ATE202708T1 - Peptidantagonisten des bradykinin - Google Patents

Peptidantagonisten des bradykinin

Info

Publication number: ATE202708T1
Authority: AT; Austria
Prior art keywords: bradykinin; antagonists; produced; analogs; peptide antagonists
Prior art date: 1991-04-19

Application number

AT92917374T

Other languages

English (en)

Inventor

Donald James Kyle

Roger Neal Hiner

Original Assignee

Scios Nova Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-19

Filing date

1992-04-16

Publication date

2001-07-15

1992-04-16 Application filed by Scios Nova Inc filed Critical Scios Nova Inc

2001-07-15 Application granted granted Critical

2001-07-15 Publication of ATE202708T1 publication Critical patent/ATE202708T1/de

Links

QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title abstract 6
101800004538 Bradykinin Proteins 0.000 title abstract 5
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 title abstract 5
102100035792 Kininogen-1 Human genes 0.000 title abstract 5
239000005557 antagonist Substances 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title 1
239000003152 bradykinin antagonist Substances 0.000 abstract 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
208000006877 Insect Bites and Stings Diseases 0.000 abstract 1
108010093008 Kinins Proteins 0.000 abstract 1
102000002397 Kinins Human genes 0.000 abstract 1
125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 abstract 1
229960002591 hydroxyproline Drugs 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
239000000813 peptide hormone Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
150000003568 thioethers Chemical class 0.000 abstract 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Pain & Pain Management (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT92917374T 1991-04-19 1992-04-16 Peptidantagonisten des bradykinin ATE202708T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68795991A	1991-04-19	1991-04-19
US86624692A	1992-04-14	1992-04-14
PCT/US1992/003033 WO1992018156A1 (en)	1991-04-19	1992-04-16	Bradykinin antagonist peptides

Publications (1)

Publication Number	Publication Date
ATE202708T1 true ATE202708T1 (de)	2001-07-15

Family

ID=27104123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92917374T ATE202708T1 (de)	1991-04-19	1992-04-16	Peptidantagonisten des bradykinin

Country Status (11)

Country	Link
US (1)	US5385889A (de)
EP (1)	EP0618810B1 (de)
JP (1)	JPH07504155A (de)
AT (1)	ATE202708T1 (de)
AU (1)	AU1873992A (de)
CA (1)	CA2106762C (de)
DE (1)	DE69231918D1 (de)
IE (1)	IE921296A1 (de)
IL (1)	IL101648A (de)
NZ (1)	NZ242446A (de)
WO (1)	WO1992018156A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5686565A (en) *	1992-10-08	1997-11-11	Scios Inc.	Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US5521158A (en) *	1992-10-08	1996-05-28	Scios Nova Inc.	Pseudopeptide bradykinin receptor antagonists
US5541286A (en) *	1992-10-08	1996-07-30	Scios Nova Inc.	Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
WO1994019372A1 (en) *	1993-02-17	1994-09-01	Scios Nova Inc.	Cyclic bradykinin antagonist peptides
JPH11500100A (ja) *	1993-09-09	1999-01-06	サイオスノバインコーポレイテッド	偽ペプチドおよび非ペプチドブラジキニンレセプターアンタゴニスト
US5817756A (en) *	1993-09-09	1998-10-06	Scios Inc.	Pseudo- and non-peptide bradykinin receptor antagonists
DE4345062A1 (de) *	1993-12-31	1995-07-13	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen
JPH10510540A (ja) *	1994-12-12	1998-10-13	オメロスメディカルシステムズ，インコーポレーテッド	灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
WO1996019233A2 (en) *	1994-12-12	1996-06-27	Omeros Medical Systems, Inc.	Irrigation solution and method for inhibition of pain, inflammation and spasm
EP0832106A2 (de) *	1995-06-05	1998-04-01	Cortech, Inc.	Verbindungen mit bradykinin antagonistischen aktivität und mu-opioid agonistischen aktivität
US5891737A (en) *	1995-06-07	1999-04-06	Zymogenetics, Inc.	Combinatorial non-peptide libraries
CA2221865C (en) *	1995-06-09	2007-12-11	The Regents Of The University Of Michigan	Bradykinin analogs as selective thrombin inhibitors
DE19612067A1 (de) *	1996-03-27	1997-10-02	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
WO1998007746A1 (en) *	1996-08-19	1998-02-26	Universite De Sherbrooke	B1-bradykinin receptor antagonists and use thereof
US7041785B1 (en)	1996-08-19	2006-05-09	UNIVERSITé DE SHERBROOKE	B1-bradykinin receptor antagonists and use thereof
US6982249B1 (en)	1997-04-23	2006-01-03	The Regents Of The University Of Michigan	Bradykinin analogs as selective inhibitors of cell activation
GB0225379D0 (en) *	2002-10-31	2002-12-11	Pfizer Ltd	Therapeutic proline derivatives
US7659305B2 (en) *	2002-10-31	2010-02-09	Pfizer Inc.	Therapeutic proline derivatives
JP4631262B2 (ja) *	2003-10-07	2011-02-16	東レ・ファインケミカル株式会社	（シス）−４−ヒドロキシプロリン誘導体の製造方法
US7605120B2 (en) *	2003-10-22	2009-10-20	Amgen Inc.	Antagonists of the brandykinin B1 receptor
JP2005350417A (ja) *	2004-06-11	2005-12-22	Dai Ichi Seiyaku Co Ltd	還元的エーテル化法を用いたピロリジン誘導体の製造法
WO2008119005A1 (en) *	2007-03-27	2008-10-02	Trustees Of Tufts College	3,4-dehydro-proline-containing inhibitors of dipeptidylpeptidase iv

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2964956D1 (en) *	1978-07-18	1983-04-07	Kabi Ab	Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them
US4483850A (en) *	1982-05-10	1984-11-20	Merck & Co., Inc.	N-Terminal substituted oligopeptide converting enzyme inhibitors
DE3303112A1 (de) *	1983-01-31	1984-08-09	Hoechst Ag, 6230 Frankfurt	Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
US4693993A (en) *	1985-06-13	1987-09-15	Stewart John M	Bradykinin antagonist peptides
US4801613A (en) *	1985-06-13	1989-01-31	Nova Technology Limited Partnership	Bradykinin antagonist peptides
US4912231A (en) *	1987-06-15	1990-03-27	E. R. Squibb & Sons, Inc.	Process for preparing (trans)-4-phenyl-L-proline derivatives
US4923963A (en) *	1987-09-02	1990-05-08	Nova Technology Limited Partnership	Bradykinin antagonist peptides
DE3820190A1 (de) *	1988-06-14	1989-12-21	Cassella Ag	Pyrrolderivate, ihre herstellung und ihre verwendung als pharmazeutische wirkstoffe
IE63490B1 (en) *	1988-11-24	1995-05-03	Hoechst Ag	Peptides having bradykinin antagonist action
DE3926822A1 (de) *	1989-08-14	1991-02-21	Hoechst Ag	Peptide mit bradykinin-antagonistischer wirkung
US4937355A (en) *	1989-01-17	1990-06-26	E. R. Squibb & Sons, Inc.	Process for preparing (trans)-4-substituted-dl-proline derivatives
DE69226708T2 (de) *	1991-04-19	1999-04-15	Scios Nova Inc., Mountain View, Calif.	Bradykinin typische peptide

1992
- 1992-04-16 CA CA002106762A patent/CA2106762C/en not_active Expired - Lifetime
- 1992-04-16 JP JP4510290A patent/JPH07504155A/ja active Pending
- 1992-04-16 AU AU18739/92A patent/AU1873992A/en not_active Abandoned
- 1992-04-16 EP EP92917374A patent/EP0618810B1/de not_active Expired - Lifetime
- 1992-04-16 DE DE69231918T patent/DE69231918D1/de not_active Expired - Lifetime
- 1992-04-16 WO PCT/US1992/003033 patent/WO1992018156A1/en not_active Ceased
- 1992-04-16 AT AT92917374T patent/ATE202708T1/de not_active IP Right Cessation
- 1992-04-19 IL IL10164892A patent/IL101648A/en not_active IP Right Cessation
- 1992-04-22 IE IE129692A patent/IE921296A1/en not_active Application Discontinuation
- 1992-04-22 NZ NZ242446A patent/NZ242446A/en unknown
1993
- 1993-12-16 US US08/167,052 patent/US5385889A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE921296A1 (en)	1992-10-21
JPH07504155A (ja)	1995-05-11
EP0618810B1 (de)	2001-07-04
DE69231918D1 (de)	2001-08-09
WO1992018156A1 (en)	1992-10-29
NZ242446A (en)	1994-04-27
EP0618810A4 (de)	1994-12-07
CA2106762A1 (en)	1992-10-20
US5385889A (en)	1995-01-31
IL101648A0 (en)	1992-12-30
AU1873992A (en)	1992-11-17
IL101648A (en)	1996-08-04
EP0618810A1 (de)	1994-10-12
CA2106762C (en)	2000-10-10

Legal Events

Date	Code	Title	Description
2002-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69231918D1 (de)	2001-08-09	Peptidantagonisten des bradykinin
EA199800563A1 (ru)	1998-12-24	Антагонисты гормона, высвобождающего гонадотропин
ES2130265T3 (es)	1999-07-01	Region de union al receptor de la toxina difterica.
DE69226708D1 (en)	1998-09-24	Bradykinin typische peptide
ES2187958T3 (es)	2003-06-16	Antagonistas de gnrh.
EA199800559A1 (ru)	1998-12-24	Антагонисты гонадотропин-высвобождающего фактора
EA199800564A1 (ru)	1998-12-24	Антагонисты гонадотропин-высвобождающего фактора
NZ568769A (en)	2010-04-30	Human monoclonal antibodies against CD20
EA200300050A1 (ru)	2003-04-24	Гликопептидфосфонатные производные
ATE293989T1 (de)	2005-05-15	Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
ATE172742T1 (de)	1998-11-15	Peptide mit wachstumshormonfreisetzender aktivität
DE69942753D1 (de)	2010-10-21	Peptidantagonist von Zonulin und dessen Verwendung
DE69434181D1 (de)	2005-01-13	Therapeutische Peptid Derivate
EA200300856A1 (ru)	2004-08-26	Долгоживущие производные рилизинг-фактора гормона роста
EA200100780A1 (ru)	2001-12-24	Антагонисты tweak и рецептора tweak и их использование для лечения иммунологических заболеваний
HUP0002704A2 (hu)	2000-12-28	Az 5. és a 6. helyzetben módosított GnRH antagonisták
DE60033649D1 (de)	2007-04-12	Verbindungen und therapeutische methoden
ES2150901T3 (es)	2000-12-16	Antagonistas de hormonas del crecimiento.
ES2061908T3 (es)	1994-12-16	Antagonistas competitivos de gonadoliberina.
EA200000168A1 (ru)	2000-08-28	Фармацевтическая композиция, снижающая продуцирование белка мср-1
BR0207451A (pt)	2004-06-01	Derivados de quinolina, isoquinolina e ftalazina como antagonistas do hormÈnio liberador de gonadotropina
UA22667A (uk)	1998-04-07	Склад "фітодент" для лікування захворювань порожнини рота та горла
ECSP972344A (es)	1998-12-22	Proteinas antiobesidad