ATE204165T1 - Öl-im-wasser-emulsionen enthaltend taxin (taxol) und verfahren - Google Patents

Öl-im-wasser-emulsionen enthaltend taxin (taxol) und verfahren

Info

Publication number
ATE204165T1
ATE204165T1 AT95924067T AT95924067T ATE204165T1 AT E204165 T1 ATE204165 T1 AT E204165T1 AT 95924067 T AT95924067 T AT 95924067T AT 95924067 T AT95924067 T AT 95924067T AT E204165 T1 ATE204165 T1 AT E204165T1
Authority
AT
Austria
Prior art keywords
oil
taxine
taxol
taxin
water emulsions
Prior art date
Application number
AT95924067T
Other languages
English (en)
Inventor
Robert J Kaufman
Thomas J Richard
Ralph W Fuhrhop
Original Assignee
Hemagen Pfc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemagen Pfc filed Critical Hemagen Pfc
Application granted granted Critical
Publication of ATE204165T1 publication Critical patent/ATE204165T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
AT95924067T 1994-07-19 1995-06-22 Öl-im-wasser-emulsionen enthaltend taxin (taxol) und verfahren ATE204165T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/276,899 US5616330A (en) 1994-07-19 1994-07-19 Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
PCT/US1995/008007 WO1996002247A1 (en) 1994-07-19 1995-06-22 Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same

Publications (1)

Publication Number Publication Date
ATE204165T1 true ATE204165T1 (de) 2001-09-15

Family

ID=23058551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95924067T ATE204165T1 (de) 1994-07-19 1995-06-22 Öl-im-wasser-emulsionen enthaltend taxin (taxol) und verfahren

Country Status (10)

Country Link
US (1) US5616330A (de)
EP (1) EP0768876B1 (de)
JP (1) JPH10502921A (de)
CN (1) CN1097458C (de)
AT (1) ATE204165T1 (de)
AU (1) AU690299B2 (de)
CA (1) CA2194226C (de)
DE (1) DE69522227T2 (de)
IL (1) IL114212A (de)
WO (1) WO1996002247A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
WO1999000113A1 (en) * 1997-06-27 1999-01-07 Vivorx Pharmaceuticals, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
US6964946B1 (en) 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
US20070092563A1 (en) * 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
CN101579335B (zh) * 1997-06-27 2016-08-03 阿布拉科斯生物科学有限公司 药剂的制剂及其制备和应用方法
US8853260B2 (en) * 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
KR20080016756A (ko) * 1998-02-05 2008-02-21 노파르티스 아게 유기화합물 함유 조성물
DE69931617T2 (de) * 1998-04-01 2007-05-24 Jagotec Ag Taxan-mikroemulsionen
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
DE19843968A1 (de) * 1998-09-24 2000-04-13 Hans Dietl Taxane enthaltende pharmazeutische Zubereitung zur intravenösen Applikation und Verfahren zu ihrer Herstellung
KR100602725B1 (ko) * 1998-12-11 2006-07-20 파마솔루션스, 인코포레이티드 물에서 불충분하게 용해되는 약제를 위한 자가-유화용조성물
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
DE19900054A1 (de) * 1999-01-04 2000-07-06 Hans Dietl Taxane enthaltende stabile und sterile Emulsion und Verfahren zu ihrer Herstellung
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
AU763945B2 (en) * 1999-06-04 2003-08-07 Skyepharma Inc. Oil-core compositions for the sustained release of hydrophobic drugs
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
TW422706B (en) 1999-07-01 2001-02-21 Wang Iz Rung An oil-in-water emulsion type of paclitaxel
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
PL350075A1 (en) * 2000-02-02 2002-11-04 Univ Florida State Res Found Taxane formulations having improved solubility
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
DE10036871A1 (de) * 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
AU2001279168A1 (en) * 2000-08-02 2002-02-13 Atossa Healthcare, Inc. Bimodal emulsions of taxanes and butyrate polyalcohol esters
WO2002102311A2 (en) 2001-06-15 2002-12-27 Cornerstone Pharmaceuticals Nanoparticles for treating targeted tissues and cells
WO2003022248A1 (en) * 2001-09-13 2003-03-20 Korea Institute Of Science And Technology Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof
KR100533458B1 (ko) * 2002-07-20 2005-12-07 대화제약 주식회사 파클리탁셀의 가용화용 조성물 및 그의 제조 방법
KR100573289B1 (ko) * 2002-07-20 2006-04-24 대화제약 주식회사 방광내 투여를 통한 방광암치료용 파클리탁셀 조성물 및그의 제조 방법
US20040213837A1 (en) * 2002-08-05 2004-10-28 Sankaram Mantripragada Oil-core compositions for the sustained release of hydrophobic drugs
DK1585548T3 (en) * 2002-12-09 2018-09-03 Abraxis Bioscience Llc COMPOSITIONS AND PROCEDURES FOR THE DELIVERY OF PHARMACOLOGICAL AGENTS
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
CN1863506A (zh) * 2003-10-02 2006-11-15 塞姆柏奥希斯遗传学公司 制备含活性成分油体的方法
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US20050129719A1 (en) * 2003-12-15 2005-06-16 Yu-Fang Hu Concentrated emulsion formulation for silatecan
WO2005065676A1 (ja) * 2004-01-09 2005-07-21 Otsuka Pharmaceutical Factory, Inc. パクリタキセルまたはドセタキセルを含む脂肪乳剤
WO2005065677A1 (ja) * 2004-01-09 2005-07-21 Otsuka Pharmaceutical Factory, Inc. パクリタキセルまたはドセタキセルを溶解または分散させるための脂肪乳剤
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
CN100462076C (zh) * 2005-01-20 2009-02-18 江苏正大天晴药业股份有限公司 供静脉用长春花生物碱的稳定水包油乳剂及其制备方法
CN100333722C (zh) * 2005-03-11 2007-08-29 江苏正大天晴药业股份有限公司 静脉用棓丙酯的稳定水包油乳剂及其制备方法
CN101137395B (zh) * 2005-03-14 2012-10-31 株式会社大塚制药工场 含有水难溶性药物的医药组合物
US20070032438A1 (en) * 2005-08-02 2007-02-08 Tty Biopharm Company Limited Pharmaceutical compositions containing taxanes and methods for preparing the pharmaceutical compositions
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
WO2008058366A1 (en) * 2006-09-28 2008-05-22 Université de Montréal Oil-in-water emulsions, methods of use thereof, methods of preparation thereof and kits thereof
EP2025333A1 (de) * 2007-08-14 2009-02-18 Pharmatex Italia Srl Injizierbare pharmazeutische Taxoidformulierungen
US20090087460A1 (en) * 2007-10-02 2009-04-02 Hamamatsu Photonics K.K. Solid composition, microparticles, microparticle dispersion liquid, and manufacturing methods for these
US20090098168A1 (en) * 2007-10-08 2009-04-16 The Regents Of The University Of California Multiple-layer microbubble liposphere drug delivery vehicle and system
FR2922107B1 (fr) * 2007-10-10 2010-02-26 Aventis Pharma Sa Nouvelles compositions a base de taxoides
US8861813B2 (en) * 2008-03-13 2014-10-14 Mallinckrodt Llc Multi-function, foot-activated controller for imaging system
US11304960B2 (en) * 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
CN102048688B (zh) * 2009-10-29 2014-03-05 中国医学科学院药物研究所 以胆固醇复合物为中间载体的紫杉醇亚微乳
CN102048725B (zh) * 2009-10-29 2014-07-16 中国医学科学院药物研究所 紫杉醇胆固醇复合物
TWI438009B (zh) * 2010-02-19 2014-05-21 Teikoku Pharma Usa Inc 紫杉烷前－乳劑調配物及其製造與使用之方法
JP5824511B2 (ja) 2010-05-03 2015-11-25 テイコク ファーマ ユーエスエー インコーポレーテッド 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法
JP2012051823A (ja) * 2010-08-31 2012-03-15 Fujifilm Corp 難容性薬物含有水中油型乳化組成物及びその製造方法
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
KR20150000405A (ko) * 2013-06-24 2015-01-02 한국콜마주식회사 난용성 의약품의 수중유적형 에멀젼 조성물 및 이의 제조방법
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
WO2016044784A1 (en) 2014-09-19 2016-03-24 Heron Therapeutics, Inc. Emulson formulations of aprepitant
WO2016205423A2 (en) 2015-06-15 2016-12-22 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
US9974742B2 (en) 2016-02-01 2018-05-22 Heron Therapeutics, Inc. Emulsion formulations of an NK-1 receptor antagonist and uses thereof
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
EP3824296B1 (de) 2018-07-20 2026-04-01 Lipocine Inc. Orale pharmazeutische zusammensetzung mit testosterontridecanoat und/oder testosterondodecanoat zur behandlung von lebererkrankungen
CN111920782B (zh) * 2019-05-13 2025-11-18 中国医学科学院药物研究所 复合脂质纳米囊组合物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993581A (en) * 1973-10-05 1976-11-23 The Green Cross Corporation Process for preparing stable oxygen transferable emulsion
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
US4784845A (en) * 1985-09-16 1988-11-15 American Cyanamid Company Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
SE8600632D0 (sv) * 1986-02-13 1986-02-13 Kabivitrum Ab Novel pharmaceutical composition
JP2847783B2 (ja) * 1988-08-11 1999-01-20 日清製粉株式会社 抗癌活性増強剤
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5407683A (en) * 1990-06-01 1995-04-18 Research Corporation Technologies, Inc. Pharmaceutical solutions and emulsions containing taxol
JPH05221852A (ja) * 1992-02-18 1993-08-31 L T T Kenkyusho:Kk 制ガン剤の新規製剤調製方法
AU5539294A (en) * 1992-12-24 1994-07-19 Hemagen/Pfc Fluorocarbon emulsions

Also Published As

Publication number Publication date
DE69522227T2 (de) 2002-06-13
IL114212A0 (en) 1995-10-31
CN1097458C (zh) 2003-01-01
IL114212A (en) 1999-07-14
AU690299B2 (en) 1998-04-23
US5616330A (en) 1997-04-01
AU2872095A (en) 1996-02-16
CA2194226C (en) 2000-10-24
WO1996002247A1 (en) 1996-02-01
EP0768876B1 (de) 2001-08-16
EP0768876A1 (de) 1997-04-23
DE69522227D1 (de) 2001-09-20
JPH10502921A (ja) 1998-03-17
CA2194226A1 (en) 1996-02-01
CN1153474A (zh) 1997-07-02

Similar Documents

Publication Publication Date Title
DE69522227D1 (de) Öl-im-wasser-emulsionen enthaltend taxin (taxol) und verfahren
FR2731617B1 (fr) Compositions pharmaceutiques nouvelles contenant du propofol
HRP20080235T3 (hr) Formulacija vakcine koja sadrži emulziju ulje-u-vodi
DE69230254D1 (de) Herstellung von Mikropartikeln
KR870002835A (ko) 이온화성 소수성약제의 약제학적 제조방법
ATE365538T1 (de) O/w emulsion
DE3382378D1 (de) Kortikoidhaltige zubereitung zur topischen applikation.
ES2161895T3 (es) Emulsiones especificas de la glandula lagrimal para aplicacion topica a tejidos oculares.
ATE202277T1 (de) Verfahren zur stabilisierung von vesikeln aus amphiphilen lipiden und diese stabilisierte vesikeln enthaltende zusammensetzung für die topische anwendung
KR960702733A (ko) 안정한 유중수형 유제(stable water-in-oil emulsions)
BRPI0401751A (pt) Pacote de agente tensoativo e emulsão de água-em-hidrocarboneto utilizando o mesmo
BR0000707A (pt) Composição de fase aquosa contìnua, utilização de pelo menos um sequestrante associado a pelo menos um neutralizante, processo de estabilização do ácido l-2- oxotiazolidina 4-carboxìlico e utilização da composição
KR970005288A (ko) 유용성 감초추출물을 안정화시킨 지질 액정겔 및 이를 함유하는 화장료 조성물
MX9302924A (es) Agente para tratamiento de cataratas y metodo para su preparacion.
KR970020101A (ko) 케토프로펜 함유 습포제용 조성물
KR940003468A (ko) 이중유화형 마아가린 제조방법
KR940014728A (ko) 폴리에스테르섬유용 유제 조성물
DE69501785D1 (de) Neues verfahren zur behandlung einer emulsion

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties