ATE201149T1 - Vorrichtung und verfahren für mehrfachen chemischen reaktionen - Google Patents

Vorrichtung und verfahren für mehrfachen chemischen reaktionen

Info

Publication number: ATE201149T1
Authority: AT; Austria
Prior art keywords: block; manifold valve; valve block; reaction; channel
Prior art date: 1995-09-22

Application number

AT96933842T

Other languages

English (en)

Inventor

Raju Mohan

Brad O Buckman

Michael M Morrissey

Andrew I Chitty

John T Martin

Original Assignee

Berlex Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-22

Filing date

1996-09-23

Publication date

2001-06-15

1996-09-23 Application filed by Berlex Lab filed Critical Berlex Lab

2001-06-15 Application granted granted Critical

2001-06-15 Publication of ATE201149T1 publication Critical patent/ATE201149T1/de

Links

238000006243 chemical reaction Methods 0.000 title abstract 7
238000000034 method Methods 0.000 title 1
238000003776 cleavage reaction Methods 0.000 abstract 2
230000007017 scission Effects 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
239000007795 chemical reaction product Substances 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
- B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00331—Details of the reactor vessels
- B01J2219/00333—Closures attached to the reactor vessels
- B01J2219/00335—Septa
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00391—Rotary valves
- B01J2219/00394—Rotary valves in multiple arrangements
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00414—Means for dispensing and evacuation of reagents using suction
- B01J2219/00416—Vacuum
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00452—Means for the recovery of reactants or products
- B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00484—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00495—Means for heating or cooling the reaction vessels
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Degasification And Air Bubble Elimination (AREA)

AT96933842T 1995-09-22 1996-09-23 Vorrichtung und verfahren für mehrfachen chemischen reaktionen ATE201149T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53227995A	1995-09-22	1995-09-22
PCT/US1996/015124 WO1997010896A1 (en)	1995-09-22	1996-09-23	Apparatus and process for multiple chemical reactions

Publications (1)

Publication Number	Publication Date
ATE201149T1 true ATE201149T1 (de)	2001-06-15

Family

ID=24121110

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96933842T ATE201149T1 (de)	1995-09-22	1996-09-23	Vorrichtung und verfahren für mehrfachen chemischen reaktionen

Country Status (14)

Country	Link
EP (1)	EP0859661B1 (de)
JP (1)	JPH11511381A (de)
KR (1)	KR19990063660A (de)
CN (1)	CN1197413A (de)
AT (1)	ATE201149T1 (de)
AU (1)	AU723605B2 (de)
CA (1)	CA2232505A1 (de)
DE (1)	DE69612866T2 (de)
DK (1)	DK0859661T3 (de)
ES (1)	ES2159361T3 (de)
GR (1)	GR3035958T3 (de)
IL (1)	IL123662A (de)
PT (1)	PT859661E (de)
WO (1)	WO1997010896A1 (de)

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US5888830A (en)	1995-09-22	1999-03-30	Berlex Laboratories, Inc.	Apparatus and process for multiple chemical reactions
JP2001500426A (ja) *	1996-09-12	2001-01-16	カイロンコーポレイション	モジュラー反応容器の配列を含む固相化学合成における使用のための作動手段
US5866342A (en) *	1996-09-27	1999-02-02	Glaxo Group Limited	Systems and methods for the synthesis of organic compounds
CA2267769A1 (en) *	1996-10-07	1998-04-16	Irori	Matrices with memories in automated drug discovery and units therefor
US6042789A (en) *	1996-10-23	2000-03-28	Glaxo Group Limited	System for parallel synthesis of organic compounds
US6149869A (en) *	1996-10-23	2000-11-21	Glaxo Wellcome Inc.	Chemical synthesizers
US6083761A (en) *	1996-12-02	2000-07-04	Glaxo Wellcome Inc.	Method and apparatus for transferring and combining reagents
US6054325A (en) *	1996-12-02	2000-04-25	Glaxo Wellcom Inc.	Method and apparatus for transferring and combining distinct chemical compositions with reagents
US6274094B1 (en)	1997-01-13	2001-08-14	Weller, Iii Harold Norris	Nestable, modular apparatus for synthesis of multiple organic compounds
US6045755A (en) *	1997-03-10	2000-04-04	Trega Biosciences,, Inc.	Apparatus and method for combinatorial chemistry synthesis
US5961925A (en) *	1997-09-22	1999-10-05	Bristol-Myers Squibb Company	Apparatus for synthesis of multiple organic compounds with pinch valve block
KR100279552B1 (ko)	1997-10-18	2001-11-30	박한오	다중단속밸브장치
US6083682A (en)	1997-12-19	2000-07-04	Glaxo Group Limited	System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
WO1999054031A1 (en) *	1998-04-23	1999-10-28	Otter Coast Automation, Inc.	Method and apparatus for synthesis of libraries of organic compounds
JP4569850B2 (ja) *	1998-09-24	2010-10-27	株式会社島津製作所	自動合成機
US6485692B1 (en) *	1998-12-04	2002-11-26	Symyx Technologies, Inc.	Continuous feed parallel reactor
EP1159063B1 (de) *	1999-02-11	2005-08-24	Scynexis, Inc.	Verfahren zur synthese, reinigung und charakterisierung von kombinatorischen bibliotheken
GB0004456D0 (en)	2000-02-26	2000-04-19	Glaxo Group Ltd	Medicament dispenser
US6824738B1 (en)	2000-04-14	2004-11-30	Discovery Partners International, Inc.	System and method for treatment of samples on solid supports
US6503457B1 (en)	2000-04-14	2003-01-07	Discovery Partners International, Inc.	Container and method for high volume treatment of samples on solid supports
US6432365B1 (en)	2000-04-14	2002-08-13	Discovery Partners International, Inc.	System and method for dispensing solution to a multi-well container
GB0012465D0 (en)	2000-05-24	2000-07-12	Glaxo Group Ltd	Monitoring method
US6994827B2 (en)	2000-06-03	2006-02-07	Symyx Technologies, Inc.	Parallel semicontinuous or continuous reactors
GB0013619D0 (en)	2000-06-06	2000-07-26	Glaxo Group Ltd	Sample container
JP2004503338A (ja)	2000-07-15	2004-02-05	グラクソ　グループ　リミテッド	薬剤取り出し装置
US6923939B1 (en) *	2001-07-05	2005-08-02	Uop Llc	Heat activated membrane introduction apparatus and method for screening materials
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
US7998986B2 (en)	2001-12-21	2011-08-16	Exelixis Patent Company Llc	Modulators of LXR
US6893613B2 (en) *	2002-01-25	2005-05-17	Bristol-Myers Squibb Company	Parallel chemistry reactor with interchangeable vessel carrying inserts
CN1313197C (zh) *	2003-11-21	2007-05-02	苏为科	模拟工业化生产的中试试验装置
DE102005016755B3 (de) *	2005-04-11	2006-11-30	Eppendorf Ag	Vorrichtung, System mit einer solchen Vorrichtung und Verfahren zum Trocknen von Kavitäten in Mikrotiterfilterplatten und von darin angeordneten Filtern
KR100793819B1 (ko) *	2006-06-16	2008-01-10	주식회사 펩트론	히트 블록 어셈블리 및 그를 이용한 유기 화합물 합성 반응장치
DE102014103692A1 (de) *	2014-03-18	2015-09-24	Basf Se	System und Verfahren zum Rückgewinnen von flüssigen oder fließfähigen Chemikalien
CN104232467A (zh) *	2014-08-21	2014-12-24	广东凯普生物科技股份有限公司	分子杂交反应室
JP6944049B2 (ja) *	2017-09-29	2021-10-06	シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド	試験管真空保持装置
JP6481187B1 (ja) *	2018-02-05	2019-03-13	エイブル株式会社	試料計測方法、マルチウエルプレートの蓋、試料計測キット、及び、試料計測装置
JP6589190B6 (ja) *	2019-04-03	2019-12-11	ヤマト科学株式会社	反応容器の液体排出装置
CN111018931A (zh) *	2019-12-30	2020-04-17	江苏东玄基因科技有限公司	一种低聚物自动化固相合成系统

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DD239473A1 (de) *	1985-07-01	1986-09-24	Zeiss Jena Veb Carl	Probentraeger zur diskreten analyse fluessiger analysensaetze
DK492788D0 (da) *	1988-09-02	1988-09-05	Morten Meldal	Peptidsynteseapparat
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EP0542422A1 (de) *	1991-11-12	1993-05-19	General Atomics	Mikrotiterplatte mit mehreren Vertiefungen
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US5472672A (en) *	1993-10-22	1995-12-05	The Board Of Trustees Of The Leland Stanford Junior University	Apparatus and method for polymer synthesis using arrays
NZ276860A (en) *	1993-11-02	1997-09-22	Affymax Tech Nv	Apparatus and its use for synthesising diverse molecular products on substrates

1996
- 1996-09-23 WO PCT/US1996/015124 patent/WO1997010896A1/en not_active Ceased
- 1996-09-23 DE DE69612866T patent/DE69612866T2/de not_active Expired - Fee Related
- 1996-09-23 PT PT96933842T patent/PT859661E/pt unknown
- 1996-09-23 DK DK96933842T patent/DK0859661T3/da active
- 1996-09-23 CA CA002232505A patent/CA2232505A1/en not_active Abandoned
- 1996-09-23 JP JP9512925A patent/JPH11511381A/ja active Pending
- 1996-09-23 AU AU72417/96A patent/AU723605B2/en not_active Ceased
- 1996-09-23 IL IL12366296A patent/IL123662A/xx not_active IP Right Cessation
- 1996-09-23 CN CN96197139A patent/CN1197413A/zh active Pending
- 1996-09-23 ES ES96933842T patent/ES2159361T3/es not_active Expired - Lifetime
- 1996-09-23 KR KR1019980702113A patent/KR19990063660A/ko not_active Ceased
- 1996-09-23 AT AT96933842T patent/ATE201149T1/de not_active IP Right Cessation
- 1996-09-23 EP EP96933842A patent/EP0859661B1/de not_active Expired - Lifetime
2001
- 2001-05-31 GR GR20010400145T patent/GR3035958T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0859661T3 (da)	2001-08-27
JPH11511381A (ja)	1999-10-05
CA2232505A1 (en)	1997-03-27
AU723605B2 (en)	2000-08-31
EP0859661A1 (de)	1998-08-26
WO1997010896A1 (en)	1997-03-27
CN1197413A (zh)	1998-10-28
KR19990063660A (ko)	1999-07-26
DE69612866T2 (de)	2001-11-08
AU7241796A (en)	1997-04-09
IL123662A (en)	2001-01-28
PT859661E (pt)	2001-10-31
IL123662A0 (en)	1998-10-30
ES2159361T3 (es)	2001-10-01
EP0859661B1 (de)	2001-05-16
GR3035958T3 (en)	2001-08-31
DE69612866D1 (de)	2001-06-21

Legal Events

Date	Code	Title	Description
2001-08-15	UEP	Publication of translation of european patent specification
2004-06-15	REN	Ceased due to non-payment of the annual fee

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