ATE198327T1 - 2,3-substituierte pyridine zur behandlung von entzündung - Google Patents

2,3-substituierte pyridine zur behandlung von entzündung

Info

Publication number: ATE198327T1
Authority: AT; Austria
Prior art keywords: treating inflammation; substituted pyridines; hydrido; aminosulfonyl; alkylsulfonyl
Prior art date: 1995-02-10

Application number

AT96904505T

Other languages

English (en)

Inventor

Richard M Weier

Len F Lee

Richard A Partis

Francis J Koszyk

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-10

Filing date

1996-02-08

Publication date

2001-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23528689&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE198327(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-02-08 Application filed by Searle & Co filed Critical Searle & Co

2001-01-15 Application granted granted Critical

2001-01-15 Publication of ATE198327T1 publication Critical patent/ATE198327T1/de

Links

206010061218 Inflammation Diseases 0.000 title abstract 3
230000004054 inflammatory process Effects 0.000 title abstract 3
150000003222 pyridines Chemical class 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000001145 hydrido group Chemical group *[H] 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 abstract 1
125000005336 allyloxy group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
-1 aralkoxy Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
125000004438 haloalkoxy group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96904505T 1995-02-10 1996-02-08 2,3-substituierte pyridine zur behandlung von entzündung ATE198327T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/387,150 US5686470A (en)	1995-02-10	1995-02-10	2, 3-substituted pyridines for the treatment of inflammation
PCT/US1996/001111 WO1996024584A1 (en)	1995-02-10	1996-02-08	2,3-substituted pyridines for the treatment of inflammation

Publications (1)

Publication Number	Publication Date
ATE198327T1 true ATE198327T1 (de)	2001-01-15

Family

ID=23528689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96904505T ATE198327T1 (de)	1995-02-10	1996-02-08	2,3-substituierte pyridine zur behandlung von entzündung

Country Status (10)

Country	Link
US (2)	US5686470A (de)
EP (1)	EP0808304B1 (de)
AT (1)	ATE198327T1 (de)
AU (1)	AU4859396A (de)
DE (1)	DE69611354T2 (de)
DK (1)	DK0808304T3 (de)
ES (1)	ES2154398T3 (de)
GR (1)	GR3035199T3 (de)
PT (1)	PT808304E (de)
WO (1)	WO1996024584A1 (de)

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US6410729B1 (en)	1996-12-05	2002-06-25	Amgen Inc.	Substituted pyrimidine compounds and methods of use
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TW492959B (en)	1997-04-18	2002-07-01	Merck & Co Inc	Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
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WO1999032448A1 (en) *	1997-12-19	1999-07-01	Amgen Inc.	Substituted pyridine and pyridazine compounds and their pharmaceutical use
US6649645B1 (en) *	1998-12-23	2003-11-18	Pharmacia Corporation	Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
WO2001041760A2 (en)	1999-12-08	2001-06-14	Pharmacia Corporation	Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect
EP1276736A2 (de) *	2000-04-25	2003-01-22	Pharmacia Corporation	Regioselektive synthese von 3,4-di(carbocyclyl- oder heterocyclyl-)thiophenen
WO2001091856A2 (en) *	2000-06-01	2001-12-06	Pharmacia Corporation	Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation
EP1299123A2 (de) *	2000-07-13	2003-04-09	Pharmacia Corporation	Verwendung von cox-2 hemmern zur behandlung und vorbeugung von cox-2-abhängigen augenkrankheiten
MXPA03001136A (es)	2000-08-11	2003-06-24	Eisai Co Ltd	Compuesto de 2-aminopiridina y uso medico del mismo.
JP2004517870A (ja) *	2001-01-02	2004-06-17	藤沢薬品工業株式会社	シクロオキシゲナーゼ阻害剤
US7115565B2 (en) *	2001-01-18	2006-10-03	Pharmacia & Upjohn Company	Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
PE20021017A1 (es)	2001-04-03	2002-11-24	Pharmacia Corp	Composicion parenteral reconstituible
US6673818B2 (en) *	2001-04-20	2004-01-06	Pharmacia Corporation	Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
UA80682C2 (en) *	2001-08-06	2007-10-25	Pharmacia Corp	Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AR038957A1 (es)	2001-08-15	2005-02-02	Pharmacia Corp	Terapia de combinacion para el tratamiento del cancer
US7271266B2 (en) *	2002-03-28	2007-09-18	Merck & Co., Inc.	Substituted 2,3-diphenyl pyridines
US7329401B2 (en)	2002-04-15	2008-02-12	The Regents Of The University Of California	Cyclooxygenase-2 selective agents useful as imaging probes and related methods
GB0221443D0 (en) *	2002-09-16	2002-10-23	Glaxo Group Ltd	Pyridine derivates
CA2522431A1 (en) *	2003-04-24	2004-11-11	Merck & Co., Inc.	Inhibitors of akt activity
CA2522435C (en) *	2003-04-24	2011-04-12	Merck & Co., Inc.	Inhibitors of akt activity
EP2266584B1 (de) *	2003-05-07	2012-09-05	Osteologix A/S	Strontium-Vitamin D-Zusammensetzung zur Prophylaxe/Behandlung von Knorpel- und Knochenzuständen
JP4354984B2 (ja) *	2003-05-07	2009-10-28	オステオロジックスエイ／エス	水溶性ストロンチウム塩を用いる軟骨／骨症状の治療
ES2229928B1 (es) *	2003-10-02	2006-07-01	Almirall Prodesfarma, S.A.	Nuevos derivados de pirimidin-2-amina.
ES2241496B1 (es) *	2004-04-15	2006-12-01	Almirall Prodesfarma, S.A.	Nuevos derivados de piridina.
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FR2876691B1 (fr) *	2004-10-18	2006-12-29	Sanofi Aventis Sa	Derives de pyridine, leur preparation, leur application en therapeutique
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ES2274712B1 (es) *	2005-10-06	2008-03-01	Laboratorios Almirall S.A.	Nuevos derivados imidazopiridina.
FR2899899A1 (fr) *	2006-04-14	2007-10-19	Sanofi Aventis Sa	Derives d'aminomethyl pyridine, leur preparation et leur application en therapeutique
ES2303776B1 (es) *	2006-12-29	2009-08-07	Laboratorios Almirall S.A.	Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b.
US20100111858A1 (en) *	2007-01-19	2010-05-06	Howard Carol P	Diangostic and Therapeutic Cyclooxygenase-2 Binding Ligands
FR2922209B1 (fr) *	2007-10-12	2010-06-11	Sanofi Aventis	5,6-DIARYLES PYRIDINES SUBSTITUES EN POSITION 2 et 3, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE.
CN109851538B (zh) *	2019-02-18	2020-12-04	浙江师范大学	一种制备γ-芳基腈的方法及化合物
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US20240165148A1 (en)	2021-03-15	2024-05-23	Saul Yedgar	Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases
CN115260092B (zh) *	2022-08-23	2023-08-25	山东京博生物科技有限公司	一种2-氯烟酰胺及其n取代衍生物的合成方法
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US11958826B1 (en)	2023-10-13	2024-04-16	King Faisal University	6′-(2-chlorophenyl)-2′-ethoxy-3,4′-bipyridine-3′- carbonitrile as an antimicrobial compound
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1995
- 1995-02-10 US US08/387,150 patent/US5686470A/en not_active Expired - Fee Related
1996
- 1996-02-08 WO PCT/US1996/001111 patent/WO1996024584A1/en not_active Ceased
- 1996-02-08 DK DK96904505T patent/DK0808304T3/da active
- 1996-02-08 DE DE69611354T patent/DE69611354T2/de not_active Expired - Fee Related
- 1996-02-08 PT PT96904505T patent/PT808304E/pt unknown
- 1996-02-08 US US08/894,102 patent/US5916905A/en not_active Expired - Fee Related
- 1996-02-08 AU AU48593/96A patent/AU4859396A/en not_active Abandoned
- 1996-02-08 EP EP96904505A patent/EP0808304B1/de not_active Expired - Lifetime
- 1996-02-08 ES ES96904505T patent/ES2154398T3/es not_active Expired - Lifetime
- 1996-02-08 AT AT96904505T patent/ATE198327T1/de not_active IP Right Cessation
2001
- 2001-01-10 GR GR20010400017T patent/GR3035199T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0808304A1 (de)	1997-11-26
EP0808304B1 (de)	2000-12-27
DK0808304T3 (da)	2001-01-29
ES2154398T3 (es)	2001-04-01
GR3035199T3 (en)	2001-04-30
WO1996024584A1 (en)	1996-08-15
PT808304E (pt)	2001-06-29
DE69611354T2 (de)	2001-06-07
US5916905A (en)	1999-06-29
DE69611354D1 (de)	2001-02-01
US5686470A (en)	1997-11-11
AU4859396A (en)	1996-08-27

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2006-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE198327T1 (de)	2001-01-15	2,3-substituierte pyridine zur behandlung von entzündung
ATE192436T1 (de)	2000-05-15	3,4-diarryl substituierte pyridine zur behandlung von entzündungen
AU4284196A (en)	1996-06-19	Substituted biphenyl compounds for the treatment of inflammation
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ATE224374T1 (de)	2002-10-15	1,2-substituierte imidazolylverbindungen zur behandlung von entzündungen
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ATE171453T1 (de)	1998-10-15	Imidazo (1,5-a> chinoline zur behandlung von angstzuständen und schlafstörungen
TR199701213T1 (de)	1998-03-21