ATE205496T1 - Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel - Google Patents

Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel

Info

Publication number
ATE205496T1
ATE205496T1 AT93903553T AT93903553T ATE205496T1 AT E205496 T1 ATE205496 T1 AT E205496T1 AT 93903553 T AT93903553 T AT 93903553T AT 93903553 T AT93903553 T AT 93903553T AT E205496 T1 ATE205496 T1 AT E205496T1
Authority
AT
Austria
Prior art keywords
pct
desosamino
macrolids
immunosuppressive
derivatives
Prior art date
Application number
AT93903553T
Other languages
English (en)
Inventor
James R Hauske
Gary R Schulte
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE205496T1 publication Critical patent/ATE205496T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93903553T 1992-03-02 1993-01-27 Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel ATE205496T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84435092A 1992-03-02 1992-03-02
PCT/US1993/000426 WO1993018042A1 (en) 1992-03-02 1993-01-27 Desosamino derivatives of macrolides as immunosuppressants and antifungal agents

Publications (1)

Publication Number Publication Date
ATE205496T1 true ATE205496T1 (de) 2001-09-15

Family

ID=25292478

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93903553T ATE205496T1 (de) 1992-03-02 1993-01-27 Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel

Country Status (12)

Country Link
US (2) US5506233A (de)
EP (1) EP0629203B1 (de)
JP (1) JPH07500613A (de)
AT (1) ATE205496T1 (de)
CA (1) CA2131371A1 (de)
DE (1) DE69330747T2 (de)
DK (1) DK0629203T3 (de)
ES (1) ES2160593T3 (de)
FI (1) FI944014L (de)
GR (1) GR3037059T3 (de)
PT (1) PT629203E (de)
WO (1) WO1993018042A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2182004C1 (ru) * 2001-02-22 2002-05-10 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Лекарственный препарат для парентерального применения
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JP4261365B2 (ja) * 2002-02-13 2009-04-30 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 生物学的物質からのマクロライドの抽出方法
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
WO2004089958A2 (en) * 2003-03-31 2004-10-21 TEVA Gyógyszergyár Részvénytársaság Crystallization and purification of macrolides
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
US7160867B2 (en) * 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
ATE378345T1 (de) * 2003-07-24 2007-11-15 Teva Gyogyszergyar Zartkoeruee Verfahren zur aufreinigung von makroliden
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
WO2006069386A1 (en) * 2004-12-22 2006-06-29 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying tacrolimus
CA2588480A1 (en) * 2005-01-05 2006-08-10 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous tacrolimus and preparation thereof
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
US20080000834A1 (en) * 2006-03-15 2008-01-03 Ladislav Cvak Process for purifying Tacrolimus
JP2009203162A (ja) * 2006-06-05 2009-09-10 Astellas Pharma Inc マクロライド化合物の新規製造法
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
AU6286690A (en) * 1989-08-18 1991-04-03 Fisons Plc Macrocyclic compounds
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
EP0466365A3 (en) * 1990-07-03 1992-04-15 Merck & Co. Inc. Novel immunosuppressant fermentation products of a microorganism

Also Published As

Publication number Publication date
ES2160593T3 (es) 2001-11-16
GR3037059T3 (en) 2002-01-31
CA2131371A1 (en) 1993-09-16
US5563135A (en) 1996-10-08
FI944014A7 (fi) 1994-09-01
US5506233A (en) 1996-04-09
EP0629203A1 (de) 1994-12-21
DE69330747T2 (de) 2002-05-29
EP0629203B1 (de) 2001-09-12
JPH07500613A (ja) 1995-01-19
PT629203E (pt) 2002-01-30
DK0629203T3 (da) 2001-11-12
DE69330747D1 (de) 2001-10-18
WO1993018042A1 (en) 1993-09-16
FI944014A0 (fi) 1994-09-01
FI944014L (fi) 1994-09-01

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Legal Events

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REN Ceased due to non-payment of the annual fee