DK0629203T3 - Desosaminoderivater af makrolider som immunosuppressive midler og antifungale midler - Google Patents

Desosaminoderivater af makrolider som immunosuppressive midler og antifungale midler

Info

Publication number: DK0629203T3
Authority: DK; Denmark
Prior art keywords: macrolides; pct; immunosuppressants; antifungal agents; desosamine
Prior art date: 1992-03-02

Application number

DK93903553T

Other languages

Danish (da)

English (en)

Inventor

R Hauske James

R Schulte Gary

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-02

Filing date

1993-01-27

Publication date

2001-11-12

1993-01-27 Application filed by Pfizer filed Critical Pfizer

2001-11-12 Application granted granted Critical

2001-11-12 Publication of DK0629203T3 publication Critical patent/DK0629203T3/da

Links

239000003120 macrolide antibiotic agent Substances 0.000 title abstract 3
229940041033 macrolides Drugs 0.000 title abstract 3
229940121375 antifungal agent Drugs 0.000 title 1
239000003429 antifungal agent Substances 0.000 title 1
VTJCSBJRQLZNHE-CSMHCCOUSA-N desosamine Chemical class C[C@@H](O)C[C@H](N(C)C)[C@@H](O)C=O VTJCSBJRQLZNHE-CSMHCCOUSA-N 0.000 title 1
229960003444 immunosuppressant agent Drugs 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010017533 Fungal infection Diseases 0.000 abstract 1
208000031888 Mycoses Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK93903553T 1992-03-02 1993-01-27 Desosaminoderivater af makrolider som immunosuppressive midler og antifungale midler DK0629203T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US84435092A	1992-03-02	1992-03-02
PCT/US1993/000426 WO1993018042A1 (en)	1992-03-02	1993-01-27	Desosamino derivatives of macrolides as immunosuppressants and antifungal agents

Publications (1)

Publication Number	Publication Date
DK0629203T3 true DK0629203T3 (da)	2001-11-12

Family

ID=25292478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93903553T DK0629203T3 (da)	1992-03-02	1993-01-27	Desosaminoderivater af makrolider som immunosuppressive midler og antifungale midler

Country Status (12)

Country	Link
US (2)	US5506233A (de)
EP (1)	EP0629203B1 (de)
JP (1)	JPH07500613A (de)
AT (1)	ATE205496T1 (de)
CA (1)	CA2131371A1 (de)
DE (1)	DE69330747T2 (de)
DK (1)	DK0629203T3 (de)
ES (1)	ES2160593T3 (de)
FI (1)	FI944014A0 (de)
GR (1)	GR3037059T3 (de)
PT (1)	PT629203E (de)
WO (1)	WO1993018042A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2182004C1 (ru) *	2001-02-22	2002-05-10	Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан"	Лекарственный препарат для парентерального применения
CA2450073C (en)	2001-07-25	2017-08-29	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
EP1474404A4 (de) *	2002-02-13	2006-01-11	Biogal Gyogyszergyar	Verfahren zur extraktion eines makrolids aus biologischem material
US7452692B2 (en) *	2002-02-13	2008-11-18	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Method for extracting a macrolide from biomatter
US20060169199A1 (en) *	2003-03-31	2006-08-03	Vilmos Keri	Crystallization and purification of macrolides
KR20050114262A (ko) *	2003-03-31	2005-12-05	테바 기오기스제르갸르 레스즈베니타르사사그	마크로라이드의 결정화 및 정제
US7160867B2 (en) *	2003-05-16	2007-01-09	Isotechnika, Inc.	Rapamycin carbohydrate derivatives
EP1558622B1 (de) *	2003-07-24	2007-11-14	TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Verfahren zur aufreinigung von makroliden
EP1768662A2 (de)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Immunstimulatoren kleiner moleküle und assays für deren nachweis
TW200637835A (en) *	2004-12-22	2006-11-01	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Method of purifying tacrolimus
WO2006083486A1 (en) *	2005-01-05	2006-08-10	TEVA GYÓGYSZERGYÁR ZÁRTKöR..EN M..k..D.. RÉSZVÉNYTÁRSASÁG	Amorphous tacrolimus and preparation thereof
EP2671508B1 (de)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-Informatiksystem
US20080000834A1 (en) *	2006-03-15	2008-01-03	Ladislav Cvak	Process for purifying Tacrolimus
JP2009203162A (ja) *	2006-06-05	2009-09-10	Astellas Pharma Inc	マクロライド化合物の新規製造法
JP2010503710A (ja)	2006-09-18	2010-02-04	ラプトールファーマシューティカルインコーポレイテッド	受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4894366A (en) *	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
WO1991002736A1 (en) *	1989-08-18	1991-03-07	Fisons Plc	Macrocyclic compounds
IE904050A1 (en) *	1989-11-13	1991-05-22	Merck & Co Inc	Aminomacrolides and derivatives having immunosuppressive¹activity
EP0466365A3 (en) *	1990-07-03	1992-04-15	Merck & Co. Inc.	Novel immunosuppressant fermentation products of a microorganism

1993
- 1993-01-27 FI FI944014A patent/FI944014A0/fi unknown
- 1993-01-27 JP JP5515658A patent/JPH07500613A/ja active Pending
- 1993-01-27 PT PT93903553T patent/PT629203E/pt unknown
- 1993-01-27 DE DE69330747T patent/DE69330747T2/de not_active Expired - Fee Related
- 1993-01-27 DK DK93903553T patent/DK0629203T3/da active
- 1993-01-27 ES ES93903553T patent/ES2160593T3/es not_active Expired - Lifetime
- 1993-01-27 EP EP93903553A patent/EP0629203B1/de not_active Expired - Lifetime
- 1993-01-27 WO PCT/US1993/000426 patent/WO1993018042A1/en not_active Ceased
- 1993-01-27 AT AT93903553T patent/ATE205496T1/de not_active IP Right Cessation
- 1993-01-27 US US08/284,526 patent/US5506233A/en not_active Expired - Fee Related
- 1993-01-27 CA CA002131371A patent/CA2131371A1/en not_active Abandoned
1995
- 1995-06-01 US US08/457,957 patent/US5563135A/en not_active Expired - Fee Related
2001
- 2001-10-30 GR GR20010401931T patent/GR3037059T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1993018042A1 (en)	1993-09-16
JPH07500613A (ja)	1995-01-19
PT629203E (pt)	2002-01-30
CA2131371A1 (en)	1993-09-16
GR3037059T3 (en)	2002-01-31
ATE205496T1 (de)	2001-09-15
US5506233A (en)	1996-04-09
ES2160593T3 (es)	2001-11-16
FI944014A7 (fi)	1994-09-01
DE69330747D1 (de)	2001-10-18
US5563135A (en)	1996-10-08
DE69330747T2 (de)	2002-05-29
FI944014L (fi)	1994-09-01
EP0629203B1 (de)	2001-09-12
FI944014A0 (fi)	1994-09-01
EP0629203A1 (de)	1994-12-21

Publication	Publication Date	Title
FI944014A0 (fi)	1994-09-01	Makrolidien desosaminojohdannaiset immuunivastetta heikentävinä aineina ja sieniä vastustavina aineina
DE69622031D1 (de)	2002-08-01	INDOLDERIVATE ALS cGMP-PDE INHIBITOREN
NO961345L (no)	1996-06-03	O-aryl, O-alkyl-, O-alkenyl- og O-alkynylmakrolider med immunundertrykkende aktivitet
TW349843B (en)	1999-01-11	Substituted 1-arylpyrazoles
NO20020758L (no)	1999-02-19	N<o>6</o> heterocykliske substituerte adenosinderivater
ATE198708T1 (de)	2001-02-15	Verwendung von makrolid-verbindungen gegen augenerkrankungen
DE69114649D1 (de)	1995-12-21	In-line Gas/Flüssigkeitsdispersion.
DK137793A (da)	1994-06-10	Ekstrakter af Cucurbita Sp., fremgangsmåde til fremstilling og anvendelse af disse i lægemidler og kosmetiske præparater
FI944537L (fi)	1995-03-31	Rapamysiinikoostumus i.v.-ruiskeeksi
FR2678271B1 (fr)	1995-01-13	Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
DE69427286D1 (de)	2001-06-28	7,42-bis (o-demethyl)rapamycin
MX9401406A (es)	1994-08-31	Agentes receptores de adenosina selectivos para intensificar el conocimiento.
ATE179977T1 (de)	1999-05-15	Herbizide pyridinverbindungen
ZA991546B (en)	1999-08-25	Streptogramin derivatives, their preparation and compositions containing them.
NO20003397L (no)	2000-08-31	3 '-epimerie K-252A-derivater
DK0512754T3 (da)	2000-09-18	Reduktionsprodukter af rapamycin som immunosuppressive, antiinflammatoriske og antifungale midler
ITBZ940003V0 (it)	1994-02-07	Gruppo costruttivo per cassetti.
NO980654D0 (no)	1998-02-16	Fremgangsmåte for bekjempelse av fiskemykoser og encellete ektoparasitter
FI914839A0 (fi)	1991-10-14	Effektkrets foer anslutna spaenningsinverterare, vilken har (2*n+l) spaenningsnivaoer.
ATE159725T1 (de)	1997-11-15	2-aminozuckermakrolid-derivate
FR2661829B1 (fr)	1994-10-21	Nouvelles compositions hydratantes et protectrices pour le bronzage notamment sans soleil.
ATE153027T1 (de)	1997-05-15	Zuckerderivate von makroliden
Hammett	1999	The Great Commission and Evangelism in the New Testament
IT1268098B1 (it)	1997-02-20	Gruppo di condotti ottici, particolarmente per equipaggiamenti di bordo.
Hall	1983	Twenty Bright Suspected Variables