NO893387L - Stabilisering av somatotropiner ved modifikasjon av cysteinrester med sete-rettet mutagenese eller kjemisk derivatisering. - Google Patents

Stabilisering av somatotropiner ved modifikasjon av cysteinrester med sete-rettet mutagenese eller kjemisk derivatisering.

Info

Publication number
NO893387L
NO893387L NO89893387A NO893387A NO893387L NO 893387 L NO893387 L NO 893387L NO 89893387 A NO89893387 A NO 89893387A NO 893387 A NO893387 A NO 893387A NO 893387 L NO893387 L NO 893387L
Authority
NO
Norway
Prior art keywords
somatotropines
mutagenese
cyste
restrictions
stabilization
Prior art date
Application number
NO89893387A
Other languages
English (en)
Other versions
NO893387D0 (no
Inventor
Susan Mancini Cady
John Steele Logan
Brian Lee Buckwalter
Gerald W Stockton
Deborah Tardy Chaleff
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of NO893387D0 publication Critical patent/NO893387D0/no
Publication of NO893387L publication Critical patent/NO893387L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO89893387A 1988-08-24 1989-08-23 Stabilisering av somatotropiner ved modifikasjon av cysteinrester med sete-rettet mutagenese eller kjemisk derivatisering. NO893387L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23606088A 1988-08-24 1988-08-24
US37269989A 1989-07-03 1989-07-03

Publications (2)

Publication Number Publication Date
NO893387D0 NO893387D0 (no) 1989-08-23
NO893387L true NO893387L (no) 1990-02-26

Family

ID=26929421

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89893387A NO893387L (no) 1988-08-24 1989-08-23 Stabilisering av somatotropiner ved modifikasjon av cysteinrester med sete-rettet mutagenese eller kjemisk derivatisering.

Country Status (18)

Country Link
US (1) US5891840A (no)
EP (1) EP0355460B1 (no)
JP (1) JP2894355B2 (no)
AR (1) AR245138A1 (no)
AT (1) ATE198353T1 (no)
AU (1) AU630105B2 (no)
DE (1) DE68929273T2 (no)
DK (1) DK416589A (no)
ES (1) ES2154627T3 (no)
FI (1) FI104908B (no)
GR (1) GR3035608T3 (no)
HU (1) HU217095B (no)
IE (1) IE892706A1 (no)
IL (1) IL91156A (no)
NO (1) NO893387L (no)
NZ (1) NZ230342A (no)
PT (1) PT91512B (no)
YU (1) YU163289A (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2580303B2 (ja) * 1987-02-19 1997-02-12 ジ・アップジョン・カンパニー 異種蛋白をコ−ド付けするｃＤＮＡ類、発現ベクタ−類および宿主類
US5089473A (en) * 1988-08-29 1992-02-18 Monsanto Company Somatotropin variants and their use
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
EP0458064B1 (en) * 1990-05-04 1998-02-25 American Cyanamid Company Stabilization of somatotropins by modification of cysteine residues
US5951972A (en) * 1990-05-04 1999-09-14 American Cyanamid Company Stabilization of somatotropins and other proteins by modification of cysteine residues
US6894023B1 (en) 1990-07-13 2005-05-17 Novo Nordisk A/S Growth hormone crystals and a process for production of these GH-crystals
DK168790D0 (no) * 1990-07-13 1990-07-13 Novo Nordisk As
US5780599A (en) * 1990-07-13 1998-07-14 Novo Nordisk A/S Growth hormone crystals and a process for production of growth hormone crystals
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
NZ240718A (en) * 1990-11-30 1996-10-28 Bio Technology General Corp Somatotropin analogues carrying mutations in the alpha-helix-1 region
US5310882A (en) * 1990-11-30 1994-05-10 American Cyanamid Company Somatotropins with alterations in the α-helix 3 region
GB9100381D0 (en) * 1991-01-09 1991-02-20 Erba Carlo Spa Human bfgf derivatives,their analogs and process for their production
FR2671554A1 (fr) * 1991-01-11 1992-07-17 Clonatec Sa Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b.
AU654563B2 (en) * 1991-07-24 1994-11-10 Imperial Chemical Industries Plc Proteins
ZA936811B (en) * 1992-10-28 1995-03-15 Upjohn Co Somatotropin modifications
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US7270809B2 (en) 1997-07-14 2007-09-18 Bolder Biotechnology, Inc. Cysteine variants of alpha interferon-2
ATE375363T1 (de) 1997-07-14 2007-10-15 Bolder Biotechnology Inc Derivate des wachstumshormons und verwandte proteine
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
IL152804A0 (en) 2000-05-16 2003-06-24 Bolder Biotechnology Inc Methods for refolding proteins containing free cysteine residues
US6878861B2 (en) 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
US7060442B2 (en) 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US8329866B2 (en) 2005-10-03 2012-12-11 Bolder Biotechnology, Inc. Long acting VEGF inhibitors and methods of use
EP1931379B1 (en) * 2005-10-07 2013-05-29 Health Protection Agency Proteins with improved solubility and methods for producing and using same
US8617531B2 (en) 2006-12-14 2013-12-31 Bolder Biotechnology, Inc. Methods of making proteins and peptides containing a single free cysteine
KR20110039348A (ko) * 2008-08-06 2011-04-15 노보 노르디스크 헬스 케어 악티엔게젤샤프트 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질
JP5816097B2 (ja) * 2009-01-22 2015-11-18 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
JP6086528B2 (ja) 2009-08-06 2017-03-01 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 長期のインビボ有効性を有する成長ホルモン
NZ600361A (en) * 2009-12-21 2014-06-27 Ambrx Inc Modified bovine somatotropin polypeptides and their uses
JP2013515081A (ja) * 2009-12-21 2013-05-02 アンブルックス，インコーポレイテッド 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用
CN118767117A (zh) 2010-01-22 2024-10-15 诺沃—诺迪斯克保健股份有限公司 体内功效延长的生长激素
JP5980689B2 (ja) 2010-01-22 2016-08-31 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
HUE044211T2 (hu) * 2012-08-31 2019-10-28 Glaxosmithkline Biologicals Sa Staphylococcus aureus elleni immunizálásra szolgáló, stabilizált fehérjék
US11045523B2 (en) 2013-04-05 2021-06-29 Novo Nordisk Healthcare Ag Formulation of growth hormone albumin-binder conjugate
KR20180003677A (ko) * 2016-06-30 2018-01-10 주식회사 크레아플래닛 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443539A (en) * 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
US4774091A (en) * 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
KR910700264A (ko) * 1989-01-19 1991-03-14 로버트 에이. 아미테이지 소마토트로핀 유사물
AU620673B2 (en) * 1989-01-31 1992-02-20 Pharmacia & Upjohn Company Somatotropin analogs
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
ATE198353T1 (de) 2001-01-15
DE68929273T2 (de) 2001-07-05
AU630105B2 (en) 1992-10-22
DE68929273D1 (de) 2001-02-01
HU217095B (hu) 1999-11-29
NZ230342A (en) 1992-08-26
FI104908B (fi) 2000-04-28
AU4020289A (en) 1990-03-15
IE892706L (en) 1990-02-24
PT91512B (pt) 1995-05-31
IL91156A0 (en) 1990-03-19
PT91512A (pt) 1990-03-08
HUT51331A (en) 1990-04-28
IL91156A (en) 1995-05-26
US5891840A (en) 1999-04-06
NO893387D0 (no) 1989-08-23
EP0355460B1 (en) 2000-12-27
EP0355460A2 (en) 1990-02-28
EP0355460A3 (en) 1991-04-03
JP2894355B2 (ja) 1999-05-24
GR3035608T3 (en) 2001-06-29
FI893963A7 (fi) 1990-02-25
YU163289A (en) 1992-05-28
IE892706A1 (en) 1991-01-16
JPH034797A (ja) 1991-01-10
FI893963A0 (fi) 1989-08-23
AR245138A1 (es) 1993-12-30
DK416589A (da) 1990-02-25
DK416589D0 (da) 1989-08-23
ES2154627T3 (es) 2001-04-16

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