ATE234318T1 - D-pentofuranose-derivate und verfahren zu ihrer herstellung - Google Patents

D-pentofuranose-derivate und verfahren zu ihrer herstellung

Info

Publication number: ATE234318T1
Authority: AT; Austria
Prior art keywords: group; compound; formula; lower alkyl; sugar moiety
Prior art date: 1996-05-16

Application number

AT97919673T

Other languages

English (en)

Inventor

Makoto Nomura

Hideki Kazuno

Tsutomu Sato

Masato Washinosu

Motoaki Tanaka

Akira Matsuda

Tetsuji Asao

Original Assignee

Taiho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-16

Filing date

1997-04-24

Publication date

2003-03-15

1997-04-24 Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE234318T1 publication Critical patent/ATE234318T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
-1 chlorobenzoyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 abstract 2
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical class C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97919673T 1996-05-16 1997-04-24 D-pentofuranose-derivate und verfahren zu ihrer herstellung ATE234318T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP12137296		1996-05-16
PCT/JP1997/001427 WO1997043295A1 (fr)	1996-05-16	1997-04-24	Derives de d-pentofuranose et leur procede de preparation

Publications (1)

Publication Number	Publication Date
ATE234318T1 true ATE234318T1 (de)	2003-03-15

Family

ID=14809610

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97919673T ATE234318T1 (de)	1996-05-16	1997-04-24	D-pentofuranose-derivate und verfahren zu ihrer herstellung

Country Status (10)

Country	Link
US (1)	US5880294A (de)
EP (1)	EP0842942B1 (de)
JP (1)	JP3046359B2 (de)
KR (1)	KR100247734B1 (de)
AT (1)	ATE234318T1 (de)
AU (1)	AU693741B2 (de)
CA (1)	CA2226363C (de)
DE (1)	DE69719673T2 (de)
ES (1)	ES2195136T3 (de)
WO (1)	WO1997043295A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2514466C (en) *	2003-02-19	2015-05-26	Yale University	Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
MY159745A (en) *	2008-11-17	2017-01-31	Anadys Pharmaceuticals Inc	Method of preparing deoxyribofuranose compounds
AU2011263416B2 (en)	2010-06-11	2014-04-10	Rhodes Technologies	Process for N-dealkylation of tertiary amines
US9556216B2 (en)	2012-08-31	2017-01-31	Novartis Ag	2′-Ethynyl nucleoside derivatives for treatment of viral infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3480613A (en) *	1967-07-03	1969-11-25	Merck & Co Inc	2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
JPH0753586A (ja) *	1993-08-23	1995-02-28	Sankyo Co Ltd	ピリミジンヌクレオシド誘導体の製法

1997
- 1997-04-24 CA CA002226363A patent/CA2226363C/en not_active Expired - Fee Related
- 1997-04-24 AU AU24059/97A patent/AU693741B2/en not_active Ceased
- 1997-04-24 KR KR1019970709750A patent/KR100247734B1/ko not_active Expired - Fee Related
- 1997-04-24 JP JP9540715A patent/JP3046359B2/ja not_active Expired - Fee Related
- 1997-04-24 US US08/981,814 patent/US5880294A/en not_active Expired - Lifetime
- 1997-04-24 AT AT97919673T patent/ATE234318T1/de not_active IP Right Cessation
- 1997-04-24 WO PCT/JP1997/001427 patent/WO1997043295A1/ja not_active Ceased
- 1997-04-24 DE DE69719673T patent/DE69719673T2/de not_active Expired - Lifetime
- 1997-04-24 ES ES97919673T patent/ES2195136T3/es not_active Expired - Lifetime
- 1997-04-24 EP EP97919673A patent/EP0842942B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0842942A1 (de)	1998-05-20
DE69719673D1 (de)	2003-04-17
US5880294A (en)	1999-03-09
AU693741B2 (en)	1998-07-02
JP3046359B2 (ja)	2000-05-29
CA2226363C (en)	2001-03-13
KR100247734B1 (ko)	2000-03-15
WO1997043295A1 (fr)	1997-11-20
AU2405997A (en)	1997-12-05
CA2226363A1 (en)	1997-11-20
EP0842942A4 (de)	1999-01-13
KR19990028434A (ko)	1999-04-15
DE69719673T2 (de)	2003-12-18
EP0842942B1 (de)	2003-03-12
ES2195136T3 (es)	2003-12-01

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Legal Events

Date	Code	Title	Description
2003-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties