ES2162047T3 - Oxazolidinonas con resto diazinilo y carbazinilo espirociclico y biciclico. - Google Patents

Oxazolidinonas con resto diazinilo y carbazinilo espirociclico y biciclico.

Info

Publication number
ES2162047T3
ES2162047T3 ES96911768T ES96911768T ES2162047T3 ES 2162047 T3 ES2162047 T3 ES 2162047T3 ES 96911768 T ES96911768 T ES 96911768T ES 96911768 T ES96911768 T ES 96911768T ES 2162047 T3 ES2162047 T3 ES 2162047T3
Authority
ES
Spain
Prior art keywords
spirociclical
carbazinyl
diazinyl
oxazolidinones
bicycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96911768T
Other languages
English (en)
Inventor
Michael Robert Barbachyn
Steven J Brickner
Douglas K Hutchinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2162047T3 publication Critical patent/ES2162047T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN COMPUESTO DE LA FORMULA ESTRUCTURAL (I O II) UTIL PARA EL TRATAMIENTO DE INFECCIONES MICROBIANAS EN HUMANOS O EN OTROS ANIMALES DE SANGRE CALIENTE, O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS TAL COMO SE DEFINEN AQUI.
ES96911768T 1995-05-11 1996-04-18 Oxazolidinonas con resto diazinilo y carbazinilo espirociclico y biciclico. Expired - Lifetime ES2162047T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43870595A 1995-05-11 1995-05-11

Publications (1)

Publication Number Publication Date
ES2162047T3 true ES2162047T3 (es) 2001-12-16

Family

ID=23741700

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96911768T Expired - Lifetime ES2162047T3 (es) 1995-05-11 1996-04-18 Oxazolidinonas con resto diazinilo y carbazinilo espirociclico y biciclico.

Country Status (18)

Country Link
US (1) US6090820A (es)
EP (1) EP0828741B1 (es)
JP (1) JPH11506430A (es)
KR (1) KR100463771B1 (es)
CN (2) CN1068328C (es)
AT (1) ATE204874T1 (es)
AU (1) AU702752B2 (es)
CA (1) CA2218088A1 (es)
DE (1) DE69614847T2 (es)
DK (1) DK0828741T3 (es)
ES (1) ES2162047T3 (es)
FI (1) FI974180A0 (es)
HK (1) HK1042093A1 (es)
MX (1) MX9708627A (es)
NO (1) NO311298B1 (es)
NZ (1) NZ306310A (es)
PT (1) PT828741E (es)
WO (1) WO1996035691A1 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1019385E (pt) * 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
PT892792E (pt) * 1996-04-11 2002-05-31 Upjohn Co Processo para a preparacao de oxazolidinonas
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
KR100467309B1 (ko) * 1997-09-04 2005-07-18 씨제이 주식회사 옥사졸리디논유도체및그의제조방법및항균제조성물
KR100463111B1 (ko) * 1997-10-30 2005-06-13 씨제이 주식회사 신규한옥사졸리디논유도체및제조방법및그를함유하는항균제조성물
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
KR20010052615A (ko) 1998-06-05 2001-06-25 다비드 에 질레스 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6413981B1 (en) * 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ITVA20000023A1 (it) * 2000-07-19 2002-01-19 Lamberti Spa Composizioni di pvc stabili al calore.
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
MXPA03008109A (es) 2001-03-07 2003-12-12 Pfizer Prod Inc Moduladores de la actividad de receptores de quimiocinas.
CA2463794A1 (en) * 2001-11-29 2003-06-12 Merck & Co., Inc. Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
WO2004014897A1 (en) 2002-08-12 2004-02-19 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
KR100454099B1 (ko) * 2002-08-22 2004-10-26 한국화학연구원 제초활성을 갖는9-(5-이속사졸린메톡시페닐)이미노-8-치아-1,6-디아자비시클로[4.3.0]노난-7-온 유도체
WO2004045616A1 (en) 2002-11-21 2004-06-03 Pharmacia & Upjohn Company Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
EP1646629B1 (en) 2003-07-02 2010-06-23 Merck Sharp & Dohme Corp. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
EP1671972A1 (en) * 2004-11-24 2006-06-21 Pfizer Limited Octahydropyrrolo[3,4-c]pyrrole derivatives
JP2008520644A (ja) * 2004-11-24 2008-06-19 ファイザー・インク オクタヒドロピロロ［３，４−ｃ］ピロール誘導体
KR100729344B1 (ko) * 2006-02-16 2007-06-15 스마텍(주) 차량용 사방 감지 카메라의 보호 및 작동 구조
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
RU2486187C2 (ru) 2007-09-11 2013-06-27 Эбботт Лэборетриз N-ОКСИДЫ ОКТАГИДРО-ПИРРОЛО[3,4-b]ПИРРОЛА
CN102224151A (zh) 2008-11-20 2011-10-19 万能药生物有限公司 新的抗微生物剂
MX2012000231A (es) 2009-06-26 2012-03-07 Panacea Biotec Ltd Nuevos aza-biciclo-hexanos.
KR20130102614A (ko) 2010-11-03 2013-09-17 욱크하르트 리미티드 인산 모노-(1-[4-[(s)-5-(아세틸아미노메틸)-2-옥소-옥사졸리딘-3-일]-2,6-디플루오로페닐]-4-메톡시메틸피페리딘-4-일) 에스테르의 제조 방법
KR101271224B1 (ko) 2011-07-05 2013-06-10 한국과학기술연구원 항균활성을 갖는 신규 이중고리를 포함하는 옥사졸리디논 유도체 및 이의 제조방법
CN103030634B (zh) * 2011-09-30 2015-07-15 山东轩竹医药科技有限公司 含有并环的噁唑烷酮类抗菌素
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
EP4074378A1 (en) 2015-07-02 2022-10-19 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
CN113603683B (zh) 2015-07-17 2024-06-14 结核病药物开发全球联盟公司 用于抗微生物治疗的经取代苯基噁唑烷酮
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
EA201990043A1 (ru) * 2016-06-16 2019-05-31 Янссен Сайенсиз Айрлэнд Анлимитед Компани Антибактериальные соединения
EP4417262A3 (en) 2017-03-01 2024-11-27 Janssen Sciences Ireland Unlimited Company Combination therapy
CN108727406B (zh) 2017-03-28 2021-12-07 北京协和制药二厂 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
ES2059467T3 (es) * 1987-10-21 1994-11-16 Du Pont Merck Pharma Derivados de aminometil-oxooxazolidinil-etenilbenceno utiles como agentes antibacterianos.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
ATE112773T1 (de) * 1988-09-15 1994-10-15 Upjohn Co 5-indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(nitrogen- substituierte)phenyl-5-beta-amidomethyloxazolid n-2-one.
AU667198B2 (en) * 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物

Also Published As

Publication number Publication date
CA2218088A1 (en) 1996-11-14
DE69614847T2 (de) 2002-04-04
WO1996035691A1 (en) 1996-11-14
KR19990008399A (ko) 1999-01-25
JPH11506430A (ja) 1999-06-08
NO975158L (no) 1998-01-09
FI974180L (fi) 1997-11-10
MX9708627A (es) 1998-02-28
EP0828741A1 (en) 1998-03-18
CN1068328C (zh) 2001-07-11
AU702752B2 (en) 1999-03-04
FI974180A7 (fi) 1997-11-10
NO311298B1 (no) 2001-11-12
ATE204874T1 (de) 2001-09-15
DE69614847D1 (de) 2001-10-04
EP0828741B1 (en) 2001-08-29
US6090820A (en) 2000-07-18
HK1009449A1 (en) 1999-09-10
CN1336375A (zh) 2002-02-20
NZ306310A (en) 2001-05-25
NO975158D0 (no) 1997-11-10
FI974180A0 (fi) 1997-11-10
KR100463771B1 (ko) 2005-05-16
HK1042093A1 (zh) 2002-08-02
PT828741E (pt) 2002-02-28
AU5484996A (en) 1996-11-29
DK0828741T3 (da) 2001-11-26
CN1184481A (zh) 1998-06-10

Similar Documents

Publication Publication Date Title
MX9708627A (es) Oxazolidinonas de diazinilo y carbazinilo espirociclicas y biciclicas.
YU26691A (sh) BORNO KISELINSKI ADUKTI RENIJUM DIOKSIM I TEHNICIJUM-99 m DIOKSIM KOMPLEKSA I PRIBOR ZA MARKIRANJE SA TEHNICIJUMOM 99 m I/ILI RADIONUKLEIDOM RENIJUMA
FI960182A7 (fi) Herbisidisesti aktiivisia, substituoituja 2-fuusioituja fenyylipyridii nejä
GT199600026A (es) Isotiazolonas
ATE268547T1 (de) Auf tensiden basierende antimikrobielle zusammensetzungen und verfahren zu ihrer verwendung
ES2082875T3 (es) 3,5-di-terc-butil-4-hidroxifenilmetileno-derivados de tiazolidinonas, oxazolidinonas e imidazolidinonas 2-sustituidas utiles como agentes antiinflamatorios.
FI963070A0 (fi) Klooripyrimidiinivälituotteita
TR199700213A2 (xx) 2-Aril s�bstit�entli piridinler.
DK0569505T3 (da) 3-Difluormethylpyrazolcarboxamidfungicider
NL300203I2 (nl) Antiviraal werkzame heterocyclische azahexaan-derivaten.
UY24006A1 (es) Derivado del 2-(2-amino -1,6-dihidro-6-oxo-purin-9-il)metoxil-1,3-propanodiol.
DE3873839D1 (de) Mos-leistungstransistoranordnung.
FI912714L (fi) Hoelje foer batteri i armbandsur.
DE69113571D1 (de) MIS-Transistor mit Heteroübergang.
DK0841851T3 (da) Svampedræbende blandinger
BR0115121A (pt) Compostos n-((1,2,4)triazoloazinil)tiofenossulfonamida como herbicidas
ES2194971T3 (es) Derivados del pirazol.
TR199900065T2 (xx) İkame etmiş pirazolil-pirazol türevleri
DE4481032D2 (de) Niedertemperatur-Wärmekraftmaschine, Niedertemperaturmotor NTM bzw. Tieftemperaturmotor
IT1241693B (it) Dispositivo di alimentazione, in particolare per motori endotermici
FI945164A7 (fi) Biologisesti aktiivisesti ureidojohdannaiset, jotka ovat käyttökelpoisia antimetastaattisina aineina
ES2175006T3 (es) N-(pirimidinil)-benzosulfonamidas como medicamentos.
MX9708510A (es) Tetralinas.
ES2148600T3 (es) Derivados de indol sustituidos.
FI911258A0 (fi) Foer kylmaskin, i synnerhet foer hushaollskylskaop avsedd plaotkondensator.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 828741

Country of ref document: ES