ATE204277T1 - Phenyloxazolidinone mit antimikrobieller wirkung - Google Patents

Phenyloxazolidinone mit antimikrobieller wirkung

Info

Publication number
ATE204277T1
ATE204277T1 AT95933718T AT95933718T ATE204277T1 AT E204277 T1 ATE204277 T1 AT E204277T1 AT 95933718 T AT95933718 T AT 95933718T AT 95933718 T AT95933718 T AT 95933718T AT E204277 T1 ATE204277 T1 AT E204277T1
Authority
AT
Austria
Prior art keywords
phenyloxazolidinone
antimicrobial effect
species
bacteroids
enterococci
Prior art date
Application number
AT95933718T
Other languages
English (en)
Inventor
Douglas K Hutchinson
Michael R Barbachyn
Mikio Taniguchi
Kiyotaka Munesada
Hiroyoshi Yamada
Steven J Brickner
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE204277T1 publication Critical patent/ATE204277T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95933718T 1994-10-26 1995-09-12 Phenyloxazolidinone mit antimikrobieller wirkung ATE204277T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32971794A 1994-10-26 1994-10-26
PCT/US1995/010992 WO1996013502A1 (en) 1994-10-26 1995-09-12 Phenyloxazolidinone antimicrobials

Publications (1)

Publication Number Publication Date
ATE204277T1 true ATE204277T1 (de) 2001-09-15

Family

ID=23286694

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933718T ATE204277T1 (de) 1994-10-26 1995-09-12 Phenyloxazolidinone mit antimikrobieller wirkung

Country Status (22)

Country Link
EP (1) EP0788498B1 (de)
JP (1) JP3933198B2 (de)
KR (1) KR100383403B1 (de)
CN (1) CN1068325C (de)
AT (1) ATE204277T1 (de)
AU (1) AU694271B2 (de)
BR (1) BR9509136A (de)
CA (1) CA2200433C (de)
CZ (1) CZ291847B6 (de)
DE (1) DE69522234T2 (de)
DK (1) DK0788498T3 (de)
ES (1) ES2162941T3 (de)
FI (1) FI971774A7 (de)
HU (1) HU224044B1 (de)
NO (1) NO309478B1 (de)
NZ (1) NZ293741A (de)
PL (1) PL183512B1 (de)
PT (1) PT788498E (de)
RU (1) RU2134692C1 (de)
SI (1) SI0788498T1 (de)
SK (1) SK282869B6 (de)
WO (1) WO1996013502A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1019385E (pt) * 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
PT892792E (pt) * 1996-04-11 2002-05-31 Upjohn Co Processo para a preparacao de oxazolidinonas
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
WO1999037630A1 (en) 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
DK1054874T3 (da) * 1998-02-13 2002-12-30 Upjohn Co Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler
KR20010052615A (ko) 1998-06-05 2001-06-25 다비드 에 질레스 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
DE19919708A1 (de) * 1999-04-30 2001-03-01 Univ Stuttgart Stufenweise Alkylierung von polymeren Aminen
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
FR2802091A1 (fr) * 1999-12-08 2001-06-15 Oreal Compositions pour la teinture des fibres keratiniques contenant des derives de paraphenylenediamine a groupement azetidinyle
DE60118241T2 (de) 2000-10-17 2006-12-28 Pharmacia & Upjohn Co. Llc, Kalamazoo Verfahren zur herstellung von oxazolidinonverbindungen
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
US7160912B2 (en) 2000-12-26 2007-01-09 Dr.Reddy's Laboratories Ltd. Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
US6951863B2 (en) 2001-02-07 2005-10-04 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods
ES2186550B2 (es) * 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
US6914058B2 (en) * 2002-01-18 2005-07-05 Dr. Reddy's Laboratories, Limited Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
CA2492743A1 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them
WO2004007489A2 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
WO2004014897A1 (en) 2002-08-12 2004-02-19 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
WO2004045616A1 (en) 2002-11-21 2004-06-03 Pharmacia & Upjohn Company Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
FR2862969A1 (fr) * 2003-11-28 2005-06-03 Oreal Procede de preparation de derives paraphenylenediamine a groupement pyrrolidinyle, substitue par un radical azote, et composes intermediaires
CA2614105A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents
WO2007004049A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinones containing azetidine as antibacterial agents
CN101754685B (zh) 2007-07-24 2015-09-16 陶氏环球技术公司 用于降低和抑制水基流体和与它们一起使用的系统中微生物浓度增加的方法和制剂
WO2009015089A2 (en) 2007-07-24 2009-01-29 Dow Global Technologies Inc. Methods of and formulations for reducing and inhibiting the growth of the concentration of microbes in water-based fluids and systems used with them
EP2141161A1 (de) * 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-Cyano-piperidinyl-phenyl-oxazolidinone als antibakterielle Wirkstoffe
EP2141162A1 (de) * 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-(N-Heterocyclyl)-pyrrolidinyl-phenyl-oxazolidinone als antibakterielle Wirkstoffe
CN101798302B (zh) * 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
KR20130102614A (ko) 2010-11-03 2013-09-17 욱크하르트 리미티드 인산 모노-(1-[4-[(s)-5-(아세틸아미노메틸)-2-옥소-옥사졸리딘-3-일]-2,6-디플루오로페닐]-4-메톡시메틸피페리딘-4-일) 에스테르의 제조 방법
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
ES2059467T3 (es) * 1987-10-21 1994-11-16 Du Pont Merck Pharma Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
ATE112773T1 (de) * 1988-09-15 1994-10-15 Upjohn Co 5-indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(nitrogen- substituierte)phenyl-5-beta-amidomethyloxazolid n-2-one.
AU667198B2 (en) * 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents

Also Published As

Publication number Publication date
FI971774A0 (fi) 1997-04-25
CN1068325C (zh) 2001-07-11
CA2200433A1 (en) 1996-05-09
JP3933198B2 (ja) 2007-06-20
CA2200433C (en) 2006-02-07
NO309478B1 (no) 2001-02-05
PL183512B1 (pl) 2002-06-28
ES2162941T3 (es) 2002-01-16
WO1996013502A1 (en) 1996-05-09
KR970707123A (ko) 1997-12-01
BR9509136A (pt) 1998-07-21
SK282869B6 (sk) 2003-01-09
JPH10508017A (ja) 1998-08-04
PT788498E (pt) 2002-02-28
NO971946L (no) 1997-06-25
HUT77602A (hu) 1998-06-29
EP0788498B1 (de) 2001-08-16
EP0788498A1 (de) 1997-08-13
HU224044B1 (hu) 2005-05-30
PL319873A1 (en) 1997-09-01
NO971946D0 (no) 1997-04-25
AU694271B2 (en) 1998-07-16
SK49497A3 (en) 1998-01-14
CZ291847B6 (cs) 2003-06-18
KR100383403B1 (ko) 2004-05-31
DE69522234T2 (de) 2002-05-16
FI971774A7 (fi) 1997-04-25
AU3625495A (en) 1996-05-23
DK0788498T3 (da) 2001-11-05
RU2134692C1 (ru) 1999-08-20
SI0788498T1 (en) 2001-12-31
CN1162312A (zh) 1997-10-15
NZ293741A (en) 1998-06-26
CZ121797A3 (en) 1997-07-16
DE69522234D1 (de) 2001-09-20

Similar Documents

Publication Publication Date Title
DE69522234D1 (de) Phenyloxazolidinone mit antimikrobieller wirkung
DK0792273T3 (da) Bicycliske oxazin- og thiazin-oxazolidinon-antibakterielle midler
CA2168560A1 (en) Substituted oxazine and thiazine oxazolidinone antimicrobials
DK0874852T3 (da) Antibakterielt oxazolidinonmiddel med tricykliske substituenter
ATE257829T1 (de) Aminoaryl oxazolidinone n-oxide
MX9703040A (es) Antimicrobianos de feniloxazolidinona.
ATE304536T1 (de) Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee