ATE198753T1 - Androstan- und pregnanserien für die allosterische modulation des gaba-rezeptors - Google Patents

Androstan- und pregnanserien für die allosterische modulation des gaba-rezeptors

Info

Publication number: ATE198753T1
Authority: AT; Austria
Prior art keywords: androstane; gaba receptor; allosteric modulation; pregnan series; pregnan
Prior art date: 1994-11-23

Application number

AT95942879T

Other languages

English (en)

Inventor

Nancy C Lan

Kelvin W Gee

Michael B Bolger

Hasan Tahir

Robert Purdy

Ravindra B Upasani

Original Assignee

Cocensys Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-23

Filing date

1995-11-22

Publication date

2001-02-15

1995-11-22 Application filed by Cocensys Inc filed Critical Cocensys Inc

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE198753T1 publication Critical patent/ATE198753T1/de

Links

QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical compound C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
230000003281 allosteric effect Effects 0.000 title 1
JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95942879T 1994-11-23 1995-11-22 Androstan- und pregnanserien für die allosterische modulation des gaba-rezeptors ATE198753T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34692694A	1994-11-23	1994-11-23
PCT/US1995/015210 WO1996016076A1 (en)	1994-11-23	1995-11-22	Androstane and pregnane series for allosteric modulation of gaba receptor

Publications (1)

Publication Number	Publication Date
ATE198753T1 true ATE198753T1 (de)	2001-02-15

Family

ID=23361616

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95942879T ATE198753T1 (de)	1994-11-23	1995-11-22	Androstan- und pregnanserien für die allosterische modulation des gaba-rezeptors

Country Status (27)

Country	Link
EP (1)	EP0808325B1 (de)
JP (1)	JPH10509458A (de)
KR (1)	KR100394548B1 (de)
CN (1)	CN1171114A (de)
AP (1)	AP653A (de)
AT (1)	ATE198753T1 (de)
AU (1)	AU707486B2 (de)
BR (1)	BR9509764A (de)
CA (1)	CA2205919A1 (de)
CZ (1)	CZ292881B6 (de)
DE (1)	DE69519945T2 (de)
DK (1)	DK0808325T3 (de)
ES (1)	ES2155543T3 (de)
FI (1)	FI972202A7 (de)
GE (1)	GEP20002033B (de)
GR (1)	GR3035562T3 (de)
HU (1)	HUT77087A (de)
IL (1)	IL116108A (de)
IS (1)	IS4488A (de)
MX (1)	MX9703826A (de)
NO (1)	NO308950B1 (de)
NZ (1)	NZ298567A (de)
PL (1)	PL182898B1 (de)
PT (1)	PT808325E (de)
RU (1)	RU2176248C2 (de)
UA (1)	UA48154C2 (de)
WO (1)	WO1996016076A1 (de)

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CN1270718C (zh) *	1998-03-11	2006-08-23	托布乔恩·贝克斯托罗姆	表别孕烷醇酮在制备治疗甾族化合物诱导的疾病的药物中的应用
US8771740B2 (en)	1999-12-20	2014-07-08	Nicholas J. Kerkhof	Process for producing nanoparticles by spray drying
JP2003518038A (ja)	1999-12-20	2003-06-03	ニコラス，ジェイカークホフ，	流動床噴霧乾燥によるナノ粒子製造方法
AR031473A1 (es) *	2000-11-20	2003-09-24	Lundbeck & Co As H	Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide
WO2006012563A2 (en) *	2004-07-23	2006-02-02	The Regents Of The University Of California	Method for the treatment and diagnosis of certain psychiatric disorders related to the menstrual cycle
RU2413516C2 (ru) *	2004-11-18	2011-03-10	Умекрин Аб	Гамк-стероидные антагонисты и их применение в лечении нарушений цнс
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
US7985756B2 (en)	2005-10-21	2011-07-26	Braincells Inc.	Modulation of neurogenesis by PDE inhibition
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CN103880909A (zh) *	2008-05-20	2014-06-25	梅克芳股份公司	甾族化合物
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CN103819525A (zh) *	2008-05-20	2014-05-28	梅克芳股份公司	甾族化合物
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
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BR112012017136B1 (pt)	2010-01-14	2021-05-25	Umecrine Mood Ab	composição farmacêutica compreendendo 3-beta-hidróxi5-alfa-pregnan-20-ona, colesterol e uma mistura de acilgliceróis, método para preparar dita composição farmacêutica, bem como usos da mesma para o tratamento ou prevenção de condições do sistema nervoso central e para cessar a anestesia induzida por esteroide
WO2011120044A1 (en) *	2010-03-26	2011-09-29	Duke University	Conjugated neuroactive steroid compositions and methods of use
CA2843436A1 (en) *	2011-07-29	2013-02-07	The Regents Of The University Of California	Novel 17.beta.-heteroaryl-substituted steroids as modulators of gaba a receptors
FI2753632T3 (fi) *	2011-09-08	2023-08-02	Sage Therapeutics Inc	Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä
US10478505B2 (en)	2011-09-23	2019-11-19	The Regents Of The University Of California	Edible oils to enhance delivery of orally administered steroids
CA3152410A1 (en) *	2011-10-14	2013-04-18	Sage Therapeutics, Inc.	3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
SMT202000008T1 (it)	2012-01-23	2020-03-13	Sage Therapeutics Inc	Formulazione di steroide neuroattivo comprendente un complesso di allopregnanolone e solfobutil eter beta-ciclodestrina
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ES2973320T3 (es)	2012-11-30	2024-06-19	Univ California	Alopregnanolona para tratar, reducir o mitigar los síntomas de la depresión posparto
RS67266B1 (sr)	2013-03-13	2025-10-31	Sage Therapeutics Inc	Neuroaktivni steroidi i postupci za njihovu upotrebu
US20160068563A1 (en)	2013-04-17	2016-03-10	Boyd L. Harrison	19-nor neuroactive steroids and methods of use thereof
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CN113527400B (zh)	2013-04-17	2024-06-28	萨奇治疗股份有限公司	19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
RU2019126333A (ru) *	2013-04-17	2019-10-08	Сейдж Терапьютикс, Инк.	19-нор нейроактивные стероиды и способы их применения
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EP3188734A4 (de)	2014-09-02	2018-01-10	The Texas A&M University System	Verfahren zur behandlung einer organophosphatvergiftung
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DK3250210T3 (da)	2015-01-26	2021-03-08	Sage Therapeutics Inc	Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser
JP6875996B2 (ja)	2015-02-20	2021-05-26	セージセラピューティクス，インコーポレイテッド	神経刺激性ステロイド、組成物、およびその使用
FI3828194T3 (fi)	2015-07-06	2025-07-17	Sage Therapeutics Inc	Oxysteroleita ja menetelmiä niiden käyttämiseksi
MX390271B (es)	2015-07-06	2025-03-20	Sage Therapeutics Inc	Oxiesteroles y metodos de uso de los mismos
RU2766155C2 (ru)	2016-03-08	2022-02-08	Сейдж Терапьютикс, Инк.	Нейроактивные стероиды, их композиции и применения
US20190330259A1 (en)	2016-04-01	2019-10-31	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
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WO2018013613A1 (en)	2016-07-11	2018-01-18	Sage Therapeutics, Inc.	C17, c20, and c21 substituted neuroactive steroids and their methods of use
JP7149266B2 (ja)	2016-09-30	2022-10-06	セージセラピューティクス，インコーポレイテッド	Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
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1995
- 1995-11-22 AP APAP/P/1997/000998A patent/AP653A/en active
- 1995-11-22 ES ES95942879T patent/ES2155543T3/es not_active Expired - Lifetime
- 1995-11-22 CN CN95197071A patent/CN1171114A/zh active Pending
- 1995-11-22 GE GEAP19953794A patent/GEP20002033B/en unknown
- 1995-11-22 HU HU9701972A patent/HUT77087A/hu not_active Application Discontinuation
- 1995-11-22 DE DE69519945T patent/DE69519945T2/de not_active Expired - Fee Related
- 1995-11-22 BR BR9509764A patent/BR9509764A/pt not_active Application Discontinuation
- 1995-11-22 KR KR1019970703470A patent/KR100394548B1/ko not_active Expired - Fee Related
- 1995-11-22 PL PL95320416A patent/PL182898B1/pl not_active IP Right Cessation
- 1995-11-22 CZ CZ19971553A patent/CZ292881B6/cs not_active IP Right Cessation
- 1995-11-22 WO PCT/US1995/015210 patent/WO1996016076A1/en not_active Ceased
- 1995-11-22 PT PT95942879T patent/PT808325E/pt unknown
- 1995-11-22 RU RU97110790/04A patent/RU2176248C2/ru active
- 1995-11-22 DK DK95942879T patent/DK0808325T3/da active
- 1995-11-22 MX MX9703826A patent/MX9703826A/es not_active IP Right Cessation
- 1995-11-22 UA UA97063025A patent/UA48154C2/uk unknown
- 1995-11-22 AU AU44085/96A patent/AU707486B2/en not_active Ceased
- 1995-11-22 JP JP8517059A patent/JPH10509458A/ja not_active Ceased
- 1995-11-22 CA CA002205919A patent/CA2205919A1/en not_active Abandoned
- 1995-11-22 FI FI972202A patent/FI972202A7/fi not_active IP Right Cessation
- 1995-11-22 EP EP95942879A patent/EP0808325B1/de not_active Expired - Lifetime
- 1995-11-22 NZ NZ298567A patent/NZ298567A/xx unknown
- 1995-11-22 AT AT95942879T patent/ATE198753T1/de not_active IP Right Cessation
- 1995-11-23 IL IL11610895A patent/IL116108A/en not_active IP Right Cessation
1997
- 1997-05-21 NO NO972320A patent/NO308950B1/no unknown
- 1997-05-23 IS IS4488A patent/IS4488A/is unknown
2001
- 2001-03-13 GR GR20010400408T patent/GR3035562T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0808325A1 (de)	1997-11-26
PL182898B1 (pl)	2002-03-29
IL116108A0 (en)	1996-01-31
ES2155543T3 (es)	2001-05-16
UA48154C2 (uk)	2002-08-15
CZ155397A3 (cs)	1998-03-18
IS4488A (is)	1997-05-23
RU2176248C2 (ru)	2001-11-27
DE69519945T2 (de)	2001-06-07
NO972320D0 (no)	1997-05-21
CA2205919A1 (en)	1996-05-30
FI972202L (fi)	1997-07-17
EP0808325A4 (de)	1997-12-17
CZ292881B6 (cs)	2003-12-17
PL320416A1 (en)	1997-09-29
NO972320L (no)	1997-07-23
MX9703826A (es)	1998-02-28
BR9509764A (pt)	1998-07-07
PT808325E (pt)	2001-06-29
CN1171114A (zh)	1998-01-21
NO308950B1 (no)	2000-11-20
EP0808325B1 (de)	2001-01-17
AP653A (en)	1998-07-21
AU707486B2 (en)	1999-07-08
FI972202A0 (fi)	1997-05-23
NZ298567A (en)	2000-01-28
GEP20002033B (en)	2000-04-10
IL116108A (en)	2002-08-14
HUT77087A (hu)	1998-03-02
AP9700998A0 (en)	1997-07-31
DE69519945D1 (de)	2001-02-22
AU4408596A (en)	1996-06-17
DK0808325T3 (da)	2001-01-29
GR3035562T3 (en)	2001-06-29
FI972202A7 (fi)	1997-07-17
JPH10509458A (ja)	1998-09-14
WO1996016076A1 (en)	1996-05-30
KR100394548B1 (ko)	2004-02-05

Legal Events

Date	Code	Title	Description
2001-09-15	UEP	Publication of translation of european patent specification
2007-08-15	REN	Ceased due to non-payment of the annual fee

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