ATE204272T1 - Neue pyridon carbonsäure-derivate - Google Patents
Neue pyridon carbonsäure-derivateInfo
- Publication number
- ATE204272T1 ATE204272T1 AT94903116T AT94903116T ATE204272T1 AT E204272 T1 ATE204272 T1 AT E204272T1 AT 94903116 T AT94903116 T AT 94903116T AT 94903116 T AT94903116 T AT 94903116T AT E204272 T1 ATE204272 T1 AT E204272T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- lower alkyl
- hydrogen atom
- substituted
- acid derivatives
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- YSLIPUSJNFIFAB-UHFFFAOYSA-N 2-oxopyridine-1-carboxylic acid Chemical class OC(=O)N1C=CC=CC1=O YSLIPUSJNFIFAB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR920026696 | 1992-12-30 | ||
| KR930011125 | 1993-06-17 | ||
| PCT/KR1993/000123 WO1994015933A1 (en) | 1992-12-30 | 1993-12-29 | Novel pyridone carboxylic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204272T1 true ATE204272T1 (de) | 2001-09-15 |
Family
ID=26629459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94903116T ATE204272T1 (de) | 1992-12-30 | 1993-12-29 | Neue pyridon carbonsäure-derivate |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5527910A (de) |
| EP (1) | EP0677050B1 (de) |
| JP (1) | JP2948660B2 (de) |
| CN (1) | CN1042632C (de) |
| AT (1) | ATE204272T1 (de) |
| AU (2) | AU689089B2 (de) |
| CA (2) | CA2152817C (de) |
| DE (1) | DE69330612D1 (de) |
| HU (1) | HU219581B (de) |
| MX (1) | MX9400113A (de) |
| NO (2) | NO307883B1 (de) |
| RU (1) | RU2161154C2 (de) |
| WO (1) | WO1994015933A1 (de) |
| YU (1) | YU83993A (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0664288A1 (de) * | 1992-10-09 | 1995-07-26 | Chugai Seiyaku Kabushiki Kaisha | Fluorochinonderivate |
| US5527910A (en) * | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
| AU699636B2 (en) * | 1994-02-04 | 1998-12-10 | Dainippon Pharmaceutical Co. Ltd. | Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof |
| CN1090185C (zh) * | 1995-02-02 | 2002-09-04 | 大日本制药株式会社 | 有双环氨基取代的吡啶酮羧酸衍生物,其酯及盐,以及可用作其中间体的双环类胺 |
| EP1135398A1 (de) | 1998-12-03 | 2001-09-26 | Monsanto Technology LLC | Cyanophosphonamide und herstellungsverfahren |
| AU3192700A (en) | 1999-03-17 | 2000-10-04 | Daiichi Pharmaceutical Co., Ltd. | Medicinal compositions |
| CA2489128C (en) * | 2002-06-13 | 2012-01-03 | Vertex Pharmaceuticals Incorporated | 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections |
| US7334538B1 (en) * | 2004-07-27 | 2008-02-26 | Aquascience Research Group, Inc. | Topical medicants for aquatic animals |
| EP2074111A2 (de) * | 2006-10-06 | 2009-07-01 | Bausch & Lomb Incorporated | Chinoloncarbonsäuren, derivate davon, verfahren zu ihrer herstellung und ihre verwendung als antibakterielle mittel |
| US7632944B2 (en) | 2007-01-24 | 2009-12-15 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same |
| US8252783B2 (en) | 2007-01-24 | 2012-08-28 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same |
| US7902227B2 (en) | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
| NZ610978A (en) | 2009-05-15 | 2014-11-28 | Redx Pharma Ltd | Redox drug derivatives |
| TWI527818B (zh) | 2011-03-15 | 2016-04-01 | 特留斯治療學有限公司 | 三環旋轉酶抑制劑 |
| DK2796460T3 (en) * | 2011-12-21 | 2018-08-27 | Jiangsu Hengrui Medicine Co | SEXUAL PYRROL HETEROARYL RING DERIVATIVES, METHOD OF PREPARATION AND MEDICAL APPLICATIONS THEREOF |
| US10865216B2 (en) | 2012-09-12 | 2020-12-15 | Merck Sharp & Dohme Corp. | Tricyclic Gyrase inhibitors |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3252972A (en) * | 1959-11-10 | 1966-05-24 | Ciba Geigy Corp | (n, n-bicycloalkylene-imino)-lower alkyl-guanidines |
| US3246027A (en) * | 1961-03-22 | 1966-04-12 | Du Pont | Process for converting cis-1, 2-dicyanocy-clobutane to trans-1, 2-dicyanocyclobutane |
| US3246006A (en) * | 1963-08-07 | 1966-04-12 | Du Pont | 2-(3-azabicyclo [3.2.0] hept-3-ylthio) benothiazole |
| NL6504082A (de) * | 1965-03-31 | 1966-10-03 | ||
| US3639390A (en) * | 1966-12-30 | 1972-02-01 | Ciba Ltd | Azabicycloalkane derivatives |
| US3875154A (en) * | 1972-09-15 | 1975-04-01 | Univ Ca | Certain 5-thia-1-azabicyclo{8 4.2.0{9 octenes |
| EP0022288A3 (de) * | 1979-07-06 | 1981-07-01 | Shell Internationale Researchmaatschappij B.V. | Verfahren zum Sterilisieren männlicher Staubbeutel in Pflanzen, zur Verwendung in einem solchen Verfahren geeignete Zusammensetzungen und Verbindungen und Verfahren zur Herstellung von F1-gekreuzten Saatgütern |
| JPS5649382A (en) * | 1979-09-28 | 1981-05-02 | Dainippon Pharmaceut Co Ltd | 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt |
| US4382937A (en) * | 1981-02-27 | 1983-05-10 | Dainippon Pharmaceutical Co., Ltd. | Naphthyridine derivatives and their use as anti-bacterials |
| US4431661A (en) * | 1981-08-20 | 1984-02-14 | American Cyanamid Company | 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic use therefor |
| US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
| JPH0635458B2 (ja) * | 1985-02-15 | 1994-05-11 | 大日本製薬株式会社 | ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| IL77846A (en) * | 1985-03-25 | 1989-08-15 | Warner Lambert Co | Process for the preparation of 7-amino-quinolin-4-oxy-3-carboxylic acid derivatives |
| JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| US4962108A (en) * | 1987-07-31 | 1990-10-09 | Warner-Lambert Company | Antibacterial quinoline compounds |
| JPH0676400B2 (ja) * | 1987-08-25 | 1994-09-28 | 大日本製薬株式会社 | 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| FR2625200A1 (en) * | 1987-12-29 | 1989-06-30 | Esteve Labor Dr | 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments |
| JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
| JP2844079B2 (ja) * | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
| WO1990002123A1 (en) * | 1988-08-23 | 1990-03-08 | Pfizer Inc. | Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters |
| US5147873A (en) * | 1988-08-23 | 1992-09-15 | Pfizer Inc. | Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters |
| CA1336090C (en) * | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
| US5286723A (en) * | 1988-08-31 | 1994-02-15 | Daiichi Seiyaku Co., Ltd. | Spiro compound |
| PL166381B1 (pl) * | 1989-08-16 | 1995-05-31 | Pfizer | Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL |
| US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
| CA2030217A1 (en) * | 1989-11-21 | 1991-05-22 | Jun Imose | Pyridone-carboxylic acid derivatives useful as veterinary medicines |
| CA2076982A1 (en) * | 1990-12-27 | 1992-06-28 | Akira Okura | Pyridonecarboxylic acid derivatives |
| DE4120646A1 (de) * | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
| EP0549857A1 (de) * | 1991-12-31 | 1993-07-07 | Korea Research Institute Of Chemical Technology | Chinolone Carbonsäurederivate verwendbar als antibakterielles Mittel |
| DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| US5527910A (en) * | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
-
1993
- 1993-12-03 US US08/160,821 patent/US5527910A/en not_active Expired - Fee Related
- 1993-12-29 JP JP6515880A patent/JP2948660B2/ja not_active Expired - Lifetime
- 1993-12-29 AT AT94903116T patent/ATE204272T1/de not_active IP Right Cessation
- 1993-12-29 RU RU95115237/04A patent/RU2161154C2/ru active
- 1993-12-29 WO PCT/KR1993/000123 patent/WO1994015933A1/en not_active Ceased
- 1993-12-29 CA CA002152817A patent/CA2152817C/en not_active Expired - Fee Related
- 1993-12-29 HU HU9501727A patent/HU219581B/hu not_active IP Right Cessation
- 1993-12-29 AU AU57181/94A patent/AU689089B2/en not_active Ceased
- 1993-12-29 CA CA002226406A patent/CA2226406C/en not_active Expired - Fee Related
- 1993-12-29 DE DE69330612T patent/DE69330612D1/de not_active Expired - Lifetime
- 1993-12-29 EP EP94903116A patent/EP0677050B1/de not_active Expired - Lifetime
- 1993-12-30 YU YU83993A patent/YU83993A/sh unknown
- 1993-12-30 CN CN93115335A patent/CN1042632C/zh not_active Expired - Fee Related
-
1994
- 1994-01-03 MX MX9400113A patent/MX9400113A/es not_active IP Right Cessation
-
1995
- 1995-06-29 NO NO952610A patent/NO307883B1/no not_active IP Right Cessation
-
1996
- 1996-01-26 US US08/592,171 patent/US5688965A/en not_active Expired - Fee Related
-
1997
- 1997-09-24 AU AU39220/97A patent/AU704969B2/en not_active Ceased
-
1999
- 1999-11-17 NO NO995638A patent/NO309087B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995638L (no) | 1999-11-17 |
| CN1042632C (zh) | 1999-03-24 |
| YU83993A (sh) | 1996-10-09 |
| NO952610D0 (no) | 1995-06-29 |
| EP0677050A1 (de) | 1995-10-18 |
| JPH08505384A (ja) | 1996-06-11 |
| CA2226406C (en) | 2001-08-14 |
| NO952610L (no) | 1995-08-29 |
| HU219581B (hu) | 2001-05-28 |
| MX9400113A (es) | 1994-07-29 |
| CA2152817C (en) | 1998-12-29 |
| CN1098103A (zh) | 1995-02-01 |
| NO309087B1 (no) | 2000-12-11 |
| US5527910A (en) | 1996-06-18 |
| HUT72434A (en) | 1996-04-29 |
| AU704969B2 (en) | 1999-05-13 |
| US5688965A (en) | 1997-11-18 |
| RU95115237A (ru) | 1997-06-10 |
| NO307883B1 (no) | 2000-06-13 |
| AU3922097A (en) | 1997-12-18 |
| CA2152817A1 (en) | 1994-07-21 |
| AU5718194A (en) | 1994-08-15 |
| EP0677050B1 (de) | 2001-08-16 |
| NO995638D0 (no) | 1999-11-17 |
| DE69330612D1 (de) | 2001-09-20 |
| JP2948660B2 (ja) | 1999-09-13 |
| CA2226406A1 (en) | 1994-07-21 |
| AU689089B2 (en) | 1998-03-26 |
| HU9501727D0 (en) | 1995-08-28 |
| RU2161154C2 (ru) | 2000-12-27 |
| WO1994015933A1 (en) | 1994-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |