ATE202356T1 - Extraktives verfahren zur gewinnung von natürlichen makroliden - Google Patents

Extraktives verfahren zur gewinnung von natürlichen makroliden

Info

Publication number
ATE202356T1
ATE202356T1 AT94308107T AT94308107T ATE202356T1 AT E202356 T1 ATE202356 T1 AT E202356T1 AT 94308107 T AT94308107 T AT 94308107T AT 94308107 T AT94308107 T AT 94308107T AT E202356 T1 ATE202356 T1 AT E202356T1
Authority
AT
Austria
Prior art keywords
macrolide
solvent
solution
impurities
macrolids
Prior art date
Application number
AT94308107T
Other languages
English (en)
Inventor
Constantine Gletsos
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE202356T1 publication Critical patent/ATE202356T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT94308107T 1993-11-05 1994-11-03 Extraktives verfahren zur gewinnung von natürlichen makroliden ATE202356T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14809693A 1993-11-05 1993-11-05

Publications (1)

Publication Number Publication Date
ATE202356T1 true ATE202356T1 (de) 2001-07-15

Family

ID=22524259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94308107T ATE202356T1 (de) 1993-11-05 1994-11-03 Extraktives verfahren zur gewinnung von natürlichen makroliden

Country Status (25)

Country Link
US (1) US5508398A (de)
EP (1) EP0652219B1 (de)
JP (1) JP4202433B2 (de)
KR (1) KR100393952B1 (de)
CN (1) CN1037772C (de)
AT (1) ATE202356T1 (de)
AU (1) AU7759594A (de)
BR (1) BR9404265A (de)
CA (1) CA2134844C (de)
CZ (1) CZ291865B6 (de)
DE (1) DE69427513T2 (de)
DK (1) DK0652219T3 (de)
ES (1) ES2157239T3 (de)
FI (1) FI112378B (de)
GR (1) GR3036207T3 (de)
HU (1) HU222576B1 (de)
IL (1) IL111424A (de)
NZ (1) NZ264852A (de)
PT (1) PT652219E (de)
RU (1) RU2152998C2 (de)
SG (1) SG48919A1 (de)
SK (1) SK130494A3 (de)
TW (1) TW408125B (de)
UA (1) UA41884C2 (de)
ZA (1) ZA948641B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618952D0 (en) 1996-09-11 1996-10-23 Sandoz Ltd Process
IT1289815B1 (it) * 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa Stent per angioplastica e relativo procedimento di produzione
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
MXPA04007847A (es) 2002-02-13 2005-02-24 Biogal Gyogyszergyar Metodo para extraer un macrolido de biomateria.
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
CA2492153C (en) * 2002-07-16 2012-05-08 Biotica Technology Limited Production of polyketide fkbp-ligand analogues
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
WO2004089958A2 (en) 2003-03-31 2004-10-21 TEVA Gyógyszergyár Részvénytársaság Crystallization and purification of macrolides
PL1558622T3 (pl) * 2003-07-24 2008-06-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania makrolidów
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
US20050112786A1 (en) * 2003-11-25 2005-05-26 Qing Wang Method of immobilizing a substance of interest to a solid phase
EP1697383B1 (de) * 2003-12-05 2014-04-23 Biocon Limited Verfahren zur aufreinigung von tacrolimus
CA2556622A1 (en) * 2004-03-02 2005-09-15 Wyeth Macrolides and methods for producing same
US20050197356A1 (en) * 2004-03-02 2005-09-08 Wyeth Non-immunosuppressive immunophilin ligands as neuroprotective and/or neuroregenerative agents
JP4620405B2 (ja) * 2004-08-02 2011-01-26 アサヒビール株式会社 酵母変異株、グルタチオン高含有酵母の製造方法、その培養物、その分画物、酵母エキスおよびグルタチオン含有飲食品
AR050374A1 (es) * 2004-08-20 2006-10-18 Wyeth Corp Forma polimorfica de rafampicina
CA2584430A1 (en) * 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods for preparing pimecrolimus
CA2586692A1 (en) * 2004-12-22 2006-06-29 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying macrolides
JP2007527434A (ja) * 2005-01-05 2007-09-27 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 非晶質タクロリマス及びその調製
US20080000834A1 (en) * 2006-03-15 2008-01-03 Ladislav Cvak Process for purifying Tacrolimus
KR100740582B1 (ko) * 2006-09-27 2007-07-19 한국과학기술연구원 가스크로마토그래피-질량분석기를 이용한 두 생체시료군 간대사체 차별성 분석 방법
US20100029933A1 (en) * 2006-11-10 2010-02-04 Biocon Limited Pure form of rapamycin and a process for recovery and purification thereof
CN102070652B (zh) * 2011-02-21 2012-05-02 西南大学 一种从发酵液中分离提取西罗莫司的方法
WO2014072984A1 (en) 2012-11-06 2014-05-15 Natco Pharma Limited Improved process for isolation and purification of rapamycin from fermentation broth
CN108976245B (zh) * 2017-11-09 2020-08-07 北大方正集团有限公司 一种雷帕霉素的提取方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993749A (en) * 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
GB9125660D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound

Also Published As

Publication number Publication date
NZ264852A (en) 1995-12-21
EP0652219B1 (de) 2001-06-20
PT652219E (pt) 2001-09-28
KR100393952B1 (ko) 2003-12-11
BR9404265A (pt) 1995-07-04
ZA948641B (en) 1996-05-02
CZ267494A3 (en) 1995-05-17
JP4202433B2 (ja) 2008-12-24
ES2157239T3 (es) 2001-08-16
TW408125B (en) 2000-10-11
DE69427513D1 (de) 2001-07-26
HU9403164D0 (en) 1994-12-28
SK130494A3 (en) 1995-07-11
EP0652219A1 (de) 1995-05-10
UA41884C2 (uk) 2001-10-15
KR950014311A (ko) 1995-06-15
DE69427513T2 (de) 2001-11-22
DK0652219T3 (da) 2001-08-27
SG48919A1 (en) 1998-05-18
IL111424A (en) 1999-10-28
JPH07184674A (ja) 1995-07-25
HU222576B1 (hu) 2003-08-28
CA2134844C (en) 2007-10-16
CN1037772C (zh) 1998-03-18
RU94039281A (ru) 1997-03-27
CN1109058A (zh) 1995-09-27
HUT71122A (en) 1995-11-28
AU7759594A (en) 1995-05-18
FI112378B (fi) 2003-11-28
FI945186L (fi) 1995-05-06
IL111424A0 (en) 1994-12-29
CA2134844A1 (en) 1995-05-06
CZ291865B6 (cs) 2003-06-18
RU2152998C2 (ru) 2000-07-20
GR3036207T3 (en) 2001-10-31
US5508398A (en) 1996-04-16
FI945186A0 (fi) 1994-11-03

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Legal Events

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UEP Publication of translation of european patent specification