ATE201683T1 - Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden - Google Patents

Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden

Info

Publication number: ATE201683T1
Authority: AT; Austria
Prior art keywords: heterocyclyl; receptor ligands; ht1a receptor; ergoline derivatives; ergoline
Prior art date: 1996-02-15

Application number

AT97903245T

Other languages

English (en)

Inventor

Sergio Mantegani

Tiziano Bandiera

Maurizio Meroni

Mario Varasi

Carla Caccia

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-15

Filing date

1997-02-07

Publication date

2001-06-15

1997-02-07 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

2001-06-15 Application granted granted Critical

2001-06-15 Publication of ATE201683T1 publication Critical patent/ATE201683T1/de

Links

102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 title 1
101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 title 1
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97903245T 1996-02-15 1997-02-07 Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden ATE201683T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9603226.3A GB9603226D0 (en)	1996-02-15	1996-02-15	Heterocyclyl-ergoline derivatives
PCT/EP1997/000582 WO1997030050A1 (en)	1996-02-15	1997-02-07	Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands

Publications (1)

Publication Number	Publication Date
ATE201683T1 true ATE201683T1 (de)	2001-06-15

Family

ID=10788832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97903245T ATE201683T1 (de)	1996-02-15	1997-02-07	Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden

Country Status (26)

Country	Link
US (1)	US6087371A (de)
EP (1)	EP0885222B1 (de)
JP (1)	JP2000504700A (de)
KR (1)	KR19990082680A (de)
CN (1)	CN1211253A (de)
AR (1)	AR005820A1 (de)
AT (1)	ATE201683T1 (de)
AU (1)	AU1767797A (de)
BR (1)	BR9707463A (de)
CA (1)	CA2243992A1 (de)
DE (1)	DE69705032T2 (de)
DK (1)	DK0885222T3 (de)
EA (1)	EA199800720A1 (de)
ES (1)	ES2159838T3 (de)
GB (1)	GB9603226D0 (de)
GR (1)	GR3036390T3 (de)
HU (1)	HUP9900572A3 (de)
IL (1)	IL125344A0 (de)
MX (1)	MX9806341A (de)
NO (1)	NO983656L (de)
NZ (1)	NZ331087A (de)
PL (1)	PL328373A1 (de)
PT (1)	PT885222E (de)
TW (1)	TW360655B (de)
WO (1)	WO1997030050A1 (de)
ZA (1)	ZA971167B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03001472A (es) *	2000-08-16	2003-06-06	Upjohn Co	Compuestos para el tratamiento de trastornos adictivos.
EP1685838A1 (de) *	2000-08-16	2006-08-02	Pharmacia & Upjohn Company LLC	Verbindungen zur Behandlung von Suchterkrankungen
US8106074B2 (en)	2001-07-13	2012-01-31	Pierre Fabre Medicament	Pyridin-2-yl-methylamine derivatives for treating opiate dependence
EP2583556B1 (de) *	2008-07-17	2016-01-20	Bayer CropScience AG	Heterocyclische Verbindungen als Schädlingsbekämpfungsmittel
CN106866656A (zh) *	2017-02-28	2017-06-20	西南交通大学	一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU39278B (en) *	1976-12-22	1984-10-31	Lek Tovarna Farmacevtskih	Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
FI76085C (fi) *	1981-07-21	1988-09-09	Erba Farmitalia	Foerfarande foer framstaellning av ergolinderivat.
HU190105B (en) *	1983-06-03	1986-08-28	Gyogyszerkutato Intezet	Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) *	1986-05-21	1986-06-25	Erba Farmitalia	Ergoline esters
GB8702364D0 (en) *	1987-02-03	1987-03-11	Erba Farmitalia	Ergolinyl heterocycles
DE3868866D1 (de) *	1987-11-20	1992-04-09	Erba Carlo Spa	Ergolinderivate mit antiparkinsonwirkung.
US5210194A (en) *	1990-01-25	1993-05-11	Farmitalia Carlo Erba S.R.L. An Italian Body Corporate	Process for preparing ergoline derivatives
JP2888648B2 (ja) *	1990-12-28	1999-05-10	出光興産株式会社	スチレン系重合体の製造方法及びその触媒

1996
- 1996-02-15 GB GBGB9603226.3A patent/GB9603226D0/en active Pending
1997
- 1997-01-16 TW TW086100411A patent/TW360655B/zh active
- 1997-02-07 DE DE69705032T patent/DE69705032T2/de not_active Expired - Fee Related
- 1997-02-07 KR KR1019980706426A patent/KR19990082680A/ko not_active Withdrawn
- 1997-02-07 CA CA002243992A patent/CA2243992A1/en not_active Abandoned
- 1997-02-07 AU AU17677/97A patent/AU1767797A/en not_active Abandoned
- 1997-02-07 WO PCT/EP1997/000582 patent/WO1997030050A1/en not_active Ceased
- 1997-02-07 DK DK97903245T patent/DK0885222T3/da active
- 1997-02-07 AT AT97903245T patent/ATE201683T1/de not_active IP Right Cessation
- 1997-02-07 PL PL97328373A patent/PL328373A1/xx unknown
- 1997-02-07 EP EP97903245A patent/EP0885222B1/de not_active Expired - Lifetime
- 1997-02-07 ES ES97903245T patent/ES2159838T3/es not_active Expired - Lifetime
- 1997-02-07 IL IL12534497A patent/IL125344A0/xx unknown
- 1997-02-07 CN CN97192277A patent/CN1211253A/zh active Pending
- 1997-02-07 BR BR9707463A patent/BR9707463A/pt not_active Application Discontinuation
- 1997-02-07 NZ NZ331087A patent/NZ331087A/xx unknown
- 1997-02-07 HU HU9900572A patent/HUP9900572A3/hu unknown
- 1997-02-07 JP JP9528958A patent/JP2000504700A/ja not_active Withdrawn
- 1997-02-07 EA EA199800720A patent/EA199800720A1/ru unknown
- 1997-02-07 US US09/125,108 patent/US6087371A/en not_active Expired - Fee Related
- 1997-02-07 PT PT97903245T patent/PT885222E/pt unknown
- 1997-02-12 ZA ZA9701167A patent/ZA971167B/xx unknown
- 1997-02-14 AR ARP970100586A patent/AR005820A1/es unknown
1998
- 1998-08-06 MX MX9806341A patent/MX9806341A/es unknown
- 1998-08-10 NO NO983656A patent/NO983656L/no unknown
2001
- 2001-08-14 GR GR20010401246T patent/GR3036390T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EA199800720A1 (ru)	1999-02-25
US6087371A (en)	2000-07-11
ZA971167B (en)	1997-08-25
AR005820A1 (es)	1999-07-14
DE69705032T2 (de)	2001-11-22
EP0885222A1 (de)	1998-12-23
NZ331087A (en)	1999-08-30
AU1767797A (en)	1997-09-02
PT885222E (pt)	2001-10-31
DK0885222T3 (da)	2001-08-27
NO983656D0 (no)	1998-08-10
TW360655B (en)	1999-06-11
DE69705032D1 (de)	2001-07-05
PL328373A1 (en)	1999-01-18
IL125344A0 (en)	1999-03-12
EP0885222B1 (de)	2001-05-30
HUP9900572A3 (en)	2000-10-30
ES2159838T3 (es)	2001-10-16
GB9603226D0 (en)	1996-04-17
HUP9900572A2 (hu)	1999-06-28
KR19990082680A (ko)	1999-11-25
CA2243992A1 (en)	1997-08-21
GR3036390T3 (en)	2001-11-30
CN1211253A (zh)	1999-03-17
NO983656L (no)	1998-10-12
WO1997030050A1 (en)	1997-08-21
JP2000504700A (ja)	2000-04-18
MX9806341A (es)	1998-10-31
BR9707463A (pt)	1999-07-20

Legal Events

Date	Code	Title	Description
2007-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE263151T1 (de)	2004-04-15	Indolderivate verwendbar als endothelinrezeptorantagonisten
ATE226578T1 (de)	2002-11-15	Benzofuranderivate als tachykininantagonisten
DE69325167D1 (de)	1999-07-08	Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten
ATE197300T1 (de)	2000-11-15	Indolderivate als 5-ht rezeptorantagoniste
DE69127791D1 (de)	1997-11-06	Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten
DE69605430D1 (de)	2000-01-05	Chinolin-2-on derivate als serotonin antagonisten
DE69623306D1 (de)	2002-10-02	Pyrimidinderivate als 5ht2c-rezeptorantagonisten
BR9700850A (pt)	1998-09-01	Derivados de quinazolina substituídos
FI960840A7 (fi)	1996-02-23	Indolijohdannaisia tromboksaani-A2-antagonisteina
DE59712958D1 (de)	2008-09-25	Substituierte Purinderivate als Vitronectinrezeptor-Antagonisten
ATE221052T1 (de)	2002-08-15	Tetrahydrochinolinderivate als eaa antagonisten
DE69617995D1 (de)	2002-01-24	Indolalkylderivate von benzodioxanmenthylamin als 5-ht1a rezeptor liganden
DE69703242D1 (de)	2000-11-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69735811D1 (de)	2006-06-08	Piperazinoderivate als neurokinin-antagonisten
FI951798A7 (fi)	1995-04-13	Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
ATE201683T1 (de)	2001-06-15	Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden
DE69717449D1 (de)	2003-01-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69320653D1 (de)	1998-10-01	Tetrahydrocarbazolderivate als 5-ht1-ähnliche agonisten
MA26440A1 (fr)	2004-12-20	Derives de n-benzylazolium
DE69617010D1 (de)	2001-12-20	Isazole derivate als fibrinogen-rezeptor-antagonisten
DE69527785D1 (de)	2002-09-19	Chinuclidin-n-oxidderivate als muscarin rezeptor liganden
ATE223380T1 (de)	2002-09-15	Heteroaryloxyethylaminen als 5-ht1a rezeptor liganden
NO996391L (no)	1999-12-22	Angiogenese-inhiberende tiadiazolylpyridazinderivater
DE59407285D1 (de)	1998-12-17	Imidazolochinoxalinonderivate als eaa antagonisten
SI0885222T1 (en)	2001-10-31	Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands