ES2159838T3 - Derivados de ergolina heterociclicos como ligandos del receptor de 5ht1a. - Google Patents

Derivados de ergolina heterociclicos como ligandos del receptor de 5ht1a.

Info

Publication number
ES2159838T3
ES2159838T3 ES97903245T ES97903245T ES2159838T3 ES 2159838 T3 ES2159838 T3 ES 2159838T3 ES 97903245 T ES97903245 T ES 97903245T ES 97903245 T ES97903245 T ES 97903245T ES 2159838 T3 ES2159838 T3 ES 2159838T3
Authority
ES
Spain
Prior art keywords
heterociclic
group
5ht1a
ergoline derivatives
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903245T
Other languages
English (en)
Inventor
Sergio Mantegani
Tiziano Bandiera
Maurizio Meroni
Mario Varasi
Carla Caccia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2159838T3 publication Critical patent/ES2159838T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LOS DERIVADOS DE ERGOLINA QUE TIENEN LA FORMULA (I), EN LA QUE R 1 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C SUB,1-4 ; R 2 ES HIDROGENO, UN ATOMO DE CLORO, O BROMO, MET ILO O UN GRUPO TIOALQUILO C 1-4 ; N ES 0, 1 O 2; EL SUSTITUYENTE EN LA POSICION 8 ESTA EN CONFIGURACION AL O BE ; HET REPRESENTA UN ANILLO HETEROCICLICO DE 5 ESLABONES AROMATICO, TENIENDO DICHO ANILLO TRES HETEROATOMOS , LOS CUALES SON IGUALES O DIFERENTES Y SE SELECCIONAN ENTRE EL GRUPO QUE CONSISTE EN UN ATOMO DE AZUFRE, OXIGENO Y NITROGENO Y X ES UN ATOMO DE HIDROGENO, CLORO, BROMO O FLUORO O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, SON ACTIVOS A NIVEL DEL SISTEMA NERVIOSO CENTRAL. TAMBIEN SE DESCRIBE UN PROCEDIMIENTO PARA SU PREPARACION, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN.
ES97903245T 1996-02-15 1997-02-07 Derivados de ergolina heterociclicos como ligandos del receptor de 5ht1a. Expired - Lifetime ES2159838T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9603226.3A GB9603226D0 (en) 1996-02-15 1996-02-15 Heterocyclyl-ergoline derivatives

Publications (1)

Publication Number Publication Date
ES2159838T3 true ES2159838T3 (es) 2001-10-16

Family

ID=10788832

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903245T Expired - Lifetime ES2159838T3 (es) 1996-02-15 1997-02-07 Derivados de ergolina heterociclicos como ligandos del receptor de 5ht1a.

Country Status (26)

Country Link
US (1) US6087371A (es)
EP (1) EP0885222B1 (es)
JP (1) JP2000504700A (es)
KR (1) KR19990082680A (es)
CN (1) CN1211253A (es)
AR (1) AR005820A1 (es)
AT (1) ATE201683T1 (es)
AU (1) AU1767797A (es)
BR (1) BR9707463A (es)
CA (1) CA2243992A1 (es)
DE (1) DE69705032T2 (es)
DK (1) DK0885222T3 (es)
EA (1) EA199800720A1 (es)
ES (1) ES2159838T3 (es)
GB (1) GB9603226D0 (es)
GR (1) GR3036390T3 (es)
HU (1) HUP9900572A3 (es)
IL (1) IL125344A0 (es)
MX (1) MX9806341A (es)
NO (1) NO983656L (es)
NZ (1) NZ331087A (es)
PL (1) PL328373A1 (es)
PT (1) PT885222E (es)
TW (1) TW360655B (es)
WO (1) WO1997030050A1 (es)
ZA (1) ZA971167B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1685838A1 (en) * 2000-08-16 2006-08-02 Pharmacia & Upjohn Company LLC Compounds for the treatment of addictive disorders
AU2001283393B2 (en) * 2000-08-16 2005-09-22 Pharmacia & Upjohn Company Compounds for the treatment of addictive disorders
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
BRPI0916218B1 (pt) * 2008-07-17 2018-11-27 Bayer Cropscience Ag compostos heterocíclicos como composições praguicidas
CN106866656A (zh) * 2017-02-28 2017-06-20 西南交通大学 一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU39278B (en) * 1976-12-22 1984-10-31 Lek Tovarna Farmacevtskih Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
AU553809B2 (en) * 1981-07-21 1986-07-31 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
HU190105B (en) * 1983-06-03 1986-08-28 Gyogyszerkutato Intezet Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
EP0317269B1 (en) * 1987-11-20 1992-03-04 FARMITALIA CARLO ERBA S.r.l. Antiparkinson ergoline derivatives
CA2049053A1 (en) * 1990-01-25 1991-07-26 Sergio Mantegani Process for preparing ergoline derivatives
JP2888648B2 (ja) * 1990-12-28 1999-05-10 出光興産株式会社 スチレン系重合体の製造方法及びその触媒

Also Published As

Publication number Publication date
DE69705032D1 (de) 2001-07-05
AR005820A1 (es) 1999-07-14
CA2243992A1 (en) 1997-08-21
PT885222E (pt) 2001-10-31
NO983656L (no) 1998-10-12
PL328373A1 (en) 1999-01-18
HUP9900572A3 (en) 2000-10-30
CN1211253A (zh) 1999-03-17
WO1997030050A1 (en) 1997-08-21
KR19990082680A (ko) 1999-11-25
EA199800720A1 (ru) 1999-02-25
NO983656D0 (no) 1998-08-10
MX9806341A (es) 1998-10-31
EP0885222A1 (en) 1998-12-23
TW360655B (en) 1999-06-11
GB9603226D0 (en) 1996-04-17
DK0885222T3 (da) 2001-08-27
NZ331087A (en) 1999-08-30
US6087371A (en) 2000-07-11
HUP9900572A2 (hu) 1999-06-28
AU1767797A (en) 1997-09-02
EP0885222B1 (en) 2001-05-30
BR9707463A (pt) 1999-07-20
JP2000504700A (ja) 2000-04-18
IL125344A0 (en) 1999-03-12
ATE201683T1 (de) 2001-06-15
ZA971167B (en) 1997-08-25
DE69705032T2 (de) 2001-11-22
GR3036390T3 (en) 2001-11-30

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