ATE198201T1 - Tetrazolyl-substituierte chinuclidine als substanz p antagonisten - Google Patents

Tetrazolyl-substituierte chinuclidine als substanz p antagonisten

Info

Publication number: ATE198201T1
Authority: AT; Austria
Prior art keywords: alkyl; halo; disorders; hydrogen; pantagonists
Prior art date: 1996-09-12

Application number

AT97306612T

Other languages

English (en)

Inventor

Kunio Satake

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-12

Filing date

1997-08-28

Publication date

2001-01-15

1997-08-28 Application filed by Pfizer filed Critical Pfizer

2001-01-15 Application granted granted Critical

2001-01-15 Publication of ATE198201T1 publication Critical patent/ATE198201T1/de

Links

150000008584 quinuclidines Chemical class 0.000 title 1
239000000126 substance Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229940035676 analgesics Drugs 0.000 abstract 2
239000000730 antalgic agent Substances 0.000 abstract 2
239000002260 anti-inflammatory agent Substances 0.000 abstract 2
229940121363 anti-inflammatory agent Drugs 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
241000590002 Helicobacter pylori Species 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010042496 Sunburn Diseases 0.000 abstract 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
-1 halo C1-C6 alkyl Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000005059 halophenyl group Chemical group 0.000 abstract 1
229940037467 helicobacter pylori Drugs 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
208000014001 urinary system disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Oncology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT97306612T 1996-09-12 1997-08-28 Tetrazolyl-substituierte chinuclidine als substanz p antagonisten ATE198201T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IB9600934		1996-09-12

Publications (1)

Publication Number	Publication Date
ATE198201T1 true ATE198201T1 (de)	2001-01-15

Family

ID=11004477

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97306612T ATE198201T1 (de)	1996-09-12	1997-08-28	Tetrazolyl-substituierte chinuclidine als substanz p antagonisten

Country Status (10)

Country	Link
US (1)	US5939434A (de)
EP (1)	EP0829480B1 (de)
JP (1)	JP3273750B2 (de)
AT (1)	ATE198201T1 (de)
CA (1)	CA2215020C (de)
DE (1)	DE69703725T2 (de)
DK (1)	DK0829480T3 (de)
ES (1)	ES2152633T3 (de)
GR (1)	GR3035379T3 (de)
MX (1)	MX9706944A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6953855B2 (en) *	1998-12-11	2005-10-11	Targacept, Inc.	3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
US20040142929A1 (en) *	2001-07-06	2004-07-22	Ramon Merce-Vidal	Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
US6861526B2 (en)	2002-10-16	2005-03-01	Pfizer Inc.	Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
WO2005012267A1 (ja) *	2003-08-01	2005-02-10	Toyo Kasei Kogyo Company Limited	アルコキシ－テトラゾール－１－イル－ベンズアルデヒド化合物およびその製造方法
WO2005045395A2 (en) *	2003-10-27	2005-05-19	Meyer Donald W	Method of detecting bovine spongiform encephalopathy
JP5172124B2 (ja)	2006-09-29	2013-03-27	関東化学株式会社	２位に置換基を有する光学活性キヌクリジノール類の製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4680283A (en) *	1984-09-26	1987-07-14	Merck & Co., Inc.	Analogs of substance P and eledoisin
WO1990005525A1 (en) *	1988-11-23	1990-05-31	Pfizer Inc.	Quinuclidine derivatives as substance p antagonists
EP0499313B1 (de) *	1991-02-11	1997-06-11	MERCK SHARP & DOHME LTD.	Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
US5716965A (en) *	1991-05-22	1998-02-10	Pfizer Inc.	Substituted 3-aminoquinuclidines
FI935134A7 (fi) *	1991-05-22	1993-11-19	Pfizer	Substituoidut 3-aminokinuklidiinit
US5288730A (en) *	1991-06-24	1994-02-22	Merck Sharp & Dohme Limited	Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
ATE195867T1 (de) *	1991-09-20	2000-09-15	Glaxo Group Ltd	Neue medizinische indikation für tachykinin- antagonisten
JP2656702B2 (ja) *	1992-03-23	1997-09-24	ファイザー製薬株式会社	ペプチド性キヌクリジン
US5569662A (en) *	1992-03-23	1996-10-29	Pfizer Inc.	Quinuclidine derivatives as substance P antagonists
US5604241A (en) *	1992-10-21	1997-02-18	Pfizer Inc.	Substituted benzylaminoquinuclidines as substance P antagonists
JP2656700B2 (ja) *	1992-10-28	1997-09-24	ファイザー製薬株式会社	置換キヌクリジン誘導体
IL109646A0 (en) *	1993-05-19	1994-08-26	Pfizer	Heteroatom substituted alkyl benzylamino-quinuclidines
ATE171945T1 (de) *	1993-07-15	1998-10-15	Pfizer	Benzyloxychinuclidine als substanz p antagonisten
IL111002A (en) *	1993-09-22	1998-09-24	Glaxo Group Ltd	Piperidine derivatives their preparation and pharmaceutical compositions containing them

1996
- 1996-09-12 MX MX9706944A patent/MX9706944A/es active IP Right Grant
1997
- 1997-08-28 DK DK97306612T patent/DK0829480T3/da active
- 1997-08-28 AT AT97306612T patent/ATE198201T1/de not_active IP Right Cessation
- 1997-08-28 DE DE69703725T patent/DE69703725T2/de not_active Expired - Fee Related
- 1997-08-28 ES ES97306612T patent/ES2152633T3/es not_active Expired - Lifetime
- 1997-08-28 EP EP97306612A patent/EP0829480B1/de not_active Expired - Lifetime
- 1997-09-05 US US08/924,171 patent/US5939434A/en not_active Expired - Fee Related
- 1997-09-10 CA CA002215020A patent/CA2215020C/en not_active Expired - Fee Related
- 1997-09-11 JP JP26296597A patent/JP3273750B2/ja not_active Expired - Fee Related
2001
- 2001-02-07 GR GR20010400206T patent/GR3035379T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0829480T3 (da)	2001-02-19
EP0829480A2 (de)	1998-03-18
DE69703725D1 (de)	2001-01-25
JP3273750B2 (ja)	2002-04-15
EP0829480A3 (de)	1998-04-08
MX9706944A (es)	1998-08-30
CA2215020A1 (en)	1998-03-12
ES2152633T3 (es)	2001-02-01
CA2215020C (en)	2000-05-16
US5939434A (en)	1999-08-17
EP0829480B1 (de)	2000-12-20
GR3035379T3 (en)	2001-05-31
JPH1087661A (ja)	1998-04-07
DE69703725T2 (de)	2001-04-26

Legal Events

Date	Code	Title	Description
2001-04-15	UEP	Publication of translation of european patent specification
2010-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
KR100366902B1 (ko)	2003-01-09	섭스턴스 ｐ 길항제로서 피페리디닐아미노메틸트리플루오로메틸 시클릭 에테르 화합물
BR0002936A (pt)	2001-04-03	Compostos de biciclicarbonil-indol como agentes antiinflamatórios/analgésicos
DE69716810D1 (de)	2002-12-12	2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one
ATE211729T1 (de)	2002-01-15	Therapeutisch wirksame verbindungen
PT984019E (pt)	2004-08-31	Carbamatos antibacterianos em c11 de macrolidos
PT992509E (pt)	2004-12-31	Novos derivados macrolidos
ATE198201T1 (de)	2001-01-15	Tetrazolyl-substituierte chinuclidine als substanz p antagonisten
NO985202L (no)	1999-01-08	Anti-heliobacter pylori-preparater inneholdende 1-metylcarbapenemderivater
ATE264104T1 (de)	2004-04-15	Immunmodulierende arzneimittelzusammenstellung
DK1106614T3 (da)	2004-04-13	5-leddede, heteroarylsubstituerede 1,4-dihydropyridinforbindelser som bradykininantagonister
HU9400908D0 (en)	1994-06-28	Pharmaceutical compositions for treatng skin disorders
ATE223896T1 (de)	2002-09-15	3-((5-substituierte benzyl)amino)-2- phenylpiperidine als substance-p-antagonisten
DE69417472D1 (de)	1999-05-06	Loracarbef Isopropanolat und Umwandlungsverfahren vom Isopropanolat in Loracarbef Monohydrat
PT1049672E (pt)	2004-02-27	Derivados de azetidinocarboxamida para o tratamento de disturbios do snc
DK0824100T3 (da)	2000-11-20	Tricykliske piperidinylaminoforbindelser som substans P-antagonister
DE69203194D1 (de)	1995-08-03	Thiazolidine-2,4-dione für die Behandlung der Hypertonie.
ATE275560T1 (de)	2004-09-15	Bemzimidazolverbindungen und medikamente die diese enthalten
PT1049670E (pt)	2002-12-31	Derivados de azetidinocarboxamida para o tratamento de perturbacoes do snc
DE69327077D1 (de)	1999-12-30	Carbamoylpyrrolidon-Derivate zur Behandlung von Depressionen und cerebrovasculären Störungen