TR200101083T2 - (7alfa,17alfa)-17-hidroksi- 7-metil-19-nor-17-pregn-5 (10)-en-20-in-3-on içeren yüksek saflıkta bileşim. - Google Patents

(7alfa,17alfa)-17-hidroksi- 7-metil-19-nor-17-pregn-5 (10)-en-20-in-3-on içeren yüksek saflıkta bileşim.

Info

Publication number
TR200101083T2
TR200101083T2 TR2001/01083T TR200101083T TR200101083T2 TR 200101083 T2 TR200101083 T2 TR 200101083T2 TR 2001/01083 T TR2001/01083 T TR 2001/01083T TR 200101083 T TR200101083 T TR 200101083T TR 200101083 T2 TR200101083 T2 TR 200101083T2
Authority
TR
Turkey
Prior art keywords
pregn
hydroxy
methyl
7alfa
17alfa
Prior art date
Application number
TR2001/01083T
Other languages
English (en)
Inventor
Huub Gerard Maria Kirchholtes Peter
Arnoud Jozef Maria Theresia Sas Gerard
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8234220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200101083(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of TR200101083T2 publication Critical patent/TR200101083T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Bulus yüksek saflikta bir (7alfa,17alfa)-17-hidroksi-7-metil-19-nor- 17-pregn-5(10)-en-20-in-3-on bilesiminin hazirlanmasi için bir islem ile ilgilidir. Islem % 0.5' ten daha az (7alfa,17alfa)-17-hidroksi-7-metil-19-nor- 17-pregn-5(10)-en-20-in-3-on'luk bir bilesim saglanmaktadir. Bu bilesim kararli farmasötik dozaj birimlerinin hazirlanmasinda bir kaynak olarak kullanilabilmektedir.
TR2001/01083T 1998-10-16 1999-10-11 (7alfa,17alfa)-17-hidroksi- 7-metil-19-nor-17-pregn-5 (10)-en-20-in-3-on içeren yüksek saflıkta bileşim. TR200101083T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98203460 1998-10-16

Publications (1)

Publication Number Publication Date
TR200101083T2 true TR200101083T2 (tr) 2001-08-21

Family

ID=8234220

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2001/01083T TR200101083T2 (tr) 1998-10-16 1999-10-11 (7alfa,17alfa)-17-hidroksi- 7-metil-19-nor-17-pregn-5 (10)-en-20-in-3-on içeren yüksek saflıkta bileşim.
TR2005/04091T TR200504091T2 (tr) 1998-10-16 1999-10-11 (7alfa,17alfa)-17-hidroksi-7-metil-19-nor-17-pregn-5(10)-en 20-in-3-on içeren yüksek saflıkta bileşim.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2005/04091T TR200504091T2 (tr) 1998-10-16 1999-10-11 (7alfa,17alfa)-17-hidroksi-7-metil-19-nor-17-pregn-5(10)-en 20-in-3-on içeren yüksek saflıkta bileşim.

Country Status (30)

Country Link
US (3) US6969708B1 (tr)
EP (2) EP1121375B1 (tr)
JP (1) JP2002527525A (tr)
KR (3) KR20050003358A (tr)
CN (2) CN100378116C (tr)
AR (1) AR020832A1 (tr)
AT (1) ATE239032T1 (tr)
AU (1) AU763232B2 (tr)
BR (1) BR9914441A (tr)
CA (1) CA2344686C (tr)
CO (1) CO5160271A1 (tr)
CZ (1) CZ298703B6 (tr)
DE (1) DE69907495T2 (tr)
DK (1) DK1121375T3 (tr)
ES (1) ES2197677T3 (tr)
HK (1) HK1039620B (tr)
HU (1) HUP0104206A3 (tr)
ID (1) ID28463A (tr)
IL (1) IL141850A (tr)
NO (1) NO317427B1 (tr)
NZ (1) NZ510501A (tr)
PE (1) PE20001377A1 (tr)
PL (1) PL197870B1 (tr)
PT (1) PT1121375E (tr)
RU (1) RU2220975C2 (tr)
SK (1) SK284569B6 (tr)
TR (2) TR200101083T2 (tr)
TW (2) TW200403251A (tr)
WO (1) WO2000023460A1 (tr)
ZA (1) ZA200101952B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL356465A1 (en) * 2002-10-04 2004-04-05 ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE
TW200418525A (en) * 2002-11-20 2004-10-01 Akzo Nobel Nv Coated pharmaceutical tablets containing Tibolone
GB0304927D0 (en) 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
WO2005117899A1 (en) * 2004-06-02 2005-12-15 Cipla Limited Pharmaceutical composition comprising tibolone and process for procuding the same
CN101111504B (zh) * 2005-02-01 2011-12-21 霍夫曼-拉罗奇有限公司 伊班膦酸盐多晶型物a
CA2594717C (en) 2005-02-01 2015-01-20 F. Hoffmann-La Roche Ag Ibandronate polymorph b
EP1883648A1 (en) * 2005-05-23 2008-02-06 Newchem S.p.A. Process for the preparation of pure crystalline tibolone
CZ300465B6 (cs) * 2007-07-25 2009-05-27 Zentiva, A. S. Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
ITMI20130120A1 (it) * 2013-01-25 2014-07-26 Ind Chimica Srl Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one
JP7659494B2 (ja) * 2018-12-17 2025-04-09 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 卵に対する経口免疫療法のための製剤、製造方法、及び卵アレルギーの治療
CN114409717B (zh) * 2021-12-17 2023-03-17 湖南科益新生物医药有限公司 替勃龙中间体醚化物和替勃龙的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665514A (tr) * 1964-06-16
CH488682A (de) 1965-07-30 1970-04-15 Ciba Geigy Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
NL146838B (nl) 1966-06-24 1975-08-15 Organon Nv Werkwijze voor het bereiden van (delta)5(10)-3- keto-19-norsteroiden.
US3515719A (en) 1967-03-15 1970-06-02 Upjohn Co 7-methyl-6,19-epoxy steroids of the androstane series
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
EP0406279A1 (en) 1988-03-25 1991-01-09 Akzo N.V. Pharmaceutical preparation containing a fluoride salt
IE63051B1 (en) * 1989-03-18 1995-03-22 Akzo Nv Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
ES2134313T3 (es) * 1993-03-05 1999-10-01 Akzo Nobel Nv Utilizacion de derivados de pregnano para el tratamiento de tumores.
IL115445A (en) * 1994-10-17 1999-08-17 Akzo Nobel Nv Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation
IL123422A (en) * 1997-03-05 2003-05-29 Akzo Nobel Nv USE OF 7alpha-METHYL-17alpha-ETHYNYL-ESTRANE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE PROPHYLAXIS OR THE TREATMENT OF ATHEROSCLEROSIS
IL123984A (en) * 1997-04-22 2004-09-27 Akzo Nobel Nv Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable

Also Published As

Publication number Publication date
BR9914441A (pt) 2001-06-26
NO20011664L (no) 2001-04-03
US6969708B1 (en) 2005-11-29
AU763232B2 (en) 2003-07-17
HUP0104206A3 (en) 2002-06-28
SK284569B6 (sk) 2005-06-02
RU2220975C2 (ru) 2004-01-10
IL141850A (en) 2005-11-20
HK1039620B (en) 2003-08-22
PL197870B1 (pl) 2008-05-30
TW200403251A (en) 2004-03-01
NO20011664D0 (no) 2001-04-03
ID28463A (id) 2001-05-24
CZ298703B6 (cs) 2007-12-27
DE69907495D1 (de) 2003-06-05
CN100378116C (zh) 2008-04-02
PL347264A1 (en) 2002-03-25
KR20050003358A (ko) 2005-01-10
PT1121375E (pt) 2003-07-31
TW577893B (en) 2004-03-01
CN1769293A (zh) 2006-05-10
CN1322210A (zh) 2001-11-14
CO5160271A1 (es) 2002-05-30
DE69907495T2 (de) 2004-05-06
US20050245496A1 (en) 2005-11-03
NZ510501A (en) 2003-10-31
ATE239032T1 (de) 2003-05-15
ES2197677T3 (es) 2004-01-01
CA2344686A1 (en) 2000-04-27
CZ2001976A3 (cs) 2001-08-15
EP1275379A2 (en) 2003-01-15
CA2344686C (en) 2009-04-28
IL141850A0 (en) 2002-03-10
HUP0104206A2 (hu) 2002-04-29
JP2002527525A (ja) 2002-08-27
EP1121375B1 (en) 2003-05-02
KR20010080133A (ko) 2001-08-22
KR100635018B1 (ko) 2006-10-17
US20040248870A1 (en) 2004-12-09
AR020832A1 (es) 2002-05-29
ZA200101952B (en) 2002-06-10
HK1039620A1 (en) 2002-05-03
NO317427B1 (no) 2004-10-25
EP1121375A1 (en) 2001-08-08
TR200504091T2 (tr) 2006-05-22
EP1275379A3 (en) 2003-03-26
AU6202999A (en) 2000-05-08
PE20001377A1 (es) 2000-12-09
CN100432093C (zh) 2008-11-12
DK1121375T3 (da) 2003-08-04
SK4932001A3 (en) 2001-12-03
WO2000023460A1 (en) 2000-04-27
KR20060071897A (ko) 2006-06-27

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