ATE197479T1 - Verfahren zur vervielfältigung von nukleinsäuresequenzen - Google Patents

Verfahren zur vervielfältigung von nukleinsäuresequenzen

Info

Publication number
ATE197479T1
ATE197479T1 AT93306169T AT93306169T ATE197479T1 AT E197479 T1 ATE197479 T1 AT E197479T1 AT 93306169 T AT93306169 T AT 93306169T AT 93306169 T AT93306169 T AT 93306169T AT E197479 T1 ATE197479 T1 AT E197479T1
Authority
AT
Austria
Prior art keywords
duplication
nucleic acid
acid sequences
oligonucleotides
kits
Prior art date
Application number
AT93306169T
Other languages
English (en)
Inventor
Sherrol Mcdonough
Daniel Kacian
Nanibhushan Dattagupta
Diane Mcallister
Philip Hammond
Thomas Ryder
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of ATE197479T1 publication Critical patent/ATE197479T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93306169T 1992-08-04 1993-08-04 Verfahren zur vervielfältigung von nukleinsäuresequenzen ATE197479T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92540592A 1992-08-04 1992-08-04

Publications (1)

Publication Number Publication Date
ATE197479T1 true ATE197479T1 (de) 2000-11-11

Family

ID=25451694

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93306169T ATE197479T1 (de) 1992-08-04 1993-08-04 Verfahren zur vervielfältigung von nukleinsäuresequenzen
AT99121906T ATE346954T1 (de) 1992-08-04 1993-08-04 Nachweis von mycobacterium tuberculosis durch vervielfältigung von nukleinsäuresequenzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99121906T ATE346954T1 (de) 1992-08-04 1993-08-04 Nachweis von mycobacterium tuberculosis durch vervielfältigung von nukleinsäuresequenzen

Country Status (11)

Country Link
EP (2) EP0587298B1 (de)
JP (3) JP4372837B2 (de)
KR (1) KR100316498B1 (de)
AT (2) ATE197479T1 (de)
AU (2) AU670116B2 (de)
CA (1) CA2141430C (de)
DE (2) DE69334092T2 (de)
ES (1) ES2277679T3 (de)
NO (1) NO950381L (de)
TW (1) TW278099B (de)
WO (1) WO1994003472A1 (de)

Families Citing this family (79)

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US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
DE69431240T2 (de) 1993-12-01 2003-04-17 Toyo Boseki K.K., Osaka Verfahren zur ampflifizierung und zum nachweis bestimmter nukleinsäuresequenzen mittels thermostabiler enzyme
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
DK0805876T3 (da) * 1995-01-19 2000-11-06 Gen Probe Inc Nukleinsyreamplifikationsoligonukleotider og prober til Lyme-sygdom-associeret Borrelia
US5622827A (en) * 1995-02-07 1997-04-22 Gen-Probe Incorporated Amplification primers and nucleic acid probes targeted to coccidioides immitis nucleic acid
CA2219891C (en) * 1995-05-05 2002-01-29 Applied Biosystems, Llc Methods and reagents for combined pcr amplification and hybridization probing assay
US5925518A (en) * 1995-05-19 1999-07-20 Akzo Nobel N.V. Nucleic acid primers for amplification of a mycobacteria RNA template
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
JP3996639B2 (ja) * 1995-06-07 2007-10-24 ジェン−プローブ・インコーポレーテッド 生成物の増幅後レベルから核酸標的配列の増幅前レベルを決定するための方法とキット
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
JP4293635B2 (ja) * 1995-06-07 2009-07-08 ジェン−プローブ・インコーポレーテッド Neisseria種用の核酸プローブおよび増幅オリゴヌクレオチド
US5705365A (en) * 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5882857A (en) * 1995-06-07 1999-03-16 Behringwerke Ag Internal positive controls for nucleic acid amplification
US5710029A (en) * 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
DE69734576T2 (de) * 1996-03-01 2006-08-03 E.I. Dupont De Nemours And Co., Wilmington Methode zur vervielfältigung und zum nachweis eines gewünschten nukleinsäurefragments
JP4241929B2 (ja) 1996-05-22 2009-03-18 ジェン―プローブ・インコーポレーテッド Mycobacterium Kansasiiを検出するための組成物および方法
US6013488A (en) * 1996-07-25 2000-01-11 The Institute Of Physical And Chemical Research Method for reverse transcription
US6057134A (en) * 1996-10-07 2000-05-02 Ambion, Inc. Modulating the efficiency of nucleic acid amplification reactions with 3' modified oligonucleotides
CA2276251A1 (en) 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
GB9626074D0 (en) 1996-12-16 1997-02-05 Cytocell Ltd Nucleic acids amplification assay
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
DK0975807T3 (da) * 1997-05-02 2007-01-29 Gen Probe Inc To-trins hybridisering og indfangning af et polynukleotid
KR100454172B1 (ko) * 1997-08-14 2004-10-26 다카라 바이오 가부시키가이샤 Dna 증폭방법 및 그의 키트
WO1999023258A1 (en) * 1997-10-31 1999-05-14 Gen-Probe Incorporated Methods of nucleic acid detection
US5932451A (en) * 1997-11-19 1999-08-03 Incyte Pharmaceuticals, Inc. Method for unbiased mRNA amplification
JP4438110B2 (ja) * 1998-07-01 2010-03-24 東ソー株式会社 標的核酸の定量方法
AU4739600A (en) * 1999-05-17 2000-12-05 Mcgill University Method for subtracting cdnas by suppressing the synthesis of specifically targeted mrnas
WO2001007661A2 (en) 1999-07-23 2001-02-01 Gen-Probe Incorporated Polynucleotide amplification method
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
JP2002051778A (ja) * 2000-05-31 2002-02-19 Tosoh Corp 小型球形ウイルス(srsv)rna検出のためのオリゴヌクレオチドおよび検出法
AUPR050700A0 (en) 2000-10-03 2000-10-26 Id+Plus Ltd Detection method
AU2001291513B2 (en) * 2000-10-03 2007-06-07 Id+Plus Ltd Nucleotide detection method
JP4202750B2 (ja) 2000-10-23 2008-12-24 ジェン−プローブ・インコーポレーテッド ヒト免疫不全ウイルス2(hiv−2)を検出するための組成物および方法
JP2002125688A (ja) * 2000-10-30 2002-05-08 Tosoh Corp C型肝炎ウイルスの高感度検出のためのオリゴヌクレオチドおよび検出法
DE10119203B4 (de) * 2001-04-19 2004-09-16 Rolf Dr. Postina Verfahren zur Erzeugung von doppelsträngigen Nukleinsäuren mit einzelsträngigen Überhängen beliebiger Länge und Nukleotidzusammensetzung
CA2486420C (en) 2002-06-14 2014-04-15 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
AU2003298605B2 (en) 2002-10-16 2007-10-18 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
ATE478968T1 (de) 2003-12-19 2010-09-15 Gen Probe Inc Zusammensetzungen, verfahren und kits zum nachweis der nukleinsäuren von hiv-1 und hiv-2
ES2759991T3 (es) 2004-09-30 2020-05-12 Gen Probe Inc Ensayo para detectar y cuantificar el VIH-1
EP1809772B1 (de) 2004-11-09 2013-06-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von gruppe-a-streptococcen
AU2006214141B2 (en) 2005-02-18 2010-07-15 Gen-Probe Incorporated Sample preparation method incorporating an alkaline shock
WO2006121773A2 (en) 2005-05-06 2006-11-16 Gen-Probe Incorporated Compositions and assays to detect influenza virus a and b nucleic acids
CA2627259C (en) 2005-11-14 2016-02-23 Gen-Probe Incorporated Parametric calibration method
EP2027293B1 (de) * 2006-05-24 2014-11-19 Gen-Probe Incorporated Verfahren zum lysieren von mycobacterium und amplifikation seiner nukleinsäuren
EP1921156A1 (de) * 2006-11-10 2008-05-14 bioMerieux B.V. Verbesserte multiplexe Nukleinsäureamplifikation mittels blockierter Primer
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
EP1978111B1 (de) * 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
CA2721536A1 (en) 2008-04-21 2009-10-29 Gen-Probe Incorporated Method for detecting chikungunya virus
EP3257859B1 (de) 2009-02-26 2020-09-23 Gen-Probe Incorporated Assay zum nachweisen menschlicher parvoviren-nukleinsäure
WO2012009373A2 (en) 2010-07-12 2012-01-19 Gen-Probe Incorporated Compositions and assays to detect swine h1n1 influenza a virus, seasonal h1 influenza a virus and seasonal h3 influenza a virus nucleic acids
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
CN103703148B (zh) 2011-07-15 2021-03-12 简.探针公司 在单路或多路测定法中用于检测人细小病毒核酸和用于检测甲型肝炎病毒核酸的组合物和方法
WO2014018885A2 (en) 2012-07-27 2014-01-30 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
US9976175B2 (en) 2013-03-15 2018-05-22 Gen-Probe Incorporated Calibration method, apparatus and computer program product
EP3601617B3 (de) 2017-03-24 2024-03-20 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus
CA3176529C (en) 2017-03-24 2024-03-05 Gen-Probe Incorporated Compositions and methods for detection of viral pathogens in samples
EP3665309B1 (de) 2017-08-11 2023-02-22 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von staphylococcus aureus
EP3724354A1 (de) 2017-12-15 2020-10-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile
GB2590210B (en) 2018-06-13 2023-01-25 Gen Probe Inc Compositions and methods for detecting group B Streptococcus nucleic acid
CA3106975A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
US12460254B2 (en) 2018-08-08 2025-11-04 Gen-Probe Incorporated Compositions, methods and kits for detecting Mycoplasma genitalium
US12454728B2 (en) 2018-08-21 2025-10-28 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
CA3116895A1 (en) 2018-10-22 2020-04-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus
WO2021041056A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
CA3153514A1 (en) 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
WO2021119124A1 (en) 2019-12-09 2021-06-17 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
AU2021230341C8 (en) 2020-03-04 2026-05-07 Gen-Probe Incorporated Compositions and methods for detecting SARS-CoV-2 nucleic acid
EP4382621A3 (de) 2021-07-27 2024-08-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von c. coli und mindestens einer von salmonella, c. jejuni, shigella und stec
KR102544380B1 (ko) 2022-01-29 2023-06-16 (주)동방지퍼 지퍼용 슬라이더와 손잡이의 결착방법 및 이로 인해 제조된 지퍼
EP4282980A1 (de) 2022-05-23 2023-11-29 Mobidiag Oy Methoden zum verstärken einer nukleinsäure
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024233375A1 (en) 2023-05-05 2024-11-14 Gen-Probe Incorporated Method and system for improving specificity of analyte detection using real-time nucleic acid amplification

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US5521300A (en) * 1991-08-13 1996-05-28 Norval B. Galloway Oligonucleotides complementary to mycobacterial nucleic acids
WO1993022461A1 (en) * 1992-05-06 1993-11-11 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit

Also Published As

Publication number Publication date
EP0978570A2 (de) 2000-02-09
AU6802796A (en) 1996-12-19
AU700253B2 (en) 1998-12-24
AU670116B2 (en) 1996-07-04
NO950381L (no) 1995-04-03
EP0978570B1 (de) 2006-11-29
JP2006238892A (ja) 2006-09-14
NO950381D0 (no) 1995-02-02
TW278099B (de) 1996-06-11
EP0587298A2 (de) 1994-03-16
JPH07509368A (ja) 1995-10-19
DE69334092T2 (de) 2007-07-05
CA2141430A1 (en) 1994-02-17
EP0978570A3 (de) 2000-04-12
DE69329636T2 (de) 2001-03-01
ES2277679T3 (es) 2007-07-16
DE69334092D1 (de) 2007-01-11
AU4792093A (en) 1994-03-03
JP4372837B2 (ja) 2009-11-25
CA2141430C (en) 2009-05-12
EP0587298A3 (en) 1995-08-30
EP0587298B1 (de) 2000-11-08
KR100316498B1 (ko) 2002-06-20
KR950702999A (ko) 1995-08-23
ATE346954T1 (de) 2006-12-15
JP2004194662A (ja) 2004-07-15
DE69329636D1 (de) 2000-12-14
WO1994003472A1 (en) 1994-02-17
JP3860809B2 (ja) 2006-12-20

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