ATE223728T1 - Stabilisierte pharmazeutische zusammensetzung von bdnf - Google Patents
Stabilisierte pharmazeutische zusammensetzung von bdnfInfo
- Publication number
- ATE223728T1 ATE223728T1 AT97922156T AT97922156T ATE223728T1 AT E223728 T1 ATE223728 T1 AT E223728T1 AT 97922156 T AT97922156 T AT 97922156T AT 97922156 T AT97922156 T AT 97922156T AT E223728 T1 ATE223728 T1 AT E223728T1
- Authority
- AT
- Austria
- Prior art keywords
- bdnf
- pct
- pharmaceutical composition
- sec
- lyophilized
- Prior art date
Links
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 title abstract 5
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Psychology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8156070A JPH10212241A (ja) | 1996-05-27 | 1996-05-27 | Ｂｄｎｆを安定に含有する製剤 |
| PCT/JP1997/001746 WO1997045135A1 (en) | 1996-05-27 | 1997-05-26 | Stable pharmaceutical composition of bdnf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE223728T1 true ATE223728T1 (de) | 2002-09-15 |
Family
ID=15619654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97922156T ATE223728T1 (de) | 1996-05-27 | 1997-05-26 | Stabilisierte pharmazeutische zusammensetzung von bdnf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6077829A (de) |
| EP (1) | EP0910399B1 (de) |
| JP (1) | JPH10212241A (de) |
| AT (1) | ATE223728T1 (de) |
| AU (1) | AU715571B2 (de) |
| CA (1) | CA2256410C (de) |
| DE (1) | DE69715414T2 (de) |
| DK (1) | DK0910399T3 (de) |
| ES (1) | ES2183170T3 (de) |
| PT (1) | PT910399E (de) |
| WO (1) | WO1997045135A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2265743A1 (en) * | 1996-09-13 | 1998-03-19 | Advanced Medicine Research Institute | Ophthalmic composition of neurotrophic factor, optic nerve functional disorder-treating agent and method for treating optic nerve functional disorder |
| US20040120891A1 (en) * | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
| WO2000075143A1 (en) * | 1999-06-03 | 2000-12-14 | Eisai Co., Ltd. | Crystals of carbapenem derivatives and pharmaceutical preparations for injection |
| AUPQ084899A0 (en) * | 1999-06-08 | 1999-07-01 | University Of Melbourne, The | Neurotrophin agonists |
| AU2001271037A1 (en) | 2000-07-13 | 2002-01-30 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing dds compounds |
| US7223406B2 (en) | 2000-07-21 | 2007-05-29 | The Regents Of The University Of California | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder |
| EP1365794A2 (de) * | 2000-07-21 | 2003-12-03 | Lue, Tom | Vorbeugung und behandlung von störungen der sexuellen erregbarkeit |
| ATE554784T1 (de) * | 2001-05-25 | 2012-05-15 | Cornell Res Foundation Inc | Hochaffiner ligand für p75 neurotrophin-rezeptor |
| DE10149030A1 (de) * | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| US20040096828A1 (en) * | 2002-01-04 | 2004-05-20 | Lu Dyung Aina M | Cytoskeleton-associated proteins |
| US20030219696A1 (en) * | 2002-05-23 | 2003-11-27 | Moreland Gerald W. | Method and apparatus for preventing backflow in dental saliva evacuators |
| EP1587545A2 (de) * | 2003-01-13 | 2005-10-26 | Mahendra S. Rao | Anhaltende expression von molekülkandidaten in proliferierenden stamm- und vorläuferzellen zur abgabe von therapeutischen produkten |
| US20050048041A1 (en) * | 2003-01-13 | 2005-03-03 | Rao Mahendra S. | Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products |
| GT200600240A (es) | 2005-06-06 | 2007-03-14 | Anticuerpos monoclonales anti-trkb y usos de los mismos | |
| JP5713377B2 (ja) | 2005-12-28 | 2015-05-07 | ザ スクリプス リサーチ インスティテュート | 薬物標的としての天然アンチセンスおよび非コードｒｎａ転写物 |
| WO2008019431A1 (en) * | 2006-08-14 | 2008-02-21 | Brc Operations Pty Limited | Method and compositions for simultaneously regulating memory and mood |
| IT1396607B1 (it) | 2009-11-16 | 2012-12-14 | Hmfra Hungary Ltd Liability Company | Preparazioni oftalmiche a base di bdnf (brain-derived neurotrophic factor) e loro uso. |
| RU2607526C2 (ru) | 2009-11-23 | 2017-01-10 | Кьюбист Фармасьютикалз ЭлЭлСи | Липопептидные композиции и родственные способы |
| HK1210211A1 (en) | 2012-03-15 | 2016-04-15 | 科纳公司 | Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf |
| CA3105879A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
| JP2021019532A (ja) * | 2019-07-26 | 2021-02-18 | 花王株式会社 | 血液脳関門保護剤 |
| EP4117625A1 (de) | 2020-03-12 | 2023-01-18 | Baxter International Inc. | Daptomycin-formulierungen mit einer kombination aus sorbitol und mannitol |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
| CA2070823C (en) * | 1989-12-05 | 1999-01-12 | William H. Ii Frey | Neurologic agents for nasal administration to the brain |
| US5604202A (en) * | 1990-11-13 | 1997-02-18 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Use of NGF growth factors to treat drug-induced neuropathy |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
-
1996
- 1996-05-27 JP JP8156070A patent/JPH10212241A/ja active Pending
-
1997
- 1997-05-26 CA CA002256410A patent/CA2256410C/en not_active Expired - Fee Related
- 1997-05-26 WO PCT/JP1997/001746 patent/WO1997045135A1/en not_active Ceased
- 1997-05-26 ES ES97922156T patent/ES2183170T3/es not_active Expired - Lifetime
- 1997-05-26 AT AT97922156T patent/ATE223728T1/de not_active IP Right Cessation
- 1997-05-26 AU AU27923/97A patent/AU715571B2/en not_active Ceased
- 1997-05-26 US US09/180,884 patent/US6077829A/en not_active Expired - Fee Related
- 1997-05-26 DE DE69715414T patent/DE69715414T2/de not_active Expired - Lifetime
- 1997-05-26 PT PT97922156T patent/PT910399E/pt unknown
- 1997-05-26 EP EP97922156A patent/EP0910399B1/de not_active Expired - Lifetime
- 1997-05-26 DK DK97922156T patent/DK0910399T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2256410C (en) | 2007-02-27 |
| PT910399E (pt) | 2002-11-29 |
| CA2256410A1 (en) | 1997-12-04 |
| JPH10212241A (ja) | 1998-08-11 |
| EP0910399B1 (de) | 2002-09-11 |
| AU2792397A (en) | 1998-01-05 |
| DK0910399T3 (da) | 2003-01-06 |
| AU715571B2 (en) | 2000-02-03 |
| DE69715414D1 (de) | 2002-10-17 |
| WO1997045135A1 (en) | 1997-12-04 |
| US6077829A (en) | 2000-06-20 |
| EP0910399A1 (de) | 1999-04-28 |
| ES2183170T3 (es) | 2003-03-16 |
| DE69715414T2 (de) | 2003-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0910399 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |