ATE204567T1 - 1,4-dihydropyridine als bradykinin antagonisten - Google Patents
1,4-dihydropyridine als bradykinin antagonistenInfo
- Publication number
- ATE204567T1 ATE204567T1 AT95918113T AT95918113T ATE204567T1 AT E204567 T1 ATE204567 T1 AT E204567T1 AT 95918113 T AT95918113 T AT 95918113T AT 95918113 T AT95918113 T AT 95918113T AT E204567 T1 ATE204567 T1 AT E204567T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- dihydropyridines
- sec
- bradykinine
- antagonists
- Prior art date
Links
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1994/001398 WO1996006083A1 (en) | 1994-08-24 | 1994-08-24 | 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists |
| PCT/IB1995/000400 WO1996006082A1 (en) | 1994-08-24 | 1995-05-26 | Dihydropyridine derivatives as bradykinin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204567T1 true ATE204567T1 (de) | 2001-09-15 |
Family
ID=14098614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95918113T ATE204567T1 (de) | 1994-08-24 | 1995-05-26 | 1,4-dihydropyridine als bradykinin antagonisten |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5859011A (de) |
| EP (1) | EP0777653B1 (de) |
| JP (1) | JP3001978B2 (de) |
| KR (1) | KR100235285B1 (de) |
| CN (1) | CN1087737C (de) |
| AT (1) | ATE204567T1 (de) |
| AU (1) | AU689587B2 (de) |
| CA (1) | CA2198231C (de) |
| DE (1) | DE69522332T2 (de) |
| DK (1) | DK0777653T3 (de) |
| ES (1) | ES2159637T3 (de) |
| FI (1) | FI970745A0 (de) |
| GR (1) | GR3036907T3 (de) |
| IL (1) | IL114968A (de) |
| MX (1) | MX9701363A (de) |
| MY (1) | MY115372A (de) |
| NO (1) | NO970806L (de) |
| NZ (1) | NZ285155A (de) |
| TW (1) | TW500722B (de) |
| WO (2) | WO1996006083A1 (de) |
| ZA (1) | ZA977057B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4345062A1 (de) * | 1993-12-31 | 1995-07-13 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen |
| MX9701245A (es) * | 1996-02-19 | 1998-04-30 | Pfizer | Compuestos de 1,4 dihidropiridina. |
| TNSN97037A1 (fr) * | 1996-02-19 | 2005-03-15 | Pfizer | Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| JP3823388B2 (ja) * | 1996-09-04 | 2006-09-20 | カシオ計算機株式会社 | 印刷装置 |
| JPH11106375A (ja) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物 |
| KR100579792B1 (ko) | 1998-05-13 | 2006-05-12 | 동화약품공업주식회사 | 신규 2,5-피리딘디카복실산 유도체 |
| EP1110962A1 (de) * | 1999-12-10 | 2001-06-27 | Pfizer Inc. | Verfahren zur herstellung von 1,4-dihydropyridine verbindungen |
| DK1106614T3 (da) * | 1999-12-10 | 2004-04-13 | Pfizer | 5-leddede, heteroarylsubstituerede 1,4-dihydropyridinforbindelser som bradykininantagonister |
| DE60001535T2 (de) * | 1999-12-10 | 2003-10-02 | Pfizer Inc., New York | Substituierte 1,4-Dihydropyridinverbindungen zur Verwendung als Bradykininantagonisten |
| US6653313B2 (en) | 2000-08-10 | 2003-11-25 | Warner-Lambert Company Llc | 1,4-dihydropyridine compounds as bradykinin antagonists |
| PT2813502T (pt) | 2013-06-14 | 2017-04-06 | Dompé Farm S P A | Antagonistas do recetor da bradicinina e composições farmacêuticas que os contêm |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162497A (en) * | 1987-09-24 | 1992-11-10 | The Administrators Of The Tulane Educational Fund | Bradykinin analogs with non-peptide bond |
| US5120750A (en) * | 1989-01-17 | 1992-06-09 | Synphar Laboratories, Inc. | Generation of 1,4-dihydropyridine derivatives |
| US5610142A (en) * | 1992-10-08 | 1997-03-11 | Scios Inc. | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids |
-
1994
- 1994-08-24 WO PCT/JP1994/001398 patent/WO1996006083A1/en not_active Ceased
-
1995
- 1995-05-26 AT AT95918113T patent/ATE204567T1/de not_active IP Right Cessation
- 1995-05-26 KR KR1019970701151A patent/KR100235285B1/ko not_active Expired - Fee Related
- 1995-05-26 AU AU24166/95A patent/AU689587B2/en not_active Ceased
- 1995-05-26 DK DK95918113T patent/DK0777653T3/da active
- 1995-05-26 MX MX9701363A patent/MX9701363A/es not_active IP Right Cessation
- 1995-05-26 EP EP95918113A patent/EP0777653B1/de not_active Expired - Lifetime
- 1995-05-26 JP JP8507896A patent/JP3001978B2/ja not_active Expired - Fee Related
- 1995-05-26 ES ES95918113T patent/ES2159637T3/es not_active Expired - Lifetime
- 1995-05-26 CN CN95194758A patent/CN1087737C/zh not_active Expired - Fee Related
- 1995-05-26 DE DE69522332T patent/DE69522332T2/de not_active Expired - Fee Related
- 1995-05-26 WO PCT/IB1995/000400 patent/WO1996006082A1/en not_active Ceased
- 1995-05-26 US US08/793,561 patent/US5859011A/en not_active Expired - Fee Related
- 1995-05-26 CA CA002198231A patent/CA2198231C/en not_active Expired - Fee Related
- 1995-07-11 TW TW084107170A patent/TW500722B/zh not_active IP Right Cessation
- 1995-08-17 IL IL11496895A patent/IL114968A/xx not_active IP Right Cessation
- 1995-08-22 MY MYPI95002477A patent/MY115372A/en unknown
- 1995-08-23 ZA ZA9707057A patent/ZA977057B/xx unknown
-
1997
- 1997-02-21 NO NO970806A patent/NO970806L/no not_active Application Discontinuation
- 1997-02-21 FI FI970745A patent/FI970745A0/fi not_active Application Discontinuation
- 1997-02-24 NZ NZ285155A patent/NZ285155A/en unknown
-
2001
- 2001-10-16 GR GR20010401777T patent/GR3036907T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996006082A1 (en) | 1996-02-29 |
| GR3036907T3 (en) | 2002-01-31 |
| NO970806D0 (no) | 1997-02-21 |
| MY115372A (en) | 2003-05-31 |
| NO970806L (no) | 1997-04-21 |
| CN1087737C (zh) | 2002-07-17 |
| AU2416695A (en) | 1996-03-14 |
| CN1156449A (zh) | 1997-08-06 |
| FI970745A7 (fi) | 1997-02-21 |
| JP3001978B2 (ja) | 2000-01-24 |
| MX9701363A (es) | 1997-05-31 |
| NZ285155A (en) | 1998-06-26 |
| JPH09510992A (ja) | 1997-11-04 |
| EP0777653B1 (de) | 2001-08-22 |
| US5859011A (en) | 1999-01-12 |
| ES2159637T3 (es) | 2001-10-16 |
| DK0777653T3 (da) | 2001-10-08 |
| IL114968A0 (en) | 1995-12-08 |
| KR970705555A (ko) | 1997-10-09 |
| CA2198231A1 (en) | 1996-02-29 |
| IL114968A (en) | 1999-08-17 |
| CA2198231C (en) | 1999-12-07 |
| AU689587B2 (en) | 1998-04-02 |
| DE69522332T2 (de) | 2002-01-03 |
| FI970745A0 (fi) | 1997-02-21 |
| ZA977057B (en) | 1997-02-24 |
| WO1996006083A1 (en) | 1996-02-29 |
| DE69522332D1 (de) | 2001-09-27 |
| KR100235285B1 (ko) | 2000-02-01 |
| TW500722B (en) | 2002-09-01 |
| EP0777653A1 (de) | 1997-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69719778D1 (de) | Benzonaphthyridine als bronchialtherapeutika | |
| DK0553191T3 (da) | Pyridin- og pyridin-N-oxidderivater af diarylmethylpiperidiner eller -piperaziner, præparater og an vendelse deraf | |
| AP9901442A0 (en) | 4-(2-Keto-1-benzimidazolinyl) piperidine compounds as orl1-receptor agonists. | |
| DE69225970D1 (de) | Substituierte 2-phenyl-3-methocypropensäurenester als fungizide mittel. | |
| DK0882021T3 (da) | Nye phenanthridiner | |
| DK0783501T3 (da) | Pyrimidonderivater med anti-fungal aktivitet | |
| TR199801268T2 (xx) | Ta�ikinin antagonistleri olarak 3-Azetidinilalkilpiperidinler veya pirolidinler. | |
| DK0738269T3 (da) | Piperidinderivater med PAF-antagonistaktivitet | |
| DE69522332D1 (de) | 1,4-dihydropyridine als bradykinin antagonisten | |
| TR199701173T1 (xx) | Yeni arilglisinamid t�revleri, bunlar�n �retilmesine mahsus usul. | |
| BR9607335A (pt) | Compostos 1-aril-2-acrilamino-etano e seu uso como neuroquinina especialmente antogonistas de neuroquinina 1 | |
| DE59510713D1 (de) | N-substituierte 3-azabicyclo(3.2.0)heptan-derivate als neuroleptika | |
| ATE171949T1 (de) | Neue endothelin-antagonisten und ihre herstellung | |
| ATE384049T1 (de) | Therapeutische heterocyclen als bradykinin b2 rezeptor antagonisten | |
| IL116526A0 (en) | Piperazinediones their preparation and use | |
| AU693241B2 (en) | New 3-substituted 3h-2,3-benzodiazepine derivatives, their preparation and use as medicaments | |
| SE9504662D0 (sv) | New compounds | |
| BR9406765A (pt) | N-((1-(4-(4-fluorofenoxi)Butil)-4-Piperidinil)-N-Metilamino)-2-Benzotiazolois como agentes antiarritmicos classe III | |
| SE9402241L (sv) | Inhibitor | |
| TR200302031T4 (tr) | İkame edilmiş 1,2,3,4,5,6-Heksahidro-2,6-Metano-3-Benzazosin'ler ve farmasotik preparat olarak kullanımları | |
| DE69403896D1 (de) | 4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |