IT1241674B - Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono. - Google Patents

Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.

Info

Publication number
IT1241674B
IT1241674B IT22004A IT2200489A IT1241674B IT 1241674 B IT1241674 B IT 1241674B IT 22004 A IT22004 A IT 22004A IT 2200489 A IT2200489 A IT 2200489A IT 1241674 B IT1241674 B IT 1241674B
Authority
IT
Italy
Prior art keywords
alkyl
chain
pct
phenyl
hydrogen
Prior art date
Application number
IT22004A
Other languages
English (en)
Other versions
IT8922004A1 (it
IT8922004A0 (it
Inventor
Sergio Tognella
Valeria Livi
Ernesto Menta
Silvano Spinelli
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Publication of IT8922004A0 publication Critical patent/IT8922004A0/it
Priority to IT22004A priority Critical patent/IT1241674B/it
Priority to HU9201215A priority patent/HUT61027A/hu
Priority to KR1019920700825A priority patent/KR927003610A/ko
Priority to JP2513900A priority patent/JPH05500949A/ja
Priority to US07/847,067 priority patent/US5300671A/en
Priority to ZA908131A priority patent/ZA908131B/xx
Priority to CA002067191A priority patent/CA2067191A1/en
Priority to ES90915106T priority patent/ES2090143T3/es
Priority to AT90915106T priority patent/ATE137757T1/de
Priority to PCT/EP1990/001710 priority patent/WO1991005791A1/en
Priority to DE69026964T priority patent/DE69026964T2/de
Priority to EP90915106A priority patent/EP0593437B1/en
Priority to FI921562A priority patent/FI921562L/fi
Priority to AU65108/90A priority patent/AU639495B2/en
Publication of IT8922004A1 publication Critical patent/IT8922004A1/it
Priority to NO921406A priority patent/NO921406D0/no
Application granted granted Critical
Publication of IT1241674B publication Critical patent/IT1241674B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
IT22004A 1989-10-12 1989-10-12 Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono. IT1241674B (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT22004A IT1241674B (it) 1989-10-12 1989-10-12 Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.
AT90915106T ATE137757T1 (de) 1989-10-12 1990-10-11 Gem-diphosphonsäuren, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE69026964T DE69026964T2 (de) 1989-10-12 1990-10-11 Gem-diphosphonsäuren, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JP2513900A JPH05500949A (ja) 1989-10-12 1990-10-11 ｇｅｍ―ジホスホン酸、その製造法、およびそれを含む医薬組成物
US07/847,067 US5300671A (en) 1989-10-12 1990-10-11 Gem-diphosphonic acids, and pharmaceutical compositions containing them
ZA908131A ZA908131B (en) 1989-10-12 1990-10-11 Gem-diphosphonic acids,a process for the preparation thereof and pharmaceutical compositions containing them
CA002067191A CA2067191A1 (en) 1989-10-12 1990-10-11 Gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them
ES90915106T ES2090143T3 (es) 1989-10-12 1990-10-11 Acidos gem-difosfonicos, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
HU9201215A HUT61027A (en) 1989-10-12 1990-10-11 Process for producing diphosphonic acids having antitumorous effect and pharmaceutical compositions comprising such compounds
PCT/EP1990/001710 WO1991005791A1 (en) 1989-10-12 1990-10-11 Gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them
KR1019920700825A KR927003610A (ko) 1989-10-12 1990-10-11 젬-디포스폰산, 그의 제조방법 및 이를 함유하는 약제학적 조성물
EP90915106A EP0593437B1 (en) 1989-10-12 1990-10-11 Gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them
FI921562A FI921562L (fi) 1989-10-12 1990-10-11 Gem-difosfonsyror, foerfarande foer framstaellning av dessa och farmaceutiska sammansaettningar som inne- haoller dem.
AU65108/90A AU639495B2 (en) 1989-10-12 1990-10-11 Gem-diphosphonic acids, a process for the preparation thereof and pharmaceutical compositions containing them
NO921406A NO921406D0 (no) 1989-10-12 1992-04-09 Gem-difosfonsyrer, fremgangsmaate ved deres fremstilling og farmasoeytiske sammensetninger som inneholder dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22004A IT1241674B (it) 1989-10-12 1989-10-12 Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.

Publications (3)

Publication Number Publication Date
IT8922004A0 IT8922004A0 (it) 1989-10-12
IT8922004A1 IT8922004A1 (it) 1991-04-12
IT1241674B true IT1241674B (it) 1994-01-27

Family

ID=11190055

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22004A IT1241674B (it) 1989-10-12 1989-10-12 Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.

Country Status (14)

Country Link
US (1) US5300671A (it)
EP (1) EP0593437B1 (it)
JP (1) JPH05500949A (it)
KR (1) KR927003610A (it)
AT (1) ATE137757T1 (it)
AU (1) AU639495B2 (it)
CA (1) CA2067191A1 (it)
DE (1) DE69026964T2 (it)
ES (1) ES2090143T3 (it)
FI (1) FI921562L (it)
HU (1) HUT61027A (it)
IT (1) IT1241674B (it)
WO (1) WO1991005791A1 (it)
ZA (1) ZA908131B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183815A (en) * 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
EP0496520A1 (en) * 1991-01-22 1992-07-29 Merck & Co. Inc. Novel bone acting agents
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1284070B1 (it) * 1996-06-26 1998-05-08 Boehringer Mannheim Italia Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che
IT1290444B1 (it) * 1997-03-27 1998-12-03 Boehringer Mannheim Italia Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
EP1115396A4 (en) * 1998-09-25 2002-05-22 Sunol Molecular Corp PHARMACEUTICALLY ACTIVE COMPOUNDS, AND METHODS OF USE THEREOF
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
JP2008535862A (ja) 2005-04-08 2008-09-04 キメリクス，インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
EP2254582B1 (en) * 2008-01-25 2016-01-20 Chimerix, Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes
US11246905B2 (en) 2016-08-15 2022-02-15 President And Fellows Of Harvard College Treating infections using IdsD from Proteus mirabilis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
DE69026964T2 (de) 1996-10-24
EP0593437A1 (en) 1994-04-27
KR927003610A (ko) 1992-12-18
CA2067191A1 (en) 1991-04-13
WO1991005791A1 (en) 1991-05-02
AU639495B2 (en) 1993-07-29
HUT61027A (en) 1992-11-30
FI921562A7 (fi) 1992-04-08
ES2090143T3 (es) 1996-10-16
FI921562A0 (fi) 1992-04-08
DE69026964D1 (de) 1996-06-13
HU9201215D0 (en) 1992-07-28
IT8922004A1 (it) 1991-04-12
FI921562L (fi) 1992-04-08
US5300671A (en) 1994-04-05
ZA908131B (en) 1991-07-31
ATE137757T1 (de) 1996-05-15
AU6510890A (en) 1991-05-16
EP0593437B1 (en) 1996-05-08
IT8922004A0 (it) 1989-10-12
JPH05500949A (ja) 1993-02-25

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971030