ATE197762T1 - Verwendung von optisch reines (+) norcisapride zur behandlung von erbrechen und zns-störungen - Google Patents

Verwendung von optisch reines (+) norcisapride zur behandlung von erbrechen und zns-störungen

Info

Publication number
ATE197762T1
ATE197762T1 AT97932467T AT97932467T ATE197762T1 AT E197762 T1 ATE197762 T1 AT E197762T1 AT 97932467 T AT97932467 T AT 97932467T AT 97932467 T AT97932467 T AT 97932467T AT E197762 T1 ATE197762 T1 AT E197762T1
Authority
AT
Austria
Prior art keywords
norcisapride
optically pure
cns disorders
treat vomiting
isomer
Prior art date
Application number
AT97932467T
Other languages
English (en)
Inventor
John R Mccullough
Thomas P Jerussi
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ATE197762T1 publication Critical patent/ATE197762T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97932467T 1996-07-19 1997-07-02 Verwendung von optisch reines (+) norcisapride zur behandlung von erbrechen und zns-störungen ATE197762T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/684,753 US5739151A (en) 1996-07-19 1996-07-19 Method for treating emesis and central nervous system disorders using optically pure (+) norcisapride
PCT/US1997/011629 WO1998003173A1 (en) 1996-07-19 1997-07-02 Methods for treating emesis and central nervous system disorders using optically pure (+) norcisapride

Publications (1)

Publication Number Publication Date
ATE197762T1 true ATE197762T1 (de) 2000-12-15

Family

ID=24749413

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97932467T ATE197762T1 (de) 1996-07-19 1997-07-02 Verwendung von optisch reines (+) norcisapride zur behandlung von erbrechen und zns-störungen

Country Status (25)

Country Link
US (3) US5739151A (de)
EP (1) EP0896539B1 (de)
JP (1) JP3097697B2 (de)
KR (4) KR100328731B1 (de)
CN (1) CN1215992A (de)
AT (1) ATE197762T1 (de)
AU (1) AU3592097A (de)
BG (1) BG63190B1 (de)
BR (1) BR9708287A (de)
CA (1) CA2245768C (de)
CZ (1) CZ293478B6 (de)
DE (1) DE69703617T2 (de)
DK (1) DK0896539T3 (de)
ES (1) ES2152687T3 (de)
GR (1) GR3035460T3 (de)
HU (1) HUP9904360A3 (de)
IL (1) IL125703A0 (de)
IS (1) IS4820A (de)
NO (2) NO317178B1 (de)
NZ (1) NZ331291A (de)
PL (1) PL189610B1 (de)
PT (1) PT896539E (de)
SK (1) SK282673B6 (de)
TR (1) TR199801816T2 (de)
WO (1) WO1998003173A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712293A (en) * 1995-06-07 1998-01-27 Sepracor, Inc. Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (-) norcisapride
US5739151A (en) * 1996-07-19 1998-04-14 Sepracor Inc. Method for treating emesis and central nervous system disorders using optically pure (+) norcisapride
US6147093A (en) * 1996-07-19 2000-11-14 Sepracor Inc. Methods for treating gastroesophageal reflux disease
ES2180032T3 (es) * 1996-10-15 2003-02-01 Janssen Pharmaceutica Nv Procedimiento para preparar un compuesto intermedio util en la sintesis de cisaprida.
KR100358374B1 (ko) * 1997-07-11 2002-10-25 얀센 파마슈티카 엔.브이. 5-ｈｔ3 및 5-ｈｔ4 매개된 질환에 유용한(+)-노르시사프라이드
EP1464333A3 (de) * 1998-06-15 2004-12-15 Sepracor Inc. Verwendung von optisch reines (-) Norcisapride in der Behandlung von Apnea, Bulimia und andere Krankheiten
EP1468685A3 (de) * 1998-06-15 2004-12-15 Sepracor Inc. Verwendung von optisch reines (+)-Norcisapride für die Behandlung von Apnea, Bulimia und andere Krankheiten
TR200103054T2 (tr) 1998-06-15 2002-06-21 Sepracor Inc. Apne,bulimi ve başka bozuklukların tedavi edilmesi için optik açıdan saf (+)-norsisapridin kullanımı
EP1087765B1 (de) 1998-06-15 2005-03-30 Sepracor Inc. Verwendung von optisch reinem (-) norcisapride in der behandlung des reizdarmsyndroms
ES2257869T3 (es) * 1998-08-21 2006-08-01 Novartis Ag Nueva formulacion oral para agonistas o antagonistas de 5-ht4.
US6362202B1 (en) * 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6803387B1 (en) * 1999-03-19 2004-10-12 Abbott Gmbh & Co. Kg Treatment of neuropathic pain or fibromyalgia
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
EP1321142A1 (de) * 2001-12-21 2003-06-25 Novartis AG Feste orale Zubereitung mit Tegaserod
FR2854072B1 (fr) * 2003-04-23 2006-08-04 Centre Nat Rech Scient Vecteur pour administration par voie orale
WO2005068461A1 (en) 2004-01-07 2005-07-28 Aryx Therapeutics Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8524736B2 (en) 2004-01-07 2013-09-03 Armetheon, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8138204B2 (en) * 2004-01-07 2012-03-20 Aryx Therapeutics, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
WO2006029520A1 (en) * 2004-09-14 2006-03-23 Mcgill University Stimulators of 5-ht4 receptors and uses thereof
CA2620379C (en) * 2005-08-31 2015-02-24 Aryx Therapeutics, Inc. Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders
US20080085915A1 (en) * 2006-06-23 2008-04-10 Cyrus Becker Compounds and methods for the treatment of gastrointestinal and central nervous system disorders
CN102655860B (zh) 2009-10-16 2013-11-06 艾皮奥梅医药公司 呕吐的治疗
DK2678332T3 (en) * 2011-02-25 2016-08-15 Yuhan Corp Diaminopyrimidine derivatives and process for their preparation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5137896A (en) * 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5057525A (en) * 1981-10-01 1991-10-15 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5114715A (en) * 1990-11-29 1992-05-19 Sepracor Inc. Methods of use and compositions of (s)-isoflurane and (s)-desflurane
US5114714A (en) * 1990-11-29 1992-05-19 Sepracor, Inc. Methods of use and compositions of (r)-isoflurane and (r)-desflurane
EP1145715A3 (de) * 1992-07-07 2004-05-19 Sepracor Inc. Verfahren zur Verwendung von (-) Cisapride zur Behandlung von Magenspeiseroehrenruechstornung und anderen Erkrankungen
WO1994001111A1 (en) * 1992-07-07 1994-01-20 Sepracor Inc. Methods of using (+) cisapride for the treatment of gastro-esophageal reflux disease and other disorders
EP0707492A1 (de) * 1993-07-06 1996-04-24 Merck & Co. Inc. Kombinationen aus h 2? antagonisten und gastrointestinalen motilitässubstanzen
US5712293A (en) * 1995-06-07 1998-01-27 Sepracor, Inc. Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (-) norcisapride
US5739151A (en) * 1996-07-19 1998-04-14 Sepracor Inc. Method for treating emesis and central nervous system disorders using optically pure (+) norcisapride

Also Published As

Publication number Publication date
PL189610B1 (pl) 2005-08-31
CA2245768C (en) 2003-09-30
US5877188A (en) 1999-03-02
KR100422492B1 (ko) 2004-03-11
IL125703A0 (en) 1999-04-11
HUP9904360A2 (hu) 2000-05-28
CZ293478B6 (cs) 2004-05-12
KR20000064524A (ko) 2000-11-06
SK123998A3 (en) 1999-03-12
BG63190B1 (bg) 2001-06-29
BR9708287A (pt) 2000-01-18
ES2152687T3 (es) 2001-02-01
CN1215992A (zh) 1999-05-05
NZ331291A (en) 2000-06-23
KR100533237B1 (ko) 2005-12-05
NO317178B1 (no) 2004-09-06
KR20040007505A (ko) 2004-01-24
PL335254A1 (en) 2000-04-10
KR100328731B1 (ko) 2002-10-19
NO983636L (no) 1998-10-19
US6114356A (en) 2000-09-05
HUP9904360A3 (en) 2001-07-30
CZ250898A3 (cs) 1999-04-14
JP3097697B2 (ja) 2000-10-10
NO983636D0 (no) 1998-08-07
EP0896539B1 (de) 2000-11-29
PT896539E (pt) 2001-05-31
SK282673B6 (sk) 2002-11-06
WO1998003173A1 (en) 1998-01-29
CA2245768A1 (en) 1998-01-29
KR100399808B1 (ko) 2003-09-29
IS4820A (is) 1998-08-10
DK0896539T3 (da) 2001-02-19
DE69703617T2 (de) 2001-04-12
AU3592097A (en) 1998-02-10
GR3035460T3 (en) 2001-05-31
DE69703617D1 (de) 2001-01-04
BG102757A (en) 1999-08-31
NO20041166L (no) 2004-03-19
TR199801816T2 (xx) 2000-10-23
EP0896539A1 (de) 1999-02-17
US5739151A (en) 1998-04-14
JPH11510828A (ja) 1999-09-21

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