NO983656L - Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander - Google Patents

Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander

Info

Publication number: NO983656L
Authority: NO; Norway
Prior art keywords: hydrogen; atom; heterocyclyl; ergoline derivatives; receptor ligands
Prior art date: 1996-02-15

Application number

NO983656A

Other languages

English (en)

Norwegian (no)

Other versions

NO983656D0 (no

Inventor

Sergio Mantegani

Tiziano Bandiera

Maurizio Meroni

Mario Varasi

Carla Caccia

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-15

Filing date

1998-08-10

Publication date

1998-10-12

1998-08-10 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

1998-08-10 Publication of NO983656D0 publication Critical patent/NO983656D0/no

1998-10-12 Publication of NO983656L publication Critical patent/NO983656L/no

Links

102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 title 1
101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 title 1
239000003446 ligand Substances 0.000 title 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910052794 bromium Chemical group 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
229910052731 fluorine Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO983656A 1996-02-15 1998-08-10 Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander NO983656L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9603226.3A GB9603226D0 (en)	1996-02-15	1996-02-15	Heterocyclyl-ergoline derivatives
PCT/EP1997/000582 WO1997030050A1 (en)	1996-02-15	1997-02-07	Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands

Publications (2)

Publication Number	Publication Date
NO983656D0 NO983656D0 (no)	1998-08-10
NO983656L true NO983656L (no)	1998-10-12

Family

ID=10788832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO983656A NO983656L (no)	1996-02-15	1998-08-10	Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander

Country Status (26)

Country	Link
US (1)	US6087371A (de)
EP (1)	EP0885222B1 (de)
JP (1)	JP2000504700A (de)
KR (1)	KR19990082680A (de)
CN (1)	CN1211253A (de)
AR (1)	AR005820A1 (de)
AT (1)	ATE201683T1 (de)
AU (1)	AU1767797A (de)
BR (1)	BR9707463A (de)
CA (1)	CA2243992A1 (de)
DE (1)	DE69705032T2 (de)
DK (1)	DK0885222T3 (de)
EA (1)	EA199800720A1 (de)
ES (1)	ES2159838T3 (de)
GB (1)	GB9603226D0 (de)
GR (1)	GR3036390T3 (de)
HU (1)	HUP9900572A3 (de)
IL (1)	IL125344A0 (de)
MX (1)	MX9806341A (de)
NO (1)	NO983656L (de)
NZ (1)	NZ331087A (de)
PL (1)	PL328373A1 (de)
PT (1)	PT885222E (de)
TW (1)	TW360655B (de)
WO (1)	WO1997030050A1 (de)
ZA (1)	ZA971167B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03001472A (es) *	2000-08-16	2003-06-06	Upjohn Co	Compuestos para el tratamiento de trastornos adictivos.
EP1685838A1 (de) *	2000-08-16	2006-08-02	Pharmacia & Upjohn Company LLC	Verbindungen zur Behandlung von Suchterkrankungen
US8106074B2 (en)	2001-07-13	2012-01-31	Pierre Fabre Medicament	Pyridin-2-yl-methylamine derivatives for treating opiate dependence
EP2583556B1 (de) *	2008-07-17	2016-01-20	Bayer CropScience AG	Heterocyclische Verbindungen als Schädlingsbekämpfungsmittel
CN106866656A (zh) *	2017-02-28	2017-06-20	西南交通大学	一类麦角碱衍生物及其在预防和治疗精神疾病的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU39278B (en) *	1976-12-22	1984-10-31	Lek Tovarna Farmacevtskih	Process for preparing 5-bromo nicotinic acid esters
GB8714767D0 (en) *	1987-06-24	1987-07-29	Erba Farmitalia	Egoline derivatives
FI76085C (fi) *	1981-07-21	1988-09-09	Erba Farmitalia	Foerfarande foer framstaellning av ergolinderivat.
HU190105B (en) *	1983-06-03	1986-08-28	Gyogyszerkutato Intezet	Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU193781B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
GB8612366D0 (en) *	1986-05-21	1986-06-25	Erba Farmitalia	Ergoline esters
GB8702364D0 (en) *	1987-02-03	1987-03-11	Erba Farmitalia	Ergolinyl heterocycles
DE3868866D1 (de) *	1987-11-20	1992-04-09	Erba Carlo Spa	Ergolinderivate mit antiparkinsonwirkung.
US5210194A (en) *	1990-01-25	1993-05-11	Farmitalia Carlo Erba S.R.L. An Italian Body Corporate	Process for preparing ergoline derivatives
JP2888648B2 (ja) *	1990-12-28	1999-05-10	出光興産株式会社	スチレン系重合体の製造方法及びその触媒

1996
- 1996-02-15 GB GBGB9603226.3A patent/GB9603226D0/en active Pending
1997
- 1997-01-16 TW TW086100411A patent/TW360655B/zh active
- 1997-02-07 DE DE69705032T patent/DE69705032T2/de not_active Expired - Fee Related
- 1997-02-07 KR KR1019980706426A patent/KR19990082680A/ko not_active Withdrawn
- 1997-02-07 CA CA002243992A patent/CA2243992A1/en not_active Abandoned
- 1997-02-07 AU AU17677/97A patent/AU1767797A/en not_active Abandoned
- 1997-02-07 WO PCT/EP1997/000582 patent/WO1997030050A1/en not_active Ceased
- 1997-02-07 DK DK97903245T patent/DK0885222T3/da active
- 1997-02-07 AT AT97903245T patent/ATE201683T1/de not_active IP Right Cessation
- 1997-02-07 PL PL97328373A patent/PL328373A1/xx unknown
- 1997-02-07 EP EP97903245A patent/EP0885222B1/de not_active Expired - Lifetime
- 1997-02-07 ES ES97903245T patent/ES2159838T3/es not_active Expired - Lifetime
- 1997-02-07 IL IL12534497A patent/IL125344A0/xx unknown
- 1997-02-07 CN CN97192277A patent/CN1211253A/zh active Pending
- 1997-02-07 BR BR9707463A patent/BR9707463A/pt not_active Application Discontinuation
- 1997-02-07 NZ NZ331087A patent/NZ331087A/xx unknown
- 1997-02-07 HU HU9900572A patent/HUP9900572A3/hu unknown
- 1997-02-07 JP JP9528958A patent/JP2000504700A/ja not_active Withdrawn
- 1997-02-07 EA EA199800720A patent/EA199800720A1/ru unknown
- 1997-02-07 US US09/125,108 patent/US6087371A/en not_active Expired - Fee Related
- 1997-02-07 PT PT97903245T patent/PT885222E/pt unknown
- 1997-02-12 ZA ZA9701167A patent/ZA971167B/xx unknown
- 1997-02-14 AR ARP970100586A patent/AR005820A1/es unknown
1998
- 1998-08-06 MX MX9806341A patent/MX9806341A/es unknown
- 1998-08-10 NO NO983656A patent/NO983656L/no unknown
2001
- 2001-08-14 GR GR20010401246T patent/GR3036390T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EA199800720A1 (ru)	1999-02-25
ATE201683T1 (de)	2001-06-15
US6087371A (en)	2000-07-11
ZA971167B (en)	1997-08-25
AR005820A1 (es)	1999-07-14
DE69705032T2 (de)	2001-11-22
EP0885222A1 (de)	1998-12-23
NZ331087A (en)	1999-08-30
AU1767797A (en)	1997-09-02
PT885222E (pt)	2001-10-31
DK0885222T3 (da)	2001-08-27
NO983656D0 (no)	1998-08-10
TW360655B (en)	1999-06-11
DE69705032D1 (de)	2001-07-05
PL328373A1 (en)	1999-01-18
IL125344A0 (en)	1999-03-12
EP0885222B1 (de)	2001-05-30
HUP9900572A3 (en)	2000-10-30
ES2159838T3 (es)	2001-10-16
GB9603226D0 (en)	1996-04-17
HUP9900572A2 (hu)	1999-06-28
KR19990082680A (ko)	1999-11-25
CA2243992A1 (en)	1997-08-21
GR3036390T3 (en)	2001-11-30
CN1211253A (zh)	1999-03-17
WO1997030050A1 (en)	1997-08-21
JP2000504700A (ja)	2000-04-18
MX9806341A (es)	1998-10-31
BR9707463A (pt)	1999-07-20

Publication	Publication Date	Title
DE3781080D1 (de)	1992-09-17	2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
CY1117132T1 (el)	2017-04-05	Παραγωγο θειαζολιου
NO20023218L (no)	2002-09-16	2-amino-nikotinamidderivater og deres anvendelse som VEGF- reseptor tyrosinkinaseinhibitorer
NO20053133L (no)	2005-07-15	Kjemiske forbindelser.
ATE424393T1 (de)	2009-03-15	3-substituierte 4-pyrimidonderivate
ATE496035T1 (de)	2011-02-15	Stickstoffenthaltende heterocyclische verbindungen
NO303778B1 (no)	1998-08-31	Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt
DK0958296T3 (da)	2003-08-18	Heterocykliske forbindelser, fremgangsmåde til deres fremstilling og farmaceutiske præparater, der indeholder dem, og deres anvendelse i behandlingen af diabetes og beslægtede sygdomme
AU572405B2 (en)	1988-05-05	Heterocyclic-substituted indole
FI953968A0 (fi)	1995-08-23	Antraniiliset happojohdannaiset
IL88122A0 (en)	1989-06-30	Heterocyclic derivatives and pharmaceutical compositions containing them
DK0622361T3 (da)	2001-12-03	Heterocykliske forbindelser som bradykininantagonister
KR970705545A (ko)	1997-10-09	복소환 유도체 및 의약(heterocyclic derivative and medicine)
NO976047L (no)	1998-02-25	Triazol antisoppmiddel
NO983656L (no)	1998-10-12	Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander
NO921159L (no)	1992-09-28	Tiazolidinon- og oksazolidinonderivater, fremgangsmaate til fremstilling derav, samt anvendelse av derivatene som vasodilatorer
ATE261441T1 (de)	2004-03-15	Analoga von distamycin-zimtsäurederivaten, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
NO933478L (no)	1994-04-05	6-heterocyklisk-4-amino-1,2,2a,3,4,5-heksahydrobenz(CD)indoler for behandling av reisesyke og oppkast
NO20053302D0 (no)	2005-07-05	Imidazolderivater med affinitet for alfa 2-reseptoraktivitet.
KR940018362A (ko)	1994-08-16	니코틴산 유도체
DE60239324D1 (de)	2011-04-14	Phenyl- und pyridyl-piperidine mit tnf-wirkung
MY104164A (en)	1994-02-28	Heterocyclic compounds.
NO944888L (no)	1995-02-16	5-(1,2,4-triazol-1-ylmetyl)-3H-isobenzofuran-1-on derivater, deres fremstilling og anvendelse som aromataseinhibitorer