ATE198353T1 - Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung - Google Patents

Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung

Info

Publication number: ATE198353T1
Authority: AT; Austria
Prior art keywords: somatotropines; stabilization; site; modification; specific mutagenesis
Prior art date: 1988-08-24

Application number

AT89113852T

Other languages

English (en)

Inventor

Susan Mancini Cady

John Steele Logan

Brian Lee Buckwalter

Gerald W Stockton

Deborah Tardy Chaleff

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-24

Filing date

1989-07-27

Publication date

2001-01-15

1989-07-27 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

2001-01-15 Application granted granted Critical

2001-01-15 Publication of ATE198353T1 publication Critical patent/ATE198353T1/de

Links

XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title 1
238000001212 derivatisation Methods 0.000 title 1
230000004048 modification Effects 0.000 title 1
238000012986 modification Methods 0.000 title 1
238000002741 site-directed mutagenesis Methods 0.000 title 1
230000006641 stabilisation Effects 0.000 title 1
238000011105 stabilization Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Toxicology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT89113852T 1988-08-24 1989-07-27 Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung ATE198353T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23606088A	1988-08-24	1988-08-24
US37269989A	1989-07-03	1989-07-03

Publications (1)

Publication Number	Publication Date
ATE198353T1 true ATE198353T1 (de)	2001-01-15

Family

ID=26929421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89113852T ATE198353T1 (de)	1988-08-24	1989-07-27	Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung

Country Status (18)

Country	Link
US (1)	US5891840A (de)
EP (1)	EP0355460B1 (de)
JP (1)	JP2894355B2 (de)
AR (1)	AR245138A1 (de)
AT (1)	ATE198353T1 (de)
AU (1)	AU630105B2 (de)
DE (1)	DE68929273T2 (de)
DK (1)	DK416589A (de)
ES (1)	ES2154627T3 (de)
FI (1)	FI104908B (de)
GR (1)	GR3035608T3 (de)
HU (1)	HU217095B (de)
IE (1)	IE892706A1 (de)
IL (1)	IL91156A (de)
NO (1)	NO893387L (de)
NZ (1)	NZ230342A (de)
PT (1)	PT91512B (de)
YU (1)	YU163289A (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988006186A2 (en) *	1987-02-19	1988-08-25	The Upjohn Company	cDNAs ENCODING SOMATOTROPIN, EXPRESSION VECTORS AND HOSTS
US5089473A (en) *	1988-08-29	1992-02-18	Monsanto Company	Somatotropin variants and their use
US5079230A (en) *	1988-09-12	1992-01-07	Pitman-Moore, Inc.	Stable bioactive somatotropins
US5166322A (en) *	1989-04-21	1992-11-24	Genetics Institute	Cysteine added variants of interleukin-3 and chemical modifications thereof
DK0458064T3 (da) *	1990-05-04	1998-04-27	American Cyanamid Co	Stabilisering af somatotropiner ved modificering af cysteinrester
US5951972A (en) *	1990-05-04	1999-09-14	American Cyanamid Company	Stabilization of somatotropins and other proteins by modification of cysteine residues
US5780599A (en) *	1990-07-13	1998-07-14	Novo Nordisk A/S	Growth hormone crystals and a process for production of growth hormone crystals
US6894023B1 (en)	1990-07-13	2005-05-17	Novo Nordisk A/S	Growth hormone crystals and a process for production of these GH-crystals
DK168790D0 (de) *	1990-07-13	1990-07-13	Novo Nordisk As
US5849694A (en) *	1990-07-16	1998-12-15	Synenki; Richard M.	Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
US5310882A (en) *	1990-11-30	1994-05-10	American Cyanamid Company	Somatotropins with alterations in the α-helix 3 region
NZ260103A (en) *	1990-11-30	1996-10-28	Bio Technology General Corp	Somatotropin with alterations in the alpha-helix-1 region
GB9100381D0 (en) *	1991-01-09	1991-02-20	Erba Carlo Spa	Human bfgf derivatives,their analogs and process for their production
FR2671554A1 (fr) *	1991-01-11	1992-07-17	Clonatec Sa	Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b.
AU654563B2 (en) *	1991-07-24	1994-11-10	Imperial Chemical Industries Plc	Proteins
ZA936811B (en) *	1992-10-28	1995-03-15	Upjohn Co	Somatotropin modifications
US7153943B2 (en)	1997-07-14	2006-12-26	Bolder Biotechnology, Inc.	Derivatives of growth hormone and related proteins, and methods of use thereof
CN1269805A (zh)	1997-07-14	2000-10-11	博尔德生物技术公司	生长激素和相关蛋白的衍生物
US7495087B2 (en)	1997-07-14	2009-02-24	Bolder Biotechnology, Inc.	Cysteine muteins in the C-D loop of human interleukin-11
US7270809B2 (en)	1997-07-14	2007-09-18	Bolder Biotechnology, Inc.	Cysteine variants of alpha interferon-2
US6753165B1 (en)	1999-01-14	2004-06-22	Bolder Biotechnology, Inc.	Methods for making proteins containing free cysteine residues
US20080076706A1 (en)	1997-07-14	2008-03-27	Bolder Biotechnology, Inc.	Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US8288126B2 (en)	1999-01-14	2012-10-16	Bolder Biotechnology, Inc.	Methods for making proteins containing free cysteine residues
IL152804A0 (en) *	2000-05-16	2003-06-24	Bolder Biotechnology Inc	Methods for refolding proteins containing free cysteine residues
US6878861B2 (en)	2000-07-21	2005-04-12	Washington State University Research Foundation	Acyl coenzyme A thioesterases
US7060442B2 (en)	2000-10-30	2006-06-13	Regents Of The University Of Michigan	Modulators on Nod2 signaling
CA2498319A1 (en) *	2002-09-09	2004-03-18	Nautilus Biotech	Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7998930B2 (en)	2004-11-04	2011-08-16	Hanall Biopharma Co., Ltd.	Modified growth hormones
US8329866B2 (en)	2005-10-03	2012-12-11	Bolder Biotechnology, Inc.	Long acting VEGF inhibitors and methods of use
EP1931379B1 (de) *	2005-10-07	2013-05-29	Health Protection Agency	Proteine mit verbesserter löslichkeit und herstellungs- und anwendungsverfahren
US8617531B2 (en)	2006-12-14	2013-12-31	Bolder Biotechnology, Inc.	Methods of making proteins and peptides containing a single free cysteine
AU2009279090A1 (en) *	2008-08-06	2010-02-11	Novo Nordisk Health Care Ag	Conjugated proteins with prolonged in vivo efficacy
CA2747825A1 (en) *	2009-01-22	2010-07-29	Novo Nordisk Health Care Ag	Stable growth hormone compounds
EP2461831B1 (de)	2009-08-06	2018-11-21	Novo Nordisk Health Care AG	Wachstumshormone mit verlängerter in-vivo-wirksamkeit
NZ600361A (en) *	2009-12-21	2014-06-27	Ambrx Inc	Modified bovine somatotropin polypeptides and their uses
EP2516455A4 (de) *	2009-12-21	2013-05-22	Ambrx Inc	Modifizierte schweine-somatotropin-polypeptide und deren verwendungen
RU2012134974A (ru)	2010-01-22	2014-02-27	Ново Нордиск Хелс Кеа Аг	Стабилизированное соединение гормона роста
RU2605627C2 (ru)	2010-01-22	2016-12-27	Ново Нордиск Хелс Кеа Аг	Гормоны роста с пролонгированной эффективностью in vivo
EP2890394B1 (de) *	2012-08-31	2019-05-01	GlaxoSmithKline Biologicals SA	Stabilisierte proteine zur immunisierung gegen staphylococcus aureus
EP2981282B1 (de)	2013-04-05	2020-11-04	Novo Nordisk Health Care AG	Wachstumshormonverbindungsformulierung
KR20180003677A (ko) *	2016-06-30	2018-01-10	주식회사 크레아플래닛	인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4443539A (en) *	1980-02-05	1984-04-17	The Upjohn Company	Process for preparing bovine growth hormone
FI82266C (fi) *	1982-10-19	1991-02-11	Cetus Corp	Foerfarande foer framstaellning av il-2 -mutein.
US4774091A (en) *	1983-10-14	1988-09-27	Sumitomo Pharmaceuticals Company, Ltd.	Long-term sustained-release preparation
US4855238A (en) *	1983-12-16	1989-08-08	Genentech, Inc.	Recombinant gamma interferons having enhanced stability and methods therefor
US4959314A (en) *	1984-11-09	1990-09-25	Cetus Corporation	Cysteine-depleted muteins of biologically active proteins
US4761289A (en) *	1986-10-10	1988-08-02	International Minerals & Chemical Corp.	Sustained release implant and method for preparing same
US5079230A (en) *	1988-09-12	1992-01-07	Pitman-Moore, Inc.	Stable bioactive somatotropins
WO1990008164A1 (en) *	1989-01-19	1990-07-26	The Upjohn Company	Somatotropin analogs
AU620673B2 (en) *	1989-01-31	1992-02-20	Pharmacia & Upjohn Company	Somatotropin analogs
US5849694A (en) *	1990-07-16	1998-12-15	Synenki; Richard M.	Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof

1989
- 1989-07-27 ES ES89113852T patent/ES2154627T3/es not_active Expired - Lifetime
- 1989-07-27 EP EP89113852A patent/EP0355460B1/de not_active Expired - Lifetime
- 1989-07-27 DE DE68929273T patent/DE68929273T2/de not_active Expired - Fee Related
- 1989-07-27 AT AT89113852T patent/ATE198353T1/de not_active IP Right Cessation
- 1989-07-30 IL IL9115689A patent/IL91156A/en not_active IP Right Cessation
- 1989-08-17 NZ NZ230342A patent/NZ230342A/en unknown
- 1989-08-22 PT PT91512A patent/PT91512B/pt not_active IP Right Cessation
- 1989-08-23 YU YU01632/89A patent/YU163289A/xx unknown
- 1989-08-23 NO NO89893387A patent/NO893387L/no unknown
- 1989-08-23 AR AR89314728A patent/AR245138A1/es active
- 1989-08-23 IE IE270689A patent/IE892706A1/en unknown
- 1989-08-23 JP JP1217185A patent/JP2894355B2/ja not_active Expired - Lifetime
- 1989-08-23 FI FI893963A patent/FI104908B/fi not_active IP Right Cessation
- 1989-08-23 HU HU894322A patent/HU217095B/hu not_active IP Right Cessation
- 1989-08-23 DK DK416589A patent/DK416589A/da not_active Application Discontinuation
- 1989-08-24 AU AU40202/89A patent/AU630105B2/en not_active Ceased
1995
- 1995-05-09 US US08/437,578 patent/US5891840A/en not_active Expired - Fee Related
2001
- 2001-03-20 GR GR20010400454T patent/GR3035608T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK416589A (da)	1990-02-25
US5891840A (en)	1999-04-06
IE892706A1 (en)	1991-01-16
AU630105B2 (en)	1992-10-22
NO893387L (no)	1990-02-26
JPH034797A (ja)	1991-01-10
AR245138A1 (es)	1993-12-30
HU217095B (hu)	1999-11-29
YU163289A (en)	1992-05-28
IL91156A (en)	1995-05-26
AU4020289A (en)	1990-03-15
DE68929273D1 (de)	2001-02-01
EP0355460A3 (de)	1991-04-03
FI893963A0 (fi)	1989-08-23
PT91512B (pt)	1995-05-31
FI893963A7 (fi)	1990-02-25
PT91512A (pt)	1990-03-08
NO893387D0 (no)	1989-08-23
ES2154627T3 (es)	2001-04-16
EP0355460B1 (de)	2000-12-27
FI104908B (fi)	2000-04-28
DK416589D0 (da)	1989-08-23
JP2894355B2 (ja)	1999-05-24
HUT51331A (en)	1990-04-28
IL91156A0 (en)	1990-03-19
DE68929273T2 (de)	2001-07-05
NZ230342A (en)	1992-08-26
IE892706L (en)	1990-02-24
EP0355460A2 (de)	1990-02-28
GR3035608T3 (en)	2001-06-29

Legal Events

Date	Code	Title	Description
2001-06-15	UEP	Publication of translation of european patent specification
2003-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE68929273D1 (de)	2001-02-01	Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
DE69024868D1 (de)	1996-02-29	Verbessertes Chloren von Sucrose-6-Ester
NO820350L (no)	1982-08-09	Fortykningsmiddel og vandig blanding inneholdende dette
FI875395A0 (fi)	1987-12-08	Substituerade basiska 2-aminotetraliner.
DE3856113D1 (de)	1998-02-19	Trennung von Wasserstoff enthaltenden Gasgemischen
FI890831A7 (fi)	1989-08-23	Räjähdysainekoostumus
KR860003870U (ko)	1986-04-25	스크류 그로메트(screw grommet)
AU96583S (en)	1987-05-21	Electronic insect killer
AU96584S (en)	1987-05-21	Electronic insect killer
IT213956Z2 (it)	1990-03-05	Cassa per alloggiare componenti elettrici e/oppure elettronici.
DE69008640D1 (de)	1994-06-09	Zersetzung von Schadstoffen.
BR8406687A (pt)	1985-10-22	Composicao fumigante
DK163842C (da)	1992-08-24	Programmerbart elektrisk ur
GR3001564T3 (en)	1992-11-23	Substituted alkynic thiocyanates, biocidal compositions containing them and uses of such compositions
KR870017509U (ko)	1987-11-30	화면 안정화회로
KR880006046U (ko)	1988-05-30	염소가스 중화장치
KR880011722U (ko)	1988-08-26	세정식 염소가스 중화장치
KR870002694U (ko)	1987-03-18	전자시계용 무브먼트 하우징
KR870018109U (ko)	1987-12-22	염소가스 중화장치
KR850007811U (ko)	1985-10-15	전자식 타이머를 사용한 가스배출기
KR880003802U (ko)	1988-04-14	전자제품 보호용 패드를 이용한 리모콘 수용구조
DD263655A3 (de)	1989-01-11	Loetgemisch
KR900013487U (ko)	1990-07-05	터미날 하우징
GB8629442D0 (en)	1987-01-21	Assembly of electronic components
BR8604304A (pt)	1987-03-10	Composicao explosiva