ATE196092T1 - Wachstumshormon-enthaltendeproteinformulierung - Google Patents

Wachstumshormon-enthaltendeproteinformulierung

Info

Publication number: ATE196092T1
Authority: AT; Austria
Prior art keywords: growth hormone; pct; formulation; citrate; buffer substance
Prior art date: 1992-04-03

Application number

AT93908252T

Other languages

English (en)

Inventor

Staffan Castensson

Ebba Florin-Robertsson

Elvy Hoekby

Sirkka Thome

Original Assignee

Pharmacia & Upjohn Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-03

Filing date

1993-04-01

Publication date

2000-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20385860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE196092(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-04-01 Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE196092T1 publication Critical patent/ATE196092T1/de

Links

102000018997 Growth Hormone Human genes 0.000 title abstract 5
108010051696 Growth Hormone Proteins 0.000 title abstract 5
239000000122 growth hormone Substances 0.000 title abstract 5
238000009472 formulation Methods 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
239000012928 buffer substance Substances 0.000 abstract 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
229930195725 Mannitol Natural products 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
235000014633 carbohydrates Nutrition 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
239000013020 final formulation Substances 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
239000007972 injectable composition Substances 0.000 abstract 1
239000000594 mannitol Substances 0.000 abstract 1
235000010355 mannitol Nutrition 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
230000002335 preservative effect Effects 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000005846 sugar alcohols Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

AT93908252T 1992-04-03 1993-04-01 Wachstumshormon-enthaltendeproteinformulierung ATE196092T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9201073A SE9201073D0 (sv)	1992-04-03	1992-04-03	Protein formulation
PCT/SE1993/000281 WO1993019776A1 (en)	1992-04-03	1993-04-01	Protein formulation comprising growth hormone

Publications (1)

Publication Number	Publication Date
ATE196092T1 true ATE196092T1 (de)	2000-09-15

Family

ID=20385860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93908252T ATE196092T1 (de)	1992-04-03	1993-04-01	Wachstumshormon-enthaltendeproteinformulierung

Country Status (15)

Country	Link
US (1)	US5567677A (de)
EP (1)	EP0587858B2 (de)
JP (1)	JP3268557B2 (de)
AT (1)	ATE196092T1 (de)
AU (1)	AU666007B2 (de)
CA (1)	CA2102693C (de)
DE (1)	DE69329367T3 (de)
DK (1)	DK0587858T3 (de)
ES (1)	ES2150940T5 (de)
GR (1)	GR3034925T3 (de)
NO (1)	NO310804B1 (de)
NZ (1)	NZ251498A (de)
PT (1)	PT587858E (de)
SE (1)	SE9201073D0 (de)
WO (1)	WO1993019776A1 (de)

Families Citing this family (58)

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US5849700A (en) *	1991-12-20	1998-12-15	Novo Nordisk A/S	Pharmaceutical formulation
US5849704A (en) *	1991-12-20	1998-12-15	Novo Nordisk A/S	Pharmaceutical formulation
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2719479B1 (fr) *	1994-05-04	1996-07-26	Sanofi Elf	Formulation stable lyophilisée comprenant une protéine: kit de dosage.
US5654278A (en) *	1994-10-13	1997-08-05	Novo Nordisk A/S	Composition and method comprising growth hormone and leucine
IL115592A (en) *	1994-10-13	2000-07-26	Novo Nordisk As	Stabilized pharmaceutical formulation comprising a growth hormone and leucine
US5631225A (en) *	1994-10-13	1997-05-20	Novo Nordisk A/S	Pharmaceutical formulation
US5547696A (en) *	1994-10-13	1996-08-20	Novo Nordisk A/S	Pharmaceutical formulation
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DE19539574A1 (de)	1995-10-25	1997-04-30	Boehringer Mannheim Gmbh	Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
GB9526733D0 (en) *	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
AUPN801296A0 (en)	1996-02-12	1996-03-07	Csl Limited	Stabilised growth hormone formulation and method of preparation thereof
US20070179096A1 (en)	1996-04-24	2007-08-02	Novo Nordisk A/S	Pharmaceutical Formulation
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ZA9711733B (en)	1996-12-31	1998-07-01	Monsanto Co	Method for solubilization and naturation of somatotropins
JP3723857B2 (ja) *	1998-02-04	2005-12-07	日本ケミカルリサーチ株式会社	ヒト成長ホルモン含有水性医薬組成物
US6979442B1 (en)	1998-08-17	2005-12-27	Pfizer Inc.	Stabilized protein compositions
CA2378949C (en) *	1999-07-12	2015-03-31	Grandis Biotech Gmbh	Growth hormone formulations
RU2298415C2 (ru) *	2000-07-11	2007-05-10	Сандоз Аг	Композиции, включающие гормон роста
WO2002011695A2 (en) *	2000-08-07	2002-02-14	Inhale Therapeutic Systems, Inc.	Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
GB2371227A (en) *	2001-01-10	2002-07-24	Grandis Biotech Gmbh	Crystallisation - resistant aqueous growth hormone formulations
US7271150B2 (en) *	2001-05-14	2007-09-18	United States Of America, Represented By The Secretary, Department Of Health And Human Services	Modified growth hormone
EP1463752A4 (de)	2001-12-21	2005-07-13	Human Genome Sciences Inc	Albuminfusionsproteine
EP1485116A4 (de) *	2002-02-27	2006-06-07	Univ Wake Forest	Angiotensin-(1-7)- und angiotensin-(1-7)-agonisten zur hemmung des krebszellenwachstums
US20070065469A1 (en) *	2002-07-09	2007-03-22	Michael Betz	Liquid formulations with high concentration of human growth hormone (high) comprising glycine
AU2003249992A1 (en) *	2002-07-09	2004-01-23	Sandoz Ag	Liquid formulations with high concentration of human growth hormone (hgh) comprising phenol
JP4949828B2 (ja) *	2003-03-18	2012-06-13	アレストレーディングソシエテアノニム	溶液中での成長ホルモンの安定化
US8338374B2 (en)	2003-12-23	2012-12-25	Pharmacia Corporation	Stable growth hormone liquid formulation
UA89781C2 (uk) *	2004-04-07	2010-03-10	Арес Трейдінг С.А.	Рідкий склад гормона росту
AP2007003893A0 (en) *	2004-08-03	2007-02-28	Transtech Pharma Inc	Rage fusion proteins and methods of use
CN1993378A (zh) *	2004-08-03	2007-07-04	转化技术制药公司	Rage融合蛋白及使用方法
KR101149454B1 (ko) *	2004-08-24	2012-05-25	간가와 겐지	생리활성 펩티드의 액상 제제
DE602005009856D1 (de) *	2004-11-09	2008-10-30	Ares Trading Sa	Verfahren zur reinigung von fsh
US20070015689A1 (en) *	2005-06-23	2007-01-18	Alza Corporation	Complexation of metal ions with polypeptides
DK1917276T3 (en)	2005-08-26	2018-05-07	Ares Trading Sa	Process for Preparation of Glycosylated Interferon Beta
JP5522939B2 (ja) *	2005-11-02	2014-06-18	トランスファーマメディカルリミテッド	ヒト成長ホルモンパッチ製剤
AU2006323925B2 (en) *	2005-12-09	2012-08-02	Ares Trading S.A.	Method for purifying FSH or a FSH mutant
WO2007073272A1 (en) *	2005-12-23	2007-06-28	Gcoder Systems Ab	Positioning pattern
CN101410411A (zh) *	2006-02-09	2009-04-15	转化技术制药公司	Rage融合蛋白及使用方法
BRPI0711193A2 (pt)	2006-05-05	2013-06-18	Transtech Pharma Inc	proteÍnas de fusço rage, formulaÇÕes e mÉtodos de uso dos mesmos
US20080199467A1 (en) *	2007-02-15	2008-08-21	Mjalli Adnan M M	Immunoglobulin fusion proteins and methods of making
EP2738257A1 (de)	2007-05-22	2014-06-04	Amgen Inc.	Zusammensetzungen und Verfahren zur Herstellung bioaktiver Fusionsproteine
AU2008314687A1 (en) *	2007-10-22	2009-04-30	Merck Serono S.A.	Method for purifying Fc-fusion proteins
EP2203465A1 (de) *	2007-10-22	2010-07-07	Merck Serono S.A.	Verfahren zu reinigung eines fc enthaltenden proteins
CN102803292A (zh)	2009-04-20	2012-11-28	辉瑞公司	蛋白质糖基化的控制及其相关组合物和方法
US20120108512A1 (en) *	2009-05-07	2012-05-03	Novo Nordisk Health Care Ag	Stable pharmaceutical compositions of peptide derivatized using an oxime linker
EP2501367B1 (de) *	2009-11-17	2015-01-21	Ipsen Pharma S.A.S.	Formulierung für HGH- und RHIGF-1-Kombination
KR101337797B1 (ko)	2010-07-14	2013-12-06	한미사이언스 주식회사	지속형 인간 성장 호르몬 결합체 액상 제제
US10064951B2 (en)	2012-03-30	2018-09-04	Hanmi Science Co., Ltd.	Liquid formulation of highly concentrated long-acting human growth hormone conjugate
BR112016006455A2 (pt) *	2013-09-27	2017-08-01	Hanmi Pharm Ind Co Ltd	?formulação de conjugado de hormônio de crescimento humano de ação prolongada?
US20160303242A1 (en)	2013-12-09	2016-10-20	Durect Corporation	Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
US20160015789A1 (en) *	2014-07-17	2016-01-21	Teva Pharmaceutical Industries, Ltd.	FORMULATIONS OF AN ALBUMIN hGH FUSION PROTEIN
US11738068B2 (en) *	2018-06-25	2023-08-29	Jcr Pharmaceuticals Co., Ltd.	Protein-containing aqueous liquid formulation

Family Cites Families (19)

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US4783441A (en) *	1979-04-30	1988-11-08	Hoechst Aktiengesellschaft	Aqueous protein solutions stable to denaturation
US4774091A (en) *	1983-10-14	1988-09-27	Sumitomo Pharmaceuticals Company, Ltd.	Long-term sustained-release preparation
DE3579911D1 (de) *	1984-12-24	1990-10-31	Sumitomo Pharma	Stabiles grf-praeparat.
BR8603586A (pt) *	1985-07-30	1987-03-10	Int Minerals & Chem Corp	Processo para manter a fluidez de um homonio;processo para efetuar a promocao de crescimento em animais e formulacao promotora de crescimento
US4917685A (en) *	1986-05-16	1990-04-17	International Minerals & Chem. Corp.	Delivery device for the administration of stabilized growth promoting hormones
US4816568A (en) *	1986-05-16	1989-03-28	International Minerals & Chemical Corp.	Stabilization of growth hormones
ATE82506T1 (de) *	1987-08-21	1992-12-15	Imcera Group Inc	Stabilisierung von wachstumshormonen.
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US5096885A (en) *	1988-04-15	1992-03-17	Genentech, Inc.	Human growth hormone formulation
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CA2020654A1 (en) *	1989-07-07	1991-01-08	Yohko Akiyama	Stabilized fgf composition and production thereof
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US5126324A (en)	1990-06-07	1992-06-30	Genentech, Inc.	Method of enhancing growth in patients using combination therapy
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DK204791D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Hidtil ukendt farmaceutisk praeparat
DE69322268T2 (de) *	1992-04-30	1999-08-05	Cor Therapeutics Inc	Stabile zusammensetzung von polypeptiden
MD1699F2 (ro) *	1992-07-31	2001-07-31	Genentech, Inc.	Compoziţie apoasă a hormonului somatotrop uman şi procedeu de prevenire a denaturării ei

1992
- 1992-04-03 SE SE9201073A patent/SE9201073D0/xx unknown
1993
- 1993-04-01 AT AT93908252T patent/ATE196092T1/de not_active IP Right Cessation
- 1993-04-01 US US08/162,017 patent/US5567677A/en not_active Expired - Lifetime
- 1993-04-01 WO PCT/SE1993/000281 patent/WO1993019776A1/en not_active Ceased
- 1993-04-01 EP EP93908252A patent/EP0587858B2/de not_active Expired - Lifetime
- 1993-04-01 DK DK93908252T patent/DK0587858T3/da active
- 1993-04-01 PT PT93908252T patent/PT587858E/pt unknown
- 1993-04-01 ES ES93908252T patent/ES2150940T5/es not_active Expired - Lifetime
- 1993-04-01 CA CA002102693A patent/CA2102693C/en not_active Expired - Lifetime
- 1993-04-01 NZ NZ251498A patent/NZ251498A/en not_active IP Right Cessation
- 1993-04-01 AU AU39135/93A patent/AU666007B2/en not_active Ceased
- 1993-04-01 DE DE69329367T patent/DE69329367T3/de not_active Expired - Fee Related
- 1993-04-01 JP JP51737893A patent/JP3268557B2/ja not_active Expired - Lifetime
- 1993-11-30 NO NO19934355A patent/NO310804B1/no unknown
2000
- 2000-11-28 GR GR20000402632T patent/GR3034925T3/el unknown

Also Published As

Publication number	Publication date
GR3034925T3 (en)	2001-02-28
JP3268557B2 (ja)	2002-03-25
JPH06508156A (ja)	1994-09-14
DE69329367T2 (de)	2001-06-21
WO1993019776A1 (en)	1993-10-14
PT587858E (pt)	2001-02-28
NZ251498A (en)	1995-07-26
ES2150940T5 (es)	2008-04-16
DE69329367T3 (de)	2008-06-19
NO934355D0 (no)	1993-11-30
EP0587858B2 (de)	2007-11-14
NO310804B1 (no)	2001-09-03
EP0587858B1 (de)	2000-09-06
CA2102693A1 (en)	1993-10-04
DE69329367D1 (de)	2000-10-12
CA2102693C (en)	2008-06-17
ES2150940T3 (es)	2000-12-16
AU3913593A (en)	1993-11-08
AU666007B2 (en)	1996-01-25
SE9201073D0 (sv)	1992-04-03
EP0587858A1 (de)	1994-03-23
NO934355L (no)	1993-12-01
DK0587858T3 (da)	2000-12-18
US5567677A (en)	1996-10-22

Legal Events

Date	Code	Title
2000-12-15	UEP	Publication of translation of european patent specification
2008-04-15	EEFA	Change of the company name
2008-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69329367D1 (de)	2000-10-12	Wachstumshormon-enthaltendeproteinformulierung
EP0747092A3 (de)	1998-04-08	Lösungsflüssigkeit für durch Iontophorese zugeführte Medikamente
CA2275890A1 (en)	1998-07-02	Stable liquid interferon formulations
JPS6440433A (en)	1989-02-10	Aqueous liquid composition of thrombin
IL135186A0 (en)	2001-05-20	LIQUID INTERFERON-β FORMULATIONS
DE59504750D1 (de)	1999-02-18	Verfahren zur gewinnung von hochreinem von willebrand-faktor
PL274485A1 (en)	1989-04-17	Method of obtaining stable preparations of human proteins
DK0607156T3 (da)	1997-04-07	Fremgangsmåde til fremstilling af konserverede lægemidler indeholdende humane proteiner til infusions- eller injektionsformål
DE3585556D1 (de)	1992-04-16	Pharmazeutische zusammensetzungen, welche ein dipeptid enthalten.
DK1044015T3 (da)	2008-12-08	Formuleringer med amylinagonistpeptider og insulin
ATE223728T1 (de)	2002-09-15	Stabilisierte pharmazeutische zusammensetzung von bdnf
EE9900428A (et)	2000-04-17	Köhavastased ravimkoostised
ATE228005T1 (de)	2002-12-15	Pharmazeutische formulierungen aus corticotropin freisetzenden faktor mit verbesserter stabilitaet in fluessiger form
Holbrook et al.	1975	The identification of a peptide in human parotid saliva particularly active in enhancing the glycolytic activity of the salivary micro-organisms
DK0641216T3 (da)	1998-01-26	Farmaceutisk præparat indeholdende IL-6
KR860006982A (ko)	1986-10-06	안정한 감마 인터페론 제형의 제조방법
Donohue Jr et al.	1981	Glucose-6-phosphate dehydrogenase Partial characterization of the rat liver and uterine enzymes
SE9302006D0 (sv)	1993-06-11	Protein formulation
Leaver	1969	Studies on certain peptide fractions isolated from human dentine
YU44292A (sh)	1994-06-24	Superaktivni analozi faktora oslobadjanja hormona rasta
BR9006746A (pt)	1991-08-06	Peptideo fisiologicamente ativo e agente regulador do metabolismo de calcio
Lafeber	1988	Comparison of PTH and hypocalcin in mammalian and teleost bioassays
KR920700666A (ko)	1992-08-10	소형 펩티드의 안정화 액상제제