ATE205496T1 - Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel - Google Patents

Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel

Info

Publication number
ATE205496T1
ATE205496T1 AT93903553T AT93903553T ATE205496T1 AT E205496 T1 ATE205496 T1 AT E205496T1 AT 93903553 T AT93903553 T AT 93903553T AT 93903553 T AT93903553 T AT 93903553T AT E205496 T1 ATE205496 T1 AT E205496T1
Authority
AT
Austria
Prior art keywords
pct
desosamino
macrolids
immunosuppressive
derivatives
Prior art date
Application number
AT93903553T
Other languages
English (en)
Inventor
James R Hauske
Gary R Schulte
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE205496T1 publication Critical patent/ATE205496T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT93903553T 1992-03-02 1993-01-27 Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel ATE205496T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84435092A 1992-03-02 1992-03-02
PCT/US1993/000426 WO1993018042A1 (en) 1992-03-02 1993-01-27 Desosamino derivatives of macrolides as immunosuppressants and antifungal agents

Publications (1)

Publication Number Publication Date
ATE205496T1 true ATE205496T1 (de) 2001-09-15

Family

ID=25292478

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93903553T ATE205496T1 (de) 1992-03-02 1993-01-27 Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel

Country Status (12)

Country Link
US (2) US5506233A (de)
EP (1) EP0629203B1 (de)
JP (1) JPH07500613A (de)
AT (1) ATE205496T1 (de)
CA (1) CA2131371A1 (de)
DE (1) DE69330747T2 (de)
DK (1) DK0629203T3 (de)
ES (1) ES2160593T3 (de)
FI (1) FI944014A0 (de)
GR (1) GR3037059T3 (de)
PT (1) PT629203E (de)
WO (1) WO1993018042A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2182004C1 (ru) * 2001-02-22 2002-05-10 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Лекарственный препарат для парентерального применения
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1474404A4 (de) * 2002-02-13 2006-01-11 Biogal Gyogyszergyar Verfahren zur extraktion eines makrolids aus biologischem material
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
KR20050114262A (ko) * 2003-03-31 2005-12-05 테바 기오기스제르갸르 레스즈베니타르사사그 마크로라이드의 결정화 및 정제
US7160867B2 (en) * 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
EP1558622B1 (de) * 2003-07-24 2007-11-14 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Verfahren zur aufreinigung von makroliden
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
TW200637835A (en) * 2004-12-22 2006-11-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying tacrolimus
WO2006083486A1 (en) * 2005-01-05 2006-08-10 TEVA GYÓGYSZERGYÁR ZÁRTKöR..EN M..k..D.. RÉSZVÉNYTÁRSASÁG Amorphous tacrolimus and preparation thereof
EP2671508B1 (de) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-Informatiksystem
US20080000834A1 (en) * 2006-03-15 2008-01-03 Ladislav Cvak Process for purifying Tacrolimus
JP2009203162A (ja) * 2006-06-05 2009-09-10 Astellas Pharma Inc マクロライド化合物の新規製造法
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
WO1991002736A1 (en) * 1989-08-18 1991-03-07 Fisons Plc Macrocyclic compounds
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
EP0466365A3 (en) * 1990-07-03 1992-04-15 Merck & Co. Inc. Novel immunosuppressant fermentation products of a microorganism

Also Published As

Publication number Publication date
WO1993018042A1 (en) 1993-09-16
DK0629203T3 (da) 2001-11-12
JPH07500613A (ja) 1995-01-19
PT629203E (pt) 2002-01-30
CA2131371A1 (en) 1993-09-16
GR3037059T3 (en) 2002-01-31
US5506233A (en) 1996-04-09
ES2160593T3 (es) 2001-11-16
FI944014A7 (fi) 1994-09-01
DE69330747D1 (de) 2001-10-18
US5563135A (en) 1996-10-08
DE69330747T2 (de) 2002-05-29
FI944014L (fi) 1994-09-01
EP0629203B1 (de) 2001-09-12
FI944014A0 (fi) 1994-09-01
EP0629203A1 (de) 1994-12-21

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Legal Events

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REN Ceased due to non-payment of the annual fee