime
- 1995-10-30 ES ES95937026T patent/ES2150589T3/es not_active Expired - Lifetime
- 1995-10-30 CA CA002204366A patent/CA2204366A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ITMI942240A1 (it)	1996-05-04
DE69518333D1 (en)	2000-09-14
ES2150589T3 (es)	2000-12-01
CA2204366A1 (en)	1996-05-17
US5958899A (en)	1999-09-28
PT789777E (pt)	2001-01-31
AU3926195A (en)	1996-05-31
IT1271057B (it)	1997-05-26
JPH10508204A (ja)	1998-08-18
CN1094977C (zh)	2002-11-27
ITMI942240A0 (it)	1994-11-04
EP0789777B1 (de)	2000-08-09
DE69518333T2 (de)	2001-02-22
WO1996014425A1 (en)	1996-05-17
DK0789777T3 (da)	2000-11-06
JP3640259B2 (ja)	2005-04-20
EP0789777A1 (de)	1997-08-20
CN1162339A (zh)	1997-10-15

Legal Events

Date	Code	Title	Description
2001-01-15	UEP	Publication of translation of european patent specification
2008-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69518333D1 (en)	2000-09-14	Polysaccharide mit hohem anteil an iduronsäure
Linhardt et al.	1987	Polysaccharide lyases
Oldberg et al.	1980	Characterization of platelet endoglycosidase degrading heparin-like polysaccharides
TW209225B (de)	1993-07-11
AU3026597A (en)	1997-12-05	Derivatives of k5 polysaccharide having high anticoagulant activity
EP1654288B1 (de)	2010-02-17	Polysaccharidderivate mit antithrombotischer wirkung im plasma
Pejler et al.	1987	Basement-membrane heparan sulphate with high affinity for antithrombin synthesized by normal and transformed mouse mammary epithelial cells
AU2235802A (en)	2002-07-01	Glycosaminoglycans derived from k5 polysaccharide having high antithrombin activity and process for their preparation
JP2022540849A5 (de)	2023-07-12
Linker et al.	1957	The hyaluronidase of the leech: an endoglucuronidase
JPS63191801A (ja)	1988-08-09	多糖類の制御された解重合方法
EA199800778A1 (ru)	1999-02-25	Способ окисления полисахарида
Pinhal et al.	1994	Antithrombotic agents stimulate the synthesis and modify the sulfation pattern of a heparan sulfate proteoglycan from endothelial cells
Göhler et al.	1984	Purification and characterization of 3′‐phosphoadenylylsulfate: N‐desulfoheparan sulfate sulfotransferase from arterial tissue
Mirelman et al.	1970	The location of the D-alanyl ester in the ribitol teichoic acid of Staphylococcusaureus
Manzoni et al.	1996	Production of K5 polysaccharides of different molecular weight by Escherichia coli
RU95110112A (ru)	1997-06-10	Способ получения хитозан-глюканового комплекса
Hannesson	1997	Bacterial polysaccharides as substrates for D-glucuronyl C-5 epimerases in studies of glycosaminoglycan biosynthesis.
Lohse	1992	The heparin lyases of Flavobacterium heparinum
ES2001748A6 (es)	1988-06-16	Un procedimiento para la produccion del heteropolisacarido s-184.
Steel et al.	1957	A highly specific growth-inhibitory factor produced by certain Acetobacter species
Dodgson	1966	Sulfatases of glycosaminoglycans
FR2831553B1 (fr)	2004-08-27	Milieu de culture solide pour micro-organismes et cellules eucaryotes ainsi que son procede d'obtention
Kusche	1991	O-Sulfotransferase reactions in the biosynthesis of mast cell glycosaminoglycans.
JPH06113873A (ja)	1994-04-26	微生物セルロースの製造方法