ATE203016T1 - Cryptophycine - Google Patents
CryptophycineInfo
- Publication number
- ATE203016T1 ATE203016T1 AT95906059T AT95906059T ATE203016T1 AT E203016 T1 ATE203016 T1 AT E203016T1 AT 95906059 T AT95906059 T AT 95906059T AT 95906059 T AT95906059 T AT 95906059T AT E203016 T1 ATE203016 T1 AT E203016T1
- Authority
- AT
- Austria
- Prior art keywords
- cryptophycins
- methods
- pharmaceuticals
- proliferation
- inhibit
- Prior art date
Links
- 229930188224 Cryptophycin Natural products 0.000 title abstract 6
- 108010002156 Depsipeptides Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108010006226 cryptophycin Proteins 0.000 abstract 1
- -1 cryptophycin compound Chemical class 0.000 abstract 1
- PSNOPSMXOBPNNV-UHFFFAOYSA-N cryptophycin-327 Natural products C1=C(Cl)C(OC)=CC=C1CC1C(=O)NCC(C)C(=O)OC(CC(C)C)C(=O)OC(C(C)C2C(O2)C=2C=CC=CC=2)CC=CC(=O)N1 PSNOPSMXOBPNNV-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17263293A | 1993-12-21 | 1993-12-21 | |
| US24995594A | 1994-05-27 | 1994-05-27 | |
| PCT/US1994/014740 WO1995017093A1 (en) | 1993-12-21 | 1994-12-21 | New cryptophycins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE203016T1 true ATE203016T1 (de) | 2001-07-15 |
Family
ID=26868303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95906059T ATE203016T1 (de) | 1993-12-21 | 1994-12-21 | Cryptophycine |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6013626A (de) |
| EP (1) | EP0735819B1 (de) |
| JP (1) | JPH09510436A (de) |
| AT (1) | ATE203016T1 (de) |
| AU (1) | AU695873B2 (de) |
| CA (1) | CA2179490A1 (de) |
| DE (1) | DE69427706T2 (de) |
| WO (1) | WO1995017093A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09510436A (ja) * | 1993-12-21 | 1997-10-21 | ユニバーシティー オブ ハワイ | 新規なクリプトフィシン類 |
| AP737A (en) * | 1995-03-07 | 1999-03-15 | Univ Hawaii | New cryptophycins from synthesis. |
| MA23823A1 (fr) | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| US6372780B2 (en) | 1995-03-27 | 2002-04-16 | Aventis Pharma S.A. | Methods of treating cell lines expressing multidrug resistance P-glycoprotein |
| EP0869786B1 (de) * | 1995-12-22 | 2003-03-05 | Eli Lilly And Company | Arzneistoffe |
| ATE201018T1 (de) * | 1996-02-27 | 2001-05-15 | Lilly Co Eli | Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel |
| AU722492B2 (en) * | 1996-08-30 | 2000-08-03 | University Of Hawaii | Pharmaceutical compounds |
| US5977387A (en) * | 1996-08-30 | 1999-11-02 | Eli Lilly And Company | Process for preparing pharmaceutical compounds |
| US6680311B1 (en) | 1996-08-30 | 2004-01-20 | Eli Lilly And Company | Cryptophycin compounds |
| EP0957912A1 (de) * | 1996-08-30 | 1999-11-24 | Eli Lilly And Company | Pharmazeutische zusammensetzungen |
| HUP0000291A3 (en) * | 1996-09-06 | 2000-10-30 | Lilly Co Eli | Process to prepare cryptophycin compounds |
| HUP0000212A3 (en) * | 1996-09-06 | 2001-12-28 | Wayne State University Detroit | Process to prepare cryptophycin derivatives and intermediates thereof |
| EP0929535A4 (de) * | 1996-09-06 | 2001-05-23 | Lilly Co Eli | Verfahren und neue zwischenprodukte |
| JP2002512603A (ja) * | 1997-02-26 | 2002-04-23 | イーライ・リリー・アンド・カンパニー | 医薬化合物の製造方法 |
| US6180679B1 (en) * | 1998-04-07 | 2001-01-30 | Eli Lilly And Company | Method for treating fungal infections |
| US6103913A (en) * | 1998-10-16 | 2000-08-15 | Eli Lilly And Company | Process for preparing enollactone derivatives |
| US6376230B1 (en) | 1998-10-16 | 2002-04-23 | Eli Lilly And Company | Stereoselective process for producing intermediates of cryptophycins |
| IT1307320B1 (it) * | 1999-06-29 | 2001-10-30 | Univ Firenze | Ceppo cianobatterico del genere nostoc, nonche' colture, biomasse,estratti, molocole bioattive derivate da tale ceppo e loro uso in |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6747021B2 (en) | 2000-10-02 | 2004-06-08 | Eli Lilly And Company | Cryptophycin compound |
| WO2002056872A2 (en) * | 2000-10-31 | 2002-07-25 | Chemgenex Therapeutics, Inc. | Antiproliferative colchicine compositions and uses thereof |
| US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
| US6743598B2 (en) * | 2001-08-10 | 2004-06-01 | Mycologics, Inc. | Methods for the identification of fungal glucose utilization inhibitors and antifungal agents |
| CA2556550A1 (en) * | 2004-02-17 | 2005-09-01 | University Of South Florida | Cytotoxin compound and method of isolation |
| WO2005116200A2 (en) | 2004-05-05 | 2005-12-08 | Regents Of The University Of Minnesota | Nucleic acids and polypeptides involved in the production of cryptophycin |
| US7566558B2 (en) * | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
| JP5053444B2 (ja) * | 2009-01-02 | 2012-10-17 | チュン−アン ユニバーシティー インダストリー−アカデミー コーポレーション ファンデーション | 環状ペンタデプシペプチドおよびそれを生産するフザリウム属微生物 |
| TWI714661B (zh) * | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
| WO2017141253A1 (en) * | 2016-02-16 | 2017-08-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Non-protein phenylalanine analogues for inhibiting cyanobacteria and plant growth |
| TN2019000303A1 (en) | 2017-05-10 | 2021-05-07 | Sanofi Sa | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
| US11530204B2 (en) | 2019-09-30 | 2022-12-20 | The Regents Of The University Of Michigan | Biocatalytic synthesis of cryptophycin anticancer agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946835A (en) * | 1988-07-15 | 1990-08-07 | Merck & Co., Inc. | Antifungal fermentation product and method |
| US4868208A (en) * | 1988-07-15 | 1989-09-19 | Merck & Co., Inc. | Antifungal agent and method |
| US4845085A (en) * | 1988-08-09 | 1989-07-04 | Merck & Co., Inc. | Antifungal agent |
| US4845086A (en) * | 1988-08-09 | 1989-07-04 | Merck & Co., Inc. | Antifungal agent |
| JPH09510436A (ja) * | 1993-12-21 | 1997-10-21 | ユニバーシティー オブ ハワイ | 新規なクリプトフィシン類 |
-
1994
- 1994-12-21 JP JP7517579A patent/JPH09510436A/ja active Pending
- 1994-12-21 AU AU14423/95A patent/AU695873B2/en not_active Ceased
- 1994-12-21 WO PCT/US1994/014740 patent/WO1995017093A1/en not_active Ceased
- 1994-12-21 EP EP95906059A patent/EP0735819B1/de not_active Expired - Lifetime
- 1994-12-21 DE DE69427706T patent/DE69427706T2/de not_active Expired - Fee Related
- 1994-12-21 CA CA002179490A patent/CA2179490A1/en not_active Abandoned
- 1994-12-21 AT AT95906059T patent/ATE203016T1/de not_active IP Right Cessation
-
1995
- 1995-03-07 US US08/400,057 patent/US6013626A/en not_active Expired - Lifetime
-
1996
- 1996-11-04 US US08/743,506 patent/US5945315A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6013626A (en) | 2000-01-11 |
| CA2179490A1 (en) | 1995-06-29 |
| US5945315A (en) | 1999-08-31 |
| JPH09510436A (ja) | 1997-10-21 |
| AU695873B2 (en) | 1998-08-27 |
| DE69427706T2 (de) | 2001-10-25 |
| WO1995017093A1 (en) | 1995-06-29 |
| EP0735819A4 (de) | 1997-03-19 |
| EP0735819B1 (de) | 2001-07-11 |
| DE69427706D1 (en) | 2001-08-16 |
| EP0735819A1 (de) | 1996-10-09 |
| AU1442395A (en) | 1995-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |