ATE203668T1 - Verwendung von 11-(3-dimethylaminopropyliden)-6, 11-dihydrodibenz(b,e)oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation - Google Patents

Verwendung von 11-(3-dimethylaminopropyliden)-6, 11-dihydrodibenz(b,e)oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation

Info

Publication number
ATE203668T1
ATE203668T1 AT99928600T AT99928600T ATE203668T1 AT E203668 T1 ATE203668 T1 AT E203668T1 AT 99928600 T AT99928600 T AT 99928600T AT 99928600 T AT99928600 T AT 99928600T AT E203668 T1 ATE203668 T1 AT E203668T1
Authority
AT
Austria
Prior art keywords
ovascularization
dimethylaminopropyliden
dihydrodibenz
oxepine
occular
Prior art date
Application number
AT99928600T
Other languages
English (en)
Inventor
John M Yanni
Daniel A Gamache
Lori K Weimer
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE203668T1 publication Critical patent/ATE203668T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99928600T 1998-07-14 1999-06-15 Verwendung von 11-(3-dimethylaminopropyliden)-6, 11-dihydrodibenz(b,e)oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation ATE203668T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9276298P 1998-07-14 1998-07-14
PCT/US1999/013275 WO2000003705A1 (en) 1998-07-14 1999-06-15 Use of 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid for the manufacture of a medicament for treating non-allergic ophthalmic inflammatory disorders and for the prevention of ocular neovascularization

Publications (1)

Publication Number Publication Date
ATE203668T1 true ATE203668T1 (de) 2001-08-15

Family

ID=22235027

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99928600T ATE203668T1 (de) 1998-07-14 1999-06-15 Verwendung von 11-(3-dimethylaminopropyliden)-6, 11-dihydrodibenz(b,e)oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation

Country Status (17)

Country Link
EP (1) EP1037627B1 (de)
JP (1) JP2002520355A (de)
KR (1) KR100598723B1 (de)
CN (1) CN1114401C (de)
AR (1) AR019916A1 (de)
AT (1) ATE203668T1 (de)
AU (1) AU742237B2 (de)
BR (1) BR9906772A (de)
CA (1) CA2306393C (de)
DE (1) DE69900207T2 (de)
DK (1) DK1037627T3 (de)
ES (1) ES2159209T3 (de)
GR (1) GR3036422T3 (de)
PT (1) PT1037627E (de)
TW (1) TW561046B (de)
WO (1) WO2000003705A1 (de)
ZA (1) ZA200001593B (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1187617E (pt) 1999-06-18 2004-06-30 Alcon Mfg Ltd Metodo para seleccionar a concentracao de um farmaco antipatico anti-histaminico pela determinacao da taxa de actividade superficial do farmaco
US20020077358A1 (en) * 2000-10-23 2002-06-20 Alcon Universal Ltd. Use of hydroperoxyeicosatetraenoic acid derivatives following refractive surgery
ATE353667T1 (de) 2001-05-21 2007-03-15 Alcon Inc Verwendung von proteasom-inhibitoren zur behandlung des trockenen auges
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US7112588B2 (en) 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
BR0209965A (pt) 2001-05-21 2004-04-06 Alcon Inc Uso de inibidores de nf-kappab para tratar distúrbios do olho seco
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
TWI231759B (en) 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
US7977376B2 (en) 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
US6825232B2 (en) 2002-06-14 2004-11-30 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
CN103143022A (zh) 2002-07-30 2013-06-12 奥默罗斯公司 眼科冲洗液及方法
BR0314603A (pt) * 2002-09-20 2005-07-26 Alcon Inc Uso de inibidores da sìntese de citoquina para o tratamento de distúrbios de olhos secos
US7235556B2 (en) 2003-04-16 2007-06-26 Alcon, Inc. Methods of treating dry eye disorders
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US7923471B2 (en) 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
EP1765454B1 (de) 2004-07-02 2016-04-13 Mati Therapeutics Inc. Behandlungsmittelabgabevorrichtung für das auge
US7223737B1 (en) 2004-08-13 2007-05-29 Alcon, Inc. Method of treating dry eye disorders using glycosides
US8168655B2 (en) * 2005-05-17 2012-05-01 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
AR059927A1 (es) 2006-03-17 2008-05-07 Johnson & Johnson Vision Care Metodos para la estabilizacion de composiciones inestables a la oxidacion y composiciones oftalmicas estabilizadas
EP2004172B1 (de) 2006-03-31 2019-03-13 Mati Therapeutics Inc. Wirkstofffreisetzungsstrukturen und zusammensetzungen für nasolacrimales system
US9011361B2 (en) 2007-09-07 2015-04-21 Mati Therapeutics Inc. Lacrimal implant detection
US8207226B1 (en) 2008-06-03 2012-06-26 Alcon Research, Ltd. Use of FAAH antagonists for treating dry eye and ocular pain
WO2011057183A1 (en) 2009-11-06 2011-05-12 Alcon Research, Ltd. Nutritional supplements for relief of dry eye
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
CN109311976A (zh) 2016-06-20 2019-02-05 诺华股份有限公司 使用TNFα拮抗剂治疗干眼症的方法

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JPS6310784A (ja) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
JPH02138215A (ja) * 1988-08-05 1990-05-28 Dai Ichi Seiyaku Co Ltd 抗アレルギー・抗炎症剤
IE920499A1 (en) * 1991-02-21 1992-08-26 Merck Frosst Canada Inc Quinoline-containing ketoacids as leukotriene antagonists
IL102414A (en) * 1991-07-25 1996-08-04 Univ Louisville Res Found Medicinal preparations for the treatment of ocular inflammation, containing rapamycin
JP3453152B2 (ja) * 1992-04-06 2003-10-06 格 冨山 抗炎症点眼剤
FR2701948B1 (fr) * 1993-02-22 1996-07-26 Exsymol Sa Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
CA2159091C (en) * 1993-03-26 2006-12-19 Richard J. Sharpe Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses
FR2711990B1 (fr) * 1993-11-05 1995-12-08 Exsymol Sa Produit pseudodipeptide possédant un groupement imidazole, et applications thérapeutiques, cosmétologiques et agroalimentaires.
JP2852607B2 (ja) * 1994-06-10 1999-02-03 雪印乳業株式会社 ドライアイ治療剤
US5641805A (en) * 1995-06-06 1997-06-24 Alcon Laboratories, Inc. Topical ophthalmic formulations for treating allergic eye diseases
JPH1067684A (ja) * 1996-06-17 1998-03-10 Mitsubishi Chem Corp 涙液分泌促進剤
CA2272073A1 (en) * 1996-11-19 1998-05-28 The Schepens Eye Research Institute, Inc. Local use of il-1ra in corneal transplant rejection or disorders of the eye

Also Published As

Publication number Publication date
GR3036422T3 (en) 2001-11-30
EP1037627A1 (de) 2000-09-27
JP2002520355A (ja) 2002-07-09
KR100598723B1 (ko) 2006-07-11
ES2159209T3 (es) 2001-09-16
AU4563499A (en) 2000-02-07
TW561046B (en) 2003-11-11
CN1114401C (zh) 2003-07-16
CA2306393C (en) 2008-12-23
ZA200001593B (en) 2000-10-25
HK1030362A1 (en) 2001-05-04
AU742237B2 (en) 2001-12-20
CA2306393A1 (en) 2000-01-27
AR019916A1 (es) 2002-03-27
DE69900207T2 (de) 2001-11-22
EP1037627B1 (de) 2001-08-01
DE69900207D1 (de) 2001-09-06
PT1037627E (pt) 2001-11-30
WO2000003705A1 (en) 2000-01-27
BR9906772A (pt) 2000-09-26
DK1037627T3 (da) 2001-10-01
CN1275078A (zh) 2000-11-29
KR20010024508A (ko) 2001-03-26

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