PL1735321T3 - Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała - Google Patents

Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała

Info

Publication number: PL1735321T3
Authority: PL; Poland
Prior art keywords: esters; rapamycin; dicarboxylic acid; precursors; antibodies
Prior art date: 2004-04-14

Application number

PL05735488T

Other languages

English (en)

Inventor

Jianxin Gu

Ping Cai

Mark E Ruppen

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-14

Filing date

2005-04-12

Publication date

2009-04-30

2005-04-12 Application filed by Wyeth Corp filed Critical Wyeth Corp

2009-04-30 Publication of PL1735321T3 publication Critical patent/PL1735321T3/pl

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 4
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 4
229960002930 sirolimus Drugs 0.000 title abstract 4
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000002243 precursor Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 2
102000004882 Lipase Human genes 0.000 abstract 1
108090001060 Lipase Proteins 0.000 abstract 1
239000004367 Lipase Substances 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
230000001588 bifunctional effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
235000019421 lipase Nutrition 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

PL05735488T 2004-04-14 2005-04-12 Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała PL1735321T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US56196604P	2004-04-14	2004-04-14
PCT/US2005/012268 WO2005105812A1 (en)	2004-04-14	2005-04-12	Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
EP05735488A EP1735321B1 (en)	2004-04-14	2005-04-12	Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies

Publications (1)

Publication Number	Publication Date
PL1735321T3 true PL1735321T3 (pl)	2009-04-30

Family

ID=34965703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL05735488T PL1735321T3 (pl)	2004-04-14	2005-04-12	Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała

Country Status (14)

Country	Link
US (2)	US7445916B2 (pl)
EP (1)	EP1735321B1 (pl)
JP (1)	JP2007532655A (pl)
CN (1)	CN1942478A (pl)
AT (1)	ATE410431T1 (pl)
AU (1)	AU2005238432A1 (pl)
BR (1)	BRPI0509810A (pl)
CA (1)	CA2562962A1 (pl)
DE (1)	DE602005010228D1 (pl)
DK (1)	DK1735321T3 (pl)
ES (1)	ES2313328T3 (pl)
MX (1)	MXPA06011882A (pl)
PL (1)	PL1735321T3 (pl)
WO (1)	WO2005105812A1 (pl)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR040693A1 (es)	2002-07-30	2005-04-13	Wyeth Corp	Formulaciones parenterales
PL1735321T3 (pl) *	2004-04-14	2009-04-30	Wyeth Corp	Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała
CN1946852A (zh) *	2004-04-27	2007-04-11	惠氏公司	利用雷帕霉素特异性甲基化酶标记雷帕霉素
CA2577011A1 (en) *	2004-08-10	2006-04-13	Wyeth	Cci-779 derivatives and methods of making same
CN101321770A (zh) *	2005-12-07	2008-12-10	惠氏公司	由雷帕霉素42-酯硼酸酯制备雷帕霉素42-酯的可放大方法
AR058282A1 (es) *	2005-12-07	2008-01-30	Wyeth Corp	Forma cristalina purificada de cci-779, un proceso para la preparacion del mismo, un metodo para monitorear la cristalizacion del cci-779, un kit y una composicion farmaceutica que lo comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer.
WO2007067566A2 (en) *	2005-12-07	2007-06-14	Wyeth	Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
CN101394867A (zh) *	2006-03-07	2009-03-25	惠氏公司	大环内酯类免疫抑制剂的水溶性聚乙二醇结合物的制备方法
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US8414526B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US9737640B2 (en)	2006-11-20	2017-08-22	Lutonix, Inc.	Drug releasing coatings for medical devices
US8425459B2 (en)	2006-11-20	2013-04-23	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en)	2006-11-20	2008-11-13	Lixiao Wang	Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8998846B2 (en)	2006-11-20	2015-04-07	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US8414525B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8414910B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8430055B2 (en)	2008-08-29	2013-04-30	Lutonix, Inc.	Methods and apparatuses for coating balloon catheters
US8414909B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US9700704B2 (en)	2006-11-20	2017-07-11	Lutonix, Inc.	Drug releasing coatings for balloon catheters
TW200845960A (en) *	2007-04-05	2008-12-01	Wyeth Corp	Wortmannin-rapalog conjugate and uses thereof
ES2645692T3 (es)	2008-11-11	2017-12-07	The Board Of Regents,The University Of Texas System	Microcápsulas de rapamicina y su uso para el tratamiento del cáncer
US9283211B1 (en)	2009-11-11	2016-03-15	Rapamycin Holdings, Llc	Oral rapamycin preparation and use for stomatitis
DK2885007T3 (en) *	2012-08-16	2018-12-03	Pfizer	Methods for glycoconjugation and compositions
WO2014160328A1 (en)	2013-03-13	2014-10-02	The Board Of Regents Of The University Of Texas System	Mtor inhibitors for prevention of intestinal polyp growth
EP3089737B1 (en)	2013-12-31	2021-11-03	Rapamycin Holdings, LLC	Oral rapamycin nanoparticle preparations and use
US9700544B2 (en)	2013-12-31	2017-07-11	Neal K Vail	Oral rapamycin nanoparticle preparations
US20210154372A1 (en)	2017-05-15	2021-05-27	C.R. Bard, Inc.	Medical device with drug-eluting coating and intermediate layer
EP3880266B1 (en)	2018-11-14	2025-05-07	Lutonix, Inc.	Medical device with drug-eluting coating on modified device surface
EP3952937A1 (en)	2019-04-08	2022-02-16	Bard Peripheral Vascular, Inc.	Medical device with drug-eluting coating on modified device surface
CN118027062B (zh) *	2023-11-03	2025-02-14	沈阳药科大学	一种雷帕霉素前药及其纳米制剂的制备和应用
GB202415232D0 (en)	2024-10-16	2024-11-27	Nacamed As	Composition

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA737247B (en)	1972-09-29	1975-04-30	Ayerst Mckenna & Harrison	Rapamycin and process of preparation
US4316885A (en)	1980-08-25	1982-02-23	Ayerst, Mckenna And Harrison, Inc.	Acyl derivatives of rapamycin
US4650803A (en)	1985-12-06	1987-03-17	University Of Kansas	Prodrugs of rapamycin
US5210030A (en)	1990-06-25	1993-05-11	Merck & Co., Inc.	Process for selectively acylating immunomycin
US5023264A (en)	1990-07-16	1991-06-11	American Home Products Corporation	Rapamycin oximes
PT98990A (pt)	1990-09-19	1992-08-31	American Home Prod	Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5221670A (en)	1990-09-19	1993-06-22	American Home Products Corporation	Rapamycin esters
US5378696A (en)	1990-09-19	1995-01-03	American Home Products Corporation	Rapamycin esters
US5130307A (en)	1990-09-28	1992-07-14	American Home Products Corporation	Aminoesters of rapamycin
US5233036A (en)	1990-10-16	1993-08-03	American Home Products Corporation	Rapamycin alkoxyesters
US5078999A (en)	1991-02-22	1992-01-07	American Home Products Corporation	Method of treating systemic lupus erythematosus
US5080899A (en)	1991-02-22	1992-01-14	American Home Products Corporation	Method of treating pulmonary inflammation
US5120842A (en)	1991-04-01	1992-06-09	American Home Products Corporation	Silyl ethers of rapamycin
US5100883A (en)	1991-04-08	1992-03-31	American Home Products Corporation	Fluorinated esters of rapamycin
US5118678A (en)	1991-04-17	1992-06-02	American Home Products Corporation	Carbamates of rapamycin
US5118667A (en)	1991-05-03	1992-06-02	Celtrix Pharmaceuticals, Inc.	Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5130507A (en) *	1991-05-23	1992-07-14	Eaton Corporation	Capacitive switch assembly
DK0525960T3 (da)	1991-06-18	1996-04-15	American Home Prod	Anvendelse af rapamycin til behandling af T-celle leukæmi/lymfon
US5162333A (en)	1991-09-11	1992-11-10	American Home Products Corporation	Aminodiesters of rapamycin
US5177203A (en)	1992-03-05	1993-01-05	American Home Products Corporation	Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
US5256790A (en)	1992-08-13	1993-10-26	American Home Products Corporation	27-hydroxyrapamycin and derivatives thereof
GB9221220D0 (en)	1992-10-09	1992-11-25	Sandoz Ag	Organic componds
US5434260A (en)	1992-10-13	1995-07-18	American Home Products Corporation	Carbamates of rapamycin
US5480989A (en)	1992-10-13	1996-01-02	American Home Products Corporation	Carbamates of rapamycin
US5302584A (en)	1992-10-13	1994-04-12	American Home Products Corporation	Carbamates of rapamycin
US5489680A (en)	1992-10-13	1996-02-06	American Home Products Corporation	Carbamates of rapamycin
US5411967A (en)	1992-10-13	1995-05-02	American Home Products Corporation	Carbamates of rapamycin
US5480988A (en)	1992-10-13	1996-01-02	American Home Products Corporation	Carbamates of rapamycin
US5262423A (en)	1992-10-29	1993-11-16	American Home Products Corporation	Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
US5258389A (en)	1992-11-09	1993-11-02	Merck & Co., Inc.	O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
US5260300A (en)	1992-11-19	1993-11-09	American Home Products Corporation	Rapamycin carbonate esters as immuno-suppressant agents
US5252579A (en)	1993-02-16	1993-10-12	American Home Products Corporation	Macrocyclic immunomodulators
GB9307491D0 (en)	1993-04-08	1993-06-02	Sandoz Ltd	Organic compounds
US5504091A (en)	1993-04-23	1996-04-02	American Home Products Corporation	Biotin esters of rapamycin
ES2295093T3 (es)	1993-04-23	2008-04-16	Wyeth	Conjugados y anticuerpos de rapamicina.
WO1994025072A1 (en)	1993-04-23	1994-11-10	American Home Products Corporation	Rapamycin conjugates and antibodies
GB2281294A (en)	1993-08-23	1995-03-01	Fujisawa Pharmaceutical Co	Process for producing half esters of the macrolide FK506
US5378836A (en)	1993-10-08	1995-01-03	American Home Products Corporation	Rapamycin oximes and hydrazones
US5391730A (en)	1993-10-08	1995-02-21	American Home Products Corporation	Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5373014A (en)	1993-10-08	1994-12-13	American Home Products Corporation	Rapamycin oximes
US5385908A (en)	1993-11-22	1995-01-31	American Home Products Corporation	Hindered esters of rapamycin
US5385910A (en)	1993-11-22	1995-01-31	American Home Products Corporation	Gem-distributed esters of rapamycin
US5385909A (en)	1993-11-22	1995-01-31	American Home Products Corporation	Heterocyclic esters of rapamycin
US5389639A (en)	1993-12-29	1995-02-14	American Home Products Company	Amino alkanoic esters of rapamycin
US5362718A (en)	1994-04-18	1994-11-08	American Home Products Corporation	Rapamycin hydroxyesters
US5463048A (en)	1994-06-14	1995-10-31	American Home Products Corporation	Rapamycin amidino carbamates
US5491231A (en)	1994-11-28	1996-02-13	American Home Products Corporation	Hindered N-oxide esters of rapamycin
US5563145A (en)	1994-12-07	1996-10-08	American Home Products Corporation	Rapamycin 42-oximes and hydroxylamines
US6261813B1 (en)	1995-09-11	2001-07-17	Albany Molecular Research, Inc.	Two step enzymatic acylation
US5780462A (en)	1995-12-27	1998-07-14	American Home Products Corporation	Water soluble rapamycin esters
CA2286311A1 (en)	1997-04-09	1998-10-15	Isotechnika, Inc.	Method for production of antibodies to specific sites of rapamycin
US6277983B1 (en)	2000-09-27	2001-08-21	American Home Products Corporation	Regioselective synthesis of rapamycin derivatives
US7153983B2 (en) *	2002-03-25	2006-12-26	Council Of Scientific And Industrial Research	Chemo-enzymatic process for the preparation of opticaly enriched β-benzyl-γ-butyrolactones
US6745478B2 (en)	2002-07-18	2004-06-08	Delillo Dominick D.	Multi-purpose work knife
JP4227649B2 (ja)	2003-08-07	2009-02-18	ワイス	Ｃｃｉ−７７９の位置選択的合成
PL1735321T3 (pl) *	2004-04-14	2009-04-30	Wyeth Corp	Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała
MXPA06011883A (es) *	2004-04-14	2006-12-14	Wyeth Corp	42-ester de prolina-rapamicina con acido 2,2-bis(hidroximetil)propionico y sintesis enzimatica de dos etapas de 42-ester de prolina-rapamicina con acido 2,2-bis(hidroximetil)propionico y 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionic
JP4224115B2 (ja) *	2004-04-14	2009-02-12	ワイス	ラパマイシン４２−エステル誘導体の位置特異的合成
JP2008505176A (ja) *	2004-06-30	2008-02-21	コンビナトアールエックスインコーポレーティッド	代謝障害を治療するための方法および試薬

2005
- 2005-04-12 PL PL05735488T patent/PL1735321T3/pl unknown
- 2005-04-12 BR BRPI0509810-6A patent/BRPI0509810A/pt not_active IP Right Cessation
- 2005-04-12 ES ES05735488T patent/ES2313328T3/es not_active Expired - Lifetime
- 2005-04-12 EP EP05735488A patent/EP1735321B1/en not_active Expired - Lifetime
- 2005-04-12 WO PCT/US2005/012268 patent/WO2005105812A1/en not_active Ceased
- 2005-04-12 AU AU2005238432A patent/AU2005238432A1/en not_active Withdrawn
- 2005-04-12 MX MXPA06011882A patent/MXPA06011882A/es active IP Right Grant
- 2005-04-12 CA CA002562962A patent/CA2562962A1/en not_active Abandoned
- 2005-04-12 DK DK05735488T patent/DK1735321T3/da active
- 2005-04-12 JP JP2007508443A patent/JP2007532655A/ja not_active Withdrawn
- 2005-04-12 US US11/104,349 patent/US7445916B2/en not_active Expired - Lifetime
- 2005-04-12 DE DE602005010228T patent/DE602005010228D1/de not_active Expired - Fee Related
- 2005-04-12 CN CNA200580011299XA patent/CN1942478A/zh not_active Withdrawn
- 2005-04-12 AT AT05735488T patent/ATE410431T1/de not_active IP Right Cessation
2008
- 2008-09-29 US US12/240,230 patent/US7625726B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BRPI0509810A (pt)	2007-09-18
US20050234087A1 (en)	2005-10-20
WO2005105812A1 (en)	2005-11-10
EP1735321B1 (en)	2008-10-08
US20090029426A1 (en)	2009-01-29
DK1735321T3 (da)	2009-01-12
AU2005238432A1 (en)	2005-11-10
US7625726B2 (en)	2009-12-01
DE602005010228D1 (de)	2008-11-20
ATE410431T1 (de)	2008-10-15
MXPA06011882A (es)	2006-12-14
US7445916B2 (en)	2008-11-04
CA2562962A1 (en)	2005-11-10
JP2007532655A (ja)	2007-11-15
EP1735321A1 (en)	2006-12-27
ES2313328T3 (es)	2009-03-01
CN1942478A (zh)	2007-04-04

Publication	Publication Date	Title
PL1735321T3 (pl)	2009-04-30	Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała
WO2006078809A3 (en)	2007-07-12	Method for the preparation of maytansinoid esters
WO2003082795A3 (en)	2003-12-24	METHODS OF MANUFACTURING DERIVATIVES OF β-HYDROXYCARBOXYLIC ACIDS
EP1077212A4 (en)	2001-11-21	METHOD FOR PRODUCING VIVIVES OF 6-CYANOMETHYL-1,3-DIOXANE-4-ACETIC ACID
EP1660669A4 (en)	2008-10-01	ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
TW200745015A (en)	2007-12-16	Process for the preparation of carboxylic acids and/or derivatives thereof
EP2514828A3 (en)	2013-07-03	Methods for the production of ansamitocins
HUP0402444A2 (en)	2006-11-28	Process for enhancing the biogas production of thermophyl anaerobic fermenter
WO2007147827A3 (en)	2008-06-12	Production of pravastatin
Gruttadauria et al.	2004	Short and efficient chemoenzymatic synthesis of goniothalamin
WO2004016625A3 (en)	2005-05-06	Enzyme catalyzed organosilicon esters and amides
WO2010037653A9 (en)	2010-05-27	Apparatus and process for gas phase fluidised bed polymerisation reaction
WO2004104205A3 (en)	2005-08-04	Enzymatic preparation of chiral indole esters
Klomp et al.	2005	Enzymatic kinetic resolution of tropic acid
ZA200409433B (en)	2005-07-14	Process for the preparation of carboxylic acid esters.
HUP0204173A2 (hu)	2003-03-28	Eljárás konjugált linolénsav előállítására
TW200609211A (en)	2006-03-16	Esterification catalyst and process therewith
TW200609268A (en)	2006-03-16	Composition comprising titanium and clay and process therewith
WO2007026373A3 (en)	2007-07-12	Process for preparing rivastigmine
EP1715480A3 (en)	2009-01-07	Magnetic disk drive
Zheng	1997	Photochemical reactions of 2, 3-dihydro-4-pyridones and their application in natural product synthesis: Total synthesis of plumerinine and perhydrohistrionicotoxin.
WO2006133332A3 (en)	2007-02-01	Enzyme-catalyzed process for the preparation of macrocyclic polyester oligomers
AU5416600A (en)	2001-01-02	Process for the preparation of fumagillin
HUP0105000A3 (en)	2004-03-01	Process for producing hmg-coa reductase inhibitors
Schink	1993	1, 4-Allylic stereocontrol via palladium catalysis in the synthesis of some natural products.