ATE207055T1 - Verfahren zur herstellung von 4-aryl-3- hydroxymethyl-piperidinen - Google Patents
Verfahren zur herstellung von 4-aryl-3- hydroxymethyl-piperidinenInfo
- Publication number
- ATE207055T1 ATE207055T1 AT97106096T AT97106096T ATE207055T1 AT E207055 T1 ATE207055 T1 AT E207055T1 AT 97106096 T AT97106096 T AT 97106096T AT 97106096 T AT97106096 T AT 97106096T AT E207055 T1 ATE207055 T1 AT E207055T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- aryl
- producing
- hydrogen atom
- piperidines
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP09279196A JP3446468B2 (ja) | 1996-04-15 | 1996-04-15 | ピペリジンカルビノール類の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE207055T1 true ATE207055T1 (de) | 2001-11-15 |
Family
ID=14064248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97106096T ATE207055T1 (de) | 1996-04-15 | 1997-04-14 | Verfahren zur herstellung von 4-aryl-3- hydroxymethyl-piperidinen |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6197960B1 (de) |
| EP (1) | EP0802185B1 (de) |
| JP (1) | JP3446468B2 (de) |
| AT (1) | ATE207055T1 (de) |
| CA (1) | CA2202577C (de) |
| DE (1) | DE69707341T2 (de) |
| DK (1) | DK0802185T3 (de) |
| ES (1) | ES2166021T3 (de) |
| PT (1) | PT802185E (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1384720A1 (de) | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Verfahren zur Trocknung von Paroxetinhydrochlorid |
| DE69827000D1 (de) * | 1997-05-29 | 2004-11-18 | Smithkline Beecham Plc | Neues verfahren |
| KR100543614B1 (ko) | 1997-06-10 | 2006-01-20 | 신톤 비.브이. | 4-페닐피페리딘 화합물 |
| ES2137131B1 (es) * | 1998-02-06 | 2000-09-16 | Vita Invest Sa | Derivado de piperidinona procedimiento de obtencion y procedimiento para su utilizacion. |
| ES2149687B1 (es) * | 1998-04-08 | 2001-05-16 | Medichem Sa | Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas. |
| DE69910691T2 (de) | 1998-06-29 | 2004-07-08 | Sumika Fine Chemical Co. Ltd. | L-Tartrate von Trans-(-)-4-(4-Fluorphenyl)-3-Hydroxymethyl-Piperidin Verbindungen und Verfahren zu ihrer Herstellung |
| CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
| WO2000026187A1 (en) * | 1998-11-02 | 2000-05-11 | Synthon B.V. | Process for producing 4-arylpiperidine-3-carbinols and related compounds |
| AU2200400A (en) * | 1998-12-22 | 2000-07-12 | Pentech Pharmaceuticals, Inc. | Process for preparing arylpiperidine carbinol intermediates and derivatives |
| GB9915727D0 (en) * | 1999-07-03 | 1999-09-08 | Smithkline Beecham Plc | Novel compound and process |
| EP1280775A1 (de) | 2000-05-12 | 2003-02-05 | Synthon B.V. | Tosylsalzen von 4-(p-fluorophenyl)-piperidine-3-carbinolen |
| CA2464327A1 (en) | 2001-10-22 | 2003-05-30 | Synthon B.V. | N-formyl derivatives of paroxetine |
| CN101312752B (zh) * | 2005-12-01 | 2012-09-05 | Sca卫生产品股份公司 | 新型吸收性物品 |
| IN2013MU03596A (de) * | 2013-11-18 | 2015-07-24 | Piramal Entpr Ltd | |
| CN115108968A (zh) * | 2021-03-23 | 2022-09-27 | 上药康丽（常州）药业有限公司 | 一种3-(4-溴苯基)-哌啶的生产方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| CH636858A5 (de) * | 1977-01-17 | 1983-06-30 | Ciba Geigy Ag | Verfahren zur herstellung neuer phenylazacycloalkane. |
| US4593036A (en) | 1984-02-07 | 1986-06-03 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator |
| EP0190496A3 (de) * | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Piperidinderivate mit gastro-intestinaler Wirkung |
| GB8520154D0 (en) | 1985-08-10 | 1985-09-18 | Beecham Group Plc | Chemical process |
| EP0223334B1 (de) | 1985-08-10 | 1991-07-10 | Beecham Group Plc | Verfahren zur Herstellung von Arylpiperidincarbinol |
| IE66332B1 (en) | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
| US5227379A (en) | 1986-11-03 | 1993-07-13 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
| DK716088D0 (da) | 1988-12-22 | 1988-12-22 | Ferrosan As | Reduktion af piperidin-dion-derivater samt intermediat |
| US5258517A (en) | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
| JPH0696551A (ja) | 1992-09-11 | 1994-04-08 | Kao Corp | 磁気ディスクカートリッジ |
| GB9305175D0 (en) | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
| EP1384720A1 (de) * | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Verfahren zur Trocknung von Paroxetinhydrochlorid |
| US5672612A (en) | 1996-09-09 | 1997-09-30 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
-
1996
- 1996-04-15 JP JP09279196A patent/JP3446468B2/ja not_active Expired - Lifetime
-
1997
- 1997-04-11 US US08/835,646 patent/US6197960B1/en not_active Expired - Lifetime
- 1997-04-14 AT AT97106096T patent/ATE207055T1/de active
- 1997-04-14 PT PT97106096T patent/PT802185E/pt unknown
- 1997-04-14 EP EP97106096A patent/EP0802185B1/de not_active Expired - Lifetime
- 1997-04-14 ES ES97106096T patent/ES2166021T3/es not_active Expired - Lifetime
- 1997-04-14 DK DK97106096T patent/DK0802185T3/da active
- 1997-04-14 DE DE69707341T patent/DE69707341T2/de not_active Expired - Lifetime
- 1997-04-14 CA CA002202577A patent/CA2202577C/en not_active Expired - Fee Related
-
2000
- 2000-09-20 US US09/666,585 patent/US6476228B1/en not_active Expired - Lifetime
- 2000-11-27 US US09/721,762 patent/US6590102B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2166021T3 (es) | 2002-04-01 |
| CA2202577A1 (en) | 1997-10-15 |
| PT802185E (pt) | 2002-01-30 |
| JPH09278754A (ja) | 1997-10-28 |
| EP0802185A1 (de) | 1997-10-22 |
| CA2202577C (en) | 2006-05-30 |
| DK0802185T3 (da) | 2001-11-19 |
| US6590102B1 (en) | 2003-07-08 |
| US6197960B1 (en) | 2001-03-06 |
| US6476228B1 (en) | 2002-11-05 |
| JP3446468B2 (ja) | 2003-09-16 |
| EP0802185B1 (de) | 2001-10-17 |
| DE69707341T2 (de) | 2002-07-25 |
| DE69707341D1 (de) | 2001-11-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE282020T1 (de) | Verfahren zur herstellung von 2-aminomalonsäure- derivaten | |
| ATE223900T1 (de) | Verfahren zur herstellung von 4- trifluormethylnicotinsäure | |
| ATE207055T1 (de) | Verfahren zur herstellung von 4-aryl-3- hydroxymethyl-piperidinen | |
| ATE174589T1 (de) | Verfahren zur herstellung von piperidinderivaten | |
| ATE145891T1 (de) | Verfahren zur herstellung von alkoxyiminoacetamid-derivaten und ein zwischenproduckt dafür | |
| DE69801764D1 (de) | Verfahren zur herstellung von citalopram | |
| DE69706366D1 (de) | Verfahren zur Herstellung von Paroxetine | |
| DE69814635D1 (de) | Verfahren zur herstellung von 2-hydroxybenzamidderivaten | |
| ATE210136T1 (de) | Verfahren zur herstellung von alkylhydrogenchlorsilanen | |
| FI913067A0 (fi) | Bisfosfonsyraderivat, deras framstaellning och anvaendning. | |
| DE69516156D1 (de) | Verfahren zur herstellung von alkoxyimino acetamid-derivaten | |
| ATE189453T1 (de) | Verfahren zur herstellung von 2-cyanobiphenyl- verbindungen | |
| ATE123286T1 (de) | Verfahren zur herstellung von 3-alkoxymethyl cephalosporinderivate. | |
| ATE293095T1 (de) | Verfahren zur herstellung von cyclopropancarboxylaten | |
| ATE155132T1 (de) | Verfahren zur herstellung von amino- thiadiazolylacetylhaliden | |
| ATE299498T1 (de) | Verfahren zur herstellung von imidazolderivaten | |
| ATE184600T1 (de) | Verfahren zur herstellung von substituierten 4- hydroxy-kumarine | |
| ATE115112T1 (de) | Verfahren zur herstellung von cyclischen ketonen. | |
| ATE209180T1 (de) | Verfahren zur herstellung von malonsäuredinitril | |
| ATE248841T1 (de) | Verfahren zur herstellung von penicilling- phenylester | |
| DE3881458D1 (de) | Verfahren zur herstellung von makrolid-derivaten. | |
| ATE206109T1 (de) | Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten | |
| ATE157357T1 (de) | Verfahren zur herstellung von dihydrofuranonderivaten | |
| ATE133948T1 (de) | Xanthon-derivate, verfahren zu ihrer herstellung und ihrer verwendung | |
| ATE167474T1 (de) | Verfahren zur herstellung von n-alkylpyrazolen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |