ATE202551T1 - Lignane, verfahren zu ihrer herstellung, ihre pharmazeutische compositionen und anwendungen - Google Patents

Lignane, verfahren zu ihrer herstellung, ihre pharmazeutische compositionen und anwendungen

Info

Publication number: ATE202551T1
Authority: AT; Austria
Prior art keywords: lignans; production; pharmaceutical compositions; agents; applications
Prior art date: 1995-10-18

Application number

AT95936521T

Other languages

English (en)

Inventor

Guenther Boos

Matthias Schoettner

Dietmar Gansser

Gerhard Spiteller

Original Assignee

Kanoldt Arzneimittel Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-18

Filing date

1995-10-18

Publication date

2001-07-15

1995-10-18 Application filed by Kanoldt Arzneimittel Gmbh filed Critical Kanoldt Arzneimittel Gmbh

2001-07-15 Application granted granted Critical

2001-07-15 Publication of ATE202551T1 publication Critical patent/ATE202551T1/de

Links

229930013686 lignan Natural products 0.000 title abstract 5
150000005692 lignans Chemical class 0.000 title abstract 5
235000009408 lignans Nutrition 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 3
QWUWMCYKGHVNAV-UHFFFAOYSA-N 1,2-dihydrostilbene Chemical group C=1C=CC=CC=1CCC1=CC=CC=C1 QWUWMCYKGHVNAV-UHFFFAOYSA-N 0.000 abstract 1
206010060862 Prostate cancer Diseases 0.000 abstract 1
208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
108010089417 Sex Hormone-Binding Globulin Proteins 0.000 abstract 1
102100030758 Sex hormone-binding globulin Human genes 0.000 abstract 1
238000006600 Stobbe condensation reaction Methods 0.000 abstract 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
JILPJDVXYVTZDQ-UHFFFAOYSA-N lithium methoxide Chemical compound [Li+].[O-]C JILPJDVXYVTZDQ-UHFFFAOYSA-N 0.000 abstract 1
-1 succinyl diesters Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/04—Seven-membered rings not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Furan Compounds (AREA)

AT95936521T 1995-10-18 1995-10-18 Lignane, verfahren zu ihrer herstellung, ihre pharmazeutische compositionen und anwendungen ATE202551T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP1995/004096 WO1997014670A1 (en)	1995-10-18	1995-10-18	Lignans, a process for their production and pharmaceutical compositions and uses thereof

Publications (1)

Publication Number	Publication Date
ATE202551T1 true ATE202551T1 (de)	2001-07-15

Family

ID=8166108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95936521T ATE202551T1 (de)	1995-10-18	1995-10-18	Lignane, verfahren zu ihrer herstellung, ihre pharmazeutische compositionen und anwendungen

Country Status (5)

Country	Link
EP (1)	EP0797564B1 (de)
JP (1)	JPH10511699A (de)
AT (1)	ATE202551T1 (de)
DE (1)	DE69521525T2 (de)
WO (1)	WO1997014670A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3237107B2 (ja)	1996-03-29	2001-12-10	田辺製薬株式会社	ブタジエン誘導体及びその製法
WO2000023432A1 (en) *	1998-10-20	2000-04-27	Hughes, E., John, L.	Therapeutic compounds and methods
US6689809B2 (en)	1999-03-30	2004-02-10	Hormos Nutraceutical Oy Ltd.	Food additive or product or a pharmaceutical preparation, comprising hydroxymatairesinol
US6451849B1 (en)	1999-03-30	2002-09-17	Hormos Nutraceutical Oy Ltd.	Use of hydroxymatairesinol for prevention of cancers, non-cancer, hormone dependent diseases and cardiovascular diseases by hydroxymatairesinol, and a pharmaceutical preparation, food additive and food product comprising hydroxymatairesinol
KR20010105064A (ko) *	2000-05-18	2001-11-28	함종천	삼백초로부터 추출한 화합물 ｈｎｐ－９８７０１ａ,ｈｎｐ－９８７０１ｂ 및 ｈｎｐ－９８７０１ｃ의항암제로서의 용도와 이의 제조방법 및 이를 유효성분으로함유하는 항암제용 약학적 조성물
US7251285B2 (en) *	2000-07-11	2007-07-31	Lg Electronics Inc.	Method and apparatus for transmitting and receiving using turbo code
US6767565B2 (en)	2001-03-22	2004-07-27	Archer Daniels Midland Company	Process for obtaining lignan
WO2003057209A1 (en) *	2002-01-09	2003-07-17	Hormos Medical Corporation	Method for the preparation of matairesinol
FI114022B (fi) *	2002-01-17	2004-07-30	Hormos Nutraceutical Oy Ltd	Menetelmä kasvislignaanien valmistamiseksi ja uusi välituote
FI111636B (fi) *	2002-02-05	2003-08-29	Hormos Nutraceutical Oy Ltd	Menetelmä enterolaktonin valmistamiseksi
US7528166B2 (en)	2002-02-05	2009-05-05	Hormos Medical Corporation	Lignan derivatives
FI20020223A0 (fi) *	2002-02-05	2002-02-05	Hormos Nutraceutical Oy Ltd	Menetelmä biologisesti aktiivisen yhdisteen valmistamiseksi ja ryhmä uusia välituotteita
US7048960B2 (en)	2002-03-22	2006-05-23	Glenn Roy Pizzey	High lignan flaxseed product and product by process
JP2006516571A (ja)	2003-01-17	2006-07-06	スレッシュオールドファーマシューティカルズ，インコーポレイテッド	良性前立腺増殖症の処置
US7595078B2 (en)	2005-03-15	2009-09-29	Glanbia Nutritionals Ireland Limited	Methods of increasing flaxseed hull recovery and resultant flax products
JP2011195465A (ja) *	2010-03-17	2011-10-06	Wakayama Prefecture	桂皮酸誘導体の製造方法及び桂皮酸誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01228928A (ja) *	1988-03-09	1989-09-12	Tsumura & Co	リグナン類およびリグナン類を有効成分とする抗腫瘍剤
JPH0240323A (ja) *	1988-07-28	1990-02-09	Tsumura & Co	免疫抑制剤

1995
- 1995-10-18 DE DE69521525T patent/DE69521525T2/de not_active Expired - Fee Related
- 1995-10-18 WO PCT/EP1995/004096 patent/WO1997014670A1/en not_active Ceased
- 1995-10-18 JP JP9515436A patent/JPH10511699A/ja active Pending
- 1995-10-18 AT AT95936521T patent/ATE202551T1/de not_active IP Right Cessation
- 1995-10-18 EP EP95936521A patent/EP0797564B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0797564A1 (de)	1997-10-01
DE69521525T2 (de)	2002-04-25
JPH10511699A (ja)	1998-11-10
EP0797564B1 (de)	2001-06-27
WO1997014670A1 (en)	1997-04-24
DE69521525D1 (de)	2001-08-02

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Legal Events

Date	Code	Title	Description
2001-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties