PT1054874E - Derivados de aminofenil-isoxazolina substituidos uteis como anti-microbianos - Google Patents
Derivados de aminofenil-isoxazolina substituidos uteis como anti-microbianosInfo
- Publication number
- PT1054874E PT1054874E PT99904393T PT99904393T PT1054874E PT 1054874 E PT1054874 E PT 1054874E PT 99904393 T PT99904393 T PT 99904393T PT 99904393 T PT99904393 T PT 99904393T PT 1054874 E PT1054874 E PT 1054874E
- Authority
- PT
- Portugal
- Prior art keywords
- aminofenyl
- microbials
- utilized
- isoxazoline derivatives
- isoxazoline
- Prior art date
Links
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002547 isoxazolines Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7512698P | 1998-02-13 | 1998-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1054874E true PT1054874E (pt) | 2003-01-31 |
Family
ID=22123719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99904393T PT1054874E (pt) | 1998-02-13 | 1999-02-03 | Derivados de aminofenil-isoxazolina substituidos uteis como anti-microbianos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6069141A (pt) |
| EP (1) | EP1054874B1 (pt) |
| JP (1) | JP2002503655A (pt) |
| AT (1) | ATE222894T1 (pt) |
| AU (1) | AU757197B2 (pt) |
| CA (1) | CA2315735A1 (pt) |
| DE (1) | DE69902634T2 (pt) |
| DK (1) | DK1054874T3 (pt) |
| ES (1) | ES2182485T3 (pt) |
| NZ (1) | NZ506292A (pt) |
| PT (1) | PT1054874E (pt) |
| WO (1) | WO1999041244A1 (pt) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200003595T2 (tr) | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
| EP1102755B1 (en) | 1998-08-07 | 2006-01-04 | Chiron Corporation | Substituted isoxazole derivatives as estrogen receptor modulators |
| US6297242B1 (en) * | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6861433B2 (en) | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| ES2256331T3 (es) | 2000-12-21 | 2006-07-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas. |
| ES2180456B1 (es) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| EP1443930A1 (en) * | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazoline derivatives useful as antimicrobials |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| WO2004033449A1 (en) * | 2002-10-10 | 2004-04-22 | Pharmacia & Upjohn Company Llc | Antimicrobial 1-aryl dihydropyridone compounds |
| BRPI0413018B8 (pt) * | 2003-07-30 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, e, uso de um composto |
| GB0403629D0 (en) * | 2004-02-19 | 2004-03-24 | Imp College Innovations Ltd | Methods |
| AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| CA2580762A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| EP1807085B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| WO2006124897A2 (en) * | 2005-05-13 | 2006-11-23 | Lexicon Genetics Incorporated | Methods and compositions for improving cognition |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| WO2007024789A1 (en) * | 2005-08-24 | 2007-03-01 | Lexicon Genetics Incorporated | Pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use |
| CN101070308B (zh) * | 2007-06-19 | 2011-05-04 | 天津药物研究院 | 异噁唑啉衍生物及其用途 |
| CN101220000B (zh) * | 2007-12-28 | 2010-12-22 | 天津药物研究院 | 酰氯和磺酰氯类衍生物及其用途 |
| WO2009102761A1 (en) * | 2008-02-12 | 2009-08-20 | Bristol-Myers Squibb Company | 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors |
| CN101675931B (zh) * | 2008-09-19 | 2011-09-07 | 天津药物研究院 | 酰氯和磺酰氯类衍生物在制备抗肿瘤药物的用途 |
| CN101781294B (zh) * | 2010-03-10 | 2012-02-01 | 天津药物研究院 | 一类咪唑的衍生物、其制备方法和用途 |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| DK3300500T3 (da) | 2015-05-20 | 2020-05-18 | Amgen Inc | Triazolagonister af apj-receptoren |
| WO2017192485A1 (en) | 2016-05-03 | 2017-11-09 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
| EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| WO2018093576A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
| EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| EP3576742B1 (en) * | 2017-02-03 | 2025-07-02 | The Broad Institute, Inc. | 6-[3,5-dihalogeno-4-(morpholin-4-yl)phenyl]-5-methyl-4,5-dihydropyridazin-3(2h)-one, modulators of pde3a or 3b for use in the treatment of cancer |
| US11149040B2 (en) | 2017-11-03 | 2021-10-19 | Amgen Inc. | Fused triazole agonists of the APJ receptor |
| WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
| WO2021000297A1 (en) * | 2019-07-03 | 2021-01-07 | Merck Sharp & Dohme Corp. | Compounds and methods of use thereof as antibacterial agents |
| CN113372276B (zh) * | 2021-05-25 | 2022-04-22 | 三峡大学 | 吲唑类衍生物及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL137326C (pt) * | 1967-08-26 | |||
| IE44819B1 (en) * | 1976-06-14 | 1982-04-07 | Lilly Co Eli | Isoxazoline derivatives and their use as fungicides |
| US4283403A (en) * | 1976-06-14 | 1981-08-11 | Eli Lilly And Company | Substituted isoxazolines for control of plant phytopathogens |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| EP0730591B1 (en) * | 1993-11-22 | 1999-07-14 | PHARMACIA & UPJOHN COMPANY | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
| WO1995014680A1 (en) * | 1993-11-26 | 1995-06-01 | Pfizer Inc. | 3-aryl-2-isoxazolines as antiinflammatory agents |
| JPH0873455A (ja) * | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
| JP3933198B2 (ja) * | 1994-10-26 | 2007-06-20 | ファルマシア・アンド・アップジョン・カンパニー | フェニルオキサゾリジノン抗菌剤 |
| DK0807112T3 (da) * | 1995-02-03 | 2001-12-17 | Upjohn Co | Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon |
| ZA969622B (en) * | 1995-12-13 | 1998-05-15 | Upjohn Co | Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring. |
| DE69716925T2 (de) * | 1996-08-21 | 2003-09-11 | Pharmacia & Upjohn Co., Kalamazoo | Isoxazoline derivate und ihre verwendung als antimikroben |
| CN1138765C (zh) * | 1997-05-30 | 2004-02-18 | 法玛西雅厄普约翰美国公司 | 带有硫代羰基功能基的噁唑烷酮抗菌剂 |
-
1999
- 1999-02-03 US US09/243,871 patent/US6069141A/en not_active Expired - Fee Related
- 1999-02-03 EP EP99904393A patent/EP1054874B1/en not_active Expired - Lifetime
- 1999-02-03 AU AU24797/99A patent/AU757197B2/en not_active Ceased
- 1999-02-03 ES ES99904393T patent/ES2182485T3/es not_active Expired - Lifetime
- 1999-02-03 DK DK99904393T patent/DK1054874T3/da active
- 1999-02-03 JP JP2000531439A patent/JP2002503655A/ja active Pending
- 1999-02-03 DE DE69902634T patent/DE69902634T2/de not_active Expired - Fee Related
- 1999-02-03 AT AT99904393T patent/ATE222894T1/de not_active IP Right Cessation
- 1999-02-03 WO PCT/US1999/001854 patent/WO1999041244A1/en not_active Ceased
- 1999-02-03 NZ NZ506292A patent/NZ506292A/en unknown
- 1999-02-03 CA CA002315735A patent/CA2315735A1/en not_active Abandoned
- 1999-02-03 PT PT99904393T patent/PT1054874E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2182485T3 (es) | 2003-03-01 |
| EP1054874B1 (en) | 2002-08-28 |
| EP1054874A1 (en) | 2000-11-29 |
| NZ506292A (en) | 2003-05-30 |
| WO1999041244A1 (en) | 1999-08-19 |
| JP2002503655A (ja) | 2002-02-05 |
| DK1054874T3 (da) | 2002-12-30 |
| US6069141A (en) | 2000-05-30 |
| AU2479799A (en) | 1999-08-30 |
| CA2315735A1 (en) | 1999-08-19 |
| DE69902634D1 (de) | 2002-10-02 |
| AU757197B2 (en) | 2003-02-06 |
| DE69902634T2 (de) | 2003-04-24 |
| ATE222894T1 (de) | 2002-09-15 |
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