ATE198892T1 - Trennung von cephalosporinisomeren - Google Patents

Trennung von cephalosporinisomeren

Info

Publication number: ATE198892T1
Authority: AT; Austria
Prior art keywords: cephalosporine; isomers; separation; cephem; thiazolyl
Prior art date: 1993-11-17

Application number

AT94118048T

Other languages

English (en)

Inventor

Johannes Ludescher

Harald Dr Summer

Siegfried Wolf

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-17

Filing date

1994-11-15

Publication date

2001-02-15

1993-11-17 Priority claimed from AT232993A external-priority patent/AT400843B/de

1993-11-17 Priority claimed from AT233093A external-priority patent/AT400844B/de

1994-11-15 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE198892T1 publication Critical patent/ATE198892T1/de

Links

HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
238000000926 separation method Methods 0.000 title 1
SDEIKNWRVHSKQN-FFFFSGIJSA-N (6R)-7-amino-3-[2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound Cc1ncsc1C=CC1=C(N2[C@H](SC1)C(N)C2=O)C(O)=O SDEIKNWRVHSKQN-FFFFSGIJSA-N 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
-1 amine salt Chemical class 0.000 abstract 2
SDEIKNWRVHSKQN-TXDNFOJSSA-N (6r)-7-amino-3-[(e)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N1=CSC(\C=C\C=2CS[C@H]3N(C(C3N)=O)C=2C(O)=O)=C1C SDEIKNWRVHSKQN-TXDNFOJSSA-N 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
230000000779 depleting effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT94118048T 1993-11-17 1994-11-15 Trennung von cephalosporinisomeren ATE198892T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT232993A AT400843B (de)	1993-11-17	1993-11-17	Abreicherungsverfahren des e-isomeren in z/e-7-amino-3-(2-(4-methyl-5-thiazolyl)vinyl)-3 cephem-4-carbonsäure
AT233093A AT400844B (de)	1993-11-17	1993-11-17	Abreicherungsverfahren des e-isomeren in z/e-7-amino-3-(2-(4-methyl-5-thiazolyl)vinyl)-3 cephem-4-carbonsäure

Publications (1)

Publication Number	Publication Date
ATE198892T1 true ATE198892T1 (de)	2001-02-15

Family

ID=25598227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94118048T ATE198892T1 (de)	1993-11-17	1994-11-15	Trennung von cephalosporinisomeren

Country Status (10)

Country	Link
US (3)	US5616703A (de)
EP (1)	EP0658558B1 (de)
JP (1)	JP3675863B2 (de)
CN (2)	CN1050843C (de)
AT (1)	ATE198892T1 (de)
DE (1)	DE69427312T2 (de)
DK (1)	DK0658558T3 (de)
ES (1)	ES2155839T3 (de)
GR (1)	GR3035535T3 (de)
PT (1)	PT658558E (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK284973B6 (sk) *	1996-09-20	2006-03-02	Meiji Seika Kaisha Ltd.	Kryštalická forma Cefditoren pivoxylu a spôsob jej výroby
UA55463C2 (uk) *	1997-06-24	2003-04-15	Мейджі Сейка Кайся, Лтд.,	Спосіб селективного одержання z-ізомеру 3-(2-заміщений -вініл)цефалоспорину (варіанти)
AT406773B (de)	1998-04-02	2000-08-25	Biochemie Gmbh	Neues salz von 7-(2-(aminothiazol-4yl)-2-
US7459550B2 (en)	2003-07-04	2008-12-02	Orchid Chemicals & Pharmaceuticals Ltd.	Process for the preparation of Cefditoren
EP1660505A2 (de) *	2003-08-14	2006-05-31	Ranbaxy Laboratories Limited	Verfahren zur selektiven herstellung des z-isomers von cefditoren und dessen pharmazeutisch unbedenklichen salzen und estern
WO2005100369A1 (en) *	2004-04-13	2005-10-27	Ranbaxy Laboratories Limited	Depletion of e-isomers in preparation of z-enriched 3-(2-substituted vinyl) cephalosporins
JP4046708B2 (ja) *	2004-06-04	2008-02-13	明治製菓株式会社	３−アルケニルセフェム化合物の製造方法
JP4064948B2 (ja)	2004-06-04	2008-03-19	明治製菓株式会社	３−アルケニルセフェム化合物及び製造方法
JP4892821B2 (ja) *	2004-09-30	2012-03-07	大日本印刷株式会社	エパルレスタット製造法
JP4892915B2 (ja) *	2005-10-04	2012-03-07	大日本印刷株式会社	エパルレスタット製造法
WO2007054777A1 (en) *	2005-11-09	2007-05-18	Orchid Chemicals & Pharmaceuticals Limited	Depletion of isomer in cephalosporin antibiotic
JP4659074B2 (ja) *	2008-07-15	2011-03-30	日本化学工業株式会社	３−アルケニルセフェム化合物の製造方法
EA013864B1 (ru) *	2008-08-29	2010-08-30	Лимонова, Анастасия Викторовна	Способ повышения антимикробной активности цефалоспориновых антибиотиков
CN102725297A (zh) *	2010-01-27	2012-10-10	日本化学工业株式会社	头孢菌素衍生物的制造方法
GB201620044D0 (en) *	2016-11-28	2017-01-11	Givaudan Sa	Improvements in or relating to organic compounds
CN113788844A (zh) *	2021-09-08	2021-12-14	湖北凌晟药业有限公司	一种e型头孢妥仑钠的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3830809A (en)	1972-08-25	1974-08-20	Bristol Myers Co	Bis-dicyclohexylamine n-carbisobutoxycephalosporin c
CH614447A5 (en)	1974-12-11	1979-11-30	Biochemie Gmbh	Process for the preparation of dicyclohexylamine salts of cephalosporin derivatives, and their use
DE3063683D1 (en)	1979-08-24	1983-07-14	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
GB8324152D0 (en) *	1983-09-09	1983-10-12	Glaxo Group Ltd	Chemical process
IE58487B1 (en) *	1984-09-07	1993-09-22	Kaisha Maiji Seika	New cephalosporin compounds and the production thereof
JPS62205088A (ja) *	1986-03-03	1987-09-09	Meiji Seika Kaisha Ltd	新規セフエム化合物
US5073551A (en) *	1988-03-30	1991-12-17	Sagami Chemical Research Center	Cephalosporin compounds
TW209223B (de) *	1989-09-26	1993-07-11	Yamanouchi Pharma Co Ltd
AT400436B (de) *	1992-11-10	1995-12-27	Biochemie Gmbh	Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
DK0503453T3 (da) *	1991-03-08	2001-07-16	Biochemie Gmbh	Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde
DE69233249T2 (de)	1992-02-05	2004-08-19	Biochemie Ges.M.B.H., Kundl	Verfahren zur Herstellung von einem 3-Cephem-4-Carbonsäurederivat
AT400033B (de)	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl)	1992-06-11	1998-06-30	Smithkline Beecham P.L.C.	Postopek in intermedianti za pripravo klavulanske kisline
JP2846186B2 (ja) *	1992-07-21	1999-01-13	明治製菓株式会社	セファロスポリン誘導体
KR100200239B1 (ko)	1992-10-21	1999-06-15	김충환	클라불란산 칼륨염의 제조방법

1994
- 1994-11-15 DK DK94118048T patent/DK0658558T3/da active
- 1994-11-15 EP EP94118048A patent/EP0658558B1/de not_active Expired - Lifetime
- 1994-11-15 AT AT94118048T patent/ATE198892T1/de not_active IP Right Cessation
- 1994-11-15 PT PT94118048T patent/PT658558E/pt unknown
- 1994-11-15 ES ES94118048T patent/ES2155839T3/es not_active Expired - Lifetime
- 1994-11-15 DE DE69427312T patent/DE69427312T2/de not_active Expired - Fee Related
- 1994-11-16 JP JP28215494A patent/JP3675863B2/ja not_active Expired - Fee Related
- 1994-11-16 CN CN94118099A patent/CN1050843C/zh not_active Expired - Fee Related
- 1994-11-16 US US08/340,580 patent/US5616703A/en not_active Expired - Lifetime
1997
- 1997-03-25 US US08/824,100 patent/US6235897B1/en not_active Expired - Fee Related
1999
- 1999-06-19 CN CN99108694A patent/CN1248581A/zh active Pending
2001
- 2001-01-23 US US09/767,658 patent/US20010016581A1/en not_active Abandoned
- 2001-03-09 GR GR20010400376T patent/GR3035535T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT658558E (pt)	2001-06-29
US6235897B1 (en)	2001-05-22
DK0658558T3 (da)	2001-04-17
EP0658558A1 (de)	1995-06-21
CN1248581A (zh)	2000-03-29
EP0658558B1 (de)	2001-01-24
US5616703A (en)	1997-04-01
ES2155839T3 (es)	2001-06-01
GR3035535T3 (en)	2001-06-29
JPH07188250A (ja)	1995-07-25
CN1050843C (zh)	2000-03-29
DE69427312T2 (de)	2001-08-23
DE69427312D1 (de)	2001-06-28
CN1107850A (zh)	1995-09-06
JP3675863B2 (ja)	2005-07-27
US20010016581A1 (en)	2001-08-23

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Legal Events

Date	Code	Title	Description
2010-08-15	REN	Ceased due to non-payment of the annual fee