ATE195531T1 - Inhibitoren und substrate für thrombin - Google Patents

Inhibitoren und substrate für thrombin

Info

Publication number: ATE195531T1
Authority: AT; Austria
Prior art keywords: sub; thrombin; inhibitors; substrates; pro
Prior art date: 1990-11-06

Application number

AT91919539T

Other languages

English (en)

Inventor

Vijay Vir Kakkar

John Joseph Deadman

Goran Karl Claeson

Leifeng Cheng

Naoyashi Chino

Said Mohamed Anwar Elgendy

Michael Finbarr Scully

Original Assignee

Trigen Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-06

Filing date

1991-11-06

Publication date

2000-09-15

1991-11-06 Application filed by Trigen Ltd filed Critical Trigen Ltd

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE195531T1 publication Critical patent/ATE195531T1/de

Links

108090000190 Thrombin Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
239000000758 substrate Substances 0.000 title abstract 2
229960004072 thrombin Drugs 0.000 title abstract 2
-1 isothioureido Chemical group 0.000 abstract 2
JEDOBLVMBKRNHF-UHFFFAOYSA-N 5-amino-1H-imidazole-2-carboximidamide Chemical compound NC(=N)C1=NC(N)=CN1 JEDOBLVMBKRNHF-UHFFFAOYSA-N 0.000 abstract 1
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
101100379075 Burkholderia cepacia andAa gene Proteins 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002877 alkyl aryl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052796 boron Inorganic materials 0.000 abstract 1
ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 1
125000004802 cyanophenyl group Chemical group 0.000 abstract 1
150000002009 diols Chemical class 0.000 abstract 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000006501 nitrophenyl group Chemical group 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91919539T 1990-11-06 1991-11-06 Inhibitoren und substrate für thrombin ATE195531T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909024129A GB9024129D0 (en)	1990-11-06	1990-11-06	Inhibitors and substrates of thrombin
PCT/GB1991/001946 WO1992007869A1 (en)	1990-11-06	1991-11-06	Inhibitors and substrates of thrombin

Publications (1)

Publication Number	Publication Date
ATE195531T1 true ATE195531T1 (de)	2000-09-15

Family

ID=10684957

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91919539T ATE195531T1 (de)	1990-11-06	1991-11-06	Inhibitoren und substrate für thrombin

Country Status (14)

Country	Link
US (1)	US5858979A (de)
EP (3)	EP0807638A1 (de)
JP (2)	JP3173786B2 (de)
AT (1)	ATE195531T1 (de)
AU (1)	AU636521B2 (de)
DE (2)	DE69132369D1 (de)
DK (1)	DK0509080T3 (de)
ES (1)	ES2149158T3 (de)
GB (1)	GB9024129D0 (de)
GR (1)	GR3034839T3 (de)
IE (2)	IE20000539A1 (de)
NZ (2)	NZ264128A (de)
WO (1)	WO1992007869A1 (de)
ZA (1)	ZA918805B (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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WO1993009134A1 (en) *	1991-11-06	1993-05-13	The Scripps Research Institute	Phosphonamidate ester-containing pseudopeptides
SE9103612D0 (sv) *	1991-12-04	1991-12-04	Astra Ab	New peptide derivatives
US5492895A (en) *	1992-02-14	1996-02-20	Corvas International, Inc.	Inhibitors of thrombosis
US6387881B1 (en) *	1992-09-19	2002-05-14	Trigen Ltd	Inhibitors and substrates of thrombin
FR2701951B1 (fr) *	1993-02-24	1995-06-09	Adir	Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU6448794A (en) *	1993-03-24	1994-10-11	Du Pont Merck Pharmaceutical Company, The	Boronic acid and ester inhibitors of thrombin
IL109319A0 (en) *	1993-04-27	1994-07-31	Du Pont Merck Pharma	Amidino and guanidino substituted boronic acid compounds
WO1994025051A1 (en) *	1993-04-30	1994-11-10	Merck & Co., Inc.	Thrombin inhibitors
US5783563A (en) *	1993-06-03	1998-07-21	Astra Aktiebolag	Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
US6984627B1 (en)	1993-06-03	2006-01-10	Astrazeneca Ab	Peptide derivatives
GB9318637D0 (en) *	1993-09-08	1993-10-27	Ferring Res Ltd	Enzyme inhibitors
AU7922794A (en) *	1993-10-07	1995-05-01	Du Pont Merck Pharmaceutical Company, The	Boropeptide inhibitors of thrombin which contain a substituted pyrrolidine ring
IL111176A0 (en) *	1993-10-07	1994-12-29	Du Pont Merck Pharma	Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them
IL111175A0 (en) *	1993-10-07	1994-12-29	Du Pont Merck Pharma	Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
US5462964A (en) *	1993-10-20	1995-10-31	The Du Pont Merck Pharmaceutical Company	Dipeptide boronic acid inhibitors of trypsin-like enzymes
US6060462A (en) *	1993-10-20	2000-05-09	Dupont Pharmaceuticals Company	Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
US5686419A (en) *	1994-01-21	1997-11-11	Georgia Tech Research Corp.	Basic α-aminoalkylphosphonate derivatives
US5693617A (en) *	1994-03-15	1997-12-02	Proscript, Inc.	Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
US5561146A (en) *	1994-06-10	1996-10-01	Bristol-Myers Squibb Company	Modified guanidino and amidino thrombin inhibitors
FR2721611B1 (fr) *	1994-06-22	1996-09-27	Adir	Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .
US5510369A (en) *	1994-07-22	1996-04-23	Merck & Co., Inc.	Pyrrolidine thrombin inhibitors
US6083903A (en)	1994-10-28	2000-07-04	Leukosite, Inc.	Boronic ester and acid compounds, synthesis and uses
SE9404196D0 (sv) *	1994-12-02	1994-12-02	Astra Ab	New antithrombotic formulation
GB9502985D0 (en) *	1995-02-16	1995-04-05	Thrombosis Res Inst	Enzyme inhibitors
KR100388185B1 (ko) *	1995-02-17	2003-11-28	애보트 게엠베하 운트 콤파니 카게	트롬빈 억제제로서의 신규 디펩티드 아미딘
US5629324A (en) *	1995-04-10	1997-05-13	Merck & Co., Inc.	Thrombin inhibitors
TW541316B (en)	1995-12-21	2003-07-11	Astrazeneca Ab	Prodrugs of thrombin inhibitors
US6525761B2 (en)	1996-07-23	2003-02-25	Canon Kabushiki Kaisha	Apparatus and method for controlling a camera connected to a network
US6004955A (en) *	1996-08-15	1999-12-21	Dupont Pharmaceuticals Company	Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
US5798377A (en) *	1996-10-21	1998-08-25	Merck & Co., Inc.	Thrombin inhibitors
HUP0100082A3 (en)	1998-01-26	2001-12-28	Abbott Gmbh & Co Kg	Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use
WO1999050249A2 (en)	1998-04-01	1999-10-07	Du Pont Pharmaceuticals Company	Pyrimidines and triazines as integrin antagonists
CA2348740A1 (en)	1998-12-23	2000-07-06	Ruth R. Wexler	Thrombin or factor xa inhibitors
WO2000055188A1 (en) *	1999-03-16	2000-09-21	C & C Research Laboratories	Substituted proline derivatives and medicinal compositions containing the same
US6258932B1 (en) *	1999-08-09	2001-07-10	Tripep Ab	Peptides that block viral infectivity and methods of use thereof
HUP0202512A2 (hu) *	1999-08-09	2002-11-28	Tripep Ab	Fehérjék polimerizációját gátló anyagok és eljárások ezek alkalmazására
JP2004516286A (ja)	2000-12-18	2004-06-03	メルクエンドカムパニーインコーポレーテッド	ベンジルアミン誘導体およびそれのトロンビン阻害薬としての使用
US6528503B2 (en)	2000-12-18	2003-03-04	Merck & Co., Inc.	Thrombin inhibitors
US7144899B2 (en)	2001-02-09	2006-12-05	Merck & Co., Inc.	Thrombin inhibitors
US6593455B2 (en) *	2001-08-24	2003-07-15	Tripep Ab	Tripeptide amides that block viral infectivity and methods of use thereof
US6455670B1 (en) *	2001-09-06	2002-09-24	Tripep Ab	Pentamer peptide amide, ALGPG-NH2, that inhibits viral infectivity and methods of use thereof
WO2003024995A1 (en) *	2001-09-19	2003-03-27	Tripep Ab	Molecules that block viral infectivity and methods of use thereof
US7084134B2 (en)	2002-05-02	2006-08-01	Merk & Co., Inc.	Thrombin inhibitors
AU2003263343A1 (en)	2002-09-09	2004-03-29	Trigen Limited	Boronic acid salts ant their use in the treatment of thromobis
US7112572B2 (en)	2002-09-09	2006-09-26	Trigen Limited	Multivalent metal salts of boronic acids
NZ541883A (en) *	2003-02-21	2008-12-24	Tripep Ab	Glycinamide derivative for inhibiting HIV replication
US20050096319A1 (en) *	2003-02-21	2005-05-05	Balzarini Jan M.R.	Identification of compounds that inhibit replication of human immunodeficiency virus
GB0405267D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
EP1724253A3 (de) *	2005-05-10	2009-11-04	Ajinomoto Co., Inc.	Herstellungsverfahren von optisch aktiven Diphenylalaninverbindungen
MY162041A (en) *	2007-02-28	2017-05-31	Sanofi Aventis	Imaging probes
AU2013270682A1 (en)	2012-06-08	2014-12-11	Biogen Ma Inc.	Procoagulant compounds
EP2863940A4 (de)	2012-06-08	2016-08-10	Biogen Ma Inc	Chimäre gerinnungsfaktoren
EP4257191A3 (de)	2016-06-21	2023-11-22	Orion Ophthalmology LLC	Heterocyclische prolinamidderivate
WO2017222914A1 (en)	2016-06-21	2017-12-28	Inception 4, Inc.	Carbocyclic prolinamide derivatives
DE102016009766A1 (de)	2016-08-11	2018-02-15	Julius-Maximilians-Universität Würzburg	Herstellung von Bitterstoffderivaten
CA3224494A1 (en)	2021-07-09	2023-01-12	Koen Vandyck	Anti-viral compounds
WO2023043816A1 (en)	2021-09-17	2023-03-23	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (8)

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Publication number	Priority date	Publication date	Assignee	Title
US4428874A (en) *	1981-03-25	1984-01-31	Pentapharm A.G.	Tripeptide derivatives
JPS5856695A (ja) *	1981-09-28	1983-04-04	Nitto Boseki Co Ltd	新規なトロンビン測定用基質
US4499082A (en) *	1983-12-05	1985-02-12	E. I. Du Pont De Nemours And Company	α-Aminoboronic acid peptides
DE3606480A1 (de) *	1986-02-28	1987-09-03	Behringwerke Ag	Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
US5187157A (en) *	1987-06-05	1993-02-16	Du Pont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
US4929602A (en) *	1987-11-25	1990-05-29	Scripps Clinic And Research Foundation	Method of inhibiting platelet dependent arterial thrombosis
US5023236A (en) *	1988-04-07	1991-06-11	Corvas, Inc.	Factor VII/VIIA active site inhibitors
US5288707A (en) *	1990-08-13	1994-02-22	Sandoz Ltd.	Borolysine peptidomimetics

1990
- 1990-11-06 GB GB909024129A patent/GB9024129D0/en active Pending
1991
- 1991-11-05 NZ NZ264128A patent/NZ264128A/en not_active IP Right Cessation
- 1991-11-05 NZ NZ240477A patent/NZ240477A/en not_active IP Right Cessation
- 1991-11-06 AT AT91919539T patent/ATE195531T1/de not_active IP Right Cessation
- 1991-11-06 IE IE20000539A patent/IE20000539A1/en not_active IP Right Cessation
- 1991-11-06 EP EP97201436A patent/EP0807638A1/de not_active Withdrawn
- 1991-11-06 WO PCT/GB1991/001946 patent/WO1992007869A1/en not_active Ceased
- 1991-11-06 AU AU89007/91A patent/AU636521B2/en not_active Ceased
- 1991-11-06 ZA ZA918805A patent/ZA918805B/xx unknown
- 1991-11-06 EP EP99200841A patent/EP0955309A1/de not_active Withdrawn
- 1991-11-06 DE DE69132369A patent/DE69132369D1/de not_active Expired - Fee Related
- 1991-11-06 ES ES91919539T patent/ES2149158T3/es not_active Expired - Lifetime
- 1991-11-06 DE DE69132369T patent/DE69132369T4/de not_active Expired - Lifetime
- 1991-11-06 JP JP51818591A patent/JP3173786B2/ja not_active Expired - Fee Related
- 1991-11-06 DK DK91919539T patent/DK0509080T3/da active
- 1991-11-06 EP EP91919539A patent/EP0509080B1/de not_active Expired - Lifetime
- 1991-11-06 IE IE387191A patent/IE913871A1/en not_active IP Right Cessation
1995
- 1995-06-02 US US08/459,394 patent/US5858979A/en not_active Expired - Fee Related
2000
- 2000-11-13 GR GR20000402527T patent/GR3034839T3/el not_active IP Right Cessation
- 2000-12-27 JP JP2000398079A patent/JP3453357B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU8900791A (en)	1992-05-26
NZ264128A (en)	1996-11-26
JP3173786B2 (ja)	2001-06-04
JP3453357B2 (ja)	2003-10-06
US5858979A (en)	1999-01-12
GB9024129D0 (en)	1990-12-19
EP0509080A1 (de)	1992-10-21
DK0509080T3 (da)	2000-09-18
ZA918805B (en)	1993-04-28
WO1992007869A1 (en)	1992-05-14
IE20000539A1 (en)	2002-03-20
AU636521B2 (en)	1993-04-29
DE69132369T2 (de)	2001-02-22
EP0509080B1 (de)	2000-08-16
ES2149158T3 (es)	2000-11-01
DE69132369T4 (de)	2001-09-13
GR3034839T3 (en)	2001-02-28
JPH05504775A (ja)	1993-07-22
IE913871A1 (en)	1992-05-22
JP2001226397A (ja)	2001-08-21
EP0807638A1 (de)	1997-11-19
NZ240477A (en)	1994-10-26
EP0955309A1 (de)	1999-11-10
DE69132369D1 (en)	2000-09-21

Legal Events

Date	Code	Title	Description
2000-12-15	UEP	Publication of translation of european patent specification
2007-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69132369D1 (en)	2000-09-21	Inhibitoren und substrate für thrombin
DK0685489T3 (da)	2002-03-11	Tripeptider, der antithrombotiske midler
ES2065880T3 (es)	1995-03-01	Proteina quimicamente modificada y obtencion de la misma.
NZ306625A (en)	2001-04-27	Tetrahydro-pyridine compounds, their preparation, and pharmaceuticals thereof; useful as neuraminidase inhibitors
DE69307506D1 (de)	1997-02-27	Phosphotriester-typ biologisch-aktiver verbindungen
ATE90107T1 (de)	1993-06-15	Peptide mit collagenase hemmender wirkung.
BG102691A (en)	1999-06-30	New erythromycin derivatives, method for their preparation and application as medicamentous form
IT1241674B (it)	1994-01-27	Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.
ES8801198A1 (es)	1987-12-16	Un procedimiento para la preparacion de delta 22 o delta 23 -26,-26,26,27,27,27-hexafluoro-1alfa,25-dihidroxicolecalci- ferol
EP1231208A3 (de)	2003-12-10	4-Oxozyklische Harnstoffe, nützlich als antiarrhythmische und antifibrillatorische Wirkstoffe
TR199802538T2 (xx)	2001-01-22	�ltihaplanmaya kar�� maddeler olarak yararl� dihidrobenzopiran ve ili�kili bile�ikler.
KR840005733A (ko)	1984-11-16	무라밀 펩타이드의 제조방법
NO964861L (no)	1997-01-16	Derivater av aminosulfonsyrer, fremgangsmåte for fremstilling av disse samt deres anvendelse ved syntese av pseudopeptider
EP0173510A3 (de)	1987-09-16	Tripeptidderivate welche als antihypertensive Mittel dienen
AU1843097A (en)	1997-08-22	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
ATE53215T1 (de)	1990-06-15	Oral aktive phosphonylhydroxyacylproline und verfahren zur herstellung von phosphonylhydroxyacylprolinen.
EP0314239A3 (de)	1990-12-27	Tripeptid-Renin-Inhibitoren mit N-terminalen Ureid- oder Sulfamid-Gruppen
NO20044904L (no)	2004-12-16	Forbindelse og fremgangsmater for fremstilling og anvendelse derav
MY111431A (en)	2000-05-31	Tripeptide antithrombotic agents
CA1271966C (en)	1990-07-24	ARYL-AND ARALARYLSULFONYL-L-PROLINES
JPS56161397A (en)	1981-12-11	Substituted alanylaminoethylphosphonic acid
CA2019005A1 (en)	1991-12-14	Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
MY101827A (en)	1992-01-31	2-[n-substitutedguanidino]-4-heteroarylthiazole antiulcer agents