BR0207451A - Derivados de quinolina, isoquinolina e ftalazina como antagonistas do hormÈnio liberador de gonadotropina - Google Patents

Derivados de quinolina, isoquinolina e ftalazina como antagonistas do hormÈnio liberador de gonadotropina

Info

Publication number
BR0207451A
BR0207451A BR0207451-6A BR0207451A BR0207451A BR 0207451 A BR0207451 A BR 0207451A BR 0207451 A BR0207451 A BR 0207451A BR 0207451 A BR0207451 A BR 0207451A
Authority
BR
Brazil
Prior art keywords
isoquinoline
quinoline
releasing hormone
gonadotropin releasing
hormone antagonists
Prior art date
Application number
BR0207451-6A
Other languages
English (en)
Inventor
Peter Strehlke
Peter Droescher
Ulrich Buehmann
Norbert Schmees
Peter Muhn
Holger Hess-Stumpp
Roland Kuehne
Eckhard Guenther
Emmanuel Polymeropoulos
Antonius Marinus Ter Laak
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001108271 external-priority patent/DE10108271A1/de
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BR0207451A publication Critical patent/BR0207451A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE QUINOLINA, ISOQUINOLINA E FTALAZINA COMO ANTAGONISTAS DO HORMÈNIO LIBERADOR DE GONADOTROPINA". A presente invenção refere-se a novos derivados de quinolina, isoquinolina e ftalazina como antagonistas do hormónio liberador da gonadotropina.
BR0207451-6A 2001-02-21 2002-02-21 Derivados de quinolina, isoquinolina e ftalazina como antagonistas do hormÈnio liberador de gonadotropina BR0207451A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2001108271 DE10108271A1 (de) 2001-02-21 2001-02-21 Chinolin-, Isochinolin- und Phthalazinderivate als Antagonisten des Gonadotropin freisetzenden Hormons
US27491401P 2001-03-13 2001-03-13
PCT/EP2002/001882 WO2002066437A1 (de) 2001-02-21 2002-02-21 Chinolin-, isochinolin- und phthalazinderivate als antagonisten des gonadotropin freisetzenden hormons

Publications (1)

Publication Number Publication Date
BR0207451A true BR0207451A (pt) 2004-06-01

Family

ID=26008581

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207451-6A BR0207451A (pt) 2001-02-21 2002-02-21 Derivados de quinolina, isoquinolina e ftalazina como antagonistas do hormÈnio liberador de gonadotropina

Country Status (17)

Country Link
EP (1) EP1362034A1 (pt)
JP (1) JP2004528298A (pt)
CN (1) CN1496354A (pt)
AU (1) AU2002247737B2 (pt)
BG (1) BG108165A (pt)
BR (1) BR0207451A (pt)
CA (1) CA2438709A1 (pt)
CZ (1) CZ20032514A3 (pt)
HU (1) HUP0303219A2 (pt)
IL (1) IL157303A0 (pt)
MX (1) MXPA03007348A (pt)
NO (1) NO325675B1 (pt)
NZ (1) NZ527597A (pt)
PL (1) PL367285A1 (pt)
RU (1) RU2280031C2 (pt)
SK (1) SK11622003A3 (pt)
WO (1) WO2002066437A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX365950B (es) 2013-03-13 2019-06-19 Flatley Discovery Lab Llc Compuestos de piridazinona y metodos para el tratamiento de la fibrosis quistica.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
CA2229201A1 (en) * 1995-10-19 1997-04-24 Satoshi Sasaki Quinoline derivatives, their production and use
CA2254974A1 (en) * 1996-05-20 1997-11-27 Mark Goulet Antagonists of gonadotropin releasing hormone

Also Published As

Publication number Publication date
NO20033698L (no) 2003-10-20
PL367285A1 (en) 2005-02-21
CZ20032514A3 (cs) 2004-05-12
WO2002066437A1 (de) 2002-08-29
CA2438709A1 (en) 2002-08-29
NZ527597A (en) 2004-10-29
BG108165A (en) 2004-08-31
MXPA03007348A (es) 2003-12-04
RU2003128647A (ru) 2005-03-27
RU2280031C2 (ru) 2006-07-20
IL157303A0 (en) 2004-02-19
CN1496354A (zh) 2004-05-12
NO325675B1 (no) 2008-07-07
HUP0303219A2 (hu) 2003-12-29
NO20033698D0 (no) 2003-08-20
AU2002247737B2 (en) 2006-05-18
EP1362034A1 (de) 2003-11-19
SK11622003A3 (sk) 2004-01-08
JP2004528298A (ja) 2004-09-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.