NO20003397D0 - 3 '-empiriske K-252A-derivater - Google Patents

3 '-empiriske K-252A-derivater

Info

Publication number: NO20003397D0
Authority: NO; Norway
Prior art keywords: empirical; derivatives; compounds; survival; enhancement
Prior art date: 1997-12-31

Application number

NO20003397A

Other languages

English (en)

Other versions

NO20003397L (no

Inventor

Robert L Hudkins

Diane E Gingrich

Original Assignee

Cephalon Inc

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-31

Filing date

2000-06-29

Publication date

2000-06-29

2000-06-29 Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc

2000-06-29 Publication of NO20003397D0 publication Critical patent/NO20003397D0/no

2000-08-31 Publication of NO20003397L publication Critical patent/NO20003397L/no

Links

KOZFSFOOLUUIGY-IYYJOCMQSA-N k-252a, nocardiopsis sp. Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@@H]1C[C@](C(=O)OC)(O)[C@@]4(C)O1 KOZFSFOOLUUIGY-IYYJOCMQSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
210000002932 cholinergic neuron Anatomy 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1
230000001228 trophic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO20003397A 1997-12-31 2000-06-29 3 '-epimerie K-252A-derivater NO20003397L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7026397P	1997-12-31	1997-12-31
PCT/US1998/027644 WO1999033836A1 (en)	1997-12-31	1998-12-30	3'-epimeric k-252a derivatives

Publications (2)

Publication Number	Publication Date
NO20003397D0 true NO20003397D0 (no)	2000-06-29
NO20003397L NO20003397L (no)	2000-08-31

Family

ID=22094212

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20003397A NO20003397L (no)	1997-12-31	2000-06-29	3 '-epimerie K-252A-derivater

Country Status (15)

Country	Link
US (2)	US6093713A (no)
EP (1)	EP1044203B1 (no)
JP (1)	JP4405667B2 (no)
KR (1)	KR20010033737A (no)
CN (1)	CN1285836A (no)
AT (1)	ATE234308T1 (no)
AU (1)	AU1947499A (no)
BR (1)	BR9814543A (no)
CA (1)	CA2315953C (no)
DE (1)	DE69812177T2 (no)
DK (1)	DK1044203T3 (no)
ES (1)	ES2194385T3 (no)
NO (1)	NO20003397L (no)
PT (1)	PT1044203E (no)
WO (1)	WO1999033836A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2275373C2 (ru) *	2000-12-08	2006-04-27	Орто-Макнейл Фармасьютикал, Инк.	Макрогетероциклические соединения
US7018999B2 (en)	2001-05-16	2006-03-28	Cephalon, Inc.	Methods for the treatment and prevention of pain
DE60212836T2 (de) *	2001-05-16	2007-01-25	Gpc Biotech Ag	Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten
DE10161940A1 (de) *	2001-12-17	2003-07-03	Nad Ag	N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren
US6723844B1 (en) *	2003-02-27	2004-04-20	Abbott Laboratories	Preparation of K-252a
DE102004025726B4 (de) *	2004-05-26	2006-07-06	Roder, Hanno, Dr.	Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
US20060058250A1 (en) *	2004-09-10	2006-03-16	Cephalon, Inc.	Methods of treating proliferative skin diseases using carbazole derivatives
US20080021013A1 (en) *	2006-07-21	2008-01-24	Cephalon, Inc.	JAK inhibitors for treatment of myeloproliferative disorders
EP2124554B1 (en) *	2006-12-14	2012-02-08	Tautatis, Inc.	Compositions and methods for the treatment of cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62155284A (ja) *	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja)	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
WO1988007045A1 (fr) *	1987-03-09	1988-09-22	Kyowa Hakko Kogyo Co., Ltd.	Derives de la substance physiologiquement active k-252
US5621100A (en) *	1992-07-24	1997-04-15	Cephalon, Inc.	K-252a derivatives for treatment of neurological disorders
US5461146A (en) *	1992-07-24	1995-10-24	Cephalon, Inc.	Selected protein kinase inhibitors for the treatment of neurological disorders
WO1994027982A1 (en)	1993-05-28	1994-12-08	Cephalon, Inc.	Use of indolocarbazole derivatives to treat a pathological condition of the prostate
US5468872A (en) *	1993-09-16	1995-11-21	Cephalon, Inc.	K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5585488A (en) *	1994-07-04	1996-12-17	Kyowa Hakko Kogyo Co., Ltd.	Process for producing indolocarbazole derivatives
WO1997005140A1 (en)	1995-07-31	1997-02-13	Novartis Ag	Trindene compounds
WO1997007081A2 (en)	1995-08-11	1997-02-27	Yale University	Glycosylated indolocarbazole synthesis

1998
- 1998-12-30 CN CN98812812A patent/CN1285836A/zh active Pending
- 1998-12-30 KR KR1020007007260A patent/KR20010033737A/ko not_active Withdrawn
- 1998-12-30 CA CA2315953A patent/CA2315953C/en not_active Expired - Fee Related
- 1998-12-30 AU AU19474/99A patent/AU1947499A/en not_active Abandoned
- 1998-12-30 AT AT98964309T patent/ATE234308T1/de not_active IP Right Cessation
- 1998-12-30 WO PCT/US1998/027644 patent/WO1999033836A1/en not_active Ceased
- 1998-12-30 DE DE69812177T patent/DE69812177T2/de not_active Expired - Lifetime
- 1998-12-30 DK DK98964309T patent/DK1044203T3/da active
- 1998-12-30 EP EP98964309A patent/EP1044203B1/en not_active Expired - Lifetime
- 1998-12-30 JP JP2000526515A patent/JP4405667B2/ja not_active Expired - Fee Related
- 1998-12-30 US US09/223,518 patent/US6093713A/en not_active Expired - Lifetime
- 1998-12-30 BR BR9814543-6A patent/BR9814543A/pt not_active Application Discontinuation
- 1998-12-30 PT PT98964309T patent/PT1044203E/pt unknown
- 1998-12-30 ES ES98964309T patent/ES2194385T3/es not_active Expired - Lifetime
2000
- 2000-02-15 US US09/503,812 patent/US6451786B1/en not_active Expired - Fee Related
- 2000-06-29 NO NO20003397A patent/NO20003397L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20003397L (no)	2000-08-31
DE69812177T2 (de)	2004-01-15
AU1947499A (en)	1999-07-19
US6093713A (en)	2000-07-25
CA2315953C (en)	2010-11-09
WO1999033836A1 (en)	1999-07-08
JP2001527079A (ja)	2001-12-25
PT1044203E (pt)	2003-07-31
CN1285836A (zh)	2001-02-28
KR20010033737A (ko)	2001-04-25
ES2194385T3 (es)	2003-11-16
WO1999033836A9 (en)	2000-09-14
DK1044203T3 (da)	2003-07-14
JP4405667B2 (ja)	2010-01-27
CA2315953A1 (en)	1999-07-08
ATE234308T1 (de)	2003-03-15
EP1044203B1 (en)	2003-03-12
EP1044203A1 (en)	2000-10-18
BR9814543A (pt)	2000-10-10
DE69812177D1 (de)	2003-04-17
US6451786B1 (en)	2002-09-17

Legal Events

Date	Code	Title	Description
2002-09-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
CU23126A3 (es)	2006-04-18	Inhibicion de kinasa raf usando ureas heterociclicas sustituidas
HN1998000143A (es)	1999-04-09	Tetrahidronaftalenos substituidos y compuestos analogos.
ATE302005T1 (de)	2005-09-15	N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
NO962059L (no)	1996-07-19	Antiarytmiske benzodiazepiner
ES2175079T3 (es)	2002-11-16	Derivados de indol utiles como inhibidores de cgmp-pde.
ATE302606T1 (de)	2005-09-15	N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
DE69616480D1 (de)	2001-12-06	Piperidinderivate als neurokininantagonisten
TR200000151T2 (tr)	2000-09-21	Yeni bileşimler.
FI971953A7 (fi)	1997-05-12	Proteiinityrosiinikinaasin välittämää soluproliferaatiota inhiboivat 6 -aryyli-pyrido(2,3-d)pyrimidiinit ja naftyridiinit
TR199902538T2 (xx)	2000-02-21	Yeni bile�imler.
ES2193252T3 (es)	2003-11-01	Quinolonas y su uso terapeutico.
AU1917095A (en)	1995-09-04	6-substituted mycophenolic and derivatives with immunosuppressive activity
DE69622871D1 (de)	2002-09-12	Tetralin-verbindungen mit multi-drugresistenz (mdr)-aktivitat
YU19499A (sh)	2001-09-28	Benzonaftiridini kao bronhijalni terapeutici
ATE243682T1 (de)	2003-07-15	Heterozyklisch substituierte biphenylamid derivate, deren herstellung und deren verwendung als fungizide
FI912621A7 (fi)	1991-12-02	Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä
DK1044203T3 (da)	2003-07-14	3'-epimere K-252a-derivater
ATE185133T1 (de)	1999-10-15	Proteinkinase-c-modulatoren mit entzündungshemmender und antiviraler aktivität
FI912622A7 (fi)	1991-12-02	Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä
NO20000519L (no)	2000-03-31	2-acylaminopropanaminer som takykininreseptorantagonister
NO991734L (no)	1999-04-13	Pyrazolinoner for behandling av potensforstyrrelser
DE69623819D1 (de)	2002-10-24	Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten
FI895069A0 (fi)	1989-10-25	Funktionsanordning av modulkonstruktion foer valsarna i en maskinkalander.
FI963222A0 (fi)	1996-08-16	6-substituoitu 4-amino-mykofenolihappo ja sen johdannaiset, joilla on immunosuppressiivista aktiivisuutta
BR9609801A (pt)	1999-07-06	Petídos cíclicos análogos de somatostina com atividade inibitória do desenvolvimento de hormónio