ATE204281T1 - Rapamycinamidinocarbamate und diese enthaltende pharmazeutische zubereitungen - Google Patents
Rapamycinamidinocarbamate und diese enthaltende pharmazeutische zubereitungenInfo
- Publication number
- ATE204281T1 ATE204281T1 AT95922295T AT95922295T ATE204281T1 AT E204281 T1 ATE204281 T1 AT E204281T1 AT 95922295 T AT95922295 T AT 95922295T AT 95922295 T AT95922295 T AT 95922295T AT E204281 T1 ATE204281 T1 AT E204281T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- rapamycinamidinocarbamates
- alkynyl
- alkenyl
- alkyl
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/259,763 US5463048A (en) | 1994-06-14 | 1994-06-14 | Rapamycin amidino carbamates |
| PCT/US1995/007412 WO1995034565A1 (en) | 1994-06-14 | 1995-06-09 | Rapamycin amidino carbamates and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204281T1 true ATE204281T1 (de) | 2001-09-15 |
Family
ID=22986267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95922295T ATE204281T1 (de) | 1994-06-14 | 1995-06-09 | Rapamycinamidinocarbamate und diese enthaltende pharmazeutische zubereitungen |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US5463048A (de) |
| EP (1) | EP0765329B1 (de) |
| JP (1) | JPH10501268A (de) |
| AT (1) | ATE204281T1 (de) |
| AU (1) | AU2703295A (de) |
| CA (1) | CA2192972A1 (de) |
| DE (1) | DE69522225T2 (de) |
| DK (1) | DK0765329T3 (de) |
| ES (1) | ES2159641T3 (de) |
| GR (1) | GR3036940T3 (de) |
| PT (1) | PT765329E (de) |
| WO (1) | WO1995034565A1 (de) |
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| US5023264A (en) * | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
| US5023263A (en) * | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
| US5023262A (en) * | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
| US5130307A (en) * | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
| US5221670A (en) * | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
| US5233036A (en) * | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
| US5080899A (en) * | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
| US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
| US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| IL101353A0 (en) * | 1991-04-03 | 1992-11-15 | American Home Prod | Pharmaceutical compositions for treating diabetes |
| US5100883A (en) * | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5194447A (en) * | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
| US5118678A (en) * | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| US5138051A (en) * | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
| US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
| US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US5169851A (en) * | 1991-08-07 | 1992-12-08 | American Home Products Corporation | Rapamycin analog as immunosuppressants and antifungals |
| US5286731A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory bowel disease |
| US5286730A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
| US5151413A (en) * | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
| US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| US5262423A (en) * | 1992-10-29 | 1993-11-16 | American Home Products Corporation | Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents |
| US5260300A (en) * | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
-
1994
- 1994-06-14 US US08/259,763 patent/US5463048A/en not_active Expired - Lifetime
-
1995
- 1995-05-24 US US08/450,771 patent/US5508286A/en not_active Expired - Lifetime
- 1995-05-24 US US08/448,902 patent/US5541192A/en not_active Expired - Lifetime
- 1995-05-24 US US08/448,866 patent/US5541191A/en not_active Expired - Lifetime
- 1995-05-24 US US08/450,772 patent/US5637590A/en not_active Expired - Lifetime
- 1995-06-09 EP EP95922295A patent/EP0765329B1/de not_active Expired - Lifetime
- 1995-06-09 CA CA002192972A patent/CA2192972A1/en not_active Abandoned
- 1995-06-09 AU AU27032/95A patent/AU2703295A/en not_active Abandoned
- 1995-06-09 DK DK95922295T patent/DK0765329T3/da active
- 1995-06-09 PT PT95922295T patent/PT765329E/pt unknown
- 1995-06-09 AT AT95922295T patent/ATE204281T1/de not_active IP Right Cessation
- 1995-06-09 DE DE69522225T patent/DE69522225T2/de not_active Expired - Fee Related
- 1995-06-09 WO PCT/US1995/007412 patent/WO1995034565A1/en not_active Ceased
- 1995-06-09 ES ES95922295T patent/ES2159641T3/es not_active Expired - Lifetime
- 1995-06-09 JP JP8502371A patent/JPH10501268A/ja not_active Withdrawn
-
2001
- 2001-10-18 GR GR20010401809T patent/GR3036940T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0765329A1 (de) | 1997-04-02 |
| EP0765329B1 (de) | 2001-08-16 |
| ES2159641T3 (es) | 2001-10-16 |
| JPH10501268A (ja) | 1998-02-03 |
| US5463048A (en) | 1995-10-31 |
| US5541192A (en) | 1996-07-30 |
| PT765329E (pt) | 2001-12-28 |
| HK1011030A1 (en) | 1999-07-02 |
| US5637590A (en) | 1997-06-10 |
| DK0765329T3 (da) | 2001-10-08 |
| DE69522225T2 (de) | 2002-03-21 |
| US5508286A (en) | 1996-04-16 |
| WO1995034565A1 (en) | 1995-12-21 |
| US5541191A (en) | 1996-07-30 |
| DE69522225D1 (de) | 2001-09-20 |
| CA2192972A1 (en) | 1995-12-21 |
| AU2703295A (en) | 1996-01-05 |
| GR3036940T3 (en) | 2002-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |