ATE201683T1 - Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden - Google Patents

Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden

Info

Publication number: ATE201683T1
Authority: AT; Austria
Prior art keywords: heterocyclyl; receptor ligands; ht1a receptor; ergoline derivatives; ergoline
Prior art date: 1996-02-15

Application number

AT97903245T

Other languages

English (en)

Inventor

Sergio Mantegani

Tiziano Bandiera

Maurizio Meroni

Mario Varasi

Carla Caccia

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-15

Filing date

1997-02-07

Publication date

2001-06-15

1997-02-07 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

2001-06-15 Application granted granted Critical

2001-06-15 Publication of ATE201683T1 publication Critical patent/ATE201683T1/de

Links

102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 title 1
101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 title 1
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97903245T 1996-02-15 1997-02-07 Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden ATE201683T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9603226.3A GB9603226D0 (en)	1996-02-15	1996-02-15	Heterocyclyl-ergoline derivatives
PCT/EP1997/000582 WO1997030050A1 (en)	1996-02-15	1997-02-07	Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands

Publications (1)

Publication Number	Publication Date
ATE201683T1 true ATE201683T1 (de)	2001-06-15

Family

ID=10788832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97903245T ATE201683T1 (de)	1996-02-15	1997-02-07	Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden

Country Status (26)

Country	Link
US (1)	US6087371A (de)
EP (1)	EP0885222B1 (de)
JP (1)	JP2000504700A (de)
KR (1)	KR19990082680A (de)
CN (1)	CN1211253A (de)
AR (1)	AR005820A1 (de)
AT (1)	ATE201683T1 (de)
AU (1)	AU1767797A (de)
BR (1)	BR9707463A (de)
CA (1)	CA2243992A1 (de)
DE (1)	DE69705032T2 (de)
DK (1)	DK0885222T3 (de)
EA (1)	EA199800720A1 (de)
ES (1)	ES2159838T3 (de)
GB (1)	GB9603226D0 (de)
GR (1)	GR3036390T3 (de)
HU (1)	HUP9900572A3 (de)
IL (1)	IL125344A0 (de)
MX (1)	MX9806341A (de)
NO (1)	NO983656L (de)
NZ (1)	NZ331087A (de)
PL (1)	PL328373A1 (de)
PT (1)	PT885222E (de)
TW (1)	TW360655B (de)
WO (1)	WO1997030050A1 (de)
ZA (1)	ZA971167B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1685838A1 (de) *	2000-08-16	2006-08-02	Pharmacia & Upjohn Company LLC	Verbindungen zur Behandlung von Suchterkrankungen
AU2001283393B2 (en) *	2000-08-16	2005-09-22	Pharmacia & Upjohn Company	Compounds for the treatment of addictive disorders
US8106074B2 (en)	2001-07-13	2012-01-31	Pierre Fabre Medicament	Pyridin-2-yl-methylamine derivatives for treating opiate dependence
BRPI0916218B1 (pt) *	2008-07-17	2018-11-27	Bayer Cropscience Ag	compostos heterocíclicos como composições praguicidas
CN106866656A (zh) *	2017-02-28	2017-06-20	西南交通大学	一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU39278B (en) *	1976-12-22	1984-10-31	Lek Tovarna Farmacevtskih	Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
AU553809B2 (en) *	1981-07-21	1986-07-31	Farmitalia Carlo Erba S.P.A.	Ergoline derivatives
HU190105B (en) *	1983-06-03	1986-08-28	Gyogyszerkutato Intezet	Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) *	1986-05-21	1986-06-25	Erba Farmitalia	Ergoline esters
GB8702364D0 (en) *	1987-02-03	1987-03-11	Erba Farmitalia	Ergolinyl heterocycles
EP0317269B1 (de) *	1987-11-20	1992-03-04	FARMITALIA CARLO ERBA S.r.l.	Ergolinderivate mit Antiparkinsonwirkung
CA2049053A1 (en) *	1990-01-25	1991-07-26	Sergio Mantegani	Process for preparing ergoline derivatives
JP2888648B2 (ja) *	1990-12-28	1999-05-10	出光興産株式会社	スチレン系重合体の製造方法及びその触媒

1996
- 1996-02-15 GB GBGB9603226.3A patent/GB9603226D0/en active Pending
1997
- 1997-01-16 TW TW086100411A patent/TW360655B/zh active
- 1997-02-07 PL PL97328373A patent/PL328373A1/xx unknown
- 1997-02-07 DE DE69705032T patent/DE69705032T2/de not_active Expired - Fee Related
- 1997-02-07 EA EA199800720A patent/EA199800720A1/ru unknown
- 1997-02-07 WO PCT/EP1997/000582 patent/WO1997030050A1/en not_active Ceased
- 1997-02-07 US US09/125,108 patent/US6087371A/en not_active Expired - Fee Related
- 1997-02-07 KR KR1019980706426A patent/KR19990082680A/ko not_active Withdrawn
- 1997-02-07 DK DK97903245T patent/DK0885222T3/da active
- 1997-02-07 CN CN97192277A patent/CN1211253A/zh active Pending
- 1997-02-07 BR BR9707463A patent/BR9707463A/pt not_active Application Discontinuation
- 1997-02-07 IL IL12534497A patent/IL125344A0/xx unknown
- 1997-02-07 PT PT97903245T patent/PT885222E/pt unknown
- 1997-02-07 HU HU9900572A patent/HUP9900572A3/hu unknown
- 1997-02-07 NZ NZ331087A patent/NZ331087A/xx unknown
- 1997-02-07 AT AT97903245T patent/ATE201683T1/de not_active IP Right Cessation
- 1997-02-07 EP EP97903245A patent/EP0885222B1/de not_active Expired - Lifetime
- 1997-02-07 ES ES97903245T patent/ES2159838T3/es not_active Expired - Lifetime
- 1997-02-07 AU AU17677/97A patent/AU1767797A/en not_active Abandoned
- 1997-02-07 JP JP9528958A patent/JP2000504700A/ja not_active Withdrawn
- 1997-02-07 CA CA002243992A patent/CA2243992A1/en not_active Abandoned
- 1997-02-12 ZA ZA9701167A patent/ZA971167B/xx unknown
- 1997-02-14 AR ARP970100586A patent/AR005820A1/es unknown
1998
- 1998-08-06 MX MX9806341A patent/MX9806341A/es unknown
- 1998-08-10 NO NO983656A patent/NO983656L/no unknown
2001
- 2001-08-14 GR GR20010401246T patent/GR3036390T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69705032D1 (de)	2001-07-05
AR005820A1 (es)	1999-07-14
CA2243992A1 (en)	1997-08-21
PT885222E (pt)	2001-10-31
NO983656L (no)	1998-10-12
PL328373A1 (en)	1999-01-18
HUP9900572A3 (en)	2000-10-30
CN1211253A (zh)	1999-03-17
WO1997030050A1 (en)	1997-08-21
KR19990082680A (ko)	1999-11-25
EA199800720A1 (ru)	1999-02-25
NO983656D0 (no)	1998-08-10
MX9806341A (es)	1998-10-31
EP0885222A1 (de)	1998-12-23
TW360655B (en)	1999-06-11
GB9603226D0 (en)	1996-04-17
DK0885222T3 (da)	2001-08-27
NZ331087A (en)	1999-08-30
US6087371A (en)	2000-07-11
HUP9900572A2 (hu)	1999-06-28
AU1767797A (en)	1997-09-02
EP0885222B1 (de)	2001-05-30
BR9707463A (pt)	1999-07-20
JP2000504700A (ja)	2000-04-18
IL125344A0 (en)	1999-03-12
ES2159838T3 (es)	2001-10-16
ZA971167B (en)	1997-08-25
DE69705032T2 (de)	2001-11-22
GR3036390T3 (en)	2001-11-30

Legal Events

Date	Code	Title	Description
2007-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE263151T1 (de)	2004-04-15	Indolderivate verwendbar als endothelinrezeptorantagonisten
ATE226578T1 (de)	2002-11-15	Benzofuranderivate als tachykininantagonisten
DE69325167D1 (de)	1999-07-08	Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten
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DE69605430D1 (de)	2000-01-05	Chinolin-2-on derivate als serotonin antagonisten
ATE253067T1 (de)	2003-11-15	Diazabicyloderivate als nikotin-acetylcholin- rezeptorliganden
DE69623306D1 (de)	2002-10-02	Pyrimidinderivate als 5ht2c-rezeptorantagonisten
BR9700850A (pt)	1998-09-01	Derivados de quinazolina substituídos
FI960840A7 (fi)	1996-02-23	Indolijohdannaisia tromboksaani-A2-antagonisteina
DK0925298T3 (da)	2004-08-09	Substituerede 6,6-heterobicykliske derivater
DE59712958D1 (de)	2008-09-25	Substituierte Purinderivate als Vitronectinrezeptor-Antagonisten
DE69714265D1 (de)	2002-08-29	Tetrahydrochinolinderivate als eaa antagonisten
DE69617995D1 (de)	2002-01-24	Indolalkylderivate von benzodioxanmenthylamin als 5-ht1a rezeptor liganden
DE69703242D1 (de)	2000-11-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69735811D1 (de)	2006-06-08	Piperazinoderivate als neurokinin-antagonisten
FI951798A7 (fi)	1995-04-13	Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
DE69705032D1 (de)	2001-07-05	Heterocyclyl-ergolinderivate als 5-ht1a rezeptor liganden
DE69717449D1 (de)	2003-01-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69320653D1 (de)	1998-10-01	Tetrahydrocarbazolderivate als 5-ht1-ähnliche agonisten
DE69617010D1 (de)	2001-12-20	Isazole derivate als fibrinogen-rezeptor-antagonisten
DE69527785D1 (de)	2002-09-19	Chinuclidin-n-oxidderivate als muscarin rezeptor liganden
DE69715223D1 (de)	2002-10-10	Heteroaryloxyethylaminen als 5-ht1a rezeptor liganden
NO996391D0 (no)	1999-12-22	Angiogenese-inhiberende tiadiazolylpyridazinderivater
DE59407285D1 (de)	1998-12-17	Imidazolochinoxalinonderivate als eaa antagonisten