ATE204276T1 - Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendung - Google Patents

Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendung

Info

Publication number: ATE204276T1
Authority: AT; Austria
Prior art keywords: ring; group; stands; optionally; optionally substituted
Prior art date: 1992-12-22

Application number

AT93120135T

Other languages

English (en)

Inventor

Keiji Kubo

Yoshiyuki Inada

Takehiko Naka

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-22

Filing date

1993-12-14

Publication date

2001-09-15

1993-12-14 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204276T1 publication Critical patent/ATE204276T1/de

Links

102000005862 Angiotensin II Human genes 0.000 title abstract 2
101800000733 Angiotensin-2 Proteins 0.000 title abstract 2
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title abstract 2
229950006323 angiotensin ii Drugs 0.000 title abstract 2
230000003042 antagnostic effect Effects 0.000 title abstract 2
150000002391 heterocyclic compounds Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000006618 5- to 10-membered aromatic heterocyclic group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
150000004945 aromatic hydrocarbons Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002430 hydrocarbons Chemical group 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT93120135T 1992-12-22 1993-12-14 Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendung ATE204276T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP34291792		1992-12-22

Publications (1)

Publication Number	Publication Date
ATE204276T1 true ATE204276T1 (de)	2001-09-15

Family

ID=18357523

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93120135T ATE204276T1 (de)	1992-12-22	1993-12-14	Heterocyclische verbindungen mit angiotensin-ii- antagonistischer wirkung und ihre anwendung

Country Status (5)

Country	Link
US (1)	US5496835A (de)
EP (1)	EP0603712B1 (de)
AT (1)	ATE204276T1 (de)
CA (1)	CA2112050A1 (de)
DE (1)	DE69330593T2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2115985A1 (en) *	1993-02-25	1994-08-26	Kohei Nishikawa	Vascular hypertrophy suppressor
JP3810020B2 (ja) *	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
CZ154994A3 (en) *	1993-07-02	1995-09-13	Senju Pharma Co	Visual hypotensive agent
US6297198B1 (en)	1996-05-14	2001-10-02	Syngenta Participations Ag	Isoxazole derivatives and their use as herbicides
WO1999044590A1 (en)	1998-03-04	1999-09-10	Takeda Chemical Industries, Ltd.	Sustained-release preparation for aii antagonist, production and use thereof
EP1444988A4 (de)	2001-11-13	2007-04-25	Takeda Pharmaceutical	Krebsmittel
US7232828B2 (en) *	2002-08-10	2007-06-19	Bethesda Pharmaceuticals, Inc.	PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
EP1917245A1 (de)	2005-08-21	2008-05-07	Abbott GmbH & Co. KG	Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
EA200970510A1 (ru)	2006-11-24	2009-12-30	Такеда Фармасьютикал Компани Лимитед	Гетеромоноциклическое соединение и его применение
US7803940B2 (en) *	2006-11-24	2010-09-28	Takeda Pharmaceutical Company Limited	Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
ES2553089T3 (es)	2007-11-27	2015-12-04	La Seda De Barcelona S.A.	Recipiente moldeado por inyección multicapa transparente que tiene una capa de barrera de fluoropolímero

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5104891A (en) *	1989-12-11	1992-04-14	G. D. Searle & Co.	Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension
GB9005354D0 (en) *	1990-03-09	1990-05-02	Glaxo Group Ltd	Chemical compounds
TW201738B (de) *	1990-03-20	1993-03-11	Sanofi Co
JPH05505822A (ja) *	1990-03-30	1993-08-26	メルク・エンド・カムパニー・インコーポレーテツド	ピラゾール類、イソキサゾール類及びイソチアゾール置換体
WO1991015209A1 (en) *	1990-03-30	1991-10-17	Merck & Co., Inc.	Substituted pyrimidines, pyrimidinones and pyridopyrimidines
AU636066B2 (en) *	1990-10-30	1993-04-08	Takeda Chemical Industries Ltd.	Thienoimidazole derivatives, their production and use
FR2673427B1 (fr) *	1991-03-01	1993-06-18	Sanofi Elf	Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
EP0503838A3 (en) *	1991-03-08	1992-10-07	Merck & Co. Inc.	Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists
US5157040A (en) *	1991-04-05	1992-10-20	Merck & Co., Inc.	Substituted quinolines as angiotensin ii antagonists
FR2677984B1 (fr) *	1991-06-21	1994-02-25	Elf Sanofi	Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them

1993
- 1993-12-14 EP EP93120135A patent/EP0603712B1/de not_active Expired - Lifetime
- 1993-12-14 AT AT93120135T patent/ATE204276T1/de active
- 1993-12-14 DE DE69330593T patent/DE69330593T2/de not_active Expired - Fee Related
- 1993-12-21 CA CA002112050A patent/CA2112050A1/en not_active Abandoned
- 1993-12-22 US US08/171,164 patent/US5496835A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0603712A2 (de)	1994-06-29
EP0603712A3 (en)	1994-07-13
US5496835A (en)	1996-03-05
DE69330593T2 (de)	2002-06-27
EP0603712B1 (de)	2001-08-16
DE69330593D1 (de)	2001-09-20
CA2112050A1 (en)	1994-06-23

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DK0906907T3 (da)	2002-04-22	Forbindelser, der potenserer retinoid
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ATE345122T1 (de)	2006-12-15	Stabile emulsionszubereitungen
ATE194340T1 (de)	2000-07-15	Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
ATE126219T1 (de)	1995-08-15	Benzimidazolderivate, verfahren zu deren herstellung und anwendung.
ATE338754T1 (de)	2006-09-15	Heterocyclische verbindungen, ihre herstellung und verwendung
DE69108138D1 (de)	1995-04-20	Imidazopyridinderivate und ihre Verwendung.
DE69330593D1 (de)	2001-09-20	Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
DK567089A (da)	1990-05-15	Diazacycloalkanderivater
ATE239720T1 (de)	2003-05-15	Heterozyklische verbindungen
BR9506482A (pt)	1997-10-07	Aril e heteroaril pirimidinas herbicidas
ATE164844T1 (de)	1998-04-15	Azolverbindungen, ihre herstellung und verwendung als antimykotische mittel
DE69525763D1 (de)	2002-04-11	4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE, DIE LDL OXIDATION HEMMEN
AP2000002008A0 (en)	2000-12-31	Tetrahydroquinoline derivatives as glycine antagonists.
DE69319859D1 (de)	1998-08-27	Neue tetracyclische verbindungen
SE8303913L (sv)	1984-01-09	Heterocykliska foreningar
ATE102620T1 (de)	1994-03-15	1-chlor-1-azolyl-methyloxirane und diese enthaltende fungizide.
ATE218861T1 (de)	2002-06-15	Vasculäre hypertrophicsuppressor
ATE27455T1 (de)	1987-06-15	Heterocyclische guanidino-phenylamidine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
ATE125669T1 (de)	1995-08-15	Fungizide verbindungen und zusammensetzungen, die tris(aryl)-phosphonium salze enthalten.
DE58900084D1 (de)	1991-05-16	Azolylmethylcyclopropane und ihre verwendung als pflanzenschutzmittel.
AU686642B2 (en)	1998-02-12	Cyclohexane derivatives
ATE59640T1 (de)	1991-01-15	Fungizide.
EP0781773A4 (de)	1997-12-29	Neue carbapenem-derivate
TH36860A (th)	2000-01-18	สารประกอบเฮเทอโรไซคลิค