ATE198334T1 - 1,2,4-triazolo(1,5-c)pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor - Google Patents

1,2,4-triazolo(1,5-c)pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor

Info

Publication number
ATE198334T1
ATE198334T1 AT96924840T AT96924840T ATE198334T1 AT E198334 T1 ATE198334 T1 AT E198334T1 AT 96924840 T AT96924840 T AT 96924840T AT 96924840 T AT96924840 T AT 96924840T AT E198334 T1 ATE198334 T1 AT E198334T1
Authority
AT
Austria
Prior art keywords
pct
adenosine
receptor
triazolo
antagonistic activity
Prior art date
Application number
AT96924840T
Other languages
English (en)
Inventor
Pier Giovanni Baraldi
Barbara Cacciari
Monica Viziano
Silvio Dionisotti
Ennio Ongini
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE198334T1 publication Critical patent/ATE198334T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96924840T 1995-07-28 1996-07-02 1,2,4-triazolo(1,5-c)pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor ATE198334T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI001671A IT1277392B1 (it) 1995-07-28 1995-07-28 Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
PCT/EP1996/002881 WO1997005138A1 (en) 1995-07-28 1996-07-02 1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES HAVING ANTAGONISTIC ACTIVITY ON ADENOSINE A2a RECEPTOR

Publications (1)

Publication Number Publication Date
ATE198334T1 true ATE198334T1 (de) 2001-01-15

Family

ID=11372092

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96924840T ATE198334T1 (de) 1995-07-28 1996-07-02 1,2,4-triazolo(1,5-c)pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor

Country Status (11)

Country Link
US (1) US5935964A (de)
EP (1) EP0856003B1 (de)
AT (1) ATE198334T1 (de)
CA (1) CA2227991C (de)
DE (1) DE69611377T2 (de)
DK (1) DK0856003T3 (de)
ES (1) ES2153118T3 (de)
GR (1) GR3035309T3 (de)
IT (1) IT1277392B1 (de)
PT (1) PT856003E (de)
WO (1) WO1997005138A1 (de)

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US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
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US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
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AR038366A1 (es) 2001-11-30 2005-01-12 Schering Corp Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
DK1450811T3 (da) 2001-11-30 2010-02-15 Osi Pharm Inc Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf
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US20030229067A1 (en) 2001-12-20 2003-12-11 Arlindo Castelhano Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
CN1620294A (zh) 2001-12-20 2005-05-25 Osi药物公司 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
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ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
KR20090042227A (ko) 2006-06-06 2009-04-29 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
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BRPI0922809A2 (pt) 2008-12-06 2018-05-29 Intracellular Therapies Inc compostos orgânicos
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WO2011153135A1 (en) 2010-05-31 2011-12-08 Intra-Cellular Therapies, Inc. Organic compounds
WO2011153136A1 (en) 2010-05-31 2011-12-08 Intra-Cellular Therapies, Inc. Organic compounds
AU2011306358B2 (en) * 2010-09-24 2014-08-14 Impetis Biosciences Ltd. Fused tricyclic compounds as adenosine receptor antagonist
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
US9546175B2 (en) 2014-08-07 2017-01-17 Intra-Cellular Therapies, Inc. Organic compounds
US10472347B2 (en) 2014-11-18 2019-11-12 Merck Sharp & Dohme Corp. Aminopyrazine compounds with A2A antagonist properties
EP3253390B1 (de) 2015-02-06 2022-04-13 Merck Sharp & Dohme Corp. Aminochinazolinverbindungen als a2a-antagonisten
WO2016200717A1 (en) 2015-06-11 2016-12-15 Merck Sharp & Dohme Corp. Aminopyrazine compounds with a2a antagonist properties
WO2017008205A1 (en) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
US11498923B2 (en) 2017-12-13 2022-11-15 Merck Sharp & Dohme Llc Substituted imidazo[1,2-c]quinazolines as A2A antagonists
DE102019116986A1 (de) 2019-06-24 2020-12-24 Helmholtz-Zentrum Dresden-Rossendorf E. V. Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate
CN111072676B (zh) * 2019-12-12 2021-07-16 广东东阳光药业有限公司 含氮稠合三环衍生物及其用途

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Also Published As

Publication number Publication date
EP0856003B1 (de) 2000-12-27
IT1277392B1 (it) 1997-11-10
ITMI951671A1 (it) 1997-01-28
PT856003E (pt) 2001-04-30
CA2227991A1 (en) 1997-02-13
DK0856003T3 (da) 2001-01-22
ES2153118T3 (es) 2001-02-16
US5935964A (en) 1999-08-10
GR3035309T3 (en) 2001-04-30
WO1997005138A1 (en) 1997-02-13
DE69611377D1 (de) 2001-02-01
EP0856003A1 (de) 1998-08-05
DE69611377T2 (de) 2001-04-26
CA2227991C (en) 2001-09-11
ITMI951671A0 (it) 1995-07-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee