ATE203402T1 - Verwendung von n-(2,6-dimethylphenyl)-2-(2-oxo-1- pyrrolidinyl)acetamid zur behandlung von demenz - Google Patents
Verwendung von n-(2,6-dimethylphenyl)-2-(2-oxo-1- pyrrolidinyl)acetamid zur behandlung von demenzInfo
- Publication number
- ATE203402T1 ATE203402T1 AT92107421T AT92107421T ATE203402T1 AT E203402 T1 ATE203402 T1 AT E203402T1 AT 92107421 T AT92107421 T AT 92107421T AT 92107421 T AT92107421 T AT 92107421T AT E203402 T1 ATE203402 T1 AT E203402T1
- Authority
- AT
- Austria
- Prior art keywords
- dementia
- dimethylphenyl
- pyrrolidinyl
- acetamide
- oxo
- Prior art date
Links
- 206010012289 Dementia Diseases 0.000 title abstract 3
- NGHTXZCKLWZPGK-UHFFFAOYSA-N nefiracetam Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1C(=O)CCC1 NGHTXZCKLWZPGK-UHFFFAOYSA-N 0.000 title abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 206010000117 Abnormal behaviour Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000013677 cerebrovascular dementia Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004970 emotional disturbance Effects 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 230000003340 mental effect Effects 0.000 abstract 1
- 230000008450 motivation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22981891 | 1991-05-02 | ||
| JP22981991 | 1991-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE203402T1 true ATE203402T1 (de) | 2001-08-15 |
Family
ID=26529012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92107421T ATE203402T1 (de) | 1991-05-02 | 1992-04-30 | Verwendung von n-(2,6-dimethylphenyl)-2-(2-oxo-1- pyrrolidinyl)acetamid zur behandlung von demenz |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5886023A (de) |
| EP (1) | EP0515866B1 (de) |
| KR (1) | KR100310590B1 (de) |
| AT (1) | ATE203402T1 (de) |
| AU (2) | AU1595492A (de) |
| CA (1) | CA2067614C (de) |
| CZ (1) | CZ281170B6 (de) |
| DE (1) | DE69231955T2 (de) |
| DK (1) | DK0515866T3 (de) |
| ES (1) | ES2160097T3 (de) |
| GR (1) | GR3036970T3 (de) |
| HU (1) | HU224689B1 (de) |
| IE (1) | IE921377A1 (de) |
| IL (1) | IL101738A (de) |
| MX (1) | MX9202058A (de) |
| NO (1) | NO312813B1 (de) |
| PT (1) | PT515866E (de) |
| RU (1) | RU2070042C1 (de) |
| SG (1) | SG49650A1 (de) |
| SK (1) | SK279285B6 (de) |
| TW (1) | TW199096B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000048847A (ko) * | 1996-10-01 | 2000-07-25 | 스즈키 다다시 | 미토콘드리아 막 안정화제 |
| DE69823851D1 (de) | 1997-07-15 | 2004-06-17 | Daiichi Seiyaku Co | Nefiracetam zur prophylaxe und behandlung von propofol verursachtem gedächtnisschwund |
| IT1312107B1 (it) * | 1999-05-14 | 2002-04-04 | Umberto Cornelli | Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile |
| US20040077709A1 (en) * | 1999-05-31 | 2004-04-22 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
| HK1048268A1 (zh) * | 1999-05-31 | 2003-03-28 | 第一制药株式会社 | 神经元死亡抑制剂 |
| US6376489B1 (en) * | 1999-12-23 | 2002-04-23 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6423739B1 (en) | 2000-02-23 | 2002-07-23 | Daiichi Pharmaceutical Co., Ltd. | Method for aiding cerebral recovery following neurodegeneration |
| US6348489B1 (en) * | 2000-04-11 | 2002-02-19 | Daiichi Pharmaceutical Co., Ltd. | Method of treating traumatic brain injury and other neuronal disorders |
| EP1356812B1 (de) * | 2000-12-28 | 2009-05-13 | Hamilton Pharmaceuticals, Inc. | Arzneimittel zur behandlung und vermeidung neurogener schmerzen |
| JP2005501108A (ja) * | 2001-08-22 | 2005-01-13 | 第一製薬株式会社 | 神経変性治療におけるネフィラセタムの使用 |
| US20060241144A1 (en) * | 2005-04-20 | 2006-10-26 | Albert Cha | Method for treating apathy syndrome |
| US7972633B2 (en) * | 2007-02-07 | 2011-07-05 | Applied Cognitive Sciences, LLC | Nutritional supplements for healthy memory and mental function |
| RU2327480C1 (ru) * | 2007-05-23 | 2008-06-27 | Виктор Иванович Рощин | Активный ингредиент лекарственного средства, лекарственное средство, фармацевтическая композиция и способ лечения больных с дементным синдромом |
| ES2865504T3 (es) * | 2008-10-16 | 2021-10-15 | Univ Johns Hopkins | Procedimientos y composiciones para la mejora de la función cognitiva |
| AU2011215870B2 (en) * | 2010-02-09 | 2016-01-28 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| JP6433482B2 (ja) | 2013-03-15 | 2018-12-05 | エージンバイオ, インコーポレイテッド | 認知機能を改善するための方法および組成物 |
| WO2016191288A1 (en) | 2015-05-22 | 2016-12-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
| IT1141287B (it) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
| US4385053A (en) * | 1981-03-11 | 1983-05-24 | Barry Reisberg | Treatment for human memory impairment associated with aging |
| JPH0699307B2 (ja) * | 1987-08-20 | 1994-12-07 | キッセイ薬品工業株式会社 | 抗痴呆剤 |
| IT1231477B (it) * | 1989-07-12 | 1991-12-07 | Sigma Tau Ind Farmaceuti | (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
-
1992
- 1992-04-29 SK SK1306-92A patent/SK279285B6/sk unknown
- 1992-04-29 CA CA002067614A patent/CA2067614C/en not_active Expired - Lifetime
- 1992-04-29 CZ CS921306A patent/CZ281170B6/cs not_active IP Right Cessation
- 1992-04-30 DE DE69231955T patent/DE69231955T2/de not_active Expired - Lifetime
- 1992-04-30 HU HU9201477A patent/HU224689B1/hu not_active IP Right Cessation
- 1992-04-30 RU SU5011760/14A patent/RU2070042C1/ru not_active IP Right Cessation
- 1992-04-30 ES ES92107421T patent/ES2160097T3/es not_active Expired - Lifetime
- 1992-04-30 SG SG1996002798A patent/SG49650A1/en unknown
- 1992-04-30 NO NO19921724A patent/NO312813B1/no unknown
- 1992-04-30 PT PT92107421T patent/PT515866E/pt unknown
- 1992-04-30 IL IL10173892A patent/IL101738A/en active IP Right Grant
- 1992-04-30 EP EP92107421A patent/EP0515866B1/de not_active Expired - Lifetime
- 1992-04-30 AT AT92107421T patent/ATE203402T1/de not_active IP Right Cessation
- 1992-04-30 MX MX9202058A patent/MX9202058A/es not_active IP Right Cessation
- 1992-04-30 DK DK92107421T patent/DK0515866T3/da active
- 1992-05-01 AU AU15954/92A patent/AU1595492A/en not_active Abandoned
- 1992-05-01 TW TW081103420A patent/TW199096B/zh active
- 1992-05-01 KR KR1019920007433A patent/KR100310590B1/ko not_active Expired - Fee Related
- 1992-07-01 IE IE137792A patent/IE921377A1/en not_active IP Right Cessation
-
1995
- 1995-05-22 US US08/447,054 patent/US5886023A/en not_active Expired - Fee Related
- 1995-11-08 AU AU37745/95A patent/AU697936B2/en not_active Ceased
-
2001
- 2001-10-22 GR GR20010401840T patent/GR3036970T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUT62790A (en) | 1993-06-28 |
| KR920021143A (ko) | 1992-12-18 |
| DK0515866T3 (da) | 2001-09-24 |
| AU1595492A (en) | 1992-11-05 |
| MX9202058A (es) | 1993-03-01 |
| IE921377A1 (en) | 1992-11-04 |
| NO921724L (no) | 1992-11-03 |
| DE69231955T2 (de) | 2002-04-04 |
| RU2070042C1 (ru) | 1996-12-10 |
| EP0515866A1 (de) | 1992-12-02 |
| DE69231955D1 (de) | 2001-08-30 |
| NO312813B1 (no) | 2002-07-08 |
| HU9201477D0 (en) | 1992-07-28 |
| ES2160097T3 (es) | 2001-11-01 |
| TW199096B (de) | 1993-02-01 |
| CZ281170B6 (cs) | 1996-07-17 |
| IL101738A (en) | 1999-01-26 |
| SK279285B6 (sk) | 1998-09-09 |
| KR100310590B1 (ko) | 2001-12-28 |
| HK1002153A1 (en) | 1998-07-31 |
| CA2067614A1 (en) | 1992-11-03 |
| US5886023A (en) | 1999-03-23 |
| IL101738A0 (en) | 1992-12-30 |
| PT515866E (pt) | 2001-11-30 |
| EP0515866B1 (de) | 2001-07-25 |
| GR3036970T3 (en) | 2002-01-31 |
| AU697936B2 (en) | 1998-10-22 |
| CS130692A3 (en) | 1992-11-18 |
| SG49650A1 (en) | 1998-06-15 |
| HU224689B1 (hu) | 2005-12-28 |
| NO921724D0 (no) | 1992-04-30 |
| CA2067614C (en) | 2002-07-30 |
| AU3774595A (en) | 1996-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |