IL120991A - Process for the preparation of cephem-and isooxacephem derivatives and certain such compounds - Google Patents

Process for the preparation of cephem-and isooxacephem derivatives and certain such compounds

Info

Publication number: IL120991A
Authority: IL; Israel
Prior art keywords: lower alkyl; aryl; compounds; formula; alkoxy
Prior art date: 1996-06-10

Application number

IL12099197A

Other languages

English (en)

Other versions

IL120991A0 (en

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-10

Filing date

1997-06-04

Publication date

2000-07-26

1997-06-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1997-11-20 Publication of IL120991A0 publication Critical patent/IL120991A0/xx

2000-07-26 Publication of IL120991A publication Critical patent/IL120991A/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
-1 carboxy, amino Chemical group 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL12099197A 1996-06-10 1997-06-04 Process for the preparation of cephem-and isooxacephem derivatives and certain such compounds IL120991A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96109239		1996-06-10

Publications (2)

Publication Number	Publication Date
IL120991A0 IL120991A0 (en)	1997-11-20
IL120991A true IL120991A (en)	2000-07-26

Family

ID=8222876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12099197A IL120991A (en)	1996-06-10	1997-06-04	Process for the preparation of cephem-and isooxacephem derivatives and certain such compounds

Country Status (21)

Country	Link
US (2)	US5883247A (de)
EP (1)	EP0812846B1 (de)
JP (1)	JP2950795B2 (de)
KR (1)	KR100258652B1 (de)
CN (1)	CN1167766A (de)
AT (1)	ATE204282T1 (de)
AU (1)	AU697970B2 (de)
BR (1)	BR9703517A (de)
CA (1)	CA2206199A1 (de)
CZ (1)	CZ176997A3 (de)
DE (1)	DE69706099T2 (de)
DK (1)	DK0812846T3 (de)
ES (1)	ES2162158T3 (de)
HU (1)	HUP9701013A3 (de)
IL (1)	IL120991A (de)
NO (1)	NO972461L (de)
NZ (1)	NZ314991A (de)
PL (1)	PL320452A1 (de)
TR (1)	TR199700481A2 (de)
TW (1)	TW434244B (de)
ZA (1)	ZA974885B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403049B (de)	1995-08-14	1997-10-27	Biochemie Gmbh	Abreicherung von 7-adca in 3-vinyl-aca
ES2281090T3 (es)	1996-11-06	2007-09-16	Basilea Pharmaceutica Ag	Derivados de vinilpirrolidona-cefalosporina.
WO2000032605A1 (en) *	1998-12-03	2000-06-08	F. Hoffmann-La Roche Ag	Bi-pyrrolidinylvinl (carba) cephalosporins
KR100320671B1 (ko) *	1999-11-04	2002-01-17	이균철	방폭 방탄 안전 전투화
US6504025B2 (en) *	2000-05-24	2003-01-07	Basilea Pharmaceutica Ag	Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
KR101058135B1 (ko)	2008-04-04	2011-08-24	대웅바이오 주식회사	세프디니르 합성에 유용한 중간체 및 이를 이용하여세프디니르를 제조하는 방법
WO2011029596A1 (en)	2009-09-11	2011-03-17	Lonza Ltd	Process for preparing 2-aminothiazol-4-yl-acetic acid derivates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3971778A (en) *	1972-05-12	1976-07-27	Glaxo Laboratories Limited	Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
DE2716677C2 (de) *	1977-04-15	1985-10-10	Hoechst Ag, 6230 Frankfurt	Cephemderivate und Verfahren zu ihrer Herstellung
DE2824559C2 (de) *	1977-06-10	1985-01-10	Yamanouchi Pharmaceutical Co., Ltd., Tokio / Tokyo	7α-Methoxy-7β-(4-substituierte-methylen-1,3-dithietan-2-yl)-carboxamido-3-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu deren Herstellung sowie ihre Verwendung
FR2439785A1 (fr) *	1978-10-23	1980-05-23	Roussel Uclaf	Nouveau procede de preparation des produits derives de l'acide 7-amino-thiazolyl acetamido cephalosporanique
US4409214A (en) *	1979-11-19	1983-10-11	Fujisawa Pharmaceutical, Co., Ltd.	7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4576749A (en) *	1983-10-03	1986-03-18	E. R. Squibb & Sons, Inc.	3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones
TW212181B (de) *	1992-02-14	1993-09-01	Hoechst Ag
KR950013578B1 (ko) *	1993-04-10	1995-11-09	주식회사럭키	신규 티아(디아)졸 초산의 반응성 티오포스페이트 유도체 및 그의 제조방법
PT620225E (pt) *	1993-04-16	2003-03-31	Basilea Pharmaceutica Ag	Derivados de cefalosporina
US5523400A (en) *	1993-04-16	1996-06-04	Hoffmann-La Roche Inc.	Cephalosporin antibiotics
WO1996012712A1 (en) *	1994-10-24	1996-05-02	Miwon Co., Ltd.	Reactive phosphate derivatives of thiazolylacetic acid and process for preparing cephalosporin antibiotics using the same
WO1996026943A1 (en) *	1995-02-27	1996-09-06	F.Hoffmann-La Roche Ag	Derivatives of 3-pyrrolidylidene-2-one-cephalosporines
ATE218572T1 (de) *	1995-12-27	2002-06-15	Hanmi Pharmaceutical Co Ltd	Verfahren zur herstellung von cefdinir

1997
- 1997-05-14 US US08/856,070 patent/US5883247A/en not_active Expired - Fee Related
- 1997-05-23 TW TW086106970A patent/TW434244B/zh active
- 1997-05-27 CA CA002206199A patent/CA2206199A1/en not_active Abandoned
- 1997-05-29 NO NO972461A patent/NO972461L/no not_active Application Discontinuation
- 1997-06-03 ZA ZA974885A patent/ZA974885B/xx unknown
- 1997-06-03 NZ NZ314991A patent/NZ314991A/xx unknown
- 1997-06-04 IL IL12099197A patent/IL120991A/xx not_active IP Right Cessation
- 1997-06-05 EP EP97109069A patent/EP0812846B1/de not_active Expired - Lifetime
- 1997-06-05 AT AT97109069T patent/ATE204282T1/de not_active IP Right Cessation
- 1997-06-05 ES ES97109069T patent/ES2162158T3/es not_active Expired - Lifetime
- 1997-06-05 DE DE69706099T patent/DE69706099T2/de not_active Expired - Fee Related
- 1997-06-05 DK DK97109069T patent/DK0812846T3/da active
- 1997-06-06 AU AU24746/97A patent/AU697970B2/en not_active Ceased
- 1997-06-06 HU HU9701013A patent/HUP9701013A3/hu unknown
- 1997-06-09 JP JP9151131A patent/JP2950795B2/ja not_active Expired - Fee Related
- 1997-06-09 TR TR97/00481A patent/TR199700481A2/xx unknown
- 1997-06-09 PL PL97320452A patent/PL320452A1/xx unknown
- 1997-06-09 CN CN97105447A patent/CN1167766A/zh active Pending
- 1997-06-09 CZ CZ971769A patent/CZ176997A3/cs unknown
- 1997-06-09 KR KR1019970023548A patent/KR100258652B1/ko not_active Expired - Fee Related
- 1997-06-10 BR BR9703517A patent/BR9703517A/pt active Search and Examination
1998
- 1998-05-20 US US09/081,759 patent/US5919939A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP9701013A1 (hu)	1998-08-28
IL120991A0 (en)	1997-11-20
US5919939A (en)	1999-07-06
ATE204282T1 (de)	2001-09-15
NO972461L (no)	1997-12-11
KR100258652B1 (ko)	2000-07-01
AU697970B2 (en)	1998-10-22
US5883247A (en)	1999-03-16
MX9704258A (es)	1998-07-31
DE69706099T2 (de)	2002-05-02
PL320452A1 (en)	1997-12-22
CA2206199A1 (en)	1997-12-10
DE69706099D1 (de)	2001-09-20
NO972461D0 (no)	1997-05-29
KR980002053A (ko)	1998-03-30
BR9703517A (pt)	1998-12-29
EP0812846A1 (de)	1997-12-17
JP2950795B2 (ja)	1999-09-20
EP0812846B1 (de)	2001-08-16
CN1167766A (zh)	1997-12-17
HU9701013D0 (en)	1997-07-28
HUP9701013A3 (en)	2001-04-28
ZA974885B (en)	1998-08-26
DK0812846T3 (da)	2001-11-12
CZ176997A3 (en)	1997-12-17
TR199700481A2 (xx)	1997-12-21
JPH1059978A (ja)	1998-03-03
NZ314991A (en)	2000-01-28
ES2162158T3 (es)	2001-12-16
AU2474697A (en)	1997-12-18
TW434244B (en)	2001-05-16

Legal Events

Date	Code	Title	Description
2000-12-06	FF	Patent granted
2004-02-19	RH1	Patent not in force

Publication	Publication Date	Title
EP0703902A4 (de)	1996-04-10
AU5261598A (en)	1998-06-10	A1 adenosine receptor antagonists
AU679859B2 (en)	1997-07-10	Novel compound, process for producing the same, and antitumor agent
HUT66219A (en)	1994-10-28	Alcohol or aldehyde derivatives and pharmaceutical compositions containing them, and process for producing compounds and compositions
ATE131470T1 (de)	1995-12-15	Neue arylethenylenderivate und verfahren zu ihrer herstellung
AU692583B2 (en)	1998-06-11	Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
UA27220C2 (uk)	2000-08-15	Спосіб одержання похідних 1-фенілімідазолін-2,5-діону
IL120991A (en)	2000-07-26	Process for the preparation of cephem-and isooxacephem derivatives and certain such compounds
DK0994108T3 (da)	2003-08-18	Fremgangsmåde til fremstilling af 2-hydroxybenzamidderivater
GR3029836T3 (en)	1999-06-30	Process for producing n-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IL141394A0 (en)	2002-03-10	Process for the preparation of imidazodiazepine intermediates
CA2336380A1 (en)	2000-01-13	Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
IL131380A0 (en)	2001-01-28	The use of a compound for the manufacture of a pharmaceutical preparatin for the treatment or prevention of prostate cancer
DE69803618D1 (de)	2002-03-14	Verfahren zur Herstellung von 1,7-Diaryl- oder 1,7-Diheteroarylheptan-4-olen und Synthesezwischenprodukte
GR3033353T3 (en)	2000-09-29	Prostaglandin I analogue.
DE69615814D1 (de)	2001-11-15	Uch-15-verbindungen
EP0638552A4 (de)	1995-03-29	Verfahren zur synthese von 4-substituierten azetidinon-derivaten.
EP0827961A4 (de)	1998-08-12	Verfahren zur herstellung von beta-lactam verbindungen
EP0759427A4 (de)	1998-07-08	Verfahren zur herstellung von beta-lactamderivaten