ES2162196T3 - Benzotiofenos, formulaciones que los contienen y procedimientos para su preparacion. - Google Patents
Benzotiofenos, formulaciones que los contienen y procedimientos para su preparacion.Info
- Publication number
- ES2162196T3 ES2162196T3 ES97301068T ES97301068T ES2162196T3 ES 2162196 T3 ES2162196 T3 ES 2162196T3 ES 97301068 T ES97301068 T ES 97301068T ES 97301068 T ES97301068 T ES 97301068T ES 2162196 T3 ES2162196 T3 ES 2162196T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- sup
- benzotiophenes
- formulations
- procedures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- -1 POLYMETHYLENE Polymers 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
LA PRESENTE INVENCION, PROPORCIONA COMPUESTOS FARMACEUTICOS DE BENZOTIOFENO, DE FORMULA DONDE R{SUP,1} ES HIDROGENO, HIDROXI, ALCOXI C{SUB,1}-C{SUB,4}, DONDE AR ES FENILO OPCIONALMENTE SUSTITUIDO, O -SO{SUB,2}(CADENA DE ALQUILO LINEAL C{SUB,4}-C{SUB,6}; R{SUP,2} ES R{SUP,1}, CL O F; Y R{SUP,3} Y R{SUP,4} SON, INDEPENDIENTEMENTE, ALQUILO C{SUB,1}C{SUB,4}, O SE COMBINAN PARA FORMAR UN POLIMETILENO C{SUB,4}C{SUB,6} O, CONJUNTAMENTE CON EL NITROGENO AL QUE ESTAN UNIDOS, FORMAN MORFOLINA, X ES -CH{SUB,2}, -CHOH{SUB,2}, -O-, O O UNA SAL FARMACEUTICAMENTE ACEPTABLE O SOLVATO DEL MISMO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1204496P | 1996-02-22 | 1996-02-22 | |
| GBGB9604912.7A GB9604912D0 (en) | 1996-03-08 | 1996-03-08 | Benzothiophenes, formulations containing same, and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2162196T3 true ES2162196T3 (es) | 2001-12-16 |
Family
ID=26308887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97301068T Expired - Lifetime ES2162196T3 (es) | 1996-02-22 | 1997-02-19 | Benzotiofenos, formulaciones que los contienen y procedimientos para su preparacion. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0791591B1 (es) |
| JP (1) | JP2000505455A (es) |
| KR (1) | KR19990087091A (es) |
| CN (1) | CN1211921A (es) |
| AR (2) | AR005969A1 (es) |
| AT (1) | ATE204869T1 (es) |
| AU (1) | AU713204B2 (es) |
| BR (1) | BR9707657A (es) |
| CA (1) | CA2246721A1 (es) |
| CO (1) | CO4761064A1 (es) |
| CZ (1) | CZ260798A3 (es) |
| DE (1) | DE69706338T2 (es) |
| DK (1) | DK0791591T3 (es) |
| EA (1) | EA000767B1 (es) |
| ES (1) | ES2162196T3 (es) |
| IL (1) | IL125863A (es) |
| NO (1) | NO983802D0 (es) |
| NZ (1) | NZ331461A (es) |
| PL (1) | PL328832A1 (es) |
| PT (1) | PT791591E (es) |
| TR (1) | TR199801612T2 (es) |
| WO (1) | WO1997030709A1 (es) |
| YU (1) | YU6797A (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999015521A1 (en) * | 1997-09-23 | 1999-04-01 | Eli Lilly And Company | Benzothiophenes |
| US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US6060488A (en) * | 1998-09-22 | 2000-05-09 | Eli Lilly And Company | Benzothiophenes for treating estrogen deficiency |
| EP1347963B1 (en) * | 2000-12-05 | 2004-08-25 | F. Hoffmann-La Roche Ag | Benzofuran and benzothiophene derivatives as selective cox-2 inhibitors |
| EP1782810A3 (en) * | 2002-07-22 | 2007-05-23 | Eli Lilly & Company | Selective estrogen receptor modulators containing a phenylsulfonyl group |
| EA008024B1 (ru) | 2002-07-22 | 2007-02-27 | Эли Лилли Энд Компани | Селективные модуляторы эстрогенных рецепторов, содержащие фенилсульфонильную группу |
| EP1832583A1 (en) | 2002-09-30 | 2007-09-12 | A/S GEA Farmaceutisk Fabrik | Novel raloxifene sulphuric acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these |
| PL377494A1 (pl) * | 2003-02-25 | 2006-02-06 | Eli Lilly And Company | Krystaliczny, niesolwatowany chlorowodorek 1-(4-(2-pipe-rydynyloetoksy) fenoksy)-2-(4-metanosulfonylofenylo)-6- hydroksynaftalenu |
| WO2005073190A1 (en) * | 2004-01-29 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
| GR1005694B (el) * | 2005-06-08 | 2007-10-22 | Αλεξης Μιχαηλ | Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων |
| CN111018770A (zh) * | 2019-12-26 | 2020-04-17 | 北京鑫开元医药科技有限公司 | 一种巴多昔芬氧化物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2097788B (en) * | 1981-04-03 | 1985-04-24 | Lilly Co Eli | Benzothiophene compounds and process for preparing them |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
-
1997
- 1997-02-19 WO PCT/US1997/002464 patent/WO1997030709A1/en not_active Ceased
- 1997-02-19 AT AT97301068T patent/ATE204869T1/de not_active IP Right Cessation
- 1997-02-19 KR KR1019980706479A patent/KR19990087091A/ko not_active Withdrawn
- 1997-02-19 CZ CZ982607A patent/CZ260798A3/cs unknown
- 1997-02-19 CA CA002246721A patent/CA2246721A1/en not_active Abandoned
- 1997-02-19 EA EA199800753A patent/EA000767B1/ru not_active IP Right Cessation
- 1997-02-19 ES ES97301068T patent/ES2162196T3/es not_active Expired - Lifetime
- 1997-02-19 PT PT97301068T patent/PT791591E/pt unknown
- 1997-02-19 TR TR1998/01612T patent/TR199801612T2/xx unknown
- 1997-02-19 IL IL12586397A patent/IL125863A/xx not_active IP Right Cessation
- 1997-02-19 PL PL97328832A patent/PL328832A1/xx unknown
- 1997-02-19 AU AU22764/97A patent/AU713204B2/en not_active Ceased
- 1997-02-19 NZ NZ331461A patent/NZ331461A/xx unknown
- 1997-02-19 CN CN97192469A patent/CN1211921A/zh active Pending
- 1997-02-19 EP EP97301068A patent/EP0791591B1/en not_active Expired - Lifetime
- 1997-02-19 DE DE69706338T patent/DE69706338T2/de not_active Expired - Fee Related
- 1997-02-19 DK DK97301068T patent/DK0791591T3/da active
- 1997-02-19 JP JP9530267A patent/JP2000505455A/ja not_active Withdrawn
- 1997-02-19 BR BR9707657A patent/BR9707657A/pt not_active Application Discontinuation
- 1997-02-21 AR ARP970100726A patent/AR005969A1/es unknown
- 1997-02-21 CO CO97009328A patent/CO4761064A1/es unknown
- 1997-02-21 AR ARP970100727A patent/AR005970A1/es unknown
- 1997-02-21 YU YU6797A patent/YU6797A/sh unknown
-
1998
- 1998-08-19 NO NO983802A patent/NO983802D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69706338T2 (de) | 2002-06-13 |
| EA000767B1 (ru) | 2000-04-24 |
| AU2276497A (en) | 1997-09-10 |
| BR9707657A (pt) | 1999-07-27 |
| NO983802L (no) | 1998-08-19 |
| PL328832A1 (en) | 1999-02-15 |
| PT791591E (pt) | 2001-12-28 |
| ATE204869T1 (de) | 2001-09-15 |
| IL125863A0 (en) | 1999-04-11 |
| NZ331461A (en) | 1999-05-28 |
| TR199801612T2 (xx) | 1998-11-23 |
| CN1211921A (zh) | 1999-03-24 |
| YU6797A (sh) | 1999-09-27 |
| NO983802D0 (no) | 1998-08-19 |
| CZ260798A3 (cs) | 1999-05-12 |
| DE69706338D1 (de) | 2001-10-04 |
| DK0791591T3 (da) | 2001-10-08 |
| CO4761064A1 (es) | 1999-04-27 |
| AR005970A1 (es) | 1999-07-21 |
| IL125863A (en) | 2000-10-31 |
| EP0791591B1 (en) | 2001-08-29 |
| AR005969A1 (es) | 1999-07-21 |
| CA2246721A1 (en) | 1997-08-28 |
| EA199800753A1 (ru) | 1999-02-25 |
| AU713204B2 (en) | 1999-11-25 |
| WO1997030709A1 (en) | 1997-08-28 |
| JP2000505455A (ja) | 2000-05-09 |
| KR19990087091A (ko) | 1999-12-15 |
| EP0791591A1 (en) | 1997-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2194114T3 (es) | Formulaciones liposomicas de mitoxantrona. | |
| ES2162196T3 (es) | Benzotiofenos, formulaciones que los contienen y procedimientos para su preparacion. | |
| AR028985A1 (es) | Compuestos derivados de quinolin-2-ona- sustituidos con heteroarilo utiles como agentes anticancerigenos, procedimiento de tratamiento de enfermedades utilizando dicho compuesto, composicion farmaceutica que lo contiene | |
| ES2076935T3 (es) | Compuesto de pirazolopiridina y procedimientos para su preparacion. | |
| EA200100553A1 (ru) | Замещенные бициклические производные, полезные в качестве противораковых агентов | |
| ES2167720T3 (es) | Compuestos de 1-fenilpirazol y aplicaciones medicinales de los mismos. | |
| MX9300298A (es) | Conjugados de tioeter y procedimiento para su preparacion | |
| EA200201277A1 (ru) | Замещенные бициклические производные для лечения аномального роста клеток | |
| AR026410A1 (es) | ''2-aril-3-(heteroaril)-imidazo[1,2-a]pirimidinas sustituidas, y las composiciones y metodos farmaceuticos relacionados | |
| AR029216A1 (es) | Compuestos inhibidores no peptidicos de la union celular dependiente de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias; composicion farmaceutica y procedimiento de tratamiento | |
| CO4930259A1 (es) | Derivados 6,6-heterobiciclicos sustituidos y composiciones farmaceuticas que los contienen | |
| ES2191260T3 (es) | Derivados de la imidazolidin-4-ona utiles como agentes anticancerosos. | |
| ES2092113T3 (es) | Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno. | |
| ES2084944T3 (es) | Amidas terapeuticas. | |
| AR011093A1 (es) | Compuestos derivados de sulfonil urea, composicion farmaceutica que los contiene y procedimiento para su uso. | |
| DK0562956T3 (da) | Hidtil ukendte naphthylalkylaminer, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
| ES8707974A1 (es) | Procedimiento para la obtencion de un peptido | |
| ES2179353T3 (es) | Antagonistas muscarinicos. | |
| ES2179476T3 (es) | Procedimiento para preparar derivados de pirazol. | |
| ES2180933T3 (es) | Inhibidor de la serina-proteasa. | |
| MX9306311A (es) | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| ES2148458T3 (es) | Derivados de fenil-4-tiazoles sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| ES2143644T3 (es) | Procedimiento para elaborar compuestos antimicrobianos. | |
| MX9304424A (es) | Bencimidazoles, medicamentos que contienen estos compuestos y procedimiento para su preparacion. | |
| ES2151716T3 (es) | Derivados peptidos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 791591 Country of ref document: ES |