ATE81856T1 - Verfahren zur herstellung von 2-alkoxy-n-(1azabicyclo(2.2.2>octan-3-yl)aminobenzamiden. - Google Patents

Verfahren zur herstellung von 2-alkoxy-n-(1azabicyclo(2.2.2>octan-3-yl)aminobenzamiden.

Info

Publication number: ATE81856T1
Authority: AT; Austria
Prior art keywords: aminobenzamides; octan; alkoxy; preparation; sup
Prior art date: 1985-02-04

Application number

AT86300728T

Other languages

English (en)

Inventor

Young Sek Lo

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-04

Filing date

1986-02-04

Publication date

1992-11-15

1986-02-04 Application filed by Synthelabo filed Critical Synthelabo

1992-11-15 Application granted granted Critical

1992-11-15 Publication of ATE81856T1 publication Critical patent/ATE81856T1/de

Links

238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
REUAXQZIRFXQML-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-3-amine Chemical class C1CC2C(N)CN1CC2 REUAXQZIRFXQML-UHFFFAOYSA-N 0.000 abstract 1
ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 1
XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229960004050 aminobenzoic acid Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

AT86300728T 1985-02-04 1986-02-04 Verfahren zur herstellung von 2-alkoxy-n-(1azabicyclo(2.2.2>octan-3-yl)aminobenzamiden. ATE81856T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/697,943 US4870181A (en)	1985-02-04	1985-02-04	Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides
EP86300728A EP0190915B1 (de)	1985-02-04	1986-02-04	Verfahren zur Herstellung von 2-Alkoxy-N-(1-azabicyclo[2.2.2]octan-3-yl)aminobenzamiden

Publications (1)

Publication Number	Publication Date
ATE81856T1 true ATE81856T1 (de)	1992-11-15

Family

ID=24803230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86300728T ATE81856T1 (de)	1985-02-04	1986-02-04	Verfahren zur herstellung von 2-alkoxy-n-(1azabicyclo(2.2.2>octan-3-yl)aminobenzamiden.

Country Status (21)

Country	Link
US (1)	US4870181A (de)
EP (1)	EP0190915B1 (de)
JP (1)	JPH0676407B2 (de)
KR (1)	KR930005446B1 (de)
AT (1)	ATE81856T1 (de)
AU (1)	AU589592B2 (de)
CA (1)	CA1288776C (de)
DE (1)	DE3687006T2 (de)
DK (1)	DK170098B1 (de)
FI (1)	FI84913C (de)
GR (1)	GR860320B (de)
HU (1)	HU196796B (de)
IE (1)	IE59396B1 (de)
IL (1)	IL77612A (de)
NO (1)	NO163367C (de)
NZ (1)	NZ215016A (de)
PH (1)	PH21990A (de)
PL (1)	PL148515B1 (de)
PT (1)	PT81956B (de)
YU (1)	YU45763B (de)
ZA (1)	ZA86411B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0272052B1 (de) *	1986-12-16	1992-07-08	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	Angstlösende N-(1-Azabicyclo[2.2.2)oct-3-yl)benzamide und -thiobenzamide
FR2610323B1 (fr) *	1987-02-04	1989-06-23	Delalande Sa	Enantiomeres de configuration absolue s de derives amide de l'amino-3 quinuclidine, leur procede de preparation et leur application en therapeutique
GB8718345D0 (en) *	1987-08-03	1987-09-09	Fordonal Sa	N-substituted benzamides
EP0311724A1 (de) *	1987-10-16	1989-04-19	Synthelabo	Anxiolytische R-N-(1-Azabicyclo[2.2.2]oct-3-yl)-benzamide und -thiobenzamide
US4863919A (en) *	1988-02-01	1989-09-05	A. H. Robins Company, Incorporated	Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
US4892205A (en) *	1988-07-15	1990-01-09	Hoover Universal, Inc.	Concentric ribbed preform and bottle made from same
CA2028235C (en)	1989-10-20	1997-01-21	Fumio Suzuki	Condensed purine derivatives
JP2004506735A (ja)	2000-08-18	2004-03-04	ファルマシア・アンド・アップジョン・カンパニー	疾患治療用キヌクリジン置換アリール化合物
WO2002016357A2 (en)	2000-08-18	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
US20030069296A1 (en) *	2001-08-24	2003-04-10	Wishka Donn G.	Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease
US6852716B2 (en)	2002-02-15	2005-02-08	Pfizer Inc	Substituted-aryl compounds for treatment of disease
US7001900B2 (en) *	2002-02-20	2006-02-21	Pfizer Inc.	Azabicyclic compounds for the treatment of disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3859443A (en) *	1973-11-15	1975-01-07	Merck & Co Inc	Composition and methods of treatment employing acrylanilides as anticoccidial agents
IT1046849B (it) *	1974-06-12	1980-07-31	Snam Progetti	Processo per la preparazione di derivati adeninici macromolecola rizzati e prodotti cosi ottenuti
FI763021A7 (de) *	1975-11-03	1977-05-04	Thomae Gmbh Dr K
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS5936675A (ja) *	1982-07-13	1984-02-28	サンド・アクチエンゲゼルシヤフト	二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
US4593034A (en) *	1984-04-06	1986-06-03	A. H. Robins Company, Inc.	2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides

1985
- 1985-02-04 US US06/697,943 patent/US4870181A/en not_active Expired - Fee Related
1986
- 1986-01-15 IL IL77612A patent/IL77612A/xx not_active IP Right Cessation
- 1986-01-20 ZA ZA86411A patent/ZA86411B/xx unknown
- 1986-01-21 AU AU52589/86A patent/AU589592B2/en not_active Ceased
- 1986-01-24 YU YU9586A patent/YU45763B/sh unknown
- 1986-01-31 PH PH33362A patent/PH21990A/en unknown
- 1986-02-03 CA CA000500991A patent/CA1288776C/en not_active Expired - Lifetime
- 1986-02-03 HU HU86469A patent/HU196796B/hu not_active IP Right Cessation
- 1986-02-03 IE IE28886A patent/IE59396B1/en not_active IP Right Cessation
- 1986-02-03 NZ NZ215016A patent/NZ215016A/xx unknown
- 1986-02-03 KR KR1019860000706A patent/KR930005446B1/ko not_active Expired - Fee Related
- 1986-02-03 GR GR860320A patent/GR860320B/el unknown
- 1986-02-03 DK DK051686A patent/DK170098B1/da active
- 1986-02-03 FI FI860489A patent/FI84913C/fi not_active IP Right Cessation
- 1986-02-03 NO NO860373A patent/NO163367C/no unknown
- 1986-02-03 PL PL1986257773A patent/PL148515B1/pl unknown
- 1986-02-03 PT PT81956A patent/PT81956B/pt not_active IP Right Cessation
- 1986-02-04 DE DE8686300728T patent/DE3687006T2/de not_active Expired - Fee Related
- 1986-02-04 JP JP61022818A patent/JPH0676407B2/ja not_active Expired - Lifetime
- 1986-02-04 AT AT86300728T patent/ATE81856T1/de not_active IP Right Cessation
- 1986-02-04 EP EP86300728A patent/EP0190915B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK51686A (da)	1986-08-05
KR860006463A (ko)	1986-09-11
YU9586A (en)	1987-12-31
PL148515B1 (en)	1989-10-31
EP0190915A2 (de)	1986-08-13
EP0190915B1 (de)	1992-10-28
HU196796B (en)	1989-01-30
YU45763B (sh)	1992-07-20
NO860373L (no)	1986-08-05
FI860489L (fi)	1986-08-05
ZA86411B (en)	1986-09-24
IE59396B1 (en)	1994-02-23
AU589592B2 (en)	1989-10-19
JPH0676407B2 (ja)	1994-09-28
PH21990A (en)	1988-05-02
PT81956B (pt)	1988-01-22
PT81956A (en)	1986-03-01
DK51686D0 (da)	1986-02-03
EP0190915A3 (en)	1988-12-14
KR930005446B1 (ko)	1993-06-22
NO163367B (no)	1990-02-05
AU5258986A (en)	1986-08-07
NZ215016A (en)	1989-08-29
GR860320B (en)	1986-06-04
JPS61183286A (ja)	1986-08-15
PL257773A1 (en)	1987-10-19
DE3687006T2 (de)	1993-04-22
NO163367C (no)	1990-05-16
DE3687006D1 (de)	1992-12-03
HUT40119A (en)	1986-11-28
IE860288L (en)	1986-08-04
FI860489A0 (fi)	1986-02-03
DK170098B1 (da)	1995-05-22
FI84913B (fi)	1991-10-31
US4870181A (en)	1989-09-26
CA1288776C (en)	1991-09-10
FI84913C (fi)	1992-02-10
IL77612A (en)	1989-09-10

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Legal Events

Date	Code	Title	Description
1993-05-15	UEP	Publication of translation of european patent specification
2000-11-15	REN	Ceased due to non-payment of the annual fee