ATE204874T1 - Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone - Google Patents

Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone

Info

Publication number
ATE204874T1
ATE204874T1 AT96911768T AT96911768T ATE204874T1 AT E204874 T1 ATE204874 T1 AT E204874T1 AT 96911768 T AT96911768 T AT 96911768T AT 96911768 T AT96911768 T AT 96911768T AT E204874 T1 ATE204874 T1 AT E204874T1
Authority
AT
Austria
Prior art keywords
pct
carbazinyloxazolidinones
spirocyclic
date nov
sec
Prior art date
Application number
AT96911768T
Other languages
English (en)
Inventor
Michael Robert Barbachyn
Steven J Brickner
Douglas K Hutchinson
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE204874T1 publication Critical patent/ATE204874T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT96911768T 1995-05-11 1996-04-18 Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone ATE204874T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43870595A 1995-05-11 1995-05-11
PCT/US1996/005202 WO1996035691A1 (en) 1995-05-11 1996-04-18 Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones

Publications (1)

Publication Number Publication Date
ATE204874T1 true ATE204874T1 (de) 2001-09-15

Family

ID=23741700

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96911768T ATE204874T1 (de) 1995-05-11 1996-04-18 Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone

Country Status (18)

Country Link
US (1) US6090820A (de)
EP (1) EP0828741B1 (de)
JP (1) JPH11506430A (de)
KR (1) KR100463771B1 (de)
CN (2) CN1068328C (de)
AT (1) ATE204874T1 (de)
AU (1) AU702752B2 (de)
CA (1) CA2218088A1 (de)
DE (1) DE69614847T2 (de)
DK (1) DK0828741T3 (de)
ES (1) ES2162047T3 (de)
FI (1) FI974180L (de)
HK (1) HK1042093A1 (de)
MX (1) MX9708627A (de)
NO (1) NO311298B1 (de)
NZ (1) NZ306310A (de)
PT (1) PT828741E (de)
WO (1) WO1996035691A1 (de)

Families Citing this family (46)

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DE69631347T2 (de) * 1995-09-15 2004-10-07 Upjohn Co Aminoaryl oxazolidinone n-oxide
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
DK1114819T3 (da) * 1996-04-11 2008-04-14 Pharmacia & Upjohn Co Llc Fremgangsmåde til fremstilling af oxazolidinoner
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
KR100467309B1 (ko) * 1997-09-04 2005-07-18 씨제이 주식회사 옥사졸리디논유도체및그의제조방법및항균제조성물
KR100463111B1 (ko) * 1997-10-30 2005-06-13 씨제이 주식회사 신규한옥사졸리디논유도체및제조방법및그를함유하는항균제조성물
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
WO1999064417A2 (en) 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6413981B1 (en) * 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ITVA20000023A1 (it) * 2000-07-19 2002-01-19 Lamberti Spa Composizioni di pvc stabili al calore.
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
EP1368354A1 (de) * 2001-03-07 2003-12-10 Pfizer Products Inc. Modulatoren der aktivität von chemokin-rezeptoren
WO2003048136A1 (en) * 2001-11-29 2003-06-12 Merck & Co., Inc. Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
DE60304360T2 (de) 2002-08-12 2006-11-16 Pharmacia & Upjohn Co. Llc, Kalamazoo N-aryl-2-oxazolidinone und deren derivate
KR100454099B1 (ko) * 2002-08-22 2004-10-26 한국화학연구원 제초활성을 갖는9-(5-이속사졸린메톡시페닐)이미노-8-치아-1,6-디아자비시클로[4.3.0]노난-7-온 유도체
ATE344036T1 (de) 2002-11-21 2006-11-15 Pharmacia & Upjohn Co Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2008520644A (ja) * 2004-11-24 2008-06-19 ファイザー・インク オクタヒドロピロロ［３，４−ｃ］ピロール誘導体
EP1671972A1 (de) * 2004-11-24 2006-06-21 Pfizer Limited Octahydropyrrolo[3,4-c]pyrrol-Derivate
KR100729344B1 (ko) * 2006-02-16 2007-06-15 스마텍(주) 차량용 사방 감지 카메라의 보호 및 작동 구조
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
CN101809021B (zh) 2007-09-11 2013-04-24 雅培制药有限公司 八氢-吡咯并[3,4-b]吡咯n-氧化物
CN102224151A (zh) 2008-11-20 2011-10-19 万能药生物有限公司 新的抗微生物剂
KR20120106697A (ko) 2009-06-26 2012-09-26 파나세아 바이오테크 리미티드 신규 아자비시클로헥산
EP2635589A1 (de) 2010-11-03 2013-09-11 Wockhardt Limited Verfahren zur herstellung von phosphorsäure-mono- l- {[4- (s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- - 3 yl] - 2, 6 -} difluorphenyl - 4 - methoxymethylpiperidin- 4 - yl)-ester
KR101271224B1 (ko) 2011-07-05 2013-06-10 한국과학기술연구원 항균활성을 갖는 신규 이중고리를 포함하는 옥사졸리디논 유도체 및 이의 제조방법
JP5833764B2 (ja) 2011-09-30 2015-12-16 山東軒竹医薬科技有限公司 縮合環を有するオキサゾリドン（ｏｘａｚｏｌｉｄｏｎｅ）類の抗菌物質
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
BR112017028318B1 (pt) 2015-07-02 2024-02-20 Janssen Sciences Ireland Uc Composto antibacteriano, seu uso, processo para sua preparação,produto que o contém, composição farmacêutica e combinação
EA202190167A1 (ru) * 2015-07-17 2021-07-30 Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. Замещенные фенилоксазолидиноны для антимикробной терапии
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
BR112018076126A2 (pt) 2016-06-16 2019-03-26 Janssen Sciences Ireland Unlimited Company compostos heterocíclicos como antibacterianos
EP4417262A3 (de) 2017-03-01 2024-11-27 Janssen Sciences Ireland Unlimited Company Kombinationstherapie
CN108727406B (zh) 2017-03-28 2021-12-07 北京协和制药二厂 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
ES2059467T3 (es) * 1987-10-21 1994-11-16 Du Pont Merck Pharma Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
JP2865211B2 (ja) * 1988-09-15 1999-03-08 ファルマシア・アンド・アップジョン・カンパニー ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類
EP0610265B1 (de) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituierte aryl- und heteroaryl-phenyloxazolidinone
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物

Also Published As

Publication number Publication date
NO975158D0 (no) 1997-11-10
MX9708627A (es) 1998-02-28
KR100463771B1 (ko) 2005-05-16
PT828741E (pt) 2002-02-28
FI974180A0 (fi) 1997-11-10
CA2218088A1 (en) 1996-11-14
AU5484996A (en) 1996-11-29
CN1068328C (zh) 2001-07-11
DE69614847T2 (de) 2002-04-04
CN1184481A (zh) 1998-06-10
AU702752B2 (en) 1999-03-04
EP0828741A1 (de) 1998-03-18
NO975158L (no) 1998-01-09
HK1042093A1 (zh) 2002-08-02
NO311298B1 (no) 2001-11-12
FI974180A7 (fi) 1997-11-10
FI974180L (fi) 1997-11-10
DE69614847D1 (de) 2001-10-04
ES2162047T3 (es) 2001-12-16
EP0828741B1 (de) 2001-08-29
DK0828741T3 (da) 2001-11-26
US6090820A (en) 2000-07-18
NZ306310A (en) 2001-05-25
KR19990008399A (ko) 1999-01-25
HK1009449A1 (en) 1999-09-10
WO1996035691A1 (en) 1996-11-14
JPH11506430A (ja) 1999-06-08
CN1336375A (zh) 2002-02-20

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Legal Events

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REN Ceased due to non-payment of the annual fee