ATE199726T1 - Synthese von verschiedenen und nützlichen oligonukleotidsammlungen - Google Patents

Synthese von verschiedenen und nützlichen oligonukleotidsammlungen

Info

Publication number: ATE199726T1
Authority: AT; Austria
Prior art keywords: synthesis; different; technique; oligonucleotides; insertions
Prior art date: 1992-04-15

Application number

AT93909309T

Other languages

English (en)

Inventor

David R Shortle

John Sondek

Original Assignee

Univ Johns Hopkins

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-15

Filing date

1993-04-13

Publication date

2001-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25351790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE199726(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-04-13 Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins

2001-03-15 Application granted granted Critical

2001-03-15 Publication of ATE199726T1 publication Critical patent/ATE199726T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 4
238000003780 insertion Methods 0.000 abstract 3
230000037431 insertion Effects 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
238000006467 substitution reaction Methods 0.000 abstract 2
108020004705 Codon Proteins 0.000 abstract 1
102000015636 Oligopeptides Human genes 0.000 abstract 1
108010038807 Oligopeptides Proteins 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000002703 mutagenesis Methods 0.000 abstract 1
231100000350 mutagenesis Toxicity 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT93909309T 1992-04-15 1993-04-13 Synthese von verschiedenen und nützlichen oligonukleotidsammlungen ATE199726T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86848992A	1992-04-15	1992-04-15
PCT/US1993/003418 WO1993021203A1 (en)	1992-04-15	1993-04-13	Synthesis of diverse and useful collections of oligonucleotides

Publications (1)

Publication Number	Publication Date
ATE199726T1 true ATE199726T1 (de)	2001-03-15

Family

ID=25351790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93909309T ATE199726T1 (de)	1992-04-15	1993-04-13	Synthese von verschiedenen und nützlichen oligonukleotidsammlungen

Country Status (10)

Country	Link
EP (1)	EP0638089B2 (de)
JP (1)	JP4138869B2 (de)
AT (1)	ATE199726T1 (de)
CA (1)	CA2133554C (de)
DE (1)	DE69330027T3 (de)
DK (1)	DK0638089T4 (de)
ES (1)	ES2156869T5 (de)
GR (1)	GR3035978T3 (de)
PT (1)	PT638089E (de)
WO (1)	WO1993021203A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5571902A (en) *	1993-07-29	1996-11-05	Isis Pharmaceuticals, Inc.	Synthesis of oligonucleotides
US6001982A (en)	1993-07-29	1999-12-14	Isis Pharmaceuticals, Inc.	Synthesis of oligonucleotides
US6280935B1 (en)	1994-10-13	2001-08-28	Lynx Therapeutics, Inc.	Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags
USRE43097E1 (en)	1994-10-13	2012-01-10	Illumina, Inc.	Massively parallel signature sequencing by ligation of encoded adaptors
US5846719A (en)	1994-10-13	1998-12-08	Lynx Therapeutics, Inc.	Oligonucleotide tags for sorting and identification
US5695934A (en) *	1994-10-13	1997-12-09	Lynx Therapeutics, Inc.	Massively parallel sequencing of sorted polynucleotides
US5604097A (en) *	1994-10-13	1997-02-18	Spectragen, Inc.	Methods for sorting polynucleotides using oligonucleotide tags
US5717085A (en) *	1994-11-23	1998-02-10	Terrapin Technologies, Inc.	Process for preparing codon amidites
EP0800526B1 (de) *	1994-12-30	2003-03-26	Chiron Corporation	Verfahren zur kontrollierten synthese von beliebigen peptidmischungen kodierende polynukleotidmischungen
US6060240A (en) *	1996-12-13	2000-05-09	Arcaris, Inc.	Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
EP1409505A1 (de) *	2001-07-09	2004-04-21	Chemogenix GmbH	Multimer polynukleotidsynthese
DK2528944T3 (en)	2010-01-29	2015-09-14	Morphosys Ag	Rodent combinatorial antibody libraries
CN108699551B (zh)	2016-03-04	2023-01-24	莫佛塞斯公司	多肽文库
US20210317158A1 (en) *	2018-05-02	2021-10-14	Natias Inc.	Optically active segment for use in synthesis of stereocontrolled oligonucleotide, method for producing the same, and method for synthesizing stereocontrolled oligonucleotide using the same
JP7075680B2 (ja) *	2018-05-02	2022-05-26	株式会社ナティアス	オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61152695A (ja) *	1984-12-26	1986-07-11	Nippon Shinyaku Co Ltd	長鎖ｄｎａの合成法
EP0216357A3 (de) *	1985-09-25	1988-08-31	Nippon Zeon Co., Ltd.	Phosphoramidit-Verbindungen und Verfahren zu deren Herstellung
JP2862870B2 (ja) †	1986-09-12	1999-03-03	協和醗酵工業株式会社	新規ペプチド
CA2009996A1 (en) †	1989-02-17	1990-08-17	Kathleen S. Cook	Process for making genes encoding random polymers of amino acids
US5723286A (en) †	1990-06-20	1998-03-03	Affymax Technologies N.V.	Peptide library and screening systems
US5650489A (en) *	1990-07-02	1997-07-22	The Arizona Board Of Regents	Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
EP0544809B1 (de) *	1990-08-24	1998-12-16	Ixsys, Inc.	Verfahren zur herstellung von oligonukleotiden mit regellosen codonen

1993
- 1993-04-13 AT AT93909309T patent/ATE199726T1/de active
- 1993-04-13 DE DE69330027T patent/DE69330027T3/de not_active Expired - Lifetime
- 1993-04-13 JP JP51853393A patent/JP4138869B2/ja not_active Expired - Lifetime
- 1993-04-13 CA CA002133554A patent/CA2133554C/en not_active Expired - Lifetime
- 1993-04-13 EP EP93909309A patent/EP0638089B2/de not_active Expired - Lifetime
- 1993-04-13 DK DK93909309T patent/DK0638089T4/da active
- 1993-04-13 WO PCT/US1993/003418 patent/WO1993021203A1/en not_active Ceased
- 1993-04-13 ES ES93909309T patent/ES2156869T5/es not_active Expired - Lifetime
- 1993-04-13 PT PT93909309T patent/PT638089E/pt unknown
2001
- 2001-05-31 GR GR20010400829T patent/GR3035978T3/el unknown

Also Published As

Publication number	Publication date
DK0638089T4 (da)	2008-06-16
CA2133554A1 (en)	1993-10-28
EP0638089B1 (de)	2001-03-14
PT638089E (pt)	2001-09-27
EP0638089A1 (de)	1995-02-15
JPH08502642A (ja)	1996-03-26
WO1993021203A1 (en)	1993-10-28
ES2156869T3 (es)	2001-08-01
GR3035978T3 (en)	2001-08-31
DE69330027T3 (de)	2008-09-25
DE69330027T2 (de)	2001-09-20
ES2156869T5 (es)	2008-07-01
CA2133554C (en)	2009-07-14
EP0638089B2 (de)	2008-03-05
JP4138869B2 (ja)	2008-08-27
DK0638089T3 (da)	2001-07-16
DE69330027D1 (de)	2001-04-19

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2001-08-15

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2008-09-15

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