ATE204296T1 - Verfahren zur herstellung von 1-desamino-8-d- arginin-vasopressin - Google Patents

Verfahren zur herstellung von 1-desamino-8-d- arginin-vasopressin

Info

Publication number: ATE204296T1
Authority: AT; Austria
Prior art keywords: arginine vasopressin; ddavp; gln; cys; asn
Prior art date: 1993-06-29

Application number

AT94920616T

Other languages

English (en)

Inventor

Bo Ake Krister Larsson

Thomas Bjoern Mellbrand

Ewa Maria Birgitta Moernstam

Jan Anders Ingemar Roschester

Jan-Ake Skoeldbaeck

Original Assignee

Ferring Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-29

Filing date

1994-06-22

Publication date

2001-09-15

1994-06-22 Application filed by Ferring Bv filed Critical Ferring Bv

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204296T1 publication Critical patent/ATE204296T1/de

Links

NFLWUMRGJYTJIN-PNIOQBSNSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-PNIOQBSNSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 2
108010000437 Deamino Arginine Vasopressin Proteins 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
XMKLTEGSALONPH-UHFFFAOYSA-N 1,2,4,5-tetrazinane-3,6-dione Chemical compound O=C1NNC(=O)NN1 XMKLTEGSALONPH-UHFFFAOYSA-N 0.000 abstract 1
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
108010016626 Dipeptides Proteins 0.000 abstract 1
239000003729 cation exchange resin Substances 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
239000011630 iodine Substances 0.000 abstract 1
238000004255 ion exchange chromatography Methods 0.000 abstract 1
239000003586 protic polar solvent Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

AT94920616T 1993-06-29 1994-06-22 Verfahren zur herstellung von 1-desamino-8-d- arginin-vasopressin ATE204296T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/084,847 US5500413A (en)	1993-06-29	1993-06-29	Process for manufacture of 1-deamino-8-D-arginine vasopressin
PCT/SE1994/000621 WO1995001373A1 (en)	1993-06-29	1994-06-22	Process for manufacture of 1-deamino-8-d-arginine vasopressin

Publications (1)

Publication Number	Publication Date
ATE204296T1 true ATE204296T1 (de)	2001-09-15

Family

ID=22187597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94920616T ATE204296T1 (de)	1993-06-29	1994-06-22	Verfahren zur herstellung von 1-desamino-8-d- arginin-vasopressin

Country Status (13)

Country	Link
US (1)	US5500413A (de)
EP (1)	EP0710247B1 (de)
JP (1)	JP3453144B2 (de)
KR (1)	KR0163224B1 (de)
CN (1)	CN1040648C (de)
AT (1)	ATE204296T1 (de)
CA (1)	CA2166297C (de)
DE (1)	DE69427985T2 (de)
DK (1)	DK0710247T3 (de)
ES (1)	ES2159562T3 (de)
GR (1)	GR3036935T3 (de)
PT (1)	PT710247E (de)
WO (1)	WO1995001373A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5674850A (en) *	1993-12-23	1997-10-07	Ferring Ab	High purity desmopressin produced in large single batches
EP0710243B1 (de) *	1993-06-29	2000-06-14	Ferring B.V.	Synthese zyklischer peptide
SE9400918L (sv) *	1994-03-18	1995-09-19	Anne Fjellstad Paulsen	Stabiliserad komposition för oral administrering av peptider
US5763398A (en) *	1996-06-20	1998-06-09	Ferring B.V.	Nasal administration of desmopressin
US5922680A (en) *	1996-10-23	1999-07-13	Ferring, B.V.	Stabilized composition for oral administration of peptides
US7153845B2 (en) *	1998-08-25	2006-12-26	Columbia Laboratories, Inc.	Bioadhesive progressive hydration tablets
US8765177B2 (en) *	1997-09-12	2014-07-01	Columbia Laboratories, Inc.	Bioadhesive progressive hydration tablets
EP2316468A1 (de)	2002-02-22	2011-05-04	Shire LLC	Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
GB0210397D0 (en) *	2002-05-07	2002-06-12	Ferring Bv	Pharmaceutical formulations
DK1511761T3 (da) *	2003-04-07	2006-11-27	Novetide Ltd	Fremgangsmåde til fremstilling af cykliske peptider
WO2005046707A1 (en) *	2003-11-10	2005-05-26	Fein Seymour H	Pharmaceutical compositions including low dosages of desmopressin
PT1530967E (pt) *	2003-11-13	2006-09-29	Ferring Bv	Embalagem blister e uma forma de dosagem solida que compreende desmopressina.
SE0600482L (sv) *	2006-03-02	2006-11-14	Ferring Int Ct Sa	Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
TW200821026A (en) *	2006-09-08	2008-05-16	Wyeth Corp	Arginine wash in protein purification using affinity chromatography
WO2009021007A1 (en)	2007-08-06	2009-02-12	Serenity Pharmaceuticals Corporation	Methods and devices for desmopressin drug delivery
NO3085381T3 (de) *	2008-05-21	2018-09-15
US20100286045A1 (en)	2008-05-21	2010-11-11	Bjarke Mirner Klein	Methods comprising desmopressin
US11963995B2 (en)	2008-05-21	2024-04-23	Ferring B.V.	Methods comprising desmopressin
CA2765221C (en) *	2009-06-18	2017-10-03	Allergan, Inc.	Safe desmopressin administration
JO3371B1 (ar) *	2013-07-26	2019-03-13	Ferring Bv	ناهضات مستقبل فاسوبريسين 2

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH495957A (de) *	1966-09-15	1970-09-15	Ceskoslovenska Akademie Ved	Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
US4271068A (en) *	1968-05-10	1981-06-02	Ciba-Geigy Corporation	Process for the manufacture of cystine-containing peptides
CH517705A (de) *	1969-12-16	1972-01-15	Ciba Geigy Ag	Verfahren zur Herstellung von Cystin-haltigen Peptiden
ZA733419B (en) *	1972-07-04	1974-03-27	Hoffmann La Roche	Nonapeptides and process for the preparation thereof
US3929758A (en) *	1974-09-12	1975-12-30	Armour Pharma	Cyclization of cysteine-containing peptides
US4033940A (en) *	1975-11-12	1977-07-05	Armour Pharmaceutical Company	Cyclization of peptides
US4093610A (en) *	1977-01-31	1978-06-06	American Home Products Corporation	Process for producing triglycyl-lysine vasopressin and intermediates therefor
US4216141A (en) *	1978-07-19	1980-08-05	The Salk Institute For Biological Studies	Method for cyclization of peptides
DE2923787A1 (de) *	1979-06-12	1980-12-18	Max Planck Gesellschaft	Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
IE56021B1 (en) *	1982-10-13	1991-03-27	Akzo Nv	Peptides
SE8306367L (sv) *	1983-11-18	1985-05-19	Ferring Ab	Antidiuretiskt verkande farmaceutiskt preparat
US5066716A (en) *	1988-12-13	1991-11-19	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides

1993
- 1993-06-29 US US08/084,847 patent/US5500413A/en not_active Expired - Lifetime
1994
- 1994-06-22 JP JP50342495A patent/JP3453144B2/ja not_active Expired - Fee Related
- 1994-06-22 WO PCT/SE1994/000621 patent/WO1995001373A1/en not_active Ceased
- 1994-06-22 ES ES94920616T patent/ES2159562T3/es not_active Expired - Lifetime
- 1994-06-22 PT PT94920616T patent/PT710247E/pt unknown
- 1994-06-22 AT AT94920616T patent/ATE204296T1/de active
- 1994-06-22 DE DE69427985T patent/DE69427985T2/de not_active Expired - Lifetime
- 1994-06-22 KR KR1019950706030A patent/KR0163224B1/ko not_active Expired - Fee Related
- 1994-06-22 DK DK94920616T patent/DK0710247T3/da active
- 1994-06-22 CA CA002166297A patent/CA2166297C/en not_active Expired - Fee Related
- 1994-06-22 EP EP94920616A patent/EP0710247B1/de not_active Expired - Lifetime
- 1994-06-22 CN CN94192593A patent/CN1040648C/zh not_active Expired - Fee Related
2001
- 2001-10-18 GR GR20010401803T patent/GR3036935T3/el unknown

Also Published As

Publication number	Publication date
US5500413A (en)	1996-03-19
HK1000910A1 (en)	2002-03-15
JP3453144B2 (ja)	2003-10-06
DE69427985D1 (de)	2001-09-20
GR3036935T3 (en)	2002-01-31
DK0710247T3 (da)	2001-10-01
CN1040648C (zh)	1998-11-11
WO1995001373A1 (en)	1995-01-12
DE69427985T2 (de)	2002-03-28
EP0710247A1 (de)	1996-05-08
PT710247E (pt)	2001-12-28
ES2159562T3 (es)	2001-10-16
CN1125952A (zh)	1996-07-03
JPH09502423A (ja)	1997-03-11
CA2166297A1 (en)	1995-01-12
KR960703411A (ko)	1996-08-17
EP0710247B1 (de)	2001-08-16
KR0163224B1 (ko)	1998-11-16
CA2166297C (en)	2001-03-27

Publication	Publication Date	Title
DE69427985D1 (de)	2001-09-20	Verfahren zur herstellung von 1-desamino-8-d-arginin-vasopressin
AU630951B2 (en)	1992-11-12	Enzymatic removal of a protein amino-terminal sequence
EP0233838A3 (de)	1990-01-31	Neuriten stimulierender Faktor und Prozess für seine Herstellung
DK1396542T3 (da)	2011-06-06	P-selectin ligand protein
EP0192392A3 (en)	1986-11-20	Insulin receptor, its purification, its production in recombinant cells, dna therefor, antibodies to insulin receptor and their preparation, and pharmaceutical compositions containing them
WO1991012270A3 (en)	1991-09-19	Novel platelet aggregation inhibitors from the leech
ATE85345T1 (de)	1993-02-15	Neues cadiodilatin-fragment, prozess zu dessen herstellung und dessen anwendung.
DE69715860D1 (de)	2002-10-31	Verfahren zur herstellung von peptiden
EP0927756A4 (de)	2001-10-10	Proteine mit zellulase-aktivitäten und prozess für ihre herstellung
ES488382A1 (es)	1980-10-01	Procedimiento para la preparacion de lh-rh o de analogos de lh-rh
ATE81856T1 (de)	1992-11-15	Verfahren zur herstellung von 2-alkoxy-n-(1azabicyclo(2.2.2>octan-3-yl)aminobenzamiden.
FR2632302B1 (fr)	1991-02-22	Procede de recuperation d'acide citrique a partir d'une liqueur en contenant
ATE99662T1 (de)	1994-01-15	Verfahren zur herstellung von 1,1-dichlor-1fluorethan.
DE3380819D1 (en)	1989-12-14	A precursor of a c-terminal amidated peptide and production thereof
CA2011378A1 (en)	1990-09-14	Achromobacter protease i gene and gene product thereof
MY108190A (en)	1996-08-30	Curculin b and dna encoding same,and process for production thereof.
ATE323760T1 (de)	2006-05-15	Verfahren zur herstellung eines eine hyaluronidase enthaltenden präparats
JPS57149823A (en)	1982-09-16	Purifying method for brine for electrolysis
PT73587A (en)	1981-09-01	Process for preparing novel peptides
EP0106282A3 (de)	1986-05-14	Herstellung einer Caerulein-Zwischenverbindung
ES8505939A1 (es)	1985-06-16	Procedimiento para preparar compuestos que contienen grupos amida de acido carboxilico
JPS6483058A (en)	1989-03-28	Novel tripeptide compound
ATE33854T1 (de)	1988-05-15	Verfahren zur biotechnischen herstellung von l\|pfels\|ure.
TW243453B (en)	1995-03-21	Cloning and characterization of a cardiac adenylyl cyclase
NO921496L (no)	1987-08-10	Fremgangsmaate for fremstilling av et peptid eller proteinbeslektet med det melanomaforbundne p97-antigen