ATE223898T1 - N-oxide von 4-arylpiperazinen und 4- arylpiperidinen als antipsychotische medikamente - Google Patents

N-oxide von 4-arylpiperazinen und 4- arylpiperidinen als antipsychotische medikamente

Info

Publication number
ATE223898T1
ATE223898T1 AT95906100T AT95906100T ATE223898T1 AT E223898 T1 ATE223898 T1 AT E223898T1 AT 95906100 T AT95906100 T AT 95906100T AT 95906100 T AT95906100 T AT 95906100T AT E223898 T1 ATE223898 T1 AT E223898T1
Authority
AT
Austria
Prior art keywords
arylpiperidines
arylpiperazines
oxides
antipsychotic drugs
antipsychotic
Prior art date
Application number
AT95906100T
Other languages
English (en)
Inventor
Allen B Reitz
Mark E Mcdonnell
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Application granted granted Critical
Publication of ATE223898T1 publication Critical patent/ATE223898T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95906100T 1993-12-23 1994-12-22 N-oxide von 4-arylpiperazinen und 4- arylpiperidinen als antipsychotische medikamente ATE223898T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17338293A 1993-12-23 1993-12-23
PCT/US1994/014850 WO1995017385A1 (en) 1993-12-23 1994-12-22 N-oxides of 4-arylpiperazines and 4-arylpiperidines as antipsychotic drugs

Publications (1)

Publication Number Publication Date
ATE223898T1 true ATE223898T1 (de) 2002-09-15

Family

ID=22631753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95906100T ATE223898T1 (de) 1993-12-23 1994-12-22 N-oxide von 4-arylpiperazinen und 4- arylpiperidinen als antipsychotische medikamente

Country Status (16)

Country Link
EP (1) EP0736009B1 (de)
JP (1) JPH09507077A (de)
AT (1) ATE223898T1 (de)
AU (1) AU687501B2 (de)
CA (1) CA2179735A1 (de)
DE (1) DE69431360T2 (de)
DK (1) DK0736009T3 (de)
ES (1) ES2183862T3 (de)
IL (1) IL112099A (de)
MX (1) MX9500228A (de)
NZ (1) NZ278261A (de)
PT (1) PT736009E (de)
RU (1) RU2123001C1 (de)
SI (1) SI0736009T1 (de)
WO (1) WO1995017385A1 (de)
ZA (1) ZA9410287B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2139857C1 (ru) * 1994-08-18 1999-10-20 Пфайзер Инк. Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
RU2119336C1 (ru) * 1995-12-20 1998-09-27 Валерий Ксенофонтович Смирнов Способ лечения шизофрении у женщин
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
AU7773801A (en) * 2000-08-11 2002-02-25 Ono Pharmaceutical Co Piperidine derivatives and drugs containing these derivatives as the active ingredient
SI1631557T1 (sl) 2003-06-12 2007-06-30 Btg Int Ltd Cikličen hidroksilamin kot psihoaktivne spojine
MX2009011020A (es) * 2007-04-12 2009-10-30 Nsab Af Neurosearch Sweden Ab Derivados de n-oxido y/o di-n-oxido de los estabilizadores/modulad ores del receptor de dopamina que exhiben perfiles mejorados de los efectos secundarios cardiovasculares.
EP2787997A4 (de) 2011-12-08 2015-05-27 Ivax Int Gmbh Hydrobromidsalz von pridopidin
BR112014024672A8 (pt) 2012-04-04 2018-04-03 Ivax Int Gmbh Composições farmacêuticas para terapia de combinação
WO2016106142A1 (en) 2014-12-22 2016-06-30 Teva Pharmaceuticals International Gmbh L-tartrate salt of pridopidine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
DK161148C (da) * 1988-06-14 1991-11-18 Novo Nordisk As Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne
DE10299048I2 (de) * 1989-04-14 2006-07-13 Merz Pharma Gmbh & Co Kgaa Verwendung von Adamantan-Derivaten zur Pr{vention und Behandlung der cerebralen Isch{mie
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
FR2697251B1 (fr) * 1992-10-22 1994-12-02 Synthelabo N-oxydes de dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl] pipéridin-1-yl]éthanol, leur procédé de préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
SI0736009T1 (en) 2003-04-30
EP0736009B1 (de) 2002-09-11
IL112099A0 (en) 1995-03-15
DE69431360D1 (de) 2002-10-17
WO1995017385A1 (en) 1995-06-29
AU687501B2 (en) 1998-02-26
DK0736009T3 (da) 2002-10-07
PT736009E (pt) 2003-01-31
NZ278261A (en) 1998-08-26
RU2123001C1 (ru) 1998-12-10
AU1444695A (en) 1995-07-10
ES2183862T3 (es) 2003-04-01
MX9500228A (es) 1997-02-28
CA2179735A1 (en) 1995-06-29
DE69431360T2 (de) 2003-01-23
IL112099A (en) 1999-07-14
JPH09507077A (ja) 1997-07-15
ZA9410287B (en) 1996-06-24
EP0736009A1 (de) 1996-10-09

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee