ATE204869T1 - Benzothiophene, selbige enthaltende zusammensetzungen und verfahren zu deren herstellung - Google Patents

Benzothiophene, selbige enthaltende zusammensetzungen und verfahren zu deren herstellung

Info

Publication number: ATE204869T1
Authority: AT; Austria
Prior art keywords: benzothiophenes; production; same; compositions containing; compositions
Prior art date: 1996-02-22

Application number

AT97301068T

Other languages

English (en)

Inventor

George Joseph Cullinan

Alan David Palkowitz

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-22

Filing date

1997-02-19

Publication date

2001-09-15

1996-03-08 Priority claimed from GBGB9604912.7A external-priority patent/GB9604912D0/en

1997-02-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204869T1 publication Critical patent/ATE204869T1/de

Links

239000000203 mixture Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT97301068T 1996-02-22 1997-02-19 Benzothiophene, selbige enthaltende zusammensetzungen und verfahren zu deren herstellung ATE204869T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1204496P	1996-02-22	1996-02-22
GBGB9604912.7A GB9604912D0 (en)	1996-03-08	1996-03-08	Benzothiophenes, formulations containing same, and methods

Publications (1)

Publication Number	Publication Date
ATE204869T1 true ATE204869T1 (de)	2001-09-15

Family

ID=26308887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97301068T ATE204869T1 (de)	1996-02-22	1997-02-19	Benzothiophene, selbige enthaltende zusammensetzungen und verfahren zu deren herstellung

Country Status (23)

Country	Link
EP (1)	EP0791591B1 (de)
JP (1)	JP2000505455A (de)
KR (1)	KR19990087091A (de)
CN (1)	CN1211921A (de)
AR (2)	AR005969A1 (de)
AT (1)	ATE204869T1 (de)
AU (1)	AU713204B2 (de)
BR (1)	BR9707657A (de)
CA (1)	CA2246721A1 (de)
CO (1)	CO4761064A1 (de)
CZ (1)	CZ260798A3 (de)
DE (1)	DE69706338T2 (de)
DK (1)	DK0791591T3 (de)
EA (1)	EA000767B1 (de)
ES (1)	ES2162196T3 (de)
IL (1)	IL125863A (de)
NO (1)	NO983802D0 (de)
NZ (1)	NZ331461A (de)
PL (1)	PL328832A1 (de)
PT (1)	PT791591E (de)
TR (1)	TR199801612T2 (de)
WO (1)	WO1997030709A1 (de)
YU (1)	YU6797A (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999015521A1 (en) *	1997-09-23	1999-04-01	Eli Lilly And Company	Benzothiophenes
US6465445B1 (en)	1998-06-11	2002-10-15	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en)	1998-06-11	2006-02-28	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6060488A (en) *	1998-09-22	2000-05-09	Eli Lilly And Company	Benzothiophenes for treating estrogen deficiency
EP1347963B1 (de) *	2000-12-05	2004-08-25	F. Hoffmann-La Roche Ag	Benzofuran- und benzothiophen-derivative als selektive cox-2 inhibitoren
EP1782810A3 (de) *	2002-07-22	2007-05-23	Eli Lilly & Company	Selektive Östrogenrezeptor Modulatoren, die eine Phenylsulfonyl-Gruppe enthalten
EA008024B1 (ru)	2002-07-22	2007-02-27	Эли Лилли Энд Компани	Селективные модуляторы эстрогенных рецепторов, содержащие фенилсульфонильную группу
EP1832583A1 (de)	2002-09-30	2007-09-12	A/S GEA Farmaceutisk Fabrik	Neue Schwefelsäureadditionssalze aus Raloxifen und/oder Solvate daraus sowie pharmazeutische Zusammensetzungen damit
PL377494A1 (pl) *	2003-02-25	2006-02-06	Eli Lilly And Company	Krystaliczny, niesolwatowany chlorowodorek 1-(4-(2-pipe-rydynyloetoksy) fenoksy)-2-(4-metanosulfonylofenylo)-6- hydroksynaftalenu
WO2005073190A1 (en) *	2004-01-29	2005-08-11	Eli Lilly And Company	Selective estrogen receptor modulators
GR1005694B (el) *	2005-06-08	2007-10-22	Αλεξης Μιχαηλ	Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων
CN111018770A (zh) *	2019-12-26	2020-04-17	北京鑫开元医药科技有限公司	一种巴多昔芬氧化物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2097788B (en) *	1981-04-03	1985-04-24	Lilly Co Eli	Benzothiophene compounds and process for preparing them
US5482949A (en) *	1993-03-19	1996-01-09	Eli Lilly And Company	Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) *	1993-10-12	2004-06-29	Pfizer Inc.	Benzothiophenes and related compounds as estrogen agonists
US5510357A (en) *	1995-02-28	1996-04-23	Eli Lilly And Company	Benzothiophene compounds as anti-estrogenic agents

1997
- 1997-02-19 WO PCT/US1997/002464 patent/WO1997030709A1/en not_active Ceased
- 1997-02-19 AT AT97301068T patent/ATE204869T1/de not_active IP Right Cessation
- 1997-02-19 KR KR1019980706479A patent/KR19990087091A/ko not_active Withdrawn
- 1997-02-19 CZ CZ982607A patent/CZ260798A3/cs unknown
- 1997-02-19 CA CA002246721A patent/CA2246721A1/en not_active Abandoned
- 1997-02-19 EA EA199800753A patent/EA000767B1/ru not_active IP Right Cessation
- 1997-02-19 ES ES97301068T patent/ES2162196T3/es not_active Expired - Lifetime
- 1997-02-19 PT PT97301068T patent/PT791591E/pt unknown
- 1997-02-19 TR TR1998/01612T patent/TR199801612T2/xx unknown
- 1997-02-19 IL IL12586397A patent/IL125863A/xx not_active IP Right Cessation
- 1997-02-19 PL PL97328832A patent/PL328832A1/xx unknown
- 1997-02-19 AU AU22764/97A patent/AU713204B2/en not_active Ceased
- 1997-02-19 NZ NZ331461A patent/NZ331461A/xx unknown
- 1997-02-19 CN CN97192469A patent/CN1211921A/zh active Pending
- 1997-02-19 EP EP97301068A patent/EP0791591B1/de not_active Expired - Lifetime
- 1997-02-19 DE DE69706338T patent/DE69706338T2/de not_active Expired - Fee Related
- 1997-02-19 DK DK97301068T patent/DK0791591T3/da active
- 1997-02-19 JP JP9530267A patent/JP2000505455A/ja not_active Withdrawn
- 1997-02-19 BR BR9707657A patent/BR9707657A/pt not_active Application Discontinuation
- 1997-02-21 AR ARP970100726A patent/AR005969A1/es unknown
- 1997-02-21 CO CO97009328A patent/CO4761064A1/es unknown
- 1997-02-21 AR ARP970100727A patent/AR005970A1/es unknown
- 1997-02-21 YU YU6797A patent/YU6797A/sh unknown
1998
- 1998-08-19 NO NO983802A patent/NO983802D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2162196T3 (es)	2001-12-16
DE69706338T2 (de)	2002-06-13
EA000767B1 (ru)	2000-04-24
AU2276497A (en)	1997-09-10
BR9707657A (pt)	1999-07-27
NO983802L (no)	1998-08-19
PL328832A1 (en)	1999-02-15
PT791591E (pt)	2001-12-28
IL125863A0 (en)	1999-04-11
NZ331461A (en)	1999-05-28
TR199801612T2 (xx)	1998-11-23
CN1211921A (zh)	1999-03-24
YU6797A (sh)	1999-09-27
NO983802D0 (no)	1998-08-19
CZ260798A3 (cs)	1999-05-12
DE69706338D1 (de)	2001-10-04
DK0791591T3 (da)	2001-10-08
CO4761064A1 (es)	1999-04-27
AR005970A1 (es)	1999-07-21
IL125863A (en)	2000-10-31
EP0791591B1 (de)	2001-08-29
AR005969A1 (es)	1999-07-21
CA2246721A1 (en)	1997-08-28
EA199800753A1 (ru)	1999-02-25
AU713204B2 (en)	1999-11-25
WO1997030709A1 (en)	1997-08-28
JP2000505455A (ja)	2000-05-09
KR19990087091A (ko)	1999-12-15
EP0791591A1 (de)	1997-08-27

Legal Events

Date	Code	Title	Description
2001-11-15	UEP	Publication of translation of european patent specification
2005-11-15	REN	Ceased due to non-payment of the annual fee

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