ATE200484T1 - Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen - Google Patents

Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen

Info

Publication number
ATE200484T1
ATE200484T1 AT93919593T AT93919593T ATE200484T1 AT E200484 T1 ATE200484 T1 AT E200484T1 AT 93919593 T AT93919593 T AT 93919593T AT 93919593 T AT93919593 T AT 93919593T AT E200484 T1 ATE200484 T1 AT E200484T1
Authority
AT
Austria
Prior art keywords
dihydropyridines
nitrophenyl
dihydro
dimethyl
optically active
Prior art date
Application number
AT93919593T
Other languages
English (en)
Inventor
Kunio Isshiki
Takashi Dorimu Haits Nakashima
Totsuka-Ku
Takeo Gurin Haitsu - Yoshioka
Hiroshi Tsunekawa
Takashi Taisho Pharmace Adachi
Tomomi Taisho Pharmaceutic Ota
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corp filed Critical Mercian Corp
Application granted granted Critical
Publication of ATE200484T1 publication Critical patent/ATE200484T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93919593T 1992-08-31 1993-08-31 Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen ATE200484T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23187792 1992-08-31
PCT/JP1993/001222 WO1994005637A1 (fr) 1992-08-31 1993-08-31 Compose a base de 1,4-dihydropyridine presentant une activite optique et procede de production

Publications (1)

Publication Number Publication Date
ATE200484T1 true ATE200484T1 (de) 2001-04-15

Family

ID=16930427

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93919593T ATE200484T1 (de) 1992-08-31 1993-08-31 Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen

Country Status (8)

Country Link
US (1) US5635395A (de)
EP (1) EP0657429B1 (de)
KR (1) KR100244728B1 (de)
AT (1) ATE200484T1 (de)
AU (1) AU4981893A (de)
CA (1) CA2143106A1 (de)
DE (1) DE69330130T2 (de)
WO (1) WO1994005637A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69527359T2 (de) * 1994-08-29 2003-03-06 Mercian Corp., Tokio/Tokyo 1,4-dihydropyridin-derivate
DE69630229D1 (de) 1995-07-31 2003-11-06 Mercian Corp Gen, das für ein protein mit asymmetrischer hydrolaseaktivität für 4-substituierte-1,4-dihydropyridin-derivate und sein expressionsprodukt
WO1998049144A1 (en) * 1997-04-25 1998-11-05 Ajinomoto Co., Inc. Novel dihydropyridine derivative
US6145143A (en) * 1999-06-03 2000-11-14 Kinetic Concepts, Inc. Patient support systems with layered fluid support mediums

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
US5234821A (en) * 1990-09-01 1993-08-10 Kazuo Achiwa Process for preparing 1,4 dihydropyridine compounds
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な1,4−ジヒドロピリジン化合物及びその製造方法
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
JPH0584089A (ja) * 1991-03-01 1993-04-06 Taisho Pharmaceut Co Ltd 光学活性1,4−ジヒドロピリジン化合物の製造法
JPH04299994A (ja) * 1991-03-26 1992-10-23 Taisho Pharmaceut Co Ltd 光学活性1,4−ジヒドロピリジン化合物の製造法
JP3286645B2 (ja) * 1993-03-26 2002-05-27 メルシャン株式会社 光学活性1,4−ジヒドロピリジン誘導体およびその製造方法

Also Published As

Publication number Publication date
KR100244728B1 (ko) 2000-03-02
WO1994005637A1 (fr) 1994-03-17
DE69330130T2 (de) 2001-08-02
DE69330130D1 (de) 2001-05-17
US5635395A (en) 1997-06-03
KR950702963A (ko) 1995-08-23
EP0657429A4 (de) 1996-03-27
EP0657429A1 (de) 1995-06-14
CA2143106A1 (en) 1994-03-17
EP0657429B1 (de) 2001-04-11
AU4981893A (en) 1994-03-29

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